Structural Classification of Proteins

Class: All alpha proteins

Lineage:

Root: scop
Class: All alpha proteins [46456]

Folds:

Globin-like [46457] (2)
core: 6 helices; folded leaf, partly opened
1. Globin-like [46458] (4)
  uperfamily
2. alpha-helical ferredoxin [46548] (2)
  contains two Fe4-S4 clusters
  uperfamily
Long alpha-hairpin [46556] (20)
2 helices; antiparallel hairpin, left-handed twist
1. GreA transcript cleavage protein, N-terminal domain [46557] (1)
  uperfamily
2. Ribosomal protein L29 (L29p) [46561] (1)
  uperfamily
3. Chaperone J-domain [46565] (1)
  uperfamily
4. Prefoldin [46579] (1)
  uperfamily
5. HR1 repeat [46585] (1)
  uperfamily
6. tRNA-binding arm [46589] (4)
  formerly a class II aminoacyl-tRNA synthetase N-domain
  uperfamily
7. Eukaryotic DNA topoisomerase I, dispensable insert domain [46596] (1)
  uperfamily
8. C-terminal UvrC-binding domain of UvrB [46600] (1)
  uperfamily
9. Epsilon subunit of F1F0-ATP synthase C-terminal domain [46604] (1)
  uperfamily
10. Fe,Mn superoxide dismutase (SOD), N-terminal domain [46609] (1)
  uperfamily
11. Sporulation inhibitor Sda [100985] (1)
  uperfamily
12. Transcriptional repressor TraM [109631] (1)
  similar structure to L29p (scop_sf 46561); contains extra short helix; forms homodimer: an open bundle
  uperfamily
13. DnaK suppressor protein DksA, alpha-hairpin domain [109635] (1)
  uperfamily
14. ISY1 domain-like [140102] (1)
  uperfamily
15. Calcyclin-binding protein-like [140106] (1)
  uperfamily
16. Endosomal sorting complex assembly domain [140111] (3)
  forms 'fan'-like heterooligomers, in which the domains of different subunit make similar interactions at the tip of the hairpin
  uperfamily
17. SPy1572-like [140121] (1)
  forms homodimer: an open bundle, different from the TRAM dimer
  uperfamily
18. Rabenosyn-5 Rab-binding domain-like [140125] (1)
  uperfamily
19. MxiH-like [140129] (1)
  Type III secretion system needle
  uperfamily
20. YnzC-like [158221] (1)
Type I dockerin domain [63445] (1)
tandem repeat of two calcium-binding loop-helix motifs, distinct from the EF-hand
1. Type I dockerin domain [63446] (1)
  uperfamily
LEM/SAP HeH motif [63450] (6)
helix-extended loop-helix; parallel helices
1. LEM domain [63451] (1)
  uperfamily
2. SAP domain [68906] (1)
  uperfamily
3. Rho N-terminal domain-like [68912] (2)
  uperfamily
4. Recombination endonuclease VII, C-terminal and dimerization domains [68918] (1)
  uperfamily
5. DNA-binding domain of EIN3-like [116768] (1)
  decorated with additional structures
  uperfamily
6. PRP4-like [158230] (1)
SOCS box-like [158234] (1)
helix-loop-helix motif with orthogonally packed helices
1. SOCS box-like [158235] (1)
RPB6/omega subunit-like [63561] (1)
core: 2 helices and adjacent loops
1. RPB6/omega subunit-like [63562] (2)
  the bacterial omega and eukaryotic RPB6 subunits both function in polymerase assembly; the common core is involved in conserved interactions with other subunits
  uperfamily
KRAB domain (Kruppel-associated box) [109639] (1)
2 helices: one short, one long; aromatic-rich iterface
1. KRAB domain (Kruppel-associated box) [109640] (1)
  uperfamily
Cytochrome c [46625] (1)
core: 3 helices; folded leaf, opened
1. Cytochrome c [46626] (8)
  covalently-bound heme completes the core
  uperfamily
DNA/RNA-binding 3-helical bundle [46688] (14)
core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
1. Homeodomain-like [46689] (19)
  consists only of helices
  uperfamily
2. Methylated DNA-protein cysteine methyltransferase, C-terminal domain [46767] (1)
  uperfamily
3. ARID-like [46774] (1)
  contains extra helices at both N- and C-termini
  uperfamily
4. "Winged helix" DNA-binding domain [46785] (84)
  contains a small beta-sheet (wing)
  uperfamily
5. C-terminal effector domain of the bipartite response regulators [46894] (3)
  binds to DNA and RNA polymerase; the N-terminal, receiver domain belongs to the CheY family
  uperfamily
6. TrpR-like [48295] (3)
  contains an extra shared helix after the HTH motif
  uperfamily
7. Ribosomal protein L11, C-terminal domain [46906] (1)
  uperfamily
8. Ribosomal protein S18 [46911] (1)
  uperfamily
9. Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 [46915] (1)
  uperfamily
10. N-terminal Zn binding domain of HIV integrase [46919] (1)
  uperfamily
11. RNA polymerase subunit RPB10 [46924] (1)
  uperfamily
12. Sigma3 and sigma4 domains of RNA polymerase sigma factors [88659] (3)
  uperfamily
13. KorB DNA-binding domain-like [109709] (1)
  contains HTH motif in the common core; also contains extra N-terminal helix and C-terminal subdomain of 4 helices (left-handed superhelix)
  uperfamily
14. Rps17e-like [116820] (1)
  uperfamily
Another 3-helical bundle [81602] (5)
topologically similar to the DNA/RNA-binding bundles; distinct packing
1. FF domain [81698] (1)
  uperfamily
2. Protein serine/threonine phosphatase 2C, C-terminal domain [81601] (1)
  uperfamily
3. B-form DNA mimic Ocr [101059] (1)
  uperfamily
4. DEK C-terminal domain [109715] (1)
  uperfamily
5. IscX-like [140319] (1)
  uperfamily
RuvA C-terminal domain-like [46928] (9)
3 helices; bundle, right-handed twist
1. DNA helicase RuvA subunit, C-terminal domain [46929] (1)
  possibly related to UBA-like domains
  uperfamily
2. UBA-like [46934] (4)
  uperfamily
3. post-HMGL domain-like [89000] (2)
  uperfamily
4. CRAL/TRIO N-terminal domain [46938] (1)
  uperfamily
5. Elongation factor TFIIS domain 2 [46942] (1)
  uperfamily
6. Double-stranded DNA-binding domain [46950] (1)
  uperfamily
7. Hypothetical protein AF0491, middle domain [109728] (1)
  uperfamily
8. HBS1-like domain [109732] (1)
  possibly related to UBA-like domains
  uperfamily
9. FGAM synthase PurL, linker domain [109736] (1)
  uperfamily
S13-like H2TH domain [81297] (1)
core: 3-4 helices
1. S13-like H2TH domain [46946] (3)
  contains a helix-two turns-helix (H2TH) motif
  uperfamily
Putative DNA-binding domain [46954] (1)
core: 3 helices; architecture is similar to that of the "winged helix" fold but topology is different
1. Putative DNA-binding domain [46955] (7)
  uperfamily
Spectrin repeat-like [46965] (16)
3 helices; bundle, closed, left-handed twist; up-and-down
1. Spectrin repeat [46966] (1)
  uperfamily
2. Enzyme IIa from lactose specific PTS, IIa-lac [46973] (1)
  uperfamily
3. Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain [46977] (1)
  uperfamily
4. Smac/diablo [46984] (1)
  uperfamily
5. BAG domain [63491] (1)
  uperfamily
6. GAT-like domain [89009] (2)
  uperfamily
7. Tubulin chaperone cofactor A [46988] (1)
  uperfamily
8. Ribosomal protein S20 [46992] (1)
  uperfamily
9. Glycogen synthesis protein GlgS [109747] (1)
  uperfamily
10. Alpha-hemoglobin stabilizing protein AHSP [109751] (1)
  the bundle twist angle is close to zero (small positive value); similar to the RRF alpha-helical bundle, scop_sf 55194
  uperfamily
11. PhoU-like [109755] (1)
  duplication: consists of two sequence each repeats adopting this fold
  uperfamily
12. XseB-like [116842] (1)
  helix-swapped homodimer
  uperfamily
13. MIT domain [116846] (1)
  uperfamily
14. PPK N-terminal domain-like [140356] (1)
  uperfamily
15. MIT domain-like [140361] (1)
  uperfamily
16. Efb C-domain-like [158366] (1)
immunoglobulin/albumin-binding domain-like [46996] (11)
3 helices; bundle, closed, left-handed twist; up-and-down; mirror topology to the spectrin-like fold
1. Bacterial immunoglobulin/albumin-binding domains [46997] (2)
  uperfamily
2. Plasmid maintenance system epsilon/zeta, antidote epsilon subunit [81710] (1)
  uperfamily
3. Families 57/38 glycoside transferase middle domain [88688] (3)
  uperfamily
4. Phosphoprotein XD domain [101089] (1)
  uperfamily
5. Staphylocoagulase [101094] (1)
  duplication: consists of two domains of this fold
  uperfamily
6. Heat shock protein 70kD (HSP70), C-terminal subdomain [100934] (1)
  uperfamily
7. Typo IV secretion system protein TraC [101082] (1)
  uperfamily
8. Avirulence protein AvrPto [116854] (1)
  uperfamily
9. Coronavirus NSP7-like [140367] (1)
  uperfamily
10. Vng1086c-like [140371] (1)
  homotetramer; comprises two dimers similar to the antidote epsilon subunit dimer
  uperfamily
11. AF1782-like [158372] (1)
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47004] (1)
3 helices; bundle, closed, right-handed twist; up-and-down
1. Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex [47005] (1)
  uperfamily
ChaB-like [140375] (1)
3 helices, the first one is shorter than the other two; bundle, capped by a small, C-terminal beta-hairpin
1. ChaB-like [140376] (1)
  uperfamily
Protozoan pheromone-like [47013] (2)
3 helices; bundle, closed, left-handed twist, up-and-down
1. Protozoan pheromone proteins [47014] (1)
  uperfamily
2. Hypothetical membrane protein Ta0354, soluble domain [116858] (1)
  uperfamily
Acyl-CoA binding protein-like [47026] (2)
core: 3 helices; bundle, closed, left-handed twist; up-and-down
1. Acyl-CoA binding protein [47027] (1)
  uperfamily
2. Second domain of FERM [47031] (1)
  uperfamily
YqgQ-like [158378] (1)
3 helices, bundle, left-handed twist, extended overside connection between the first and second helices
1. YqgQ-like [158379] (1)
Kix domain of CBP (creb binding protein) [47039] (1)
3 helices; bundle, partly opened
1. Kix domain of CBP (creb binding protein) [47040] (1)
  uperfamily
RAP domain-like [47044] (1)
3 helices, the first one is shorter than the other two; bundle, partly opened
1. RAP domain-like [47045] (1)
  uperfamily
VHP, Villin headpiece domain [47049] (1)
3 short helices; irregular array
1. VHP, Villin headpiece domain [47050] (1)
  uperfamily
BSD domain-like [140382] (1)
core: 3 helices; triangular array; the extra N-terminal and C-terminal helices form a coiled coil structure
1. BSD domain-like [140383] (1)
  uperfamily
TAF(II)230 TBP-binding fragment [47054] (1)
3 short helices; irregular array
1. TAF(II)230 TBP-binding fragment [47055] (1)
  uperfamily
S15/NS1 RNA-binding domain [47059] (1)
3 helices; irregular array
1. S15/NS1 RNA-binding domain [47060] (3)
  uperfamily
Frizzled cysteine-rich domain [63500] (1)
Core: 3 helices; irregular array; disulfide-rich
1. Frizzled cysteine-rich domain [63501] (1)
  uperfamily
T4 endonuclease V [47076] (1)
3 helices; irregular array
1. T4 endonuclease V [47077] (1)
  uperfamily
Fertilization protein [47081] (1)
core: 3 helices; bundle, closed, right-handed twist; up-and-down
1. Fertilization protein [47082] (1)
  uperfamily
PGBD-like [47089] (1)
core: 3 helices; bundle, closed, left-handed twist; parallel
1. PGBD-like [47090] (2)
  uperfamily
HMG-box [47094] (1)
3 helices; irregular array
1. HMG-box [47095] (1)
  uperfamily
Histone-fold [47112] (1)
core: 3 helices; long middle helix is flanked at each end with shorter ones
1. Histone-fold [47113] (4)
  uperfamily
Open three-helical up-and-down bundle [47143] (7)
core: 3 helices; bundle, open
1. HSC20 (HSCB), C-terminal oligomerisation domain [47144] (1)
  uperfamily
2. Diol dehydratase, gamma subunit [47148] (1)
  contains irregular N-terminal subdomain
  uperfamily
3. Methane monooxygenase hydrolase, gamma subunit [47152] (1)
  duplication: consists of two domains of this fold
  uperfamily
4. Mitochondrial import receptor subunit Tom20 [47157] (1)
  uperfamily
5. Hemolysin expression modulating protein HHA [68989] (1)
  uperfamily
6. EF2458-like [140404] (1)
  N-terminal helix swapped dimer; interrupted antiparallel coiled coil
  uperfamily
7. YvfG-like [158388] (1)
beta-catenin-interacting protein ICAT [81729] (1)
core: 3 helices; irregular array
1. beta-catenin-interacting protein ICAT [81730] (1)
  uperfamily
DNA polymerase III theta subunit-like [116730] (1)
3 helices; irregular array
1. DNA polymerase III theta subunit-like [46575] (1)
  uperfamily
Four-helical up-and-down bundle [47161] (28)
core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down
1. Apolipoprotein [47162] (1)
  uperfamily
2. Aspartate receptor, ligand-binding domain [47170] (1)
  uperfamily
3. Cytochromes [47175] (2)
  Heme-containing proteins
  uperfamily
4. Hemerythrin-like [47188] (1)
  uperfamily
5. TMV-like viral coat proteins [47195] (1)
  uperfamily
6. FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1)
  uperfamily
7. Proteasome activator [47216] (1)
  uperfamily
8. alpha-catenin/vinculin-like [47220] (2)
  uperfamily
9. FAT domain of focal adhesion kinase [68993] (1)
  uperfamily
10. Oxygen-evolving enhancer protein 3, [101112] (1)
  uperfamily
11. Histidine-containing phosphotransfer domain, HPT domain [47226] (6)
  contains additional, fifth helix at the N-terminus
  uperfamily
12. Bacterial GAP domain [47233] (1)
  contains extra helices in the loops at one end of the bundle
  uperfamily
13. Outer surface protein C (OspC) [63515] (1)
  uperfamily
14. Flagellar export chaperone FliS [101116] (1)
  can form closed, open and helix-swapped bundles
  uperfamily
15. Domain of the SRP/SRP receptor G-proteins [47364] (1)
  uperfamily
16. FAD-dependent thiol oxidase [69000] (1)
  uperfamily
17. Group V grass pollen allergen [81736] (1)
  uperfamily
18. Nucleotidyltransferase substrate binding subunit/domain [81593] (4)
  uperfamily
19. RecG, N-terminal domain [69008] (1)
  uperfamily
20. Colicin D immunity protein [101125] (1)
  uperfamily
21. Nickel-containing superoxide dismutase, NiSOD [109770] (1)
  uperfamily
22. Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain [109775] (1)
  contains extra alpha+beta subdomain formed by the N- and C-termini.
  uperfamily
23. Domain from hypothetical 2610208m17rik protein [109779] (1)
  uperfamily
24. TrmE connector domain [116878] (1)
  uperfamily
25. YppE-like [140415] (1)
  flattened bundle at one end with helices 2 and coming in contact and separating helices 1 and 3
  uperfamily
26. MW0975(SA0943)-like [140423] (1)
  open bundle; there is a long groove between helices 1 and 4
  uperfamily
27. VPS28 C-terminal domain-like [140427] (1)
  uperfamily
28. TM1646-like [158397] (1)
PTS-regulatory domain, PRD [63519] (1)
core: 4 helices; bundle, closed, right-handed twist; 1 crossover connection
1. PTS-regulatory domain, PRD [63520] (1)
  duplication: consists of two domains of this fold
  uperfamily
Ferritin-like [47239] (6)
core: 4 helices; bundle, closed, left-handed twist; 1 crossover connection
1. Ferritin-like [47240] (9)
  contains bimetal-ion centre in the middle of the bundle
  uperfamily
2. Cobalamin adenosyltransferase-like [89028] (2)
  crossover loop goes across a different side of the 4-helical bundle; no internal metal-binding site
  uperfamily
3. EsxAB dimer-like [140453] (1)
  (hetero)dimer of alpha-hairpin subunits similar to that of the half-ferritin family; no bound metals
  uperfamily
4. PE/PPE dimer-like [140459] (2)
  (hetero)dimer of alpha-hairpin subunits similar to that of the half-ferritin family; no bound metals inside the bundle
  uperfamily
5. HP0062-like [158414] (1)
  (homo)dimer of alpha-hairpin subunits similar to that of the half-ferritin family; no bound metals
6. SO2669-like [158418] (1)
  (homo)dimer of alpha-hairpin subunits similar to that of the half-ferritin family; no bound metals
4-helical cytokines [47265] (1)
core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
1. 4-helical cytokines [47266] (3)
  there are two different topoisomers of this fold with different entanglements of the two crossover connections
  uperfamily
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1)
core: 4 helices; bundle; one loop crosses over one side of the bundle
1. Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47323] (1)
  uperfamily
Acyl carrier protein-like [47335] (3)
4 helices, bundle; helix 3 is shorter than others; up-and-down
1. ACP-like [47336] (3)
  uperfamily
2. Colicin E immunity proteins [47345] (1)
  uperfamily
3. Retrovirus capsid dimerization domain-like [47353] (2)
  uperfamily
Bromodomain-like [47363] (15)
4 helices; bundle; minor mirror variant of up-and-down topology
1. Bromodomain [47370] (1)
  uperfamily
2. alpha-ketoacid dehydrogenase kinase, N-terminal domain [69012] (1)
  uperfamily
3. Acyl-CoA dehydrogenase C-terminal domain-like [47203] (2)
  multidomain flavoprotein; N-terminal domain is all-alpha; the middle domain is open (5,8) barrel
  uperfamily
4. Plant invertase/pectin methylesterase inhibitor [101148] (1)
  contains a short alpha-hairpin at the N-terminal extension
  uperfamily
5. Mob1/phocein [101152] (1)
  common fold is elaborated with additional short helices; contains a zinc-binding site
  uperfamily
6. Bacteriocin immunity protein-like [109797] (2)
  uperfamily
7. LemA-like [140478] (1)
  helices 2 and 3 are shorther than helices 1 and 4
  uperfamily
8. MAST3 pre-PK domain-like [140482] (1)
  this domain precedes the Protein Kinase domain in Microtubule-associated serine/threonine-protein kinase 3 (MAST3)
  uperfamily
9. PA2201 N-terminal domain-like [140486] (1)
  uperfamily
10. Nqo1C-terminal domain-like [140490] (1)
  contains extra C-terminal helix that caps the bundle at one end and Fe4-S4 cluster at the other end
  uperfamily
11. Bacillus cereus metalloprotein-like [158430] (1)
  Duplication: tandem repeat of two domains of this fold with similar sequences; binds a dimetal ion cluster between the repeats
12. Ta0600-like [158436] (1)
13. DsbB-like [158442] (1)
  contains an extra helix in a long loop between helices 3 and 4
14. IVS-encoded protein-like [158446] (1)
  IVS: Intervening sequence with conserved ORF in eubacterial 23S rRNA genes; forms a homopentamer with a toroid-shaped structure containing a tapered central channel
15. YqcC-like [158452] (1)
ROP-like [47379] (8)
4 helices; dimer of identical alpha-hairpin subunits; bundle, closed, left-handed twist
1. ROP protein [47380] (1)
  uperfamily
2. Homodimeric domain of signal transducing histidine kinase [47384] (1)
  uperfamily
3. Nonstructural protein ns2, Nep, M1-binding domain [101156] (1)
  uperfamily
4. Dimerisation domain of CENP-B [101160] (1)
  uperfamily
5. Hypothetical protein D-63 [109801] (1)
  uperfamily
6. HP1531-like [140496] (1)
  contains short extra helix in the loop between the two bundle-forming helices
  uperfamily
7. BAS1536-like [140500] (1)
  uperfamily
8. FHV B2 protein-like [140506] (1)
  uperfamily
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [47390] (1)
4 helices; bundle, closed, right-handed twist
1. Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit [47391] (1)
  dimer of identical alpha-hairpin motifs
  uperfamily
Orange domain-like [158456] (1)
4 helices; dimer of identical alpha-hairpin subunits;
1. Orange domain-like [158457] (1)
Soluble domain of poliovirus core protein 3a [89042] (1)
4 helices; bundle, closed, right-handed twist
1. Soluble domain of poliovirus core protein 3a [89043] (1)
  dimer of identical alpha-hairpin motifs
  uperfamily
Transcription factor IIA (TFIIA), alpha-helical domain [47395] (1)
4 helices; bundle, closed, right-handed twist
1. Transcription factor IIA (TFIIA), alpha-helical domain [47396] (1)
  dimer of non-identical alpha-hairpins
  uperfamily
Ectatomin subunits [47400] (1)
4 helices; bundle, closed, left-handed twist
1. Ectatomin subunits [47401] (1)
  disulfide-linked heterodimer of similar alpha-hairpin subunits
  uperfamily
Dimerisation interlock [47405] (4)
4 helices; bundle, closed, right-handed twist
1. SinR repressor dimerisation domain-like [47406] (1)
  intertwined heterodimer of two homologous chains
  uperfamily
2. Dimerization cofactor of HNF-1 alpha [100957] (1)
  uperfamily
3. Docking domain A of the erythromycin polyketide synthase (DEBS) [101166] (1)
  uperfamily
4. Phenylalanine zipper [109805] (1)
  interlocking dimer with longer helices and aromatic-rich core
  uperfamily
lambda repressor-like DNA-binding domains [47412] (1)
core: 4 helices; folded leaf, closed
1. lambda repressor-like DNA-binding domains [47413] (13)
  uperfamily
Signal peptide-binding domain [47445] (1)
4 helices; orthogonal array
1. Signal peptide-binding domain [47446] (1)
  uperfamily
A DNA-binding domain in eukaryotic transcription factors [47453] (1)
4 helices; the long C-terminal helix protrudes from the domain and binds to DNA
1. A DNA-binding domain in eukaryotic transcription factors [47454] (1)
  uperfamily
HLH-like [47458] (2)
4-helices; bundle, closed, left-handed twist; 2 crossover connections
1. HLH, helix-loop-helix DNA-binding domain [47459] (1)
  dimer of two identical helix-loop-helix subunits
  uperfamily
2. Docking domain B of the erythromycin polyketide synthase (DEBS) [101173] (1)
  uperfamily
HAMP domain-like [158471] (1)
dimer of helix-loop-helix segments; distict from the HLH-like fold; parallel four-helical bundle with two overside connections
1. HAMP domain-like [158472] (1)
EF Hand-like [47472] (4)
core: 4 helices; array of 2 hairpins, opened
1. EF-hand [47473] (11)
  Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
  uperfamily
2. Insect pheromone/odorant-binding proteins [47565] (1)
  the N-terminal extension, containing a few short helices, forms a flexible lid for the binding cavity
  uperfamily
3. Hypothetical protein MTH865 [69025] (1)
  uperfamily
4. Cloroperoxidase [47571] (1)
  duplication: consists of 2 similar domains composed of 2 EF hand-like motifs each
  uperfamily
CH domain-like [47575] (3)
core: 4 helices: bundle
1. Calponin-homology domain, CH-domain [47576] (1)
  uperfamily
2. X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain [81761] (1)
  uperfamily
3. Hook domain [116907] (1)
  uperfamily
Domain of poly(ADP-ribose) polymerase [47586] (1)
core: 4 helices: bundle; unusual topology
1. Domain of poly(ADP-ribose) polymerase [47587] (1)
  duplication: consists of 2 helix-loop-helix structural repeats
  uperfamily
SWIB/MDM2 domain [47591] (1)
core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
duplication: consists of two structural repeats
1. SWIB/MDM2 domain [47592] (1)
  binds to the transactivation domain of human p53
  uperfamily
Pre-protein crosslinking domain of SecA [81766] (1)
core: 4 helices: bundle; flanked by two short beta-hairpins
duplication: consists of two structural repeats
1. Pre-protein crosslinking domain of SecA [81767] (1)
  uperfamily
Ribbon-helix-helix [47597] (1)
core: 4 helices; array of 2 hairpins, opened
1. Ribbon-helix-helix [47598] (11)
  formerly Met repressor-like; dimeric proteins; the N-termini form a small beta-sheet ribbon
  uperfamily
GST C-terminal domain-like [47615] (1)
core: 4 helices; bundle, closed, left-handed twist; right-handed superhelix
1. GST C-terminal domain-like [47616] (2)
  this domains follows the thioredoxin-like N-terminal domain
  uperfamily
Methionine synthase domain-like [47643] (3)
4 helices; bundle, left-handed twist; right-handed superhelix
1. Methionine synthase domain [47644] (1)
  uperfamily
2. Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain [47648] (1)
  uperfamily
3. TM0693-like [140560] (1)
  helix-swapped dimer; in which the two last helices of this fold form a single coiled-coil helix
  uperfamily
KaiA/RbsU domain [101214] (1)
4 helices; bundle, right-handed twist; right-handed superhelix
1. KaiA/RbsU domain [101215] (2)
  uperfamily
STAT-like [47654] (6)
4 long helices; bundle, left-handed twist (coiled coil); right-handed superhelix
1. STAT [47655] (1)
  uperfamily
2. t-snare proteins [47661] (1)
  uperfamily
3. Cag-Z [109839] (1)
  four-helical bundle without significant twist
  uperfamily
4. CAPPD, an extracellular domain of amyloid beta A4 protein [109843] (1)
  the first three helices are longer than the fourth one and, taken separately, adopt a Spectrin repeat-like fold (scop_cf 46965)
  uperfamily
5. FlgN-like [140566] (1)
  the last helix is shorter than the three others; a short extra helix between helices 2 an 3 fills the gap in the bundle
  uperfamily
6. MukF C-terminal domain-like [140570] (1)
  uperfamily
N-cbl like [47667] (5)
4 helices; bundle, left-handed twist; left-handed superhelix
1. N-terminal domain of cbl (N-cbl) [47668] (1)
  uperfamily
2. Transferrin receptor-like dimerisation domain [47672] (1)
  uperfamily
3. Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 [47676] (1)
  uperfamily
4. HIV integrase-binding domain [140576] (1)
  uperfamily
5. PG0775 C-terminal domain-like [158494] (1)
Replisome organizer (g39p helicase loader/inhibitor protein) [89063] (1)
4 helices; bundle, right-handed twist; left-handed superhelix
1. Replisome organizer (g39p helicase loader/inhibitor protein) [89064] (1)
  uperfamily
Hypothetical protein YqbG [116914] (1)
core: 4 helices; bundle, right-handed twist; left-handed superhelix
1. Hypothetical protein YqbG [116915] (1)
  uperfamily
DnaD domain-like [158498] (1)
4 helices; bundle, right-handed twist; left-handed superhelix
1. DnaD domain-like [158499] (1)
C-terminal domain of B transposition protein [47680] (1)
4 helices; irregular array
1. C-terminal domain of B transposition protein [47681] (1)
  uperfamily
HAND domain of the nucleosome remodeling ATPase ISWI [101223] (1)
4 helices; irregular array
1. HAND domain of the nucleosome remodeling ATPase ISWI [101224] (1)
  uperfamily
N-terminal, cytoplasmic domain of anti-sigmaE factor RseA [89068] (1)
4 helices; irregular array
1. N-terminal, cytoplasmic domain of anti-sigmaE factor RseA [89069] (1)
  uperfamily
Anaphylotoxins (complement system) [47685] (1)
4 helices; irregular array, disulfide-linked
1. Anaphylotoxins (complement system) [47686] (1)
  uperfamily
Cytochrome c oxidase subunit h [47693] (1)
4 helices; irregular array, disulfide-linked
1. Cytochrome c oxidase subunit h [47694] (1)
  uperfamily
Crustacean CHH/MIH/GIH neurohormone [81777] (1)
4 helices; irregular array, disulfide-linked
1. Crustacean CHH/MIH/GIH neurohormone [81778] (1)
  uperfamily
C-terminal domain of DFF45/ICAD (DFF-C domain) [81782] (1)
4 helices; folded leaf; right-handed superhelix
1. C-terminal domain of DFF45/ICAD (DFF-C domain) [81783] (1)
  uperfamily
BH2638-like [158503] (1)
4 helices, folded leaf, right-handed superhelix; some similarity to the DFF-C domain fold (scop_cf 81782)
1. BH2638-like [158504] (1)
Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47698] (1)
4 helices; folded leaf; right-handed superhelix
1. Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin [47699] (3)
  can be classified as disulfide-rich
  uperfamily
p53 tetramerization domain [47718] (1)
core: 4 helices; bundle
1. p53 tetramerization domain [47719] (1)
  homotetramer
  uperfamily
Bcr-Abl oncoprotein oligomerization domain [69035] (1)
core: 4 long helices; bundle
1. Bcr-Abl oncoprotein oligomerization domain [69036] (1)
  homotetramer
  uperfamily
Domain of early E2A DNA-binding protein, ADDBP [47723] (1)
4 helices; bundle, partly opened
1. Domain of early E2A DNA-binding protein, ADDBP [47724] (1)
  this domain is the first in the fragment of known structure
  uperfamily
IHF-like DNA-binding proteins [47728] (1)
core: 4 helices; bundle, partly opened, capped with a beta-sheet
1. IHF-like DNA-binding proteins [47729] (2)
  dimer of identical subunits
  uperfamily
TraM-like [140580] (1)
multihelical oligomeric protein; structure of whole subunit is not known; the N-terminal part is implicated in DNA binding, the middle region forms tetrameric parallel coiled coil, surrounded by the C-terminal helices
1. TraM-like [140581] (1)
  uperfamily
CO dehydrogenase ISP C-domain like [47740] (1)
core: 4 helices, bundle
1. CO dehydrogenase ISP C-domain like [47741] (1)
  contains 2Fe-2S cluster
  uperfamily
Protein HNS-dependent expression A; HdeA [47751] (1)
4 helices; the three last helices form a bundle similar to that of the RuvA C-domain
1. Protein HNS-dependent expression A; HdeA [47752] (1)
  overall fold is similar to the fold of N-terminal subdomain of the GluRS anticodon-binding domain (1GLN)
  uperfamily
PABP domain-like [63569] (2)
4 helices; an orthogonal array
1. PABC (PABP) domain [63570] (1)
  uperfamily
2. Ribosomal protein L20 [74731] (1)
  uperfamily
Chemotaxis receptor methyltransferase CheR, N-terminal domain [47756] (1)
4 helices; an orthogonal array
1. Chemotaxis receptor methyltransferase CheR, N-terminal domain [47757] (1)
  uperfamily
Dcp2 domain-like [140585] (1)
4 helices; orthogonal array of two alpha hairpins
1. Dcp2 domain-like [140586] (1)
  uperfamily
Type III secretion system domain [140590] (1)
core: 4 helices, orthogonal array; right-handed superhelix
1. Type III secretion system domain [140591] (3)
  uperfamily
YugE-like [116921] (1)
4-helices; bundle; right-handed twist
1. YugE-like [116922] (1)
  uperfamily
PWI domain [101232] (1)
4 helices; up-and-down bundle; topological similarity to the bromodomain-like and SAM domain-like folds
1. PWI domain [101233] (1)
  uperfamily
PAH2 domain [47761] (1)
4 helices; open up-and-down bundle; binds alpha-helical peptides
1. PAH2 domain [47762] (1)
  uperfamily
Myosin phosphatase inhibitor 17kDa protein, CPI-17 [81789] (1)
4 helices; open up-and-down bundle; flexible N-terminal tail
1. Myosin phosphatase inhibitor 17kDa protein, CPI-17 [81790] (1)
  uperfamily
XPC-binding domain [101237] (1)
4 helices; array
1. XPC-binding domain [101238] (1)
  uperfamily
DinB/YfiT-like putative metalloenzymes [109853] (1)
core: 4 helices; bundle, closed, left-handed twist; an unusual topology with a higher contact order
1. DinB/YfiT-like putative metalloenzymes [109854] (4)
  contains metal-binding site on the bundle surface surrounded by loops
  uperfamily
EspA/CesA-like [116926] (1)
4 helices; bundle, closed, left ight-handed twist; interlocked (hetero)dimer of 2-helical subunits
1. EspA/CesA-like [116927] (2)
  secreted protein and its chaperone both adopt similar substructures in the heterodimer
  uperfamily
NblA-like [109858] (1)
4 helices; dimer of identical alpha-hairpin subunits; open bundle
1. NblA-like [109859] (1)
  uperfamily
EF2947-like [140606] (1)
4 helices; "diamond" array; duplication: N-terminal and C-terminal pairs of helices are related by pseudo dyad
1. EF2947-like [140607] (1)
  uperfamily
EB1 dimerisation domain-like [140611] (1)
dimeric 4-helical bundle with a coiled coil at one end formed by the longer N-terminal helices
1. EB1 dimerisation domain-like [140612] (1)
  uperfamily
SAM domain-like [47768] (16)
4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
1. SAM/Pointed domain [47769] (3)
  uperfamily
2. RuvA domain 2-like [47781] (7)
  duplication: contains two helix-hairpin-helix (HhH) motifs
  uperfamily
3. C-terminal domain of RNA polymerase alpha subunit [47789] (1)
  contains one classic and one pseudo HhH motifs
  uperfamily
4. Rad51 N-terminal domain-like [47794] (3)
  contains one classic and one pseudo HhH motifs
  uperfamily
5. Barrier-to-autointegration factor, BAF [47798] (1)
  contains one classic and one pseudo HhH motifs
  uperfamily
6. DNA polymerase beta, N-terminal domain-like [47802] (1)
  contains one classic and one pseudo HhH motifs
  uperfamily
7. PsbU/PolX domain-like [81585] (2)
  contains one classic and one pseudo HhH motifs
  uperfamily
8. 5' to 3' exonuclease, C-terminal subdomain [47807] (1)
  uperfamily
9. HRDC-like [47819] (4)
  uperfamily
10. lambda integrase-like, N-terminal domain [47823] (1)
  uperfamily
11. Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain [47831] (1)
  uperfamily
12. Hypothetical protein YjbJ [69047] (1)
  uperfamily
13. Putative methyltransferase TM0872, insert domain [81799] (1)
  uperfamily
14. eIF2alpha middle domain-like [116742] (1)
  uperfamily
15. YozE-like [140652] (1)
  uperfamily
16. GspK insert domain-like [158544] (1)
  tandem repeat of two SAM-like domains iserted into pilin fold; domain 1 contains one classic HhH motif
Retroviral matrix proteins [47835] (1)
4-5 helices; right-handed superhelix
1. Retroviral matrix proteins [47836] (6)
  the 5th, C-terminal helix is missing in some of the member structures
  uperfamily
Flavivirus capsid protein C [101256] (1)
core: 5 helices; right-handed superhelix; swapped dimer with the two long C-terminal helices
1. Flavivirus capsid protein C [101257] (1)
  uperfamily
Hepatitis B viral capsid (hbcag) [47851] (1)
5 helices; array; two long helices form a hairpin that dimerizes into a 4-helical bundle
1. Hepatitis B viral capsid (hbcag) [47852] (1)
  uperfamily
Apolipophorin-III [47856] (1)
5 helices; bundle, closed, left-handed twist
1. Apolipophorin-III [47857] (1)
  uperfamily
Methenyltetrahydrofolate cyclohydrolase-like [101261] (1)
5 helices; bundle, closed, left-handed twist
1. Methenyltetrahydrofolate cyclohydrolase-like [101262] (1)
  uperfamily
A middle domain of Talin 1 [109879] (1)
5 helices; bundle, closed, left-handed twist; helices 2-5 adopt the Four-helical up-and-down bundle fold (scop_cf 47161)
1. A middle domain of Talin 1 [109880] (1)
  uperfamily
I/LWEQ domain [109884] (1)
5 helices; bundle, closed, left-handed twist
1. I/LWEQ domain [109885] (1)
  uperfamily
RNA-binding protein She2p [116941] (1)
5 helices; bundle, closed, left-handed twist; topological similarity to the middle domain of the L-aspartase-like fold (scop_cf 48556)
1. RNA-binding protein She2p [116942] (1)
  uperfamily
Hyaluronidase domain-like [140656] (3)
5 helices; bundle, closed, left-handed twist; up-and-down (meander) topology
1. Hyaluronidase post-catalytic domain-like [140657] (1)
  uperfamily
2. TTHA0068-like [140663] (1)
  uperfamily
3. FLJ32549 domain-like [158548] (1)
YoaC-like [140669] (1)
5 helices; bundle, one crossover connection, the arrangement of the first four helices is similar to the KaiA/RbsU domain fold (scop_cf 101214)
1. YoaC-like [140670] (1)
  uperfamily
Saposin-like [47861] (2)
5 helices; folded leaf, closed
1. Saposin [47862] (4)
  Lipid-binding can promote conformational changes and oligomerisation in some members
  uperfamily
2. Bacteriocin AS-48 [47869] (1)
  uperfamily
Annexin [47873] (1)
5 helices; folded leaf, closed
1. Annexin [47874] (1)
  duplication: consists of four domains of the same fold
  uperfamily
TAFH domain-like [158552] (1)
5 helices; folded leaf, closed
1. TAFH domain-like [158553] (1)
Transducin (alpha subunit), insertion domain [47894] (1)
5 helices; folded leaf
1. Transducin (alpha subunit), insertion domain [47895] (1)
  this domain interrupts the G-protein common fold
  uperfamily
Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47911] (1)
5 helices; irregular array; left-handed superhelix
1. Wiscott-Aldrich syndrome protein, WASP, C-terminal domain [47912] (1)
  uperfamily
Left-handed superhelix [47916] (4)
core: 4-5 helices; bundle; left-handed superhelix
1. C-terminal domain of alpha and beta subunits of F1 ATP synthase [47917] (1)
  uperfamily
2. Ypt/Rab-GAP domain of gyp1p [47923] (1)
  uperfamily
3. 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain [69055] (1)
  uperfamily
4. BH3980-like [158560] (1)
ATPD N-terminal domain-like [47927] (2)
core: 5 helices; bundle
1. N-terminal domain of the delta subunit of the F1F0-ATP synthase [47928] (1)
  uperfamily
2. AF1862-like [158568] (1)
  probable biological unit is a hexamer
ERP29 C domain-like [47932] (2)
5 helices; bundle
1. ERP29 C domain-like [47933] (1)
  uperfamily
2. Helical domain of Sec23/24 [81811] (1)
  uperfamily
Functional domain of the splicing factor Prp18 [47937] (1)
core: 5 helices; bundle
1. Functional domain of the splicing factor Prp18 [47938] (1)
  uperfamily
Retrovirus capsid protein, N-terminal core domain [47942] (1)
core: 5 helices; bundle
1. Retrovirus capsid protein, N-terminal core domain [47943] (1)
  uperfamily
GINS helical bundle-like [158572] (1)
5 helices, staggered bundle;
1. GINS helical bundle-like [158573] (4)
  common to all subunits of the GINS complex
Jann4075-like [158586] (1)
core: 5 helices; the C-terminal helix is surrounded by the others; similarity to some EF-hand domains
1. Jann4075-like [158587] (1)
Cyclin-like [47953] (1)
core: 5 helices; one helix is surrounded by the others
1. Cyclin-like [47954] (3)
  duplication: consists of two domains of this fold
  uperfamily
Arp2/3 complex 21 kDa subunit ARPC3 [69059] (1)
5 helices; one helix is surrounded by the others
1. Arp2/3 complex 21 kDa subunit ARPC3 [69060] (1)
  uperfamily
RNase III domain-like [69064] (1)
core: 5 helices; one helix is surrounded by the others
1. RNase III domain-like [69065] (2)
  uperfamily
Ribosomal protein S7 [47972] (1)
core: 5 helices; contains one more helix and a beta-hairpin outside the core
1. Ribosomal protein S7 [47973] (1)
  uperfamily
post-AAA+ oligomerization domain-like [48018] (1)
core: 5 helices: bundle
1. post-AAA+ oligomerization domain-like [48019] (2)
  associated with N-terminal domain from the AAA+ family of P-loop hydrolases
  uperfamily
PAP/OAS1 substrate-binding domain [81632] (1)
core: 5-helical bundle; up-and-down; right-handed twist
1. PAP/OAS1 substrate-binding domain [81631] (5)
  this domain follows the catalytic nucleotidyltransferase domain
  uperfamily
Anti-sigma factor AsiA [69069] (1)
core: 5 helices: orthogonal array
1. Anti-sigma factor AsiA [69070] (1)
  uperfamily
Antibiotic binding domain of TipA-like multidrug resistance regulators [89081] (1)
5 helices: orthogonal array
1. Antibiotic binding domain of TipA-like multidrug resistance regulators [89082] (1)
  uperfamily
Surp module (SWAP domain) [109904] (1)
5 helices: irregular array
1. Surp module (SWAP domain) [109905] (1)
  uperfamily
YgfY-like [109909] (1)
5 helices; array; forms a tight dimer in crystals
1. YgfY-like [109910] (1)
  uperfamily
Hypothetical protein YhaI [109914] (1)
core: 5 helices; orthogonal array; folding similarity to the TipA-S domain (1ny9)
1. Hypothetical protein YhaI [109915] (1)
  oligomerizes via extra N-terminal helix forming trimeric coil-coiled
  uperfamily
Hypothetical protein At3g22680 [109919] (1)
5 helices; array; probable biological unit is a homodimer
1. Hypothetical protein At3g22680 [109920] (1)
  uperfamily
SP0561-like [140682] (1)
5 helices; array; includes extra N-terminal and C-terminal short strands forming parrallel beta-sheet ladder
1. SP0561-like [140683] (1)
  uperfamily
RbcX-like [158614] (1)
5 helices per subunit; irregular array of short and long helices; swapping of the C-terminal helices in the dimer
1. RbcX-like [158615] (1)
YheA-like [158621] (1)
5 helices; "kinked" antiparallel coiled coil; forms flexible oligomeric assemblies via two different dimerisation interfaces
1. YheA/YmcA-like [158622] (2)
RPA2825-like [158633] (1)
5 helices, array; long flexible loop between helices 1 and 2; the remaining helices are arranged similar to the PGBD-like fold (scop_cf 47089)
1. RPA2825-like [158634] (1)
ENT-like [158638] (1)
5 helices, irregular array, right-handed superhelix
1. ENT-like [158639] (1)
YfmB-like [140687] (1)
5 helices, array; buried N-terminal helix; some topological similarity (circular permutation?) to the Nucleotidyltransferase substrate binding subunit/domain (scop_sf 81593)
1. YfmB-like [140688] (1)
  uperfamily
N-terminal domain of adenylylcyclase associated protein, CAP [101277] (1)
6 helices: bundle; left-handed twist, up-and-down topology
1. N-terminal domain of adenylylcyclase associated protein, CAP [101278] (1)
  uperfamily
IpaD-like [140692] (1)
6 helices; bundle, up-and-down; can be divided into two four-helical bundles sharing two helices (3 and 6), which are twice longer than the rest
1. IpaD-like [140693] (1)
  uperfamily
Iron-dependent repressor protein, dimerization domain [47978] (1)
6 helices, homodimer of 3-helical domains
1. Iron-dependent repressor protein, dimerization domain [47979] (1)
  uperfamily
Glutamyl tRNA-reductase dimerization domain [69074] (1)
6 helices, homodimer of 3-helical domains
1. Glutamyl tRNA-reductase dimerization domain [69075] (1)
  uperfamily
GRIP domain [101282] (1)
6 helices, homodimer of 3-helical domains
1. GRIP domain [101283] (1)
  uperfamily
BAR/IMD domain-like [116747] (1)
6 helices, homodimer of 3-helical domains
1. BAR/IMD domain-like [103657] (4)
  core: dimeric six-helical bundle; protuding long helices form aniparallel coiled coils at both bundle ends
  uperfamily
L27 domain [101287] (1)
6 helices, heterodimer of 3-helical domains
1. L27 domain [101288] (1)
  uperfamily
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [109924] (1)
dimer of 3-helical segments; consists of two subdomains: 4-helical bundle and coiled coil
1. Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain [109925] (1)
  uperfamily
Phage replication organizer domain [140712] (1)
6 helices, homodimer of 3-helical domains
1. Phage replication organizer domain [140713] (1)
  DNA binding induces further oligomerization
  uperfamily
YejL-like [158650] (1)
6 helices; intertwined homodimer of three-helical subunits, bundle
1. YejL-like [158651] (1)
Mediator hinge subcomplex-like [140717] (1)
6 helices; heterodimer of structurally similar subunits; the N-terminal hairpins form a four-helical bundle, whereas the C-terminal helices form coiled coil structure
1. Mediator hinge subcomplex-like [140718] (2)
  uperfamily
DEATH domain [47985] (1)
6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
1. DEATH domain [47986] (4)
  uperfamily
GntR ligand-binding domain-like [48007] (1)
core: 6 helices: closed bundle; greek-key; internal pseudo twofold symmetry
1. GntR ligand-binding domain-like [48008] (1)
  uperfamily
AF0941-like [140725] (1)
6 helices, arranged into two interconnected 3-helical bundles; can also be described as a 'kinked' four-helical bundle; right-handed superhelix
1. AF0941-like [140726] (1)
  uperfamily
NusB-like [48012] (1)
6 helices: bundle; one central helix is surrounded by 5 others
1. NusB-like [48013] (3)
  uperfamily
YutG-like [101306] (1)
core: 6 helices; bundle; one central helix is surrounded by 5 others
1. YutG-like [101307] (1)
  uperfamily
N-terminal domain of DnaB helicase [48023] (1)
6 helices: array
1. N-terminal domain of DnaB helicase [48024] (1)
  uperfamily
Invasion protein A (SipA) , C-terminal actin binding domain [101311] (1)
6 helices: orthogonal array
1. Invasion protein A (SipA) , C-terminal actin binding domain [101312] (1)
  uperfamily
MtlR-like [158667] (1)
multihelical; 8-helical up-and-down bundle
1. MtlR-like [158668] (1)
Guanido kinase N-terminal domain [48033] (1)
irregular array of 6 short helices
1. Guanido kinase N-terminal domain [48034] (1)
  uperfamily
Scaffolding protein gpD of bacteriophage procapsid [48044] (1)
core: 6 helices; one central helix is surrounded by 5 others
1. Scaffolding protein gpD of bacteriophage procapsid [48045] (1)
  uperfamily
Hemocyanin, N-terminal domain [48049] (1)
6 helices; bundle; one central helix is surrounded by 5 others
1. Hemocyanin, N-terminal domain [48050] (1)
  uperfamily
Sama2622-like [158674] (1)
core: 6 helices; bundle; one central helix is surrounded by 5 others
1. Sama2622-like [158675] (1)
Di-copper centre-containing domain [48055] (1)
multihelical
1. Di-copper centre-containing domain [48056] (2)
  duplication: contains two structural repeats
  uperfamily
DBL homology domain (DH-domain) [48064] (1)
multihelical; core: 5-helical bundle
1. DBL homology domain (DH-domain) [48065] (1)
  uperfamily
LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48075] (1)
multihelical; contains compact array of 6 short helices
1. LigA subunit of an aromatic-ring-opening dioxygenase LigAB [48076] (1)
  uperfamily
RuBisCo LSMT C-terminal, substrate-binding domain [81821] (1)
multihelical; irregular array of long and short helices
1. RuBisCo LSMT C-terminal, substrate-binding domain [81822] (1)
  uperfamily
Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48080] (1)
multihelical bundle; contains buried central helix
1. Methyl-coenzyme M reductase alpha and beta chain C-terminal domain [48081] (1)
  uperfamily
YcfC-like [101321] (1)
multihelical; contains two buried central helices
1. YcfC-like [101322] (1)
  uperfamily
PA2201 C-terminal domain-like [140730] (1)
multihelical; seven-helical bundle with buried central helix
1. PA2201 C-terminal domain-like [140731] (1)
  uperfamily
Rv1873-like [140735] (1)
multihelical; contains unusually short buried central helix
1. Rv1873-like [140736] (1)
  uperfamily
RUN domain-like [140740] (1)
multihelical; 3-helical bundle similar to one half of the DEATH domain fold is flanked by two alpha-hairpins forming a four-helical bundle; the axes of the three-helical and four-helical bundles are aproximately orthogonal to each other
1. RUN domain-like [140741] (1)
  uperfamily
SipA N-terminal domain-like [140745] (1)
multihelical; bundle; the last helix is buried inside the bundle
1. SipA N-terminal domain-like [140746] (1)
  uperfamily
Transcription factor STAT-4 N-domain [48091] (1)
multihelical; can be divided into two subdomains
1. Transcription factor STAT-4 N-domain [48092] (1)
  uperfamily
TerB-like [158681] (1)
multihelical; contains two central helices; duplication: there are two three-helical repeats related by pseudo twofold symmetry
1. TerB-like [158682] (2)
  members of this superfamily probably related to the tellurite resistance protein TerB (Pfam 05099) of yet undetermined structure
Regulator of G-protein signaling, RGS [48096] (1)
multihelical; consists of two all-alpha subdomains
contains a 4-helical bundle with left-handed twist and up-and-down topology
1. Regulator of G-protein signaling, RGS [48097] (1)
  uperfamily
SopE-like GEF domain [81831] (1)
multihelical; consists of two all-alpha subdomains each containing a 3-helical bundle with right-handed twist
1. SopE-like GEF domain [81832] (1)
  uperfamily
Variable surface antigen VlsE [74747] (1)
multihelical; consists of two all-alpha subdomains; contains a 4-helical bundle with left-handed twist and up-and-down topology
1. Variable surface antigen VlsE [74748] (1)
  uperfamily
YgfB-like [101326] (1)
multihelical; consists of two tightly associated 3-helical bundles with different twists
1. YgfB-like [101327] (1)
  uperfamily
Hypothetical protein MTH393 [101331] (1)
multihelical; consists of two all-alpha subdomains; dimer
1. Hypothetical protein MTH393 [101332] (1)
  uperfamily
PG0816-like [140752] (1)
multihelical; comprises two helical bundles, both are topologically similar to the RuvA C-terminal domain-like fold (scop_cf 46928)
1. PG0816-like [140753] (1)
  uperfamily
UraD-like [158693] (1)
multihelical; irregular array of long and short helices
1. UraD-Like [158694] (1)
Sec63 N-terminal domain-like [158701] (1)
multihelical; consists of two helical subdomains
1. Sec63 N-terminal domain-like [158702] (2)
Carbamoyl phosphate synthetase, large subunit connection domain [48107] (1)
multihelical; consists of two all-alpha subdomains
possible duplication: subdomains have similar topologies
1. Carbamoyl phosphate synthetase, large subunit connection domain [48108] (1)
  uperfamily
Heme-dependent peroxidases [48112] (1)
multihelical; consists of two all-alpha domains
1. Heme-dependent peroxidases [48113] (3)
  uperfamily
Ribosomal protein L19 (L19e) [48139] (1)
multihelical; consists of two different 3-helical domains connected by a long, partly helical linker
1. Ribosomal protein L19 (L19e) [48140] (1)
  uperfamily
PSPTO4464-like [158709] (1)
multihelical; consists of two subdomains at the ends of a long connecting helix
1. PSPTO4464-like [158710] (1)
GatB/YqeY motif [89094] (1)
multihelical; consists of two different alpha-helical bundles (4-helical and 3-helical)
1. GatB/YqeY motif [89095] (2)
  uperfamily
YfbU-like [116959] (1)
multihelical; consist of two subdomains; forms 24-mer with the N-terminal sudbomains packing around the 4-fold axis and the C-terminal domains interacting at the 2-fold and 3-fold axes
1. YfbU-like [116960] (1)
  uperfamily
MG296-like [158714] (1)
multihelical; in crystal forms helical polymers by swapping the two N-terminal helices to the next subunit in polymer; three subunits per turn of polymer helix
1. MG296-like [158715] (1)
Hypothetical protein MPN330 [116964] (1)
multihelical; consists of three different 4-helical bundles
1. Hypothetical protein MPN330 [116965] (1)
  uperfamily
HD-domain/PDEase-like [109603] (1)
multihelical; consists of two different alpha-helical bundles
1. HD-domain/PDEase-like [109604] (5)
  uperfamily
Superantigen MAM [101343] (1)
multihelical; consists of two different alpha-helical bundles
1. Superantigen MAM [101344] (1)
  uperfamily
Influenza virus matrix protein M1 [48144] (1)
multihelical; consists of two different all-alpha subdomains, 4 helices each
1. Influenza virus matrix protein M1 [48145] (1)
  superficially similar to membrane translocation domains
  uperfamily
DNA-glycosylase [48149] (1)
multihelical; consists of two all-alpha domains
1. DNA-glycosylase [48150] (6)
  uperfamily
An anticodon-binding domain of class I aminoacyl-tRNA synthetases [48162] (1)
multihelical; consists of two all-alpha domains
1. An anticodon-binding domain of class I aminoacyl-tRNA synthetases [48163] (2)
  uperfamily
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) [101352] (1)
multihelical; consists of two all-alpha subdomains
1. Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) [101353] (1)
  uperfamily
R1 subunit of ribonucleotide reductase, N-terminal domain [48167] (1)
multihelical consists of two all-alpha subdomains
subdomain 1 (residues 10-100) is a 4-helical bundle
1. R1 subunit of ribonucleotide reductase, N-terminal domain [48168] (1)
  uperfamily
BEACH domain [81836] (1)
multihelical, complex architecture
1. BEACH domain [81837] (1)
  uperfamily
Cryptochrome/photolyase FAD-binding domain [48172] (1)
multihelical; consists of two all-alpha subdomains
1. Cryptochrome/photolyase FAD-binding domain [48173] (1)
  uperfamily
6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1)
multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry
1. 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (12)
  N-terminal domain is Rossmann-fold with a family-specific C-terminal extension
  uperfamily
Uteroglobin-like [48200] (1)
multihelical
1. Uteroglobin-like [48201] (1)
  disulfide-linked dimer of two identical chains, 4 helices in each
  uperfamily
alpha/alpha toroid [48207] (6)
multihelical; up to seven alpha-hairpins are arranged in closed circular array; there may be sequence similarities between different superfamilies
1. Six-hairpin glycosidases [48208] (9)
  uperfamily
2. Seven-hairpin glycosidases [48225] (1)
  uperfamily
3. Chondroitin AC/alginate lyase [48230] (2)
  incomplete toroid
  uperfamily
4. Family 10 polysaccharide lyase [81853] (1)
  uperfamily
5. Terpenoid cyclases/Protein prenyltransferases [48239] (4)
  uperfamily
6. LanC-like [158745] (1)
  comprises seven hairpins
Citrate synthase [48255] (1)
multihelical; consists of two all-alpha domains
1. Citrate synthase [48256] (1)
  uperfamily
Cytochrome P450 [48263] (1)
multihelical
1. Cytochrome P450 [48264] (1)
  uperfamily
Flagellar transcriptional activator FlhD [63591] (1)
multihelical; forms intertwined dimer of identical 5-helical subunits
1. Flagellar transcriptional activator FlhD [63592] (1)
  uperfamily
HP0242-like [158751] (1)
multihelical; intertwined homodimer of four-helical subunits, forming catenated triangular ring-like structures; pseudo knot
1. HP0242-like [158752] (1)
SMc04008-like [158756] (1)
multihelcal; intertwined homodimer; there are 4 core helices in each subunits; contains putative metal ion-binding motif MxxxxxCxxC in the conserved surface site
1. SMc04008-like [158757] (1)
Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48299] (1)
multihelical; intertwined tetramer
1. Ribosomal protein L7/12, oligomerisation (N-terminal) domain [48300] (1)
  uperfamily
Class II MHC-associated invariant chain ectoplasmic trimerization domain [48304] (1)
multihelical; intertwined trimer of identical 3-helical subunits
1. Class II MHC-associated invariant chain ectoplasmic trimerization domain [48305] (1)
  uperfamily
Aldehyde ferredoxin oxidoreductase, C-terminal domains [48309] (1)
multihelical; consists of two all-alpha domains
1. Aldehyde ferredoxin oxidoreductase, C-terminal domains [48310] (1)
  uperfamily
Acid phosphatase/Vanadium-dependent haloperoxidase [48316] (1)
multihelical; core: 5-helical bundle; binds cofactor at the beginning of third helix
1. Acid phosphatase/Vanadium-dependent haloperoxidase [48317] (3)
  uperfamily
BRCA2 helical domain [81871] (1)
multihelical; contains a 3-helical bundle surrounded by several shorter helices
1. BRCA2 helical domain [81872] (1)
  uperfamily
BRCA2 tower domain [81877] (1)
multihelical; contains a 3-helical Hin recombinase-like subdomain and two long dimerisation helices
1. BRCA2 tower domain [81878] (1)
  uperfamily
H-NS histone-like proteins [81274] (1)
multihelical oligomeric protein; structure of whole subunit is not known yet but are probably composed of three different domains
1. H-NS histone-like proteins [81273] (1)
  available NMR structures suggest two very different dimerisation modes of the N-terminal domain
  uperfamily
Sigma2 domain of RNA polymerase sigma factors [88945] (1)
multihelical; consists of a conserved 4-helical core and a variable insert subdomain
1. Sigma2 domain of RNA polymerase sigma factors [88946] (1)
  uperfamily
DNA repair protein MutS, domain III [48333] (1)
multihelical; consists of 2 all-alpha subdomains
1. DNA repair protein MutS, domain III [48334] (1)
  uperfamily
Helical scaffold and wing domains of SecA [81885] (1)
multihelical; consists of 2 all-alpha subdomains
1. Helical scaffold and wing domains of SecA [81886] (1)
  uperfamily
all-alpha NTP pyrophosphatases [101385] (1)
multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer
1. all-alpha NTP pyrophosphatases [101386] (4)
  basic module consist of 5 active site-forming helices; four from one subunit/structural repeat; the fifth from the other subunit/repeat
  uperfamily
Hsp90 co-chaperone CDC37 [101390] (1)
multihelical; consists of 2 all-alpha subdomains connected by a long helix
1. Hsp90 co-chaperone CDC37 [101391] (1)
  uperfamily
Nop domain [89123] (1)
multihelical; array of longer and shorter helices; contains an alpha-hairpin dimerisation subdomain
1. Nop domain [89124] (1)
  uperfamily
YidB-like [140803] (1)
multihelical; three strings of short helices are packed across one longer helix
1. YidB-like [140804] (1)
  uperfamily
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48339] (1)
multihelical; bundle of longer and shorter helices
1. Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [48340] (1)
  uperfamily
A virus capsid protein alpha-helical domain [48344] (1)
multihelical; three-helical bundle in the core is surrounded by non-conserved helices
1. A virus capsid protein alpha-helical domain [48345] (3)
  this domain is interrupted by a jelly-roll beta-sandwich domain
  uperfamily
P40 nucleoprotein [101398] (1)
multihelical; consists of two subdomains
1. P40 nucleoprotein [101399] (1)
  uperfamily
Rhabdovirus nucleoprotein-like [140808] (1)
multihelical, consist of two helical domains; each domain contains a buried helix
1. Rhabdovirus nucleoprotein-like [140809] (1)
  uperfamily
GTPase activation domain, GAP [48349] (1)
multihelical
1. GTPase activation domain, GAP [48350] (2)
  uperfamily
Ras GEF [48365] (1)
multihelical
1. Ras GEF [48366] (1)
  uperfamily
Telomeric repeat binding factor (TRF) dimerisation domain [63599] (1)
multihelical; can be divided into an alpha-alpha superhelix domain and a long alpha-hairpin dimerization domain
1. Telomeric repeat binding factor (TRF) dimerisation domain [63600] (1)
  uperfamily
Poly A polymerase C-terminal region-like [81890] (1)
multihelical; can be divided into three subdomains (neck, body and tail)
1. Poly A polymerase C-terminal region-like [81891] (1)
  the neck subdomain is an alpha-alpha superhelix; the tail subdomain is similar to the RuvA C-terminal domain-like
  uperfamily
alpha-alpha superhelix [48370] (24)
multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix
1. ARM repeat [48371] (23)
  uperfamily
2. IP3 receptor type 1 binding core, domain 2 [100909] (1)
  uperfamily
3. Chemosensory protein Csp2 [100910] (1)
  uperfamily
4. Sec7 domain [48425] (1)
  uperfamily
5. Lipovitellin-phosvitin complex, superhelical domain [48431] (1)
  uperfamily
6. Bacterial muramidases [48435] (1)
  uperfamily
7. Aconitase B, N-terminal domain [74778] (1)
  uperfamily
8. HCP-like [81901] (1)
  uperfamily
9. Protein prenylyltransferase [48439] (1)
  uperfamily
10. 14-3-3 protein [48445] (1)
  uperfamily
11. TPR-like [48452] (8)
  uperfamily
12. ENTH/VHS domain [48464] (4)
  uperfamily
13. Translin [74784] (1)
  uperfamily
14. Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain [69099] (1)
  uperfamily
15. Arp2/3 complex 16 kDa subunit ARPC5 [69103] (1)
  uperfamily
16. FliG [48029] (1)
  fragmented superhelix; consist of 3/4-helical motifs and connecting helices
  uperfamily
17. Cullin repeat-like [74788] (2)
  uperfamily
18. C-terminal domain of Ku80 [101420] (1)
  uperfamily
19. Hypothetical protein ST1625 [101424] (1)
  uperfamily
20. Cytochrome c oxidase subunit E [48479] (1)
  uperfamily
21. USP8 N-terminal domain-like [140856] (1)
  uperfamily
22. Pseudo ankyrin repeat-like [140860] (1)
  contains three helices per turn of the superhelix
  uperfamily
23. TROVE domain-like [140864] (1)
  consist of two superhelical sections arranged like a horse-shoe
  uperfamily
24. MgtE N-terminal domain-like [158791] (1)
  made of short helices; approximately 2.5 helices per turn of superhelix
GUN4-like [140868] (1)
multihelical; open array, trapping inside an extended region before the C-terminal helix
1. GUN4-like [140869] (1)
  uperfamily
Lipoxigenase [48483] (1)
multihelical
large nearly all-alpha domain
1. Lipoxigenase [48484] (2)
  uperfamily
gene 59 helicase assembly protein [48492] (1)
multihelical; consists of two all-alpha subdomains
1. gene 59 helicase assembly protein [48493] (1)
  uperfamily
Tetracyclin repressor-like, C-terminal domain [48497] (1)
multihelical; interlocked (homo)dimer
1. Tetracyclin repressor-like, C-terminal domain [48498] (1)
  uperfamily
Skp1 dimerisation domain-like [81384] (1)
multihelical; interlocked heterodimer with F-box proteins
1. Skp1 dimerisation domain-like [81382] (1)
  uperfamily
F-box domain [81385] (1)
multihelical; interlocked heterodimer with the Skp1 dimerisation domain
1. F-box domain [81383] (1)
  uperfamily
Nuclear receptor ligand-binding domain [48507] (1)
multihelical; 3 layers or orthogonally packed helices
1. Nuclear receptor ligand-binding domain [48508] (1)
  uperfamily
Phospholipase C/P1 nuclease [48536] (1)
multihelical
1. Phospholipase C/P1 nuclease [48537] (2)
  duplication: all chain but the N-terminal helix forms two structural repeats
  uperfamily
ATP-dependent DNA ligase DNA-binding domain [117017] (1)
multihelical; duplication: contains two intertwined structural repeats related by pseudo twofold symmetry
1. ATP-dependent DNA ligase DNA-binding domain [117018] (1)
  uperfamily
DNA primase DnaG, C-terminal domain [117022] (1)
multihelical; segment-swapped dimer
1. DNA primase DnaG, C-terminal domain [117023] (1)
  uperfamily
PriB N-terminal domain-like [140913] (1)
multihelical bundle; contains buried central helix; also includes the PriA interface-forming insert subdomain (alpha+beta)
1. PriB N-terminal domain-like [140914] (1)
  uperfamily
VPS9 domain [109992] (1)
multihelical; consist of two subdomains
1. VPS9 domain [109993] (1)
  uperfamily
Triger factor/SurA peptide-binding domain-like [109997] (1)
multihelical; irregular array of long and short helices
1. Triger factor/SurA peptide-binding domain-like [109998] (2)
  there are sequence and functional similarities between the families, but their structural similarity is obscured by conformational flexibility (in the TF family)
  uperfamily
DNA terminal protein [140918] (1)
multihelical, open array; contains the C-terminal four-helical bundle, left-handed superhelix
1. DNA terminal protein [140919] (1)
  uperfamily
Glycolipid transfer protein, GLTP [110003] (1)
multihelical; 2 layers or orthogonally packed helices
1. Glycolipid transfer protein, GLTP [110004] (1)
  uperfamily
Hypothetical protein MG354 [110008] (1)
multihelical bundle; contains buried central helix
1. Hypothetical protein MG354 [110009] (1)
  uperfamily
Duffy binding domain-like [140923] (1)
consist of two subdomains, each containing a three-helical bundle
1. Duffy binding domain-like [140924] (1)
  uperfamily
Fic-like [140930] (1)
multihelical; one central helix is surrounded by seven helices
1. Fic-like [140931] (1)
  uperfamily
Her-1 [110013] (1)
multihelical; consists of two topologically similar alpha-helical bundles
1. Her-1 [110014] (1)
  uperfamily
ERO1-like [110018] (1)
multihelical; consists of 2 four-helical bundles
1. ERO1-like [110019] (1)
  similar active site architecture to scop_sf 69000
  uperfamily
Serum albumin-like [48551] (1)
multihelical; one domain consists of two similar disulfide-linked subdomains
1. Serum albumin-like [48552] (1)
  uperfamily
L-aspartase-like [48556] (1)
multihelical, consists of three all-alpha domains
1. L-aspartase-like [48557] (2)
  uperfamily
Formin homology 2 domain (FH2 domain) [101446] (1)
multihelical, consists of three all-alpha domains
1. Formin homology 2 domain (FH2 domain) [101447] (1)
  uperfamily
Terpenoid synthases [48575] (1)
multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers
1. Terpenoid synthases [48576] (5)
  duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J
  uperfamily
GroEL equatorial domain-like [48591] (1)
multihelical; 8 helices arranged in 2 parallel layers
1. GroEL equatorial domain-like [48592] (2)
  duplication: two 4-helical subdomains are related by a pseudo dyad passing through the ATP-binding site
  uperfamily
TorD-like [89154] (1)
multihelical; bundle
1. TorD-like [89155] (1)
  uperfamily
Chorismate mutase II [48599] (1)
multihelical; core: 6 helices, bundle
1. Chorismate mutase II [48600] (4)
  uperfamily
Peridinin-chlorophyll protein [48607] (1)
multihelical: forms a boat-shaped protein shell around cofactors
1. Peridinin-chlorophyll protein [48608] (1)
  duplication: consists of two 8-helical repeats
  uperfamily
Heme oxygenase-like [48612] (1)
multihelical; bundle
1. Heme oxygenase-like [48613] (4)
  duplication: contains two structural repeats of 3-helical motif
  uperfamily
Indolic compounds 2,3-dioxygenase-like [140958] (1)
multihelical; bundle, contains interrupted helices
1. Indolic compounds 2,3-dioxygenase-like [140959] (2)
  contains heme-dependent enzymes
  uperfamily
AhpD-like [69117] (1)
multihelical; contains 4-helical bundle and 2-helical arm
1. AhpD-like [69118] (4)
  probable biological unit contains six domains of this fold arranged with 32 symmetry
  uperfamily
Double Clp-N motif [81922] (1)
multihelical; array
1. Double Clp-N motif [81923] (1)
  duplication: contains two structural repeats of 4-helical motif
  uperfamily
Orange carotenoid protein, N-terminal domain [81929] (1)
multihelical; array
1. Orange carotenoid protein, N-terminal domain [81930] (1)
  duplication: contains four structural repeats arranged into two intertwined 4-helical subdomains
  uperfamily
DhaL-like [101472] (1)
multihelical; bundle
1. DhaL-like [101473] (1)
  uperfamily
ADP-ribosylglycohydrolase [101477] (1)
multihelical; bundle
1. ADP-ribosylglycohydrolase [101478] (1)
  uperfamily
Topoisomerase V catalytic domain-like [140978] (1)
multihelical; irregular array; contains small amount of beta-structure and a 3-helical bundle with a variant homeofomain-like fold and HTH motif (scop_cf 46688)
1. Topoisomerase V catalytic domain-like [140979] (1)
  uperfamily
PTPA-like [140983] (1)
multihelical
1. PTPA-like [140984] (1)
  uperfamily
Tex N-terminal region-like [158831] (1)
multihelical; irregular array of long and short helices; can be divided into several subdomains
1. Tex N-terminal region-like [158832] (1)
AGR_C_984p-like [158836] (1)
multihelical, consists of two subdomains; duplication: there are two 5-helical structural repeats, one in each subdomain
1. AGR_C_984p-like [158837] (1)
PMT central region-like [158841] (1)
multihelical; comprises two four-helical bundles of different topologies and an irregular helical array packed against a small beta-sheet
1. PMT central region-like [158842] (1)
FtsH protease domain-like [140989] (1)
array of 6 helices and a 2-stranded beta-ribbon
1. FtsH protease domain-like [140990] (1)
  contains zincin-like (scop_sf 55486) metal-binding motif HExxH, embedded into a topologically different fold
  uperfamily
Gametocyte protein Pfg27 [89161] (1)
multihelical; bundle
1. Gametocyte protein Pfg27 [89162] (1)
  duplication: contains two structural repeats of four helices each
  uperfamily
N-terminal domain of bifunctional PutA protein [81934] (1)
multihelical; array
1. N-terminal domain of bifunctional PutA protein [81935] (1)
  uperfamily
Cysteine alpha-hairpin motif [47071] (1)
core: alpha-hairpin crosslinked with two disulfides
1. Cysteine alpha-hairpin motif [47072] (2)
  uperfamily
Phospholipase A2, PLA2 [48618] (1)
common core: 2 helices, disulfide-linked, and a calcium-binding loop
1. Phospholipase A2, PLA2 [48619] (3)
  uperfamily
Fungal elicitin [48646] (1)
5 helices: irregular disulfide-linked array; also contains a small beta-hairpin
1. Fungal elicitin [48647] (1)
  uperfamily
Tetraspanin [48651] (1)
5 helices: irregular disulfide-linked array; form homodimer
1. Tetraspanin [48652] (1)
  uperfamily
GDNF receptor-like [110034] (1)
5 helices: irregular disulfide-linked array; topological similarity to the Fungal elicitin fold (scop_cf 48646)
1. GDNF receptor-like [110035] (1)
  uperfamily
FinO-like [48656] (1)
6 helices: irregular non-globular array; also contains two small beta-hairpins
1. FinO-like [48657] (1)
  uperfamily
Nuclear receptor coactivator interlocking domain [69124] (1)
3 helices, non-globular array; forms interlocked heterodimers with its targets
1. Nuclear receptor coactivator interlocking domain [69125] (1)
  not a true superfamily
  uperfamily
Hermes dimerisation domain [140995] (1)
multihelical, intertwinned dimer of two 4-helical strings
1. Hermes dimerisation domain [140996] (1)
  uperfamily
Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain [101488] (1)
5 helices, non-globular array; wraps around the N-terminal tail of its target
1. Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain [101489] (1)
  not a true superfamily
  uperfamily
Non-globular all-alpha subunits of globular proteins [48661] (14)
not a true fold
1. Ribosomal protein L39e [48662] (1)
  interrupted alpha-helix
  uperfamily
2. Methanol dehydrogenase subunit [48666] (1)
  consists of single alpha-helix and irregular N-terminal tail
  uperfamily
3. Transducin (heterotrimeric G protein), gamma chain [48670] (1)
  long alpha-helix interrupted in the middle
  uperfamily
4. Fe-only hydrogenase smaller subunit [48674] (1)
  uperfamily
5. Moesin tail domain [48678] (1)
  uperfamily
6. Proteinase A inhibitor IA3 [48686] (1)
  uperfamily
7. Epsilon subunit of mitochondrial F1F0-ATP synthase [48690] (1)
  uperfamily
8. Quinohemoprotein amine dehydrogenase C chain [69131] (1)
  uperfamily
9. Stathmin [101494] (1)
  single long helix crosslinking four tubulin subunits
  uperfamily
10. Anti-sigma factor FlgM [101498] (1)
  uperfamily
11. Glu-tRNAGln amidotransferase C subunit [141000] (1)
  uperfamily
12. RelB-like [141004] (1)
  wraps around RelE subunit
  uperfamily
13. Lag-3 N-terminal region [158851] (1)
  long kinked helix, part of the CSL-Notch-Mastermind ternary complex
14. Lipase chaperone-like [158855] (1)
  open single layer scaffold of 11 helices, which engulfs the substrate protein
Multiheme cytochromes [48694] (1)
variable number of helices and little beta structure; not a true fold
1. Multiheme cytochromes [48695] (3)
  duplication: contains multiple CxxCH motifs
  uperfamily