Structural Classification of Proteins
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Family: Interferons/interleukin-10 (IL-10)

contains an additional helix in one of the crossover connections

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: 4-helical cytokines [47265]
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. Superfamily: 4-helical cytokines [47266]
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
    link to SUPERFAMILY database - Superfamily
  5. Family: Interferons/interleukin-10 (IL-10) [47305]
    contains an additional helix in one of the crossover connections

Protein Domains:

  1. Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306]
    intertwined dimer, similar to interferon-gamma
    1. Human (Homo sapiens) [TaxId: 9606] [47307] (7) picpic
    2. Epstein-Barr virus [TaxId: 10376] [47308] (3) picpic
    3. Human herpesvirus 5 [TaxId: 10359] [74708] (1) picpic
  2. Interleukin-19 [81744]
    1. Human (Homo sapiens) [TaxId: 9606] [81745] (1) picpic
  3. Interferon-beta [47309]
    1. Human (Homo sapiens) [TaxId: 9606] [47310] (1) picpic
    2. Mouse (Mus musculus) [TaxId: 10090] [47311] (2) picpic
      SQ P01575 22-182
      CA-atoms only
  4. Interleukin-22 (IL-22) [89036]
    1. Human (Homo sapiens) [TaxId: 9606] [89037] (8) picpic
  5. Interferon-alpha 2b [47312]
    1. Human (Homo sapiens) [TaxId: 9606] [47313] (1) picpic
  6. Interferon-alpha 2a [47314]
    1. Human (Homo sapiens) [TaxId: 9606] [47315] (2) picpic
  7. Interferon-tau [47316]
    1. Sheep (Ovis aries) [TaxId: 9940] [47317] (1) picpic
  8. Interferon-gamma [47318]
    intertwined dimer
    1. Cow (Bos taurus) [TaxId: 9913] [47319] (3) picpic
    2. Human (Homo sapiens) [TaxId: 9606] [47320] (5) picpic
    3. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [47321] (1) picpic
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk