Structural Classification of Proteins
home mail help root up expand collapse

Fold: P-loop containing nucleoside triphosphate hydrolases

3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: P-loop containing nucleoside triphosphate hydrolases [52539]
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

Superfamilies:

  1. P-loop containing nucleoside triphosphate hydrolases [52540] (24)
    division into families based on beta-sheet topologies
    link to SUPERFAMILY database - Superfamily
    1. Nucleotide and nucleoside kinases [52541] (46)
      parallel beta-sheet of 5 strands, order 23145
      1. Guanylate kinase [52542]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52543] (3) picpic
        2. Mouse (Mus musculus) [TaxId: 10090] [82393] (1) picpic
        3. Escherichia coli [TaxId: 562] [102338] (18) picpic
        4. Mycobacterium tuberculosis [TaxId: 1773] [102339] (5) picpic
          Rv1389
      2. Guanylate kinase-like domain of Cask [69474]
        1. Human (Homo sapiens) [TaxId: 9606] [69475] (1) picpic
      3. Guanylate kinase-like domain of Psd-95 [69476]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [69477] (3) picpic
      4. Uridylate kinase [52544]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52545] (2) picpic
      5. Deoxynucleoside monophosphate kinase [52546]
        contains insert 4-helical bundle subdomain, residues 35-145
        1. Bacteriophage T4 [TaxId: 10665] [52547] (2) picpic
      6. Deoxyribonucleoside kinase [69478]
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [69479] (37) picpic
      7. Deoxycytidine kinase [89657]
        1. Human (Homo sapiens) [TaxId: 9606] [89658] (13) picpic
      8. Deoxyguanosine kinase [69480]
        1. Human (Homo sapiens) [TaxId: 9606] [69481] (8) picpic
      9. CMP kinase [52548]
        1. Escherichia coli [TaxId: 562] [52549] (6) picpic
        2. Streptococcus pneumoniae [TaxId: 1313] [110525] (1) picpic
          SQ Q97PK6
      10. UMP/CMP kinase [52550]
        1. Dictyostelium discoideum [TaxId: 44689] [52551] (6) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [110526] (1) picpic
          SQ P30085
      11. Thymidine kinase [52552]
        contains insert all-alpha subdomain, res. 251-322
        1. Herpes simplex virus type 1, different strains [TaxId: 10298] [52553] (22) picpic
          SQ P03176 46-375
        2. Equine herpesvirus type 4 [TaxId: 10331] [102340] (4) picpic
        3. Varicella-zoster virus [TaxId: 10335] [89659] (1) picpic
      12. Adenylate kinase [52554]
        1. Pig (Sus scrofa) [TaxId: 9823] [52555] (1) picpic
        2. Archaeon Sulfolobus acidocaldarius [TaxId: 2285] [52556] (1) picpic
        3. Archaeon Methanococcus voltae [TaxId: 2188] [89660] (1) picpic
        4. Archaeon Methanococcus thermolithotrophicus [TaxId: 2186] [89661] (1) picpic
        5. Cow (Bos taurus), mitochondrial izozyme-3 [TaxId: 9913] [52557] (1) picpic
          contains a rudiment "zinc-finger" subdomain, residue 125-161
        6. Cow (Bos taurus), mitochondrial izozyme-2 [TaxId: 9913] [52558] (2) picpic
          contains a rudiment "zinc-finger" subdomain, residue 147-176
        7. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52559] (4) picpic
          contains a rudiment "zinc-finger" subdomain, residue 131-168
        8. Escherichia coli [TaxId: 562] [52560] (6) picpic
          contains a rudiment "zinc-finger" subdomain, residue 122-156
        9. Maize (Zea mays) [TaxId: 4577] [52561] (1) picpic
        10. Bacillus stearothermophilus [TaxId: 1422] [52562] (3) picpic
          contains a zinc-finger subdomain, residues 126-160
        11. Bacillus subtilis [TaxId: 1423] [102341] (1) picpic
          contains a zinc-finger subdomain, residues 126-160
        12. Bacillus globisporus [TaxId: 1459] [102342] (1) picpic
          contains a zinc-finger subdomain, residues 126-160
        13. Mycobacterium tuberculosis [TaxId: 1773] [102343] (2) picpic
          contains no zinc finger-like insertion
        14. Human (Homo sapiens), isoenzyme 6 [TaxId: 9606] [117527] (1) picpic
          SQ Q9Y3D8
      13. Thymidylate kinase [52563]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52564] (3) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [64010] (20) picpic
        3. Escherichia coli [TaxId: 562] [52565] (2) picpic
        4. Mycobacterium tuberculosis [TaxId: 1773] [69482] (13) picpic
      14. Dephospho-CoA kinase [75187]
        1. Haemophilus influenzae [TaxId: 727] [75188] (1) picpic
        2. Escherichia coli [TaxId: 562] [82394] (5) picpic
        3. Thermus thermophilus [TaxId: 274] [102344] (1) picpic
          TT1252
      15. Transcriptional regulator NadR, ribosylnicotinamide kinase domain [75189]
        1. Haemophilus influenzae [TaxId: 727] [75190] (1) picpic
      16. Polynucleotide kinase, kinase domain [75191]
        1. Bacteriophage T4 [TaxId: 10665] [75192] (17) picpic
      17. Guanylate kinase-like domain of the L-type calcium channel [110527]
        1. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [110528] (4) picpic
          SQ P54288 234-451
        2. Rat (Rattus norvegicus) [TaxId: 10116] [110529] (3) picpic
          SQ P54287 38-362
      18. Probable kinase LmjF30.1890 [117528]
        1. Leishmania major [TaxId: 5664] [117529] (1) picpic
          SQ Q4Q7A6
      19. Hypothetical protein YorR [142211]
        1. Bacillus subtilis [TaxId: 1423] [142212] (2) picpic
          SQ O31896 2-165
      20. 5' polynucleotide kinase-3' phosphatase, C-terminal domain [142213]
        1. Mouse (Mus musculus) [TaxId: 10090] [142214] (2) picpic
          SQ Q9JLV6 351-522
    2. Shikimate kinase (AroK) [52566] (4)
      similar to the nucleotide/nucleoside kinases but acts on different substrate
      1. Shikimate kinase (AroK) [52567]
        1. Escherichia coli [TaxId: 562] [75193] (1) picpic
        2. Erwinia chrysanthemi [TaxId: 556] [52568] (3) picpic
        3. Mycobacterium tuberculosis [TaxId: 1773] [75194] (24) picpic
          SQ P95014
        4. Campylobacter jejuni [TaxId: 197] [102345] (1) picpic
    3. Chloramphenicol phosphotransferase [52569] (1)
      similar to the nucleotide/nucleoside kinases but acts on different substrate
      1. Chloramphenicol phosphotransferase [52570]
        1. Streptomyces venezuelae [TaxId: 54571] [52571] (6) picpic
    4. Gluconate kinase [75195] (1)
      similar to the nucleotide/nucleoside kinases
      1. Gluconate kinase [75196]
        1. Escherichia coli [TaxId: 562] [75197] (6) picpic
    5. Plasmid maintenance system epsilon/zeta, toxin zeta subunit [82395] (1)
      similar to the nucleotide/nucleoside kinases; extra N- and C-terminal structures
      1. Plasmid maintenance system epsilon/zeta, toxin zeta subunit [82396]
        1. Streptococcus pyogenes [TaxId: 1314] [82397] (1) picpic
    6. Adenosine-5'phosphosulfate kinase (APS kinase) [52572] (2)
      1. Adenosine-5'phosphosulfate kinase (APS kinase) [52573]
        1. Fungus (Penicillium chrysogenum) [TaxId: 5076] [52574] (3) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [142215] (6) picpic
          SQ O43252 34-228
    7. ATP sulfurylase C-terminal domain [64011] (2)
      1. ATP sulfurylase C-terminal domain [64012]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [64013] (7) picpic
        2. Fungus (Penicillium chrysogenum) [TaxId: 5076] [64014] (2) picpic
    8. PAPS sulfotransferase [52575] (15)
      Pfam 00685
      similar to the nucleotide/nucleoside kinases but transfer sulphate group
      1. Estrogen sulfotransferase (STE, sult1e1) [52576]
        1. Mouse (Mus musculus) [TaxId: 10090] [52577] (3) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [75198] (2) picpic
      2. Hydroxysteroid sulfotransferase sult2a1 [52578]
        1. Human (Homo sapiens) [TaxId: 9606] [52579] (3) picpic
      3. Aryl sulfotransferase sult1a [102346]
        1. Human (Homo sapiens) [TaxId: 9606] [102347] (3) picpic
      4. Aryl sulfotransferase sult1a3 [52580]
        1. Human (Homo sapiens) [TaxId: 9606] [52581] (3) picpic
      5. Pregnenolone sulfotransferase sult2b1a [102348]
        1. Human (Homo sapiens) [TaxId: 9606] [102349] (1) picpic
          cytosolic enzyme
      6. Cholesterol sulfotransferase sult2b1b [102350]
        1. Human (Homo sapiens) [TaxId: 9606] [102351] (3) picpic
          cytosolic enzyme
      7. Putative steroid sulfotransferase rarO47 [102352]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [102353] (2) picpic
      8. Heparan sulfate N-deacetylase/N-sulfotransferase domain [52582]
        1. Human (Homo sapiens) [TaxId: 9606] [52583] (1) picpic
      9. Heparan sulfate 3-O-sulfotransferase [102354]
        1. Mouse (Mus musculus) [TaxId: 10090] [102355] (1) picpic
          SQ O35310 48-311
      10. Retinol dehydratase [64015]
        1. Fall armyworm (Spodoptera frugiperda) [TaxId: 7108] [64016] (2) picpic
      11. Stf0 sulfotransferase [110530]
        1. Mycobacterium smegmatis [TaxId: 1772] [110531] (1) picpic
          SQ P84151
      12. Heparan sulfate glucosamine 3-O-sulfotransferase 3 [110532]
        1. Human (Homo sapiens) [TaxId: 9606] [110533] (2) picpic
          SQ Q9Y663 139-406 # isoform 3A1; 100% sequence identity to isoform 3B1 domain (SQ Q9Y662 133-390)
      13. Thyroid hormone sulfotransferase Sult1b1 [117530]
        1. Human (Homo sapiens) [TaxId: 9606] [117531] (1) picpic
          SQ O43704
      14. Sulfotransferase Sult1c2 [159556]
        1. Human (Homo sapiens) [TaxId: 9606] [159557] (2) picpic
          SQ O00338 12-296
    9. Phosphoribulokinase/pantothenate kinase [52584] (5)
      1. Phosphoribulokinase [52585]
        1. Rhodobacter sphaeroides [TaxId: 1063] [52586] (1) picpic
      2. Pantothenate kinase PanK [52587]
        has a circularly permuted fold compared to the phosphoribulokinase fold
        1. Escherichia coli [TaxId: 562] [52588] (3) picpic
          SQ P15044
      3. Hypothetical protein Ygr205W [102356]
        close structural similarity to PanK
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [102357] (1) picpic
      4. Hypothetical protein rbstp0775 [102358]
        structural similarity to PanK
        1. Bacillus stearothermophilus [TaxId: 1422] [102359] (1) picpic
      5. Uridine-cytidine kinase 2 [102360]
        1. Human (Homo sapiens) [TaxId: 9606] [102361] (7) picpic
    10. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [52589] (2)
      1. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [52590]
        bifunctional enzyme
        1. Rat (Rattus norvegicus) [TaxId: 10116] [52591] (3) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [82398] (1) picpic
    11. G proteins [52592] (118)
      core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest
      1. cH-p21 Ras protein [52593]
        1. Human (Homo sapiens) [TaxId: 9606] [52594] (57) picpic
          SQ Q6P716
      2. Rac [52595]
        1. Human (Homo sapiens) [TaxId: 9606] [52596] (23) picpic
      3. Ras-related protein RalA [89662]
        1. Human (Homo sapiens) [TaxId: 9606] [89663] (7) picpic
        2. Cotton-top tamarin (Saguinus oedipus) [TaxId: 9490] [117532] (3) picpic
          SQ P63320 # 100% identical to the mouse and rat orthologs (SQ P63321 P63322)
      4. Rap1A [52597]
        1. Human (Homo sapiens) [TaxId: 9606] [52598] (2) picpic
      5. Rap2a [52599]
        1. Human (Homo sapiens) [TaxId: 9606] [52600] (3) picpic
      6. Rab3a [52601]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [52602] (2) picpic
      7. Rab5a [82399]
        1. Human (Homo sapiens) [TaxId: 9606] [82400] (11) picpic
          SQ P20339 18-182
      8. Rab5c [52603]
        1. Mouse (Mus musculus) [TaxId: 10090] [52604] (4) picpic
      9. Rab6 [52605]
        1. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [52606] (1) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [142216] (1) picpic
          SQ P20340 13-176
      10. Rab11a [102362]
        1. Human (Homo sapiens) [TaxId: 9606] [102363] (13) picpic
        2. Saccharomyces cerevisiae [TaxId: 4932] [159558] (4) picpic
      11. Rab-related protein Sec4 [52607]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52608] (5) picpic
      12. Rab-related protein ypt7p [75199]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [75200] (2) picpic
      13. Ran [52609]
        1. Dog (Canis familiaris) [TaxId: 9615] [52610] (6) picpic
          SQ P62825
        2. Human (Homo sapiens) [TaxId: 9606] [52611] (7) picpic
      14. RhoA [52612]
        1. Human (Homo sapiens) [TaxId: 9606] [52613] (14) picpic
          SQ P61586 2-181
      15. RhoE (RND3) [75201]
        1. Mouse (Mus musculus) [TaxId: 10090] [75202] (2) picpic
      16. ADP-ribosylation factor [52614]
        1. Human (Homo sapiens), ARF1 [TaxId: 9606] [52615] (14) picpic
          SQ P32889
        2. Rat (Rattus norvegicus), ARF1 [TaxId: 10116] [52616] (2) picpic
        3. Human (Homo sapiens), ARF6 [TaxId: 9606] [52617] (6) picpic
        4. Mouse (Mus musculus), ARL3 [TaxId: 10090] [52618] (2) picpic
        5. Mouse (Mus musculus), ARL2 [TaxId: 10090] [75203] (3) picpic
        6. Baker's yeast (Saccharomyces cerevisiae), ARF2 [TaxId: 4932] [82401] (1) picpic
        7. Baker's yeast (Saccharomyces cerevisiae), ARL1 [TaxId: 4932] [82402] (1) picpic
        8. Human (Homo sapiens), ARL1 [TaxId: 9606] [102364] (2) picpic
        9. Human (Homo sapiens), ARF4 [TaxId: 9606] [142217] (2) picpic
          SQ P18085 3-177
        10. Human (Homo sapiens), ARL5A [TaxId: 9606] [142218] (3) picpic
          SQ Q9Y689 2-178
        11. Human (Homo sapiens), ARL8A [TaxId: 9606] [142219] (1) picpic
          SQ Q96BM9 18-181
        12. Human (Homo sapiens) [TaxId: 9606] [142220] (1) picpic
          SQ P84085 6-179
        13. Human (Homo sapiens), ARL5B [TaxId: 9606] [142221] (1) picpic
          SQ Q96KC2 6-173
        14. Human(Homo sapiens), ARL8B [TaxId: 9606] [142222] (1) picpic
          SQ Q9NVJ2 18-182
      17. SAR1 [69483]
        1. Chinese hamster (Cricetulus griseus) [TaxId: 10029] [69484] (3) picpic
        2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [82403] (2) picpic
        3. Human (Homo sapiens) [TaxId: 9606] [142223] (2) picpic
          SQ Q9NR31 13-198
      18. CDC42 [52619]
        1. Human (Homo sapiens) [TaxId: 9606] [52620] (21) picpic
        2. Mus musculus [TaxId: 10090] [159559] (2) picpic
      19. Ypt51 [52621]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52622] (1) picpic
      20. Chloroplast protein translocon GTPase Toc34 [69485]
        1. Garden pea (Pisum sativum) [TaxId: 3888] [69486] (1) picpic
      21. Signal recognition particle receptor beta-subunit [89664]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [89665] (1) picpic
        2. Mouse (Mus musculus) [TaxId: 10090] [142224] (2) picpic
          SQ P47758 63-269
      22. Transducin (alpha subunit) [52623]
        common fold is interrupted with an all-alpha domain
        1. Cow (Bos taurus) [TaxId: 9913] [52624] (15) picpic
          SQ P04896 39-388
        2. Rat (Rattus norvegicus) [TaxId: 10116] [52625] (33) picpic
          SQ P10824
        3. Mouse (Mus musculus) [TaxId: 10090] [142225] (6) picpic
          SQ P21279 38-66,184-354! SQ P27600 53-81,204-370! SQ P27601 47-75,202-372
        4. Homo sapiens [TaxId: 9606] [159560] (4) picpic
      23. Elongation factor Tu (EF-Tu), N-terminal (G) domain [52626]
        1. Escherichia coli [TaxId: 562] [52627] (10) picpic
          SQ P02990
        2. Thermus aquaticus [TaxId: 271] [52628] (4) picpic
        3. Thermus thermophilus [TaxId: 274] [52629] (9) picpic
        4. Cow (Bos taurus), mitochondrial [TaxId: 9913] [52630] (2) picpic
          SQ P49410 56-452
      24. Elongation factor eEF-1alpha, N-terminal (G) domain [52631]
        eukaryotic and archaeal homologue of EF-Tu
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52632] (6) picpic
        2. Archaeon Sulfolobus solfataricus [TaxId: 2287] [69487] (2) picpic
          SQ P35021
      25. Elongation factor G (EF-G), N-terminal (G) domain [52633]
        has internal nucleotide exchange factor built in as an insertion subdomain
        1. Thermus thermophilus [TaxId: 274] [52634] (9) picpic
          residues 160-252 comprise insertion subdomain
        2. Thermus thermophilus, EF-G-2 [TaxId: 274] [142226] (2) picpic
          SQ Q5SI76 1-267
          TTHA1498
      26. Elongation factor 2 (eEF-2), N-terminal (G) domain [82404]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [82405] (22) picpic
          SQ P32324
      27. Initiation factor IF2/eIF5b, N-terminal (G) domain [52635]
        1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [52636] (3) picpic
      28. Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204]
        includes rubredoxin-like zinc finger insert domain, res. 56-83, similar that of the Nop10-like family (scop_fa 144211)
        1. Archaeon Pyrococcus abyssi [TaxId: 29292] [75205] (5) picpic
        2. Archaeon Methanococcus jannaschii [TaxId: 2190] [102365] (1) picpic
        3. Sulfolobus solfataricus [TaxId: 2287] [142227] (6) picpic
          SQ Q980A5 2-206
      29. GTPase Era, N-terminal domain [52637]
        1. Escherichia coli [TaxId: 562] [52638] (3) picpic
        2. Thermus thermophilus [TaxId: 274] [117533] (1) picpic
          SQ Q5SM23
      30. Probable tRNA modification GTPase TrmE (MnmE), G domain [102366]
        1. Escherichia coli [TaxId: 562] [102367] (11) picpic
      31. Probable GTPase Der, N-terminal and middle domains [82406]
        member of EngA subfamily of GTPases; contains two G domains
        1. Thermotoga maritima [TaxId: 2336] [82407] (1) picpic
      32. Obg GTP-binding protein middle domain [82408]
        1. Bacillus subtilis [TaxId: 1423] [82409] (1) picpic
        2. Thermus thermophilus [TaxId: 274] [102368] (1) picpic
          TT1381
      33. YchF GTP-binding protein N-terminal domain [82410]
        Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
        1. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [82411] (1) picpic
        2. Haemophilus influenzae [TaxId: 727] [89666] (1) picpic
          HI0393
      34. Probable GTPase EngB [89667]
        1. Escherichia coli [TaxId: 562] [89668] (1) picpic
        2. Bacillus subtilis [TaxId: 1423] [110534] (3) picpic
          SQ P38424
      35. Probable GTPase YlqF [89669]
        naturally occurring circular permutation of G-domain; includes C-terminal all-alpha subdomain
        1. Bacillus subtilis [TaxId: 1423] [89670] (1) picpic
      36. Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain [52639]
        1. Human (Homo sapiens) [TaxId: 9606] [52640] (2) picpic
      37. Dynamin G domain [69488]
        the family common core is decorated with large insertions
        1. Dictyostelium discoideum [TaxId: 44689] [69489] (2) picpic
        2. Rat (Rattus norvegicus) [TaxId: 10116] [142228] (1) picpic
          SQ P21575 6-304
          Dynamin-1
      38. Eukaryotic peptide chain release factor ERF2, G domain [110535]
        1. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [110536] (3) picpic
          SQ O74718
      39. Rab9a [110537]
        1. Dog (Canis familiaris) [TaxId: 9615] [110538] (1) picpic
          SQ P24408
        2. Human (Homo sapiens) [TaxId: 9606] [110539] (1) picpic
          SQ P51151 2-175 # 100% sequence identity do the dog protein (SQ P24408 2-175)
        3. Mouse (Mus musculus) [TaxId: 10090] [142229] (1) picpic
          SQ Q9R0M6 4-175
      40. Rab7 [110540]
        1. Rat (Rattus norvegicus) [TaxId: 10116] [110541] (4) picpic
          SQ P09527
        2. Human (Homo sapiens) [TaxId: 9606] [142230] (5) picpic
          SQ P51149 7-182
      41. Probable GTPase EngC (YjeQ), C-terminal domain [110542]
        circularly permuted G-domain similar to B. sutilis YlqF; distinct extra C-terminal all-alpha subdomain
        1. Thermotoga maritima [TaxId: 2336] [110543] (1) picpic
          SQ Q9X242 # TM1717
        2. Bacillus subtilis [TaxId: 1423] [117534] (1) picpic
          SQ O34530
      42. GTPase Ytp1 [110544]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110545] (2) picpic
          SQ P01123
      43. Interferon-inducible GTPase [110546]
        G domain is inserted in all-alpha domain
        1. Mouse (Mus musculus) [TaxId: 10090] [110547] (5) picpic
          SQ Q9QZ85 # all-alpha domain (14-68,252-415)
      44. TrmE GTPase domain [117535]
        1. Thermotoga maritima [TaxId: 2336] [117536] (2) picpic
          SQ Q9WYA4
      45. Elongation factor SelB, N-terminal domain [117537]
        1. Methanococcus maripaludis [TaxId: 39152] [117538] (3) picpic
          SQ Q8J307
      46. Rab23 [142231]
        1. Mouse (Mus musculus) [TaxId: 10090] [142232] (2) picpic
          SQ P35288 8-171
      47. Rab18 [142233]
        1. Human (Homo sapiens) [TaxId: 9606] [142234] (1) picpic
          SQ Q9NP72 2-178
      48. Rab31 [142235]
        1. Human (Homo sapiens) [TaxId: 9606] [142236] (1) picpic
          SQ Q13636 3-167
      49. Rab11b [142237]
        1. Human (Homo sapiens) [TaxId: 9606] [142238] (2) picpic
          SQ Q15907 7-181
      50. Rab30 [142239]
        1. Human (Homo sapiens) [TaxId: 9606] [142240] (1) picpic
          SQ Q15771 5-175
      51. Rab1a [142241]
        1. Human (Homo sapiens) [TaxId: 9606] [142242] (1) picpic
          SQ P62820 7-175
      52. RhoB [142243]
        1. Human (Homo sapiens) [TaxId: 9606] [142244] (1) picpic
          SQ P62745 4-185
      53. RhoC [142245]
        1. Human (Homo sapiens) [TaxId: 9606] [142246] (2) picpic
          SQ P08134 1-179
      54. Rab4a [142247]
        1. Human (Homo sapiens) [TaxId: 9606] [142248] (5) picpic
          SQ P20338 2-172! SQ P20338 4-172! SQ P20338 4-184
      55. Centaurin gamma 1, G domain [142249]
        1. Human (Homo sapiens) [TaxId: 9606] [142250] (1) picpic
          SQ Q99490 402-576
      56. GTP-binding protein PH0525 [142251]
        Member of the Obg family of GTPases; contains an alpha-hairpin insert subdomain
        1. Pyrococcus horikoshii [TaxId: 53953] [142252] (1) picpic
          SQ O58261 1-319
      57. Rab-22a [142253]
        1. Mouse (Mus musculus) [TaxId: 10090] [142254] (2) picpic
          SQ P35285 2-167! SQ P35285 2-168
      58. Rac3 [142255]
        1. Human (Homo sapiens) [TaxId: 9606] [142256] (2) picpic
          SQ P60763 3-177
      59. GTP-binding protein engB [142257]
        1. Pyrococcus horikoshii [TaxId: 53953] [142258] (3) picpic
          SQ O57939 28-211
          PH0200
      60. Rab26 [142259]
        1. Human (Homo sapiens) [TaxId: 9606] [142260] (1) picpic
          SQ Q9ULW5 58-227
      61. RhoQ [142261]
        1. Human (Homo sapiens) [TaxId: 9606] [142262] (2) picpic
          SQ P17081 1-185
      62. Rab27b [142263]
        1. Human (Homo sapiens) [TaxId: 9606] [142264] (2) picpic
          SQ O00194 4-189
      63. Rab2a [142265]
        1. Human (Homo sapiens) [TaxId: 9606] [142266] (4) picpic
          SQ P61019 2-170
      64. di-Ras2 [142267]
        1. Human (Homo sapiens) [TaxId: 9606] [142268] (2) picpic
          SQ Q96HU8 6-176
      65. Sulfate adenylate transferase subunit cysN/C, EF-Tu domain G-like domain [142269]
        1. Pseudomonas syringae pv. tomato [TaxId: 323] [142270] (1) picpic
          SQ Q87WW1 16-237
      66. Rab14 [142271]
        1. Human (Homo sapiens) [TaxId: 9606] [142272] (2) picpic
          SQ P61106 7-174
      67. r-Ras [142273]
        1. Human (Homo sapiens) [TaxId: 9606] [142274] (1) picpic
          SQ P10301 24-196
      68. GTP-binding protein RheB [142275]
        1. Human (Homo sapiens) [TaxId: 9606] [142276] (3) picpic
          SQ Q15382 3-169
      69. di-Ras1 [142277]
        1. Human (Homo sapiens) [TaxId: 9606] [142278] (4) picpic
          SQ O95057 4-176
      70. Rab-33b [142279]
        1. Mouse (Mus musculus) [TaxId: 10090] [142280] (2) picpic
          SQ O35963 32-196
      71. r-Ras2 [142281]
        1. Human (Homo sapiens) [TaxId: 9606] [142282] (2) picpic
          SQ P62070 10-180
      72. Ras-related protein M-Ras (XRas) [142283]
        1. Mouse (Mus musculus) [TaxId: 10090] [142284] (2) picpic
          SQ O08989 10-178
      73. Rab21 [142285]
        1. Human (Homo sapiens) [TaxId: 9606] [142286] (10) picpic
          SQ Q9UL25 16-182
      74. Rab2b [142287]
        1. Human (Homo sapiens) [TaxId: 9606] [142288] (1) picpic
          SQ Q8WUD1 4-176
      75. GTP-binding protein GEM [142289]
        1. Human (Homo sapiens) [TaxId: 9606] [142290] (1) picpic
          SQ P55040 73-244
      76. Ras-like estrogen-regulated growth inhibitor, RERG [142291]
        1. Human (Homo sapiens) [TaxId: 9606] [142292] (1) picpic
          SQ Q96A58 5-172
      77. Rab8a [142293]
        1. Mouse (Mus musculus) [TaxId: 10090] [142294] (2) picpic
          SQ P55258 3-175
      78. Rad [142295]
        1. Human (Homo sapiens) [TaxId: 9606] [142296] (2) picpic
          SQ P55042 91-258
    12. Motor proteins [52641] (15)
      1. Myosin S1, motor domain [52642]
        common fold is interrupted with some all-alpha subdomains
        1. Chicken (Gallus gallus), pectoral muscle [TaxId: 9031] [52643] (4) picpic
        2. Chicken (Gallus gallus), Va isoform [TaxId: 9031] [102369] (3) picpic
        3. Bay scallop (Aequipecten irradians) [TaxId: 31199] [52644] (11) picpic
          SQ P24733 3-836 ! SQ P24733 6-837
        4. Dictyostelium discoideum [TaxId: 44689] [52645] (18) picpic
        5. Dictyostelium discoideum, class-I myosin MyoE [TaxId: 44689] [75206] (1) picpic
          lacks the SH3-like insert domain
      2. Kinesin [52646]
        1. Human (Homo sapiens) [TaxId: 9606] [52647] (2) picpic
        2. Rat (Rattus norvegicus) [TaxId: 10116] [52648] (2) picpic
        3. Mouse (Mus musculus), kif1a [TaxId: 10090] [64017] (12) picpic
          SQ P33173 3-355
        4. Human (Homo sapiens), mitotic kinesin eg5 [TaxId: 9606] [64018] (34) picpic
        5. Mouse (Mus musculus), kif2c [TaxId: 10090] [102370] (2) picpic
        6. Neurospora crassa [TaxId: 5141] [69490] (1) picpic
        7. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [102371] (1) picpic
      3. Kinesin motor Ncd (non-claret disjunctional) [52649]
        contains coiled-coil neck
        1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [52650] (3) picpic
        2. Baker's yeast (Saccharomyces cerevisiae), Kar [TaxId: 4932] [52651] (5) picpic
          kinesin-like protein
      4. Kinesin heavy chain-like protein [110548]
        1. Potato (Solanum tuberosum) [TaxId: 4113] [110549] (5) picpic
          SQ Q41460 884-1252
    13. Nitrogenase iron protein-like [52652] (29)
      core: parallel beta-sheet of 7 strands; order 3241567
      1. Dethiobiotin synthetase [52653]
        1. Escherichia coli [TaxId: 562] [52654] (13) picpic
      2. Adenylosuccinate synthetase, PurA [52655]
        common fold is interrupted by an all-alpha subdomain, residues 100-200
        1. Escherichia coli [TaxId: 562] [52656] (24) picpic
        2. Mouse-ear cress (Arabidopsis thaliana) [TaxId: 3702] [52657] (1) picpic
        3. Bread wheat (Triticum aestivum) [TaxId: 4565] [52658] (1) picpic
        4. Mouse (Mus musculus) [TaxId: 10090] [69491] (9) picpic
        5. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [102372] (1) picpic
      3. Formyltetrahydrofolate synthetase [52659]
        modified P-loop; there are many insertions in the common fold
        1. Moorella thermoacetica [TaxId: 1525] [52660] (3) picpic
      4. Nitrogenase iron protein [52661]
        1. Azotobacter vinelandii [TaxId: 354] [52662] (19) picpic
        2. Clostridium pasteurianum [TaxId: 1501] [52663] (1) picpic
      5. Cell division regulator MinD [64019]
        1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [64020] (1) picpic
        2. Archaeon Pyrococcus furiosus [TaxId: 2261] [64021] (2) picpic
        3. Archaeon Pyrococcus horikoshii [TaxId: 53953] [64022] (1) picpic
      6. GTPase domain of the signal sequence recognition protein Ffh [52664]
        1. Thermus aquaticus [TaxId: 271] [52665] (25) picpic
        2. Archaeon Acidianus ambivalens [TaxId: 2283] [64023] (2) picpic
        3. Archaeon Sulfolobus solfataricus [TaxId: 2287] [102373] (2) picpic
      7. GTPase domain of the signal recognition particle receptor FtsY [52666]
        1. Escherichia coli [TaxId: 562] [52667] (2) picpic
        2. Thermus aquaticus [TaxId: 271] [102374] (8) picpic
        3. Thermotoga maritima [TaxId: 2336] [110550] (1) picpic
          SQ Q9WZ40
      8. Arsenite-translocating ATPase ArsA [52668]
        Duplication: consists of two domains of this fold arranged as the NIP subunits in the dimer
        1. Escherichia coli [TaxId: 562] [52669] (4) picpic
      9. Hypothetical protein YjiA, N-terminal domain [89671]
        homologue of the cobalamin biosynthesis protein CobW
        1. Escherichia coli [TaxId: 562] [89672] (1) picpic
      10. Molybdopterin-guanine dinucleotide biosynthesis protein MobB [89673]
        forms segment-swapped dimer
        1. Escherichia coli [TaxId: 562] [89674] (2) picpic
        2. Bacillus stearothermophilus [TaxId: 1422] [117539] (1) picpic
          SQ Q5L1X2 # 91% sequence identity
      11. CTP synthase PyrG, N-terminal domain [110551]
        1. Escherichia coli [TaxId: 562] [110552] (1) picpic
          SQ P08398
        2. Thermus thermophilus [TaxId: 274] [110553] (3) picpic
          SQ Q5SIA8
        3. Human (Homo sapiens) [TaxId: 9606] [159561] (2) picpic
          SQ Q5VW67 1-273
      12. ATP(GTP)-binding protein PAB0955 [142297]
        PYRAB14380; belongs to Pfam 03029
        1. Pyrococcus abyssi [TaxId: 29292] [142298] (9) picpic
          SQ Q9UYR9 30-273
      13. Hypothetical protein TM0796 [142299]
        member of Pfam 07755; DUF1611; contains extra N-terminal alpha/beta fold of Rossmann-fold topology, parallel beta-sheet, strand order 312456
        1. Thermotoga maritima [TaxId: 2336] [142300] (2) picpic
          SQ Q9WZQ3 1-338
      14. LAO/AO transport system kinase ArgK [159562]
        member of Pfam 03308; contains extra N-terminal 3-helical bundle and extra C-terminal helical dimerisation domain
        1. Escherichia coli [TaxId: 562] [159563] (1) picpic
          SQ P27254 1-327
      15. Metallochaperone MeaB [159564]
        ArgK-like (sub)family; Pfam 03308
        1. Methylobacterium extorquens [TaxId: 408] [159565] (4) picpic
          SQ Q8RPA0 5-327
    14. RecA protein-like (ATPase-domain) [52670] (29)
      core: mixed beta-sheet of 8 strands, order 32451678; strand 7 is antiparallel to the rest
      1. RecA protein, ATPase-domain [52671]
        C-terminal domain is alpha+beta
        1. Escherichia coli [TaxId: 562] [52672] (7) picpic
          SQ P0A7G6 P03017
        2. Mycobacterium tuberculosis [TaxId: 1773] [52673] (6) picpic
        3. Mycobacterium smegmatis [TaxId: 1772] [89675] (4) picpic
        4. Deinococcus radiodurans [TaxId: 1299] [117540] (1) picpic
          SQ P42443 15-341
      2. Gene 4 protein (g4p, DNA primase), helicase domain [52674]
        1. Bacteriophage T7 [TaxId: 10760] [52675] (7) picpic
      3. Hexameric replicative helicase repA [52676]
        1. Escherichia coli [TaxId: 562] [52677] (3) picpic
      4. Bacterial conjugative coupling protein TrwB [69492]
        1. Escherichia coli [TaxId: 562] [69493] (5) picpic
      5. Hexameric traffic ATPase, HP0525 [52719]
        type II/IV secretion system protein; includes N-terminal alpha+beta domain of a profilin-like topology
        1. Helicobacter pylori [TaxId: 210] [52720] (6) picpic
      6. Extracellular secretion NTPase EpsE [102375]
        type II/IV secretion system protein; overall structure is similar to HP0525
        1. Vibrio cholerae [TaxId: 666] [102376] (2) picpic
      7. DNA repair protein Rad51, catalytic domain [82412]
        1. Human (Homo sapiens) [TaxId: 9606] [82413] (1) picpic
        2. Archaeon Pyrococcus furiosus [TaxId: 2261] [102377] (1) picpic
        3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110554] (1) picpic
          SQ P25454 81-395
        4. Archaeon Methanococcus voltae [TaxId: 2188] [110555] (8) picpic
          SQ O73948
      8. Central domain of alpha subunit of F1 ATP synthase [88774]
        1. Cow (Bos taurus) [TaxId: 9913] [88775] (18) picpic
          SQ P19483
        2. Rat (Rattus norvegicus) [TaxId: 10116] [88776] (2) picpic
        3. Bacillus sp., strain ps3 [TaxId: 1409] [88777] (1) picpic
        4. Spinach (Spinacia oleracea), chloroplast [TaxId: 3562] [88778] (2) picpic
      9. Central domain of beta subunit of F1 ATP synthase [88779]
        1. Cow (Bos taurus) [TaxId: 9913] [88780] (12) picpic
          SQ P00829
        2. Rat (Rattus norvegicus) [TaxId: 10116] [88781] (8) picpic
        3. Bacillus sp., strain ps3 [TaxId: 1409] [88782] (1) picpic
        4. Spinach (Spinacia oleracea), chloroplast [TaxId: 3562] [88783] (2) picpic
      10. Transcription termination factor Rho, ATPase domain [89676]
        1. Escherichia coli [TaxId: 562] [89677] (10) picpic
          SQ P03002
      11. Adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase CobU [52682]
        lacks the last strand 8
        1. Salmonella typhimurium [TaxId: 90371] [52683] (2) picpic
      12. ATP:corrinoid adenosyltransferase CobA [52684]
        lacks the two last strands
        1. Salmonella typhimurium [TaxId: 90371] [52685] (3) picpic
      13. Meiotic recombination protein DMC1/LIM15 homolog [110556]
        1. Human (Homo sapiens) [TaxId: 9606] [110557] (1) picpic
          SQ Q14565
      14. Circadian clock protein KaiC [110558]
        duplication: contains two copies of this domain
        1. Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) [TaxId: 1140] [110559] (25) picpic
          SQ Q79PF4 14-497
      15. NTPase P4 [117541]
        contains extra N-terminal subdomain (~100 residues): [contains pseudo beta-barrel]
        1. Bacteriophage phi-12 [TaxId: 161736] [117542] (8) picpic
          SQ Q94M05
      16. Hypothetical kinase-like protein Aq_1292 [142301]
        member of Pfam 03266 (DUF265)
        1. Aquifex aeolicus [TaxId: 63363] [142302] (1) picpic
          SQ O67322 1-178
      17. Cancer-related NTPase, C1orf57 [159566]
        member of Pfam 03266; DUF265
        1. Human (Homo sapiens) [TaxId: 9606] [159567] (1) picpic
          SQ Q5TDE9 2-190
    15. Bacterial cell division inhibitor SulA [89678] (1)
      homologous to RecA but lacks its P-loop motif; the fold is C-terminally truncated; 5-stranded parallel beta-sheet, order: 15423
      1. Hypothetical protein PA3008 [89679]
        1. Pseudomonas aeruginosa [TaxId: 287] [89680] (2) picpic
    16. ABC transporter ATPase domain-like [52686] (29)
      there are two additional subdomains inserted into the central core that has a RecA-like topology
      1. ATP-binding subunit of the histidine permease [52687]
        1. Salmonella typhimurium [TaxId: 90371] [52688] (1) picpic
      2. Branched chain aminoacid ABC transporter [75207]
        1. Thermotoga maritima, TM1139 [TaxId: 2336] [75208] (1) picpic
      3. MJ1267 [64025]
        1. Archaeon Methanococcus jannaschii [TaxId: 2190] [64026] (3) picpic
      4. MJ0796 [64027]
        1. Archaeon Methanococcus jannaschii [TaxId: 2190] [64028] (2) picpic
      5. Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain [102378]
        1. Mouse (Mus musculus) [TaxId: 10090] [102379] (8) picpic
          SQ P26361 390-670
        2. Human (Homo sapiens) [TaxId: 9606] [117543] (2) picpic
          SQ P13569 389-671
      6. Peptide transporter Tap1, C-terminal ABC domain [64029]
        1. Human (Homo sapiens) [TaxId: 9606] [64030] (1) picpic
      7. Maltose transport protein MalK, N-terminal domain [52689]
        1. Archaeon Thermococcus litoralis [TaxId: 2265] [52690] (1) picpic
        2. Escherichia coli [TaxId: 562] [102380] (13) picpic
      8. Glucose transport protein GlcV, N-terminal domain [89681]
        1. Archaeon Sulfolobus solfataricus [TaxId: 2287] [89682] (5) picpic
      9. ABC transporter involved in vitamin B12 uptake, BtuD [75209]
        1. Escherichia coli [TaxId: 562] [75210] (1) picpic
      10. Haemolysin B ATP-binding protein [89683]
        1. Escherichia coli [TaxId: 562] [89684] (3) picpic
      11. Multidrug resistance ABC transporter MsbA, C-terminal domain [89685]
        a low-resolution structure of the E. coli MsbA in an open conformation is also available (f.35.1.1)
        1. Vibrio cholerae [TaxId: 666] [89686] (1) picpic
        2. Salmonella typhimurium [TaxId: 90371] [159568] (12) picpic
          SQ P63359 329-581
      12. Multidrug resistance ABC transporter LmrA, C-terminal domain [102381]
        1. Lactococcus lactis [TaxId: 1358] [102382] (1) picpic
      13. Rad50 [52691]
        1. Archaeon Pyrococcus furiosus [TaxId: 2261] [52692] (4) picpic
      14. Smc head domain [52693]
        1. Thermotoga maritima [TaxId: 2336] [52694] (1) picpic
        2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [117544] (1) picpic
          SQ P32908 2-214,1024-1223
        3. Pyrococcus furiosus [TaxId: 2261] [117545] (2) picpic
          SQ Q877I1 1-167,1012-1173
      15. Cell division protein MukB [52695]
        1. Escherichia coli [TaxId: 562] [52696] (1) picpic
      16. DNA repair protein MutS, the C-terminal domain [52697]
        1. Thermus aquaticus [TaxId: 271] [52698] (4) picpic
        2. Escherichia coli [TaxId: 562] [52699] (10) picpic
          SQ P23909 2-800
      17. Putative ABC transporter PF0895 [110560]
        1. Pyrococcus furiosus [TaxId: 2261] [110561] (1) picpic
          SQ Q8U2E3
      18. Hypothetical protein PH0022, N-terminal domain [117546]
        1. Pyrococcus horikoshii [TaxId: 53953] [117547] (2) picpic
          SQ O57758
      19. Putative ABC transporter TM0544 [117548]
        1. Thermotoga maritima [TaxId: 2336] [117549] (1) picpic
          SQ Q9WZ14
      20. Putative multidrug export ATP-binding/permease protein SAV1866 [142303]
        1. Staphylococcus aureus [TaxId: 1280] [142304] (4) picpic
          SQ Q99T13 324-578
      21. Molybdate/tungstate import ATP-binding protein WtpC (ModC) [159569]
        1. Archaeoglobus fulgidus [TaxId: 2234] [159570] (4) picpic
          SQ O30144 1-240
      22. Methionine import ATP-binding protein MetN [159571]
        1. Escherichia coli [TaxId: 562] [159572] (4) picpic
          SQ P30750 1-240
      23. Sulfate/molybdate ABC transporter, ATP-binding protein [159573]
        1. Methanosarcina acetivorans [TaxId: 2214] [159574] (2) picpic
          SQ Q8TTZ3 1-229
    17. Tandem AAA-ATPase domain [81268] (27)
      duplication: tandem repeat of two RecA-like (AAA) domains
      1. DEXX box DNA helicase [52701]
        each AAA domain contains an all-alpha insert subdomain
        1. Bacillus stearothermophilus, PcrA [TaxId: 1422] [52702] (5) picpic
        2. Escherichia coli, RepD [TaxId: 562] [52703] (1) picpic
      2. Putative DEAD box RNA helicase [52704]
        homologous to eIF4a and UvrB
        1. Archaeon Methanococcus jannaschii [TaxId: 2190] [52705] (1) picpic
      3. Probable DEAD box RNA helicase YqfR [102383]
        1. Bacillus stearothermophilus [TaxId: 1422] [102384] (1) picpic
      4. RecQ helicase domain [102385]
        1. Escherichia coli [TaxId: 562] [102386] (2) picpic
      5. DEAD box RNA helicase rck/p54 [102387]
        1. Human (Homo sapiens) [TaxId: 9606] [102388] (1) picpic
      6. RecG helicase domain [69494]
        1. Thermotoga maritima [TaxId: 2336] [69495] (1) picpic
      7. Initiation factor 4a [52706]
        homologous to UvrB
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52707] (5) picpic
        2. Human (Homo sapiens) [TaxId: 9606] [142305] (2) picpic
          SQ P60842 21-238
          4A-I
      8. Nucleotide excision repair enzyme UvrB [52708]
        contains large insertions in the first AAA domain
        1. Thermus thermophilus [TaxId: 274] [52709] (2) picpic
        2. Bacillus caldotenax [TaxId: 1395] [52710] (7) picpic
          SQ P56981
      9. Translocation ATPase SecA, nucleotide-binding domains [82414]
        a pre-protein crosslinking domain inserted in the first AAA domain
        1. Bacillus subtilis [TaxId: 1423] [82415] (4) picpic
          SQ P28366
        2. Mycobacterium tuberculosis [TaxId: 1773] [89687] (2) picpic
      10. Spliceosome RNA helicase BAT1 (UAP56) [110562]
        1. Human (Homo sapiens) [TaxId: 9606] [110563] (5) picpic
          SQ Q13838 45-428
      11. Exodeoxyribonuclease V beta chain (RecB), N-terminal domain [117550]
        each AAA domain contains an all-alpha insert subdomain
        1. Escherichia coli [TaxId: 562] [117551] (1) picpic
          SQ P08394
      12. Exodeoxyribonuclease V gamma chain (RecC), N-terminal domain [117552]
        each AAA domain contains an all-alpha insert subdomain
        1. Escherichia coli [TaxId: 562] [117553] (1) picpic
          SQ P07648
      13. Exodeoxyribonuclease V alpha chain (RecD) [117554]
        contains extra N-terminal alpha+beta (sub)domain (~100 residues)
        1. Escherichia coli [TaxId: 562] [117555] (1) picpic
          SQ P04993
      14. putative ATP-dependent RNA helicase VlgB [142306]
        1. Flatworm (Dugesia japonica) [TaxId: 6161] [142307] (2) picpic
          SQ O97032 164-401
      15. putative ATP-dependent RNA helicase PF2015 [142308]
        separate structures of other domains are known: the middle nuclease domain (scop_sp 89718) and the C-terminal RuvA-like HhH domain (PDB 1x2i)
        1. Pyrococcus furiosus [TaxId: 2261] [142309] (2) picpic
          SQ Q8TZH8 2-201! SQ Q8TZH8 202-487
      16. ATP-dependent RNA helicase DDX25 [142310]
        1. Human (Homo sapiens) [TaxId: 9606] [142311] (4) picpic
          SQ Q9UHL0 307-474
      17. Helicase of the SNF2/Rad54 hamily [142312]
        1. Sulfolobus solfataricus [TaxId: 2287] [142313] (8) picpic
          SQ Q97XQ7 432-661! SQ Q97XQ7 662-802! SQ Q97XQ7 663-802
      18. Probable ATP-dependent RNA helicase DDX48 [142314]
        Eukaryotic translation initiation factor 4A isoform 3
        1. Human (Homo sapiens) [TaxId: 9606] [142315] (10) picpic
          SQ P38919 22-243! SQ P38919 244-411
      19. Rad54-like, Rad54L [142316]
        1. Zebra fish (Danio rerio) [TaxId: 7955] [142317] (2) picpic
          SQ Q7ZV09 390-735! SQ Q7ZV09 92-389
      20. DNA repair protein RAD25 [142318]
        shares with the DNA helicase UvsW (scop_fa 102396) extra N-terminal alpha+beta subdomain that might be related to the DNA repair protein MutS domain I (scop_sf 55271)
        1. Archaeoglobus fulgidus [TaxId: 2234] [142319] (10) picpic
          SQ O29889 237-436! SQ O29889 238-434! SQ O29889 3-236! SQ O29889 4-209
      21. Transcription-repair coupling factor, TRCF [142320]
        similar to UvrB in the N-terminal part and DEAD helicases in the C-terminal part; also contains CarD-like domain in the middle and TRCF domain at the C-terminus
        1. Escherichia coli [TaxId: 562] [142321] (10) picpic
          SQ P30958 2-348! SQ P30958 26-333! SQ P30958 349-465! SQ P30958 546-778! SQ P30958 779-989
      22. Putative ATP-dependent RNA helicase DHH1 [142322]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [142323] (2) picpic
          SQ P39517 252-422! SQ P39517 46-251
      23. Hel308 helicase [159575]
        1. Archaeoglobus fulgidus [TaxId: 2234] [159576] (4) picpic
    18. Extended AAA-ATPase domain [81269] (34)
      fold is similar to that of RecA, but lacks the last two strands, followed by a family-specific Arg-finger domain
      1. gamma subunit of DNA polymerase III, N-domain [64031]
        1. Escherichia coli [TaxId: 562] [64032] (3) picpic
          SQ P06710 5-368
        2. Thermotoga maritima [TaxId: 2336] [142324] (1) picpic
          SQ Q9WZM9 11-208
      2. delta prime subunit of DNA polymerase III, N-domain [52711]
        contains additional alpha-helical domain after the family specific domains
        1. Escherichia coli [TaxId: 562] [52712] (6) picpic
          SQ P28631
      3. delta subunit of DNA polymerase III, N-domain [64033]
        1. Escherichia coli [TaxId: 562] [64034] (5) picpic
          SQ P28630
      4. Replication factor C [64035]
        contains additional alpha-helical domain after the family specific domains
        1. Archaeon Pyrococcus furiosus [TaxId: 2261] [64036] (1) picpic
      5. Chromosomal replication initiation factor DnaA [82416]
        contains TrpR-like DNA-binding domain after the family specific domains
        1. Aquifex aeolicus [TaxId: 63363] [82417] (5) picpic
      6. Holliday junction helicase RuvB [52713]
        contains "winged helix" DNA-binding domain after the family specific domains
        1. Thermus thermophilus [TaxId: 274] [52714] (3) picpic
        2. Thermotoga maritima [TaxId: 2336] [64037] (6) picpic
      7. Transcriptional activator sigm54 (NtrC1), C-terminal domain [102389]
        1. Aquifex aeolicus [TaxId: 63363] [102390] (2) picpic
      8. CDC6, N-domain [52715]
        contains "winged helix" DNA-binding domain after the family specific domains
        1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [52716] (1) picpic
      9. Hexamerization domain of N-ethylmalemide-sensitive fusion (NSF) protein [52717]
        1. Chinese hamster (Cricetulus griseus) [TaxId: 10029] [52718] (2) picpic
      10. Membrane fusion ATPase VCP/p97 [64038]
        1. Mouse (Mus musculus) [TaxId: 10090] [64039] (4) picpic
      11. AAA domain of cell division protein FtsH [82418]
        ATP-dependent protease
        1. Escherichia coli [TaxId: 562] [82419] (1) picpic
        2. Thermus thermophilus [TaxId: 274] [82420] (4) picpic
        3. Thermotoga maritima [TaxId: 2336] [142325] (12) picpic
          SQ Q9WZ49 150-402
      12. HslU [52721]
        ATPase subunit of ATP-dependent protease
        1. Escherichia coli [TaxId: 562] [52722] (10) picpic
        2. Haemophilus influenzae [TaxId: 727] [52723] (6) picpic
      13. ClpX [102391]
        ATPase subunit of ATP-dependent protease
        1. Helicobacter pylori [TaxId: 210] [102392] (1) picpic
      14. ATPase domain of protease Lon (La) [102393]
        1. Escherichia coli [TaxId: 562] [102394] (1) picpic
      15. ClpA, an Hsp100 chaperone, AAA+ modules [82421]
        duplication: two AAA+ modules; the first module is structurally similar to the CDC6 module whereas the second module to the HslU module
        1. Escherichia coli [TaxId: 562] [82422] (2) picpic
          SQ Q83LR6
      16. ClpB, AAA+ modules [75211]
        ATPase subunit of ATP-dependent protease; similar domain organization to ClpA
        1. Thermus thermophilus [TaxId: 274] [102395] (1) picpic
        2. Escherichia coli [TaxId: 562] [75212] (1) picpic
      17. ATPase subunit of magnesium chelatase, BchI [64040]
        1. Rhodobacter capsulatus [TaxId: 1061] [64041] (1) picpic
      18. Papillomavirus large T antigen helicase domain [89688]
        1. Simian virus 40 [TaxId: 10633] [89689] (16) picpic
          SQ P03070 265-627
      19. Rep 40 protein helicase domain [110564]
        1. Adeno-associated virus 2, AAV2 [TaxId: 10804] [110565] (2) picpic
          SQ P03132 225-490
      20. Replication factor C1 [110566]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110567] (1) picpic
          SQ P38630 295-696
      21. Replication factor C4 [110568]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110569] (1) picpic
          SQ P40339
      22. Replication factor C3 [110570]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110571] (1) picpic
          SQ P38629
      23. Replication factor C2 [110572]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110573] (1) picpic
          SQ P40348
      24. Replication factor C5 [110574]
        1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110575] (1) picpic
          SQ P38251
      25. Replication protein E1 helicase domain [110576]
        1. Human papillomavirus type 18 [TaxId: 333761] [110577] (1) picpic
          SQ P06789 428-629 # structure of the origin-binding domain (210-354) is also known, 1r9w (scop_sp 103119)
      26. CDC6-like protein APE0152, N-terminal domain [117556]
        1. Aeropyrum pernix [TaxId: 56636] [117557] (2) picpic
          SQ Q9YFU8
      27. Archaeal ATPase SSO1545 [142326]
        member of Pfam 01637 family; overall structural similarity to the archael CDC6-like protein APE0102
        1. Sulfolobus solfataricus [TaxId: 2287] [142327] (2) picpic
          SQ Q97Y08 1-283
      28. CED-4, NB-ARC domain [159577]
        belongs to Pfam 00931
        1. Caenorhabditis elegans [TaxId: 6239] [159578] (1) picpic
          SQ P30429 109-385
    19. RNA helicase [52724] (3)
      duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension
      1. HCV helicase domain [52725]
        1. Human hepatitis C virus (HCV), different isolates [TaxId: 11103] [52726] (6) picpic
      2. Dengue virus helicase [142328]
        1. Dengue virus type 2 [TaxId: 11060] [142329] (8) picpic
          SQ Q91H74 1653-1957! SQ Q91H74 1958-2093
      3. YFV helicase domain [142330]
        1. Yellow fever virus [TaxId: 11089] [142331] (2) picpic
          SQ P19901 1669-1842! SQ P19901 1843-2107
    20. Helicase-like "domain" of reverse gyrase [69496] (1)
      1. Helicase-like "domain" of reverse gyrase [69497]
        contains a mobile insertion of LEM/SAP-like HeH motif, residues 354-423
        1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [69498] (2) picpic
    21. DNA helicase UvsW [102396] (1)
      contains extra N-terminal alpha+beta subdomain
      1. DNA helicase UvsW [102397]
        1. Bacteriophage T4 [TaxId: 10665] [102398] (1) picpic
    22. YjeE-like [75213] (1)
      mixed beta-sheet; order 234156(0), strands 2 and 6 are antiparallel to the rest
      1. Hypothetical protein HI0065 [75214]
        1. Haemophilus influenzae [TaxId: 727] [75215] (2) picpic
    23. Type II thymidine kinase [117558] (3)
      N-terminal part of Pfam 00265; parallel beta-sheet of 6 strands, order 324516; topological similarity to the RecA-like proteins, especially CobA (scop_pr 52684)
      1. Thymidine kinase, TK1, N-terminal domain [117559]
        1. Human (Homo sapiens) [TaxId: 9606] [117560] (3) picpic
          SQ P04183 18-191
        2. Ureaplasma urealyticum [TaxId: 2130] [117561] (8) picpic
          SQ Q9PPP5 11-211
        3. Clostridium acetobutylicum [TaxId: 1488] [117562] (1) picpic
          SQ Q97F65
    24. Atu3015-like [142332] (2)
      unknown function; similar to the nucleotide/nucleoside kinases
      1. Hypothetical protein BH3686 [142333]
        annotated as putative gluconate kinase by NESG
        1. Bacillus halodurans [TaxId: 86665] [142334] (1) picpic
          SQ Q9K6P2 1-176
      2. Hypothetical protein Atu3015 [142335]
        1. Agrobacterium tumefaciens [TaxId: 358] [142336] (1) picpic
          SQ Q8UBK1 6-181
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk