Structural Classification of Proteins
home mail help root up expand collapse

Superfamily: 4-helical cytokines

there are two different topoisomers of this fold with different entanglements of the two crossover connections
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: 4-helical cytokines [47265]
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. Superfamily: 4-helical cytokines [47266]
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
    link to SUPERFAMILY database - Superfamily

Families:

  1. Long-chain cytokines [47267] (14)
    1. Granulocyte-colony stimulating factor (G-CSF) [47268]
      1. Human (Homo sapiens) [TaxId: 9606] [47269] (5)
        1. 1rhg picpic
          1. chain a [16812] picpiclink
          2. chain b [16813] picpiclink
          3. chain c [16814] picpiclink
        2. 1cd9 picpicxref
          complexed with nag
          1. chain a [16815] picpiclink
          2. chain c [16816] picpiclink
        3. 2d9q picpicxrefxrefxref
          automatically matched to d1cd9a_
          complexed with nag; mutant
          1. region a:7-174 [131346] picpiclink
        4. 1pgr picpicxref
          1. chain a [16817] picpiclink
          2. chain c [16818] picpiclink
          3. chain e [16819] picpiclink
          4. chain g [16820] picpiclink
        5. 1gnc picpic
          1. chain a [16821] picpiclink
      2. Cow (Bos taurus) [TaxId: 9913] [47270] (1)
        1. 1bgc picpic
          1. chain a [16822] picpiclink
      3. Dog (Canis familiaris) [TaxId: 9615] [47271] (2)
        1. 1bge picpic
          1. chain a [16823] picpiclink
          2. chain b [16824] picpiclink
        2. 1bgd picpic
          1. chain a [16825] picpiclink
    2. Interleukin-6 [47272]
      1. Human (Homo sapiens) [TaxId: 9606] [47273] (4)
        1. 1alu picpic
          complexed with so4, tar
          1. chain a [16826] picpiclink
        2. 1p9m picpicxrefxref
          1. chain b [87994] picpiclink
        3. 2il6 picpic
          1. chain a [16828] picpiclink
        4. 1il6 picpic
          1. chain a [16827] picpiclink
      2. Human herpesvirus 8, Kaposi's sarcoma herpes-virus [TaxId: 37296] [63528] (1)
        1. 1i1r picpicxref
          1. chain b [61548] picpiclink
    3. Leukemia inhibitory factor (LIF) [47274]
      1. Mouse (Mus musculus) [TaxId: 10090] [47275] (2)
        1. 1lki picpic
          1. chain a [16829] picpiclink
        2. 1a7m picpic
          mouse-human chimera, residues 48-81 are from human sequence
          mutant
          1. chain a [16830] picpiclink
      2. Human (Homo sapiens) [TaxId: 9606] [63529] (4)
        1. 1pvh picpicxref
          complexed with iod
          1. chain b [95167] picpiclink
          2. chain d [95170] picpiclink
        2. 1emr picpic
          1. chain a [59456] picpiclink
        3. 2q7n picpic
          automatically matched to d1pvhb_
          complexed with fuc, man, nag
          1. region b:12-180 [150094] picpiclink
        4. 2q7n picpic
          automatically matched to d1pvhb_
          complexed with fuc, man, nag
          1. region d:12-180 [150095] picpiclink
    4. Growth hormone, somatotropin [47276]
      1. Human (Homo sapiens) [TaxId: 9606] [47277] (9)
        1. 1huw picpic
          mutant
          1. chain a [16831] picpiclink
        2. 1axi picpicxref
          complexed with so4; mutant
          1. chain a [16832] picpiclink
        3. 1hwg picpicxref
          mutant
          1. chain a [16834] picpiclink
        4. 1a22 picpicxref
          mutant
          1. chain a [16833] picpiclink
        5. 3hhr picpicxref
          1. chain a [16835] picpiclink
        6. 1kf9 picpicxref
          phage display derived variant
          1. chain a [77351] picpiclink
          2. chain d [77356] picpiclink
        7. 1hwh picpicxref
          mutant
          1. chain a [16836] picpiclink
        8. 1hgu picpic
          1. chain a [16837] picpiclink
        9. 1bp3 picpicxref
          complexed with zn; mutant
          1. chain a [16838] picpiclink
    5. Prolactin (placental lactogen) [47278]
      1. Sheep (Ovis aries) [TaxId: 9940] [47279] (1)
        1. 1f6f picpicxref
          1. chain a [16839] picpiclink
      2. Human (Homo sapiens) [TaxId: 9606] [89035] (2)
        1. 1rw5 picpic
          automatically matched to d1n9da_
          1. region a:1-199 [118792] picpiclink
        2. 1n9d picpic
          1. chain a [85464] picpiclink
    6. Ciliary neurotrophic factor (CNTF) [47280]
      1. Human (Homo sapiens) [TaxId: 9606] [47281] (1)
        1. 1cnt picpic
          complexed with so4, yb; mutant
          1. chain 1 [16840] picpiclink
          2. chain 2 [16841] picpiclink
          3. chain 3 [16842] picpiclink
          4. chain 4 [16843] picpiclink
    7. Leptin (obesity protein) [47282]
      1. Human (Homo sapiens) [TaxId: 9606] [47283] (1)
        1. 1ax8 picpic
          mutant
          1. chain a [16844] picpiclink
    8. Oncostatin M [47284]
      1. Human (Homo sapiens) [TaxId: 9606] [47285] (1)
        1. 1evs picpic
          1. chain a [16845] picpiclink
    9. Heterodimeric interleukin-12 alpha chain [63530]
      1. Human (Homo sapiens) [TaxId: 9606] [63531] (1)
        1. 1f45 picpicxrefxref
          complexed with man, nag; mutant
          1. chain b [59642] picpiclink
  2. Short-chain cytokines [47286] (14)
    1. Erythropoietin [47287]
      long chain cytokine with a short-chain cytokine topology
      1. Human (Homo sapiens) [TaxId: 9606] [47288] (3)
        1. 1eer picpicxref
          mutant
          1. chain a [16846] picpiclink
        2. 1cn4 picpicxref
          mutant
          1. chain c [16847] picpiclink
        3. 1buy picpic
          mutant
          1. chain a [16848] picpiclink
    2. Thrombopoietin [101140]
      long chain cytokine with a short-chain cytokine topology
      1. Human (Homo sapiens) [TaxId: 9606] [101141] (2)
        1. 1v7m picpicxrefxrefxrefxref
          1. chain v [100458] picpiclink
          2. chain x [100459] picpiclink
        2. 1v7n picpicxrefxrefxrefxref
          mutant
          1. chain v [100476] picpiclink
          2. chain x [100477] picpiclink
          3. chain y [100478] picpiclink
          4. chain z [100479] picpiclink
    3. Granulocyte-macrophage colony-stimulating factor (GM-CSF) [47289]
      1. Human (Homo sapiens) [TaxId: 9606] [47290] (3)
        1. 2gmf picpic
          1. chain a [16849] picpiclink
          2. chain b [16850] picpiclink
        2. 1csg picpic
          1. chain a [16851] picpiclink
          2. chain b [16852] picpiclink
        3. 3cxe picpic
          automatically matched to d2gmfa_
          complexed with bma, nag; mutant
          1. region b:14-118 [157108] picpiclink
    4. Interleukin-4 (IL-4) [47291]
      1. Human (Homo sapiens) [TaxId: 9606] [47292] (16)
        1. 2b8u picpic
          automatically matched to d1itl__
          complexed with so4
          1. region a:1-129 [128117] picpiclink
        2. 1hzi picpic
          complexed with so4; mutant
          1. chain a [61449] picpiclink
        3. 1iar picpicxref
          mutant
          1. chain a [16853] picpiclink
        4. 2int picpic
          1. chain a [16855] picpiclink
        5. 3bpl picpicxrefxref
          automatically matched to d1itla_
          complexed with fuc, nag
          1. region a:3-128 [155485] picpiclink
        6. 1rcb picpic
          1. chain a [16854] picpiclink
        7. 1hik picpic
          1. chain a [16856] picpiclink
        8. 3bpn picpic
          automatically matched to d1itla_
          complexed with nag
          1. region a:3-128 [155488] picpiclink
        9. 1hij picpic
          mutant
          1. chain a [16857] picpiclink
        10. 1itm picpic
          1. chain a [16858] picpiclink
        11. 1itl picpic
          mutant
          1. chain a [16859] picpiclink
        12. 2cyk picpic
          1. chain a [16863] picpiclink
        13. 1iti picpic
          mutant
          1. chain a [16864] picpiclink
        14. 1cyl picpic
          1. chain a [16860] picpiclink
        15. 1bcn picpic
          1. chain a [16862] picpiclink
        16. 1bbn picpic
          1. chain a [16861] picpiclink
    5. Interleukin-5 [47293]
      intertwined dimer
      1. Human (Homo sapiens) [TaxId: 9606] [47294] (1)
        1. 1hul picpic
          1. chain a [16865] picpiclink
          2. chain b [16866] picpiclink
    6. Macrophage colony-stimulating factor (M-CSF) [47295]
      forms dimer similar to the Flt3 ligand and SCF dimers
      1. Human (Homo sapiens) [TaxId: 9606] [47296] (1)
        1. 1hmc picpic
          CA-atoms only
          1. chain a [16867] picpiclink
          2. chain b [16868] picpiclink
    7. Flt3 ligand [47297]
      forms dimer similar to the M-CSF and SCF dimers
      1. Human (Homo sapiens) [TaxId: 9606] [47298] (1)
        1. 1ete picpic
          complexed with zn
          1. chain a [16869] picpiclink
          2. chain b [16870] picpiclink
          3. chain c [16871] picpiclink
          4. chain d [16872] picpiclink
    8. Stem cell factor, SCF [47299]
      forms dimer similar to the M-CSF and Flt3 ligand dimers
      1. Human (Homo sapiens) [TaxId: 9606] [47300] (3)
        1. 1scf picpic
          complexed with 1pe, ca
          1. chain a [16873] picpiclink
          2. chain b [16874] picpiclink
          3. chain c [16875] picpiclink
          4. chain d [16876] picpiclink
        2. 1exz picpic
          complexed with ca, sm, trs
          1. chain a [16877] picpiclink
          2. chain b [16878] picpiclink
          3. chain c [16879] picpiclink
          4. chain d [16880] picpiclink
        3. 2e9w picpic
          automatically matched to d1exzb_
          complexed with nag; mutant
          1. region c:2-140 [146738] picpiclink
    9. Interleukin-2 (IL-2) [47301]
      1. Human (Homo sapiens) [TaxId: 9606] [47302] (15)
        1. 1m48 picpic
          complexed with frg
          1. chain a [74443] picpiclink
          2. chain b [74444] picpiclink
        2. 1m47 picpic
          complexed with sul
          1. chain a [74442] picpiclink
        3. 1m49 picpic
          complexed with cmm
          1. chain a [74445] picpiclink
          2. chain b [74446] picpiclink
        4. 1nbp picpic
          complexed with mhc, sul; mutant
          1. chain a [80392] picpiclink
        5. 1m4b picpic
          complexed with nmp; mutant
          1. chain a [74448] picpiclink
        6. 2b5i picpicxrefxrefxrefxrefxrefxref
          automatically matched to d1m48b_
          complexed with nag; mutant
          1. region a:6-133 [127895] picpiclink
        7. 1m4a picpic
          complexed with gol, mpe; mutant
          1. chain a [74447] picpiclink
        8. 3ink picpic
          mutant
          1. chain c [16881] picpiclink
          2. chain d [16882] picpiclink
        9. 1m4c picpic
          1. chain a [74449] picpiclink
          2. chain b [74450] picpiclink
        10. 1pw6 picpic
          complexed with a small molecule inhibitor
          complexed with frb, so4
          1. chain a [95200] picpiclink
          2. chain b [95201] picpiclink
        11. 2erj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d3inkc_
          complexed with bma, fuc, nag; mutant
          1. region d:6-133 [132294] picpiclink
        12. 2erj picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to d3inkc_
          complexed with bma, fuc, nag; mutant
          1. region h:6-133 [132301] picpiclink
        13. 1z92 picpicxrefxref
          automatically matched to d1m48b_
          1. region a:6-133 [124737] picpiclink
        14. 1py2 picpic
          complexed with a small molecule inhibitor
          complexed with frh, zn
          1. chain a [95319] picpiclink
          2. chain b [95320] picpiclink
          3. chain c [95321] picpiclink
          4. chain d [95322] picpiclink
        15. 1irl picpic
          mutant
          1. chain a [16883] picpiclink
    10. Interleukin-3 (IL-3) [47303]
      1. Human (Homo sapiens) [TaxId: 9606] [47304] (1)
        1. 1jli picpic
          mutant with truncation at both N- and C-termini and 14 residue changes
          1. chain a [16884] picpiclink
    11. Interleukin-13 (IL-13) [63532]
      1. Human (Homo sapiens) [TaxId: 9606] [63533] (3)
        1. 1ik0 picpic
          1. chain a [71240] picpiclink
        2. 1ijz picpic
          1. chain a [71239] picpiclink
        3. 1ga3 picpic
          1. chain a [60411] picpiclink
    12. Interleukin-15 (IL-15) [158422]
      1. Human (Homo sapiens) [TaxId: 9606] [158423] (10)
        SQ P40933 49-162
        1. 2z3q picpicxrefxref
          1. region a:1-114 [154002] picpiclink
        2. 2z3q picpicxrefxref
          automatically matched to 2Z3Q A:1-114
          1. region c:1-112 [154004] picpiclink
        3. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to 2Z3Q A:1-114
          complexed with gol
          1. region a:1-112 [154006] picpiclink
        4. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to 2Z3Q A:1-114
          complexed with gol
          1. region c:1-114 [154008] picpiclink
        5. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to 2Z3Q A:1-114
          complexed with gol
          1. region e:1-114 [154010] picpiclink
        6. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to 2Z3Q A:1-114
          complexed with gol
          1. region g:1-114 [154012] picpiclink
        7. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to 2Z3Q A:1-114
          complexed with gol
          1. region i:1-114 [154014] picpiclink
        8. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to 2Z3Q A:1-114
          complexed with gol
          1. region k:1-114 [154016] picpiclink
        9. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to 2Z3Q A:1-114
          complexed with gol
          1. region m:1-114 [154018] picpiclink
        10. 2z3r picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to 2Z3Q A:1-114
          complexed with gol
          1. region o:1-113 [154020] picpiclink
      2. Mouse (Mus musculus) [TaxId: 10090] [158424] (2)
        SQ P48346 49-162
        1. 2psm picpicxrefxref
          complexed with bam
          1. region a:1-114 [149820] picpiclink
        2. 2psm picpicxrefxref
          automatically matched to 2PSM A:1-114
          complexed with bam
          1. region b:1-114 [149821] picpiclink
    13. Interleukin-21 (IL-21) [158425]
      1. Human (Homo sapiens) [TaxId: 9606] [158426] (1)
        SQ Q9HBE4 23-155
        1. 2oqp picpic
          1. region a:2-134 [148997] picpiclink
  3. Interferons/interleukin-10 (IL-10) [47305] (13)
    contains an additional helix in one of the crossover connections
    1. Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306]
      intertwined dimer, similar to interferon-gamma
      1. Human (Homo sapiens) [TaxId: 9606] [47307] (7)
        1. 2ilk picpic
          complexed with so4
          1. chain a [16885] picpiclink
        2. 1lk3 picpicxrefxrefxrefxref
          1. chain a [73950] picpiclink
          2. chain b [73951] picpiclink
        3. 1ilk picpic
          1. chain a [16886] picpiclink
        4. 2h24 picpic
          automatically matched to d2ilk__
          1. region a:18-159 [135988] picpiclink
        5. 1inr picpic
          1. chain a [16887] picpiclink
        6. 1y6k picpicxrefxref
          automatically matched to d2ilk__
          mutant
          1. region l:12-156 [122662] picpiclink
        7. 1j7v picpicxref
          complexed with IL-10 receptor 1 (IL-10R1)
          mutant
          1. chain l [62704] picpiclink
      2. Epstein-Barr virus [TaxId: 10376] [47308] (3)
        1. 1vlk picpic
          1. chain a [16888] picpiclink
        2. 1y6n picpicxrefxref
          mutant
          1. region l:12-157 [144600] picpiclink
        3. 1y6m picpicxrefxref
          automatically matched to d1vlk__
          mutant
          1. region l:12-157 [122665] picpiclink
      3. Human herpesvirus 5 [TaxId: 10359] [74708] (1)
        1. 1lqs picpicxref
          complexed with nag; mutant
          1. chain l [74192] picpiclink
          2. chain m [74193] picpiclink
    2. Interleukin-19 [81744]
      1. Human (Homo sapiens) [TaxId: 9606] [81745] (1)
        1. 1n1f picpic
          complexed with nag
          1. chain a [79803] picpiclink
    3. Interferon-beta [47309]
      1. Human (Homo sapiens) [TaxId: 9606] [47310] (1)
        1. 1au1 picpic
          complexed with fuc, gal, glc, man, zn
          1. chain a [16889] picpiclink
          2. chain b [16890] picpiclink
      2. Mouse (Mus musculus) [TaxId: 10090] [47311] (2)
        SQ P01575 22-182
        CA-atoms only
        1. 1wu3 picpic
          1. chain i [114890] picpiclink
        2. 1ifa picpic
          CA-atoms only
          1. chain a [16892] picpiclink
    4. Interleukin-22 (IL-22) [89036]
      1. Human (Homo sapiens) [TaxId: 9606] [89037] (8)
        1. 3dlq picpic
          automatically matched to d1m4ra_
          mutant
          1. region i:41-179 [157802] picpiclink
        2. 1m4r picpic
          1. chain a [84799] picpiclink
          2. chain b [84800] picpiclink
        3. 1ykb picpic
          automatically matched to d1m4ra_
          complexed with fuc, man, nag
          1. region a:39-179 [123503] picpiclink
        4. 1ykb picpic
          automatically matched to d1m4ra_
          complexed with fuc, man, nag
          1. region b:39-179 [123504] picpiclink
        5. 1ykb picpic
          automatically matched to d1m4ra_
          complexed with fuc, man, nag
          1. region c:39-179 [123505] picpiclink
        6. 1ykb picpic
          automatically matched to d1m4ra_
          complexed with fuc, man, nag
          1. region d:39-179 [123506] picpiclink
        7. 1ykb picpic
          automatically matched to d1m4ra_
          complexed with fuc, man, nag
          1. region e:39-179 [123507] picpiclink
        8. 1ykb picpic
          automatically matched to d1m4ra_
          complexed with fuc, man, nag
          1. region f:39-179 [123508] picpiclink
    5. Interferon-alpha 2b [47312]
      1. Human (Homo sapiens) [TaxId: 9606] [47313] (1)
        1. 1rh2 picpic
          CA-atoms only
          complexed with zn
          1. chain a [16893] picpiclink
          2. chain b [16894] picpiclink
          3. chain c [16895] picpiclink
          4. chain d [16896] picpiclink
          5. chain e [16897] picpiclink
          6. chain f [16898] picpiclink
    6. Interferon-alpha 2a [47314]
      1. Human (Homo sapiens) [TaxId: 9606] [47315] (2)
        1. 1itf picpic
          1. chain a [16899] picpiclink
        2. 2hym picpicxrefxref
          automatically matched to d1itf__
          1. region b:1-165 [136900] picpiclink
    7. Interferon-tau [47316]
      1. Sheep (Ovis aries) [TaxId: 9940] [47317] (1)
        1. 1b5l picpic
          complexed with so4
          1. chain a [16900] picpiclink
    8. Interferon-gamma [47318]
      intertwined dimer
      1. Cow (Bos taurus) [TaxId: 9913] [47319] (3)
        1. 1d9c picpic
          1. chain a [16901] picpiclink
          2. chain b [16902] picpiclink
        2. 1d9g picpic
          1. chain a [16903] picpiclink
          2. chain b [16904] picpiclink
        3. 1rfb picpic
          1. chain a [16905] picpiclink
          2. chain b [16906] picpiclink
      2. Human (Homo sapiens) [TaxId: 9606] [47320] (5)
        1. 3bes picpic
          automatically matched to d1fg9a_
          complexed with bma, nag, po4
          1. region l:0-126 [155196] picpiclink
        2. 1fyh picpicxref
          a single-chain variant
          complexed with cl
          1. region a:0-124 [16907] picpiclink
          2. region a:201-324 [16908] picpiclink
          3. region d:0-124 [16909] picpiclink
          4. region d:201-324 [16910] picpiclink
        3. 1fg9 picpicxref
          1. chain a [16915] picpiclink
          2. chain b [16916] picpiclink
        4. 1hig picpic
          CA-atoms only
          1. chain a [16917] picpiclink
          2. chain b [16918] picpiclink
          3. chain c [16919] picpiclink
          4. chain d [16920] picpiclink
        5. 1eku picpic
          biologically active single chain mutant
          1. region a:0-121 [16911] picpiclink
          2. region a:123-242 [16912] picpiclink
          3. region b:0-121 [16913] picpiclink
          4. region b:123-241 [16914] picpiclink
      3. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [47321] (1)
        1. 2rig picpic
          CA-atoms only
          1. chain a [16921] picpiclink
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk