Structural Classification of Proteins
home mail help root up expand collapse

Superfamily: all-alpha NTP pyrophosphatases

basic module consist of 5 active site-forming helices; four from one subunit/structural repeat; the fifth from the other subunit/repeat
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: all-alpha NTP pyrophosphatases [101385]
    multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer
  4. Superfamily: all-alpha NTP pyrophosphatases [101386]
    basic module consist of 5 active site-forming helices; four from one subunit/structural repeat; the fifth from the other subunit/repeat
    link to SUPERFAMILY database - Superfamily

Families:

  1. MazG-like [116993] (3) picpic
    Pfam 03819
  2. AF0060-like [140794] (1) picpic
    consists of a single member with an orphan sequence; "circular permutation" of putative active site residues: the catalytic lysine resides in the N-terminal helix instead of the missing in this family C-terminal helix; probable biological unit is a tertramer, distinct from the MazG family tetramer
  3. Type II deoxyuridine triphosphatase [101387] (2) picpic
    one subunit comprises two degenerate structural repeats, organised into the "rigid" and "mobile" subdomains
  4. HisE-like (PRA-PH) [140797] (5) picpic
    Pfam 01503
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk