Structural Classification of Proteins
home mail help root up expand collapse

Family: Short-chain cytokines

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: 4-helical cytokines [47265]
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. Superfamily: 4-helical cytokines [47266]
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
    link to SUPERFAMILY database - Superfamily
  5. Family: Short-chain cytokines [47286]

Protein Domains:

  1. Erythropoietin [47287]
    long chain cytokine with a short-chain cytokine topology
    1. Human (Homo sapiens) [TaxId: 9606] [47288] (3) picpic
  2. Thrombopoietin [101140]
    long chain cytokine with a short-chain cytokine topology
    1. Human (Homo sapiens) [TaxId: 9606] [101141] (2) picpic
  3. Granulocyte-macrophage colony-stimulating factor (GM-CSF) [47289]
    1. Human (Homo sapiens) [TaxId: 9606] [47290] (3) picpic
  4. Interleukin-4 (IL-4) [47291]
    1. Human (Homo sapiens) [TaxId: 9606] [47292] (16) picpic
  5. Interleukin-5 [47293]
    intertwined dimer
    1. Human (Homo sapiens) [TaxId: 9606] [47294] (1) picpic
  6. Macrophage colony-stimulating factor (M-CSF) [47295]
    forms dimer similar to the Flt3 ligand and SCF dimers
    1. Human (Homo sapiens) [TaxId: 9606] [47296] (1) picpic
  7. Flt3 ligand [47297]
    forms dimer similar to the M-CSF and SCF dimers
    1. Human (Homo sapiens) [TaxId: 9606] [47298] (1) picpic
  8. Stem cell factor, SCF [47299]
    forms dimer similar to the M-CSF and Flt3 ligand dimers
    1. Human (Homo sapiens) [TaxId: 9606] [47300] (3) picpic
  9. Interleukin-2 (IL-2) [47301]
    1. Human (Homo sapiens) [TaxId: 9606] [47302] (15) picpic
  10. Interleukin-3 (IL-3) [47303]
    1. Human (Homo sapiens) [TaxId: 9606] [47304] (1) picpic
  11. Interleukin-13 (IL-13) [63532]
    1. Human (Homo sapiens) [TaxId: 9606] [63533] (3) picpic
  12. Interleukin-15 (IL-15) [158422]
    1. Human (Homo sapiens) [TaxId: 9606] [158423] (10) picpic
      SQ P40933 49-162
    2. Mouse (Mus musculus) [TaxId: 10090] [158424] (2) picpic
      SQ P48346 49-162
  13. Interleukin-21 (IL-21) [158425]
    1. Human (Homo sapiens) [TaxId: 9606] [158426] (1) picpic
      SQ Q9HBE4 23-155
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk