Structural Classification of Proteins
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Protein: Interferon-gamma from Human (Homo sapiens) [TaxId: 9606]

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: 4-helical cytokines [47265]
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. Superfamily: 4-helical cytokines [47266]
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
    link to SUPERFAMILY database - Superfamily
  5. Family: Interferons/interleukin-10 (IL-10) [47305]
    contains an additional helix in one of the crossover connections
  6. Protein: Interferon-gamma [47318]
    intertwined dimer
  7. Species: Human (Homo sapiens) [TaxId: 9606] [47320]

PDB Entry Domains:

  1. 3bes picpic
    automatically matched to d1fg9a_
    complexed with bma, nag, po4
    1. region l:0-126 [155196] picpiclink
  2. 1fyh picpicxref
    a single-chain variant
    complexed with cl
    1. region a:0-124 [16907] picpiclink
    2. region a:201-324 [16908] picpiclink
    3. region d:0-124 [16909] picpiclink
    4. region d:201-324 [16910] picpiclink
  3. 1fg9 picpicxref
    1. chain a [16915] picpiclink
    2. chain b [16916] picpiclink
  4. 1hig picpic
    CA-atoms only
    1. chain a [16917] picpiclink
    2. chain b [16918] picpiclink
    3. chain c [16919] picpiclink
    4. chain d [16920] picpiclink
  5. 1eku picpic
    biologically active single chain mutant
    1. region a:0-121 [16911] picpiclink
    2. region a:123-242 [16912] picpiclink
    3. region b:0-121 [16913] picpiclink
    4. region b:123-241 [16914] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk