Structural Classification of Proteins
Family: DnaQ-like 3'-5' exonuclease
contains
Pfam 00929
Lineage:
Root:
scop
Class:
Alpha and beta proteins (a/b)
[51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold:
Ribonuclease H-like motif
[53066]
3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest
Superfamily:
Ribonuclease H-like
[53098]
consists of one domain of this fold
uperfamily
Family:
DnaQ-like 3'-5' exonuclease
[53118]
contains
Pfam 00929
Protein Domains:
Exonuclease domain of prokaryotic DNA polymerase [53119]
part of Klenow fragment, KF
Escherichia coli
[TaxId: 562]
[53120] (14)
2kfz
protein/DNA complex; complexed with mg, s, zn
region a:324-518
[33683]
2kfn
protein/DNA complex; complexed with mg, mn, s, zn
region a:324-518
[33682]
1kfs
protein/DNA complex; complexed with mg, zn; mutant
region a:324-518
[33681]
1d8y
region a:324-518
[33684]
1d9d
region a:324-518
[33688]
1krp
protein/DNA complex; complexed with pst, zn; mutant
region a:324-518
[33685]
1ksp
protein/DNA complex; complexed with pst, zn; mutant
region a:324-518
[33687]
1qsl
complexed with eu; mutant
region a:324-518
[33686]
2kzz
protein/DNA complex; complexed with zn
region a:324-518
[33689]
2kzm
protein/DNA complex; complexed with mn, zn
region a:324-518
[33690]
1d9f
region a:324-518
[33691]
1dpi
complexed with zn
region a:326-518
[33692]
1kln
protein/DNA complex; complexed with zn; mutant
region a:324-518
[33693]
1kfd
complexed with ctp
region a:324-518
[33694]
Thermus aquaticus
[TaxId: 271]
[53121] (13)
1qtm
protein/DNA complex; complexed with 2dt, mg, ttp
region a:293-422
[33695]
1qsy
protein/DNA complex; complexed with 2da, dad, mg; mutant
region a:293-422
[33700]
1cmw
region a:290-422
[33701]
1qss
protein/DNA complex; complexed with ddg, dg3, mg; mutant
region a:293-422
[33697]
1jxe
region a:293-422
[33705]
3ktq
complexed with ctp, ddc, mg
region a:293-422
[33696]
1bgx
region t:290-422
[33699]
1taq
complexed with bgl, zn; mutant
region a:290-422
[33698]
2ktq
complexed with ctp, ddc, mg
region a:295-422
[33702]
5ktq
complexed with ctp
region a:290-422
[33704]
1ktq
region a:290-422
[33703]
4ktq
complexed with ddc
region a:294-422
[33706]
1tau
protein/DNA complex; complexed with bgl, zn
region a:290-422
[33707]
Bacillus stearothermophilus, newly identified strain as yet unnamed
[TaxId: 1422]
[53122] (45)
SQ
Q45458
298-876 # 88% sequence identity ! SQ
Q5KWC1
299-878 # 99% sequence identity; Geobacillus kaustophilus TaxID:1462
2hhv
automatically matched to d1l3sa1
complexed with 6og, mg, so4, suc
region a:298-468
[136514]
1u4b
complexed with 8og, mg, so4, suc
region a:299-468
[107664]
1nk4
complexed with mg, so4, suc
region a:297-468
[91923]
1njx
complexed with mg, so4, suc
region a:297-468
[91915]
1l3s
complexed with mg, so4, suc
region a:297-468
[84521]
1nk0
complexed with mes, so4, suc
region a:297-468
[91921]
1l3t
complexed with mg, so4, suc
region a:297-468
[84523]
1l3v
complexed with mg, so4, suc
region a:297-468
[84527]
1nkc
complexed with mg, so4, suc
region a:297-468
[91937]
2hhu
automatically matched to d1l3sa1
complexed with 6og, dcp, mg, so4, suc
region a:298-468
[136512]
1l3u
complexed with mg, so4, suc
region a:297-468
[84525]
2hhq
automatically matched to d1l3sa1
complexed with 6og, mg, so4, suc
region a:298-468
[136506]
1nke
complexed with dcp, mg, so4, suc
region a:297-468
[91939]
2hhw
automatically matched to d1l3sa1
complexed with 23t, 6og, ddg, mn, so4, suc; mutant
region a:297-468
[136516]
2hhs
automatically matched to d1l3sa1
complexed with 6og, mg, so4, suc
region a:298-468
[136508]
2hhw
automatically matched to d1l3sa1
complexed with 23t, 6og, ddg, mn, so4, suc; mutant
region d:297-468
[136518]
1nk8
complexed with mg, so4, suc
region a:297-468
[91931]
1nk7
complexed with mg, so4, suc
region a:297-468
[91929]
1nk9
complexed with mg, so4, suc
region a:297-468
[91933]
1l5u
complexed with mg, so4, suc
region a:297-468
[84529]
1njw
complexed with mg, so4, suc
region a:297-468
[91913]
2hw3
automatically matched to d1l3sa1
complexed with 6og, mg, so4, suc
region a:298-468
[136819]
2hvi
automatically matched to d1l3sa1
complexed with dct, ddg, mg, so4, suc
region a:298-468
[136808]
2hvi
automatically matched to d1l3sa1
complexed with dct, ddg, mg, so4, suc
region d:298-468
[136810]
1u45
complexed with 8og, mg, so4, suc
region a:299-468
[107654]
1xc9
complexed with bp, mg, so4, suc
region a:297-468
[115111]
2hht
automatically matched to d1l3sa1
complexed with 6og, mg, so4, suc
region a:298-468
[136510]
1njz
complexed with mg, so4, suc
region a:297-468
[91919]
1u47
complexed with 8og, mg, so4, suc
region a:299-468
[107658]
1njy
complexed with mg, so4, suc, ttp
region a:297-468
[91917]
1nkb
complexed with mg, so4, suc
region a:297-468
[91935]
1ua1
complexed with af, so4
region a:297-468
[107755]
1nk5
complexed with mg, so4, suc
region a:297-468
[91925]
1u48
complexed with 8og, mg, so4, suc
region a:299-468
[107660]
1u49
complexed with 8og, mg, so4, suc
region a:299-468
[107662]
1nk6
complexed with so4, suc
region a:297-468
[91927]
1xwl
complexed with so4
region a:297-468
[33708]
2bdp
protein/DNA complex; complexed with mg, so4
region a:297-468
[33709]
1ua0
complexed with af, so4, suc
region a:297-468
[107753]
4bdp
protein/DNA complex; complexed with mg, so4
region a:297-468
[33710]
2hhx
automatically matched to d1l3sa1
complexed with 6og, so4, suc
region a:298-468
[136520]
1lv5
complexed with dcp, mg, mn, so4; mutant
region a:297-468
[84719]
region b:297-468
[84721]
2hvh
automatically matched to d1l3sa1
complexed with 6og, dct, ddg, mn, so4, suc
region a:298-468
[136804]
2hvh
automatically matched to d1l3sa1
complexed with 6og, dct, ddg, mn, so4, suc
region d:298-468
[136806]
3bdp
protein/DNA complex; complexed with 2dt, so4
region a:297-468
[33711]
Exonuclease domain of T7 DNA polymerase [53123]
Bacteriophage T7
[TaxId: 10760]
[53124] (16)
SQ
P00581
1x9m
complexed with 2dt, 8fg, mg; mutant
region a:1-210
[114999]
1tk5
complexed with 1pe, ddg, mes, mg, so4
region a:1-210
[107074]
1t7p
protein/DNA complex; complexed with 2da, dg3, mg; mutant
region a:1-210
[33712]
1x9w
complexed with 2dt, mg; mutant
region a:1-210
[115008]
1sl2
complexed with 2da, dad, mg, ttd; mutant
region a:1-210
[105706]
1tkd
complexed with 1pe, 8og, d3t, doc, mes, mg, so4
region a:1-210
[107086]
1skr
complexed with 2da, dad, mg; mutant
region a:1-210
[105684]
1sl1
complexed with 2da, mg, ttd; mutant
region a:1-210
[105703]
1tk0
complexed with 1pe, 8og, dct, ddg, mes, mg, so4; mutant
region a:1-210
[107063]
1tk8
complexed with 1pe, 2da, 8og, d3t, mes, mg, so4
region a:1-210
[107079]
1sks
complexed with 2dt, mg, ttd; mutant
region a:1-210
[105687]
1skw
complexed with 2dt, mg; mutant
region a:1-210
[105694]
1t8e
complexed with 2dt, dct, mes, mg, pg4, so4
region a:1-210
[112316]
1x9s
complexed with 2dt, mg; mutant
region a:1-210
[115005]
1zyq
automatically matched to d1skra1
complexed with 8og, dad, ddg, mg; mutant
region a:1-210
[125846]
1sl0
complexed with 2dt, dad, mg; mutant
region a:1-210
[105697]
region c:1-210
[105700]
Exonuclease domain of family B DNA polymerases [53125]
elaborated with additional structures and the N-terminal subdomain
Escherichia coli
[TaxId: 562]
[102482] (1)
DNA polymerase II, additional N-terminal subdomain has an OB-fold with a ferredoxin-like fold insertion
1q8i
mutant
region a:2-389
[96208]
Bacteriophage T4
[TaxId: 10665]
[53126] (2)
additional N-terminal subdomain contains rudimental OB-fold
1noy
exonuclease domain only
protein/DNA complex; complexed with mn, zn
chain a
[33713]
chain b
[33714]
1noz
exonuclease domain only
chain a
[33715]
chain b
[33716]
Bacteriophage RB69
[TaxId: 12353]
[53127] (27)
additional N-terminal subdomain contains rudimental OB-fold and rudimental ferredoxin-like fold
1ih7
complexed with gmp, k
region a:1-375
[62375]
3cq8
automatically matched to d1clqa1
complexed with ca, gol, na, ttp; mutant
region a:1-375
[156927]
1ig9
complexed with ca, doc, ttp; mutant
region a:1-375
[62367]
2dy4
automatically matched to d1clqa1
complexed with ctg; mutant
region a:1-375
[131882]
2dy4
automatically matched to d1clqa1
complexed with ctg; mutant
region b:1-375
[131884]
2dy4
automatically matched to d1clqa1
complexed with ctg; mutant
region c:1-375
[131886]
2dy4
automatically matched to d1clqa1
complexed with ctg; mutant
region d:1-375
[131888]
2ozm
automatically matched to d1clqa1
complexed with 3dr, ddg, mg, n5p; mutant
region a:1-375
[149115]
1clq
region a:1-375
[33717]
2ozs
automatically matched to d1clqa1
complexed with ddg, dtp, mg; mutant
region a:1-375
[149127]
2p5g
automatically matched to d1clqa1
complexed with 3dr; mutant
region a:1-375
[149240]
2p5g
automatically matched to d1clqa1
complexed with 3dr; mutant
region b:1-375
[149242]
2p5g
automatically matched to d1clqa1
complexed with 3dr; mutant
region c:1-375
[149244]
2p5g
automatically matched to d1clqa1
complexed with 3dr; mutant
region d:2-375
[149246]
1q9y
complexed with 8og, ca, dcp, doc; mutant
region a:1-375
[96336]
1q9x
complexed with 3dr, ca, dgp, doc; mutant
region a:1-375
[96328]
region b:1-375
[96330]
region c:1-375
[96332]
region d:1-375
[96334]
2p5o
automatically matched to d1clqa1
complexed with 3dr; mutant
region a:1-375
[139498]
2p5o
automatically matched to d1clqa1
complexed with 3dr; mutant
region b:1-375
[139500]
2p5o
automatically matched to d1clqa1
complexed with 3dr; mutant
region c:1-375
[139502]
2p5o
automatically matched to d1clqa1
complexed with 3dr; mutant
region d:1-375
[139504]
2oyq
automatically matched to d1clqa1
complexed with 3dr, mg, n5i, n5p; mutant
region a:1-375
[149070]
2oyq
automatically matched to d1clqa1
complexed with 3dr, mg, n5i, n5p; mutant
region b:1-375
[149072]
2oyq
automatically matched to d1clqa1
complexed with 3dr, mg, n5i, n5p; mutant
region c:1-375
[149074]
2oyq
automatically matched to d1clqa1
complexed with 3dr, mg, n5i, n5p; mutant
region d:2-375
[149076]
1waj
complexed with 5gp
region a:1-375
[33718]
1waf
complexed with gmp
region a:1-375
[33719]
region b:1-375
[33720]
2atq
automatically matched to d1clqa1
complexed with gdp, zn; mutant
region a:1-375
[127303]
Archaeon Thermococcus gorgonarius
[TaxId: 71997]
[53128] (3)
additional N-terminal subdomain contains rudimental OB-fold but complete ferredoxin-like fold
1tgo
region a:1-347
[33721]
2vwk
automatically matched to d1tgoa1
complexed with na, so4; mutant
region a:1-347
[153677]
2vwj
automatically matched to d1qqca1
complexed with k; mutant
region a:1-347
[153675]
Archaeon Thermococcus sp., 9on-7
[TaxId: 35749]
[53129] (1)
additional N-terminal subdomain contains rudimental OB-fold but complete ferredoxin-like fold
1qht
mutant
region a:1-347
[33722]
Archaeon Desulfurococcus tok
[TaxId: 108142]
[53130] (2)
additional N-terminal subdomain contains rudimental OB-fold but complete ferredoxin-like fold
1d5a
complexed with mg, so4
region a:1-347
[33723]
1qqc
complexed with mg, so4
region a:1-347
[33724]
Archaeon Pyrococcus kodakaraensis
[TaxId: 311400]
[53131] (2)
SQ
P56689
1-758 # 93% sequence identity; Thermococcus kodakarensis KOD1 TaxID: 69014
additional N-terminal subdomain contains rudimental OB-fold but complete ferredoxin-like fold
1wn7
complexed with gol, ni; mutant
region a:1-347
[121088]
1wns
region a:1-347
[109437]
Sulfolobus solfataricus
[TaxId: 2287]
[117647] (1)
SQ
P26811
40-864
1s5j
complexed with mg, sul
region a:40-449
[112040]
N-terminal exonuclease domain of the epsilon subunit of DNA polymerase III [82444]
Escherichia coli
[TaxId: 562]
[82445] (5)
2gui
automatically matched to d1j53a_
complexed with egl, mn, peg, u5p
region a:7-180
[135737]
1j54
complexed with egl, mn, tmp
chain a
[77077]
1j53
complexed with egl, mn, tmp
chain a
[77076]
2ido
automatically matched to d1j53a_
complexed with edo, mn, tmp
region a:7-180
[137284]
2ido
automatically matched to d1j53a_
complexed with edo, mn, tmp
region c:7-180
[137286]
Exonuclease I [53132]
also includes an alpha+beta domain with SH3-like like motif and non-globular C-terminal all-alpha region
Escherichia coli
[TaxId: 562]
[53133] (1)
1fxx
complexed with gol, mg, po4
chain a
[33726]
Escherichia coli K12 (Escherichia coli K-12)
[TaxId: 83333]
[159630] (3)
2qxf
automatically matched to d1fxxa_
complexed with mg, na, tmp
region a:8-474
[151455]
3c95
automatically matched to d1fxxa_
complexed with mg
region a:8-474
[156121]
3c94
automatically matched to d1fxxa_
complexed with mg
region a:8-474
[156120]
Oligoribonuclease [89719]
Haemophilus influenzae
[TaxId: 727]
[89720] (1)
HI1715
1j9a
CASP4
structural genomics
complexed with mse, so4
chain a
[84135]
Escherichia coli
[TaxId: 562]
[142492] (6)
SQ
P0A784
1-180
2igi
automatically matched to d1ytaa1
complexed with acy, cd, zn
region a:1-180
[147657]
2igi
automatically matched to d1ytaa1
complexed with acy, cd, zn
region b:2-180
[147658]
1yta
complexed with flc
region a:1-180
[124002]
1yta
automatically matched to 1YTA A:1-180
complexed with flc
region b:1-180
[124003]
1yta
automatically matched to 1YTA A:1-180
complexed with flc
region c:1-180
[124004]
1yta
automatically matched to 1YTA A:1-180
complexed with flc
region d:1-180
[124005]
Hypothetical protein AT5G06450 [102483]
forms a ring-shaped hexamer; function unknown
Thale-cress (Arabidopsis thaliana)
[TaxId: 3702]
[102484] (7)
1vk0
structural genomics
chain a
[100839]
chain b
[100840]
chain c
[100841]
chain d
[100842]
chain e
[100843]
chain f
[100844]
2q3s
automatically matched to d1vk0a_
region a:1-206
[139802]
2q3s
automatically matched to d1vk0a_
region b:1-206
[139803]
2q3s
automatically matched to d1vk0a_
region c:1-206
[139804]
2q3s
automatically matched to d1vk0a_
region d:1-206
[139805]
2q3s
automatically matched to d1vk0a_
region e:1-206
[139806]
2q3s
automatically matched to d1vk0a_
region f:1-206
[139807]
Exonuclease ERI1 [117648]
Human (Homo sapiens)
[TaxId: 9606]
[117649] (1)
SQ
Q8IV48
122-321
1w0h
complexed with amp, mg
chain a
[114064]
Exonuclease domain of phi29 DNA polymerase [117650]
Bacteriophage phi-29
[TaxId: 10756]
[117651] (18)
SQ
P03680
2py5
automatically matched to d1xhxa1
complexed with edo; mutant
region a:5-187
[149928]
2py5
automatically matched to d1xhxa1
complexed with edo; mutant
region b:5-187
[149930]
2pyj
automatically matched to d1xhxa1
complexed with dgt, doc, edo, mg, mn; mutant
region a:5-187
[149943]
2pyj
automatically matched to d1xhxa1
complexed with dgt, doc, edo, mg, mn; mutant
region b:5-187
[149945]
2pyl
automatically matched to d1xhxa1
complexed with 2da, edo, mg, ttp; mutant
region a:5-187
[149947]
1xhx
complexed with mg, so4; mutant
region a:5-187
[115305]
1xi1
complexed with mg; mutant
region a:5-187
[115309]
1xhz
mutant
region a:5-187
[115307]
2pzs
automatically matched to d1xhxa1
mutant
region a:5-187
[149965]
2pzs
automatically matched to d1xhxa1
mutant
region b:5-187
[149967]
2pzs
automatically matched to d1xhxa1
mutant
region c:5-187
[149969]
2pzs
automatically matched to d1xhxa1
mutant
region d:5-187
[149971]
2ex3
complexed with pb; mutant
region a:6-187
[132498]
2ex3
automatically matched to 2EX3 A:6-187
complexed with pb; mutant
region c:6-187
[132501]
2ex3
automatically matched to 2EX3 A:6-187
complexed with pb; mutant
region e:6-187
[132504]
2ex3
automatically matched to 2EX3 A:6-187
complexed with pb; mutant
region g:6-187
[132507]
2ex3
automatically matched to 2EX3 A:6-187
complexed with pb; mutant
region i:6-187
[132510]
2ex3
automatically matched to 2EX3 A:6-187
complexed with pb; mutant
region k:6-187
[132513]
Interferon-stimulated gene 20 kDa protein, ISG20 [117652]
Human (Homo sapiens)
[TaxId: 9606]
[117653] (1)
SQ
Q96AZ6
6-178
1wlj
complexed with act, mn, u5p
chain a
[114734]
Exosome complex exonuclease RRP6 [142493]
Baker's yeast (Saccharomyces cerevisiae)
[TaxId: 4932]
[142494] (4)
SQ
Q12149
129-420
2hbk
automatically matched to 2HBJ A:129-420
complexed with mn; mutant
region a:129-420
[136314]
2hbj
mutant
region a:129-420
[136312]
2hbl
automatically matched to 2HBJ A:129-420
complexed with amp, mn, zn; mutant
region a:129-420
[136316]
2hbm
automatically matched to 2HBJ A:129-420
complexed with mn, u, zn; mutant
region a:129-420
[136318]
Ribonuclease D, catalytic domain [142495]
Escherichia coli
[TaxId: 562]
[142496] (1)
SQ
P09155
1-193
1yt3
complexed with so4, zn
region a:1-193
[123994]
Ribonuclease T [142497]
Pseudomonas aeruginosa
[TaxId: 287]
[142498] (2)
SQ
Q9HY82
19-220
2f96
complexed with mg
region a:19-220
[133153]
2f96
automatically matched to 2F96 A:19-220
complexed with mg
region b:19-220
[133154]
Three prime repair exonuclease 2, TREX2 [142499]
Human (Homo sapiens)
[TaxId: 9606]
[142500] (2)
SQ
Q9BQ50
44-271
1y97
region a:1-228
[122773]
1y97
automatically matched to 1Y97 A:1-228
region b:3-228
[122774]
Three prime repair exonuclease 1, TREX1 [159631]
Mouse (Mus musculus)
[TaxId: 10090]
[159632] (18)
SQ
Q91XB0
5-234! SQ
Q91XB0
9-234
3b6o
automatically matched to 2O4G A:9-234
complexed with li, tmp
region a:9-234
[154901]
3b6o
automatically matched to 2O4G A:9-234
complexed with li, tmp
region b:9-234
[154902]
3b6o
automatically matched to 2O4G A:9-234
complexed with li, tmp
region c:9-234
[154903]
3b6o
automatically matched to 2O4G A:9-234
complexed with li, tmp
region d:9-234
[154904]
2o4g
complexed with mg, tmp
region a:9-234
[148584]
2o4g
automatically matched to 2O4G A:9-234
complexed with mg, tmp
region b:9-234
[148585]
2o4g
automatically matched to 2O4G A:9-234
complexed with mg, tmp
region c:9-234
[148586]
2o4g
automatically matched to 2O4G A:9-234
complexed with mg, tmp
region d:9-234
[148587]
2ioc
complexed with d5m, mn
region a:5-234
[147742]
2ioc
automatically matched to 2IOC A:5-234
complexed with d5m, mn
region b:8-234
[147743]
2oa8
automatically matched to 2IOC A:5-234
complexed with ca
region a:5-234
[148693]
2oa8
automatically matched to 2IOC A:5-234
complexed with ca
region b:5-234
[148694]
3b6p
automatically matched to 2O4G A:9-234
complexed with na, tmp, zn
region a:9-234
[154905]
3b6p
automatically matched to 2O4G A:9-234
complexed with na, tmp, zn
region b:9-234
[154906]
3b6p
automatically matched to 2O4G A:9-234
complexed with na, tmp, zn
region c:9-234
[154907]
3b6p
automatically matched to 2O4G A:9-234
complexed with na, tmp, zn
region d:9-234
[154908]
2o4i
mutant
region a:9-234
[148588]
2o4i
automatically matched to 2O4I A:9-234
mutant
region b:9-234
[148589]
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Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright
© 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk