Structural Classification of Proteins
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Protein: Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) from Human (Homo sapiens) [TaxId: 9606]

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: 4-helical cytokines [47265]
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. Superfamily: 4-helical cytokines [47266]
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
    link to SUPERFAMILY database - Superfamily
  5. Family: Interferons/interleukin-10 (IL-10) [47305]
    contains an additional helix in one of the crossover connections
  6. Protein: Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306]
    intertwined dimer, similar to interferon-gamma
  7. Species: Human (Homo sapiens) [TaxId: 9606] [47307]

PDB Entry Domains:

  1. 2ilk picpic
    complexed with so4
    1. chain a [16885] picpiclink
  2. 1lk3 picpicxrefxrefxrefxref
    1. chain a [73950] picpiclink
    2. chain b [73951] picpiclink
  3. 1ilk picpic
    1. chain a [16886] picpiclink
  4. 2h24 picpic
    automatically matched to d2ilk__
    1. region a:18-159 [135988] picpiclink
  5. 1inr picpic
    1. chain a [16887] picpiclink
  6. 1y6k picpicxrefxref
    automatically matched to d2ilk__
    mutant
    1. region l:12-156 [122662] picpiclink
  7. 1j7v picpicxref
    complexed with IL-10 receptor 1 (IL-10R1)
    mutant
    1. chain l [62704] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk