Structural Classification of Proteins

Family: DnaQ-like 3'-5' exonuclease

: contains Pfam 00929

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: Ribonuclease H-like motif [53066]
3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest
Superfamily: Ribonuclease H-like [53098]
consists of one domain of this fold
uperfamily
Family: DnaQ-like 3'-5' exonuclease [53118]
contains Pfam 00929

Protein Domains:

Exonuclease domain of prokaryotic DNA polymerase [53119]
part of Klenow fragment, KF
1. Escherichia coli [TaxId: 562] [53120] (14)
2. Thermus aquaticus [TaxId: 271] [53121] (13)
3. Bacillus stearothermophilus, newly identified strain as yet unnamed [TaxId: 1422] [53122] (45)
  SQ Q45458 298-876 # 88% sequence identity ! SQ Q5KWC1 299-878 # 99% sequence identity; Geobacillus kaustophilus TaxID:1462
Exonuclease domain of T7 DNA polymerase [53123]
1. Bacteriophage T7 [TaxId: 10760] [53124] (16)
  SQ P00581
Exonuclease domain of family B DNA polymerases [53125]
elaborated with additional structures and the N-terminal subdomain
1. Escherichia coli [TaxId: 562] [102482] (1)
  DNA polymerase II, additional N-terminal subdomain has an OB-fold with a ferredoxin-like fold insertion
2. Bacteriophage T4 [TaxId: 10665] [53126] (2)
  additional N-terminal subdomain contains rudimental OB-fold
3. Bacteriophage RB69 [TaxId: 12353] [53127] (27)
  additional N-terminal subdomain contains rudimental OB-fold and rudimental ferredoxin-like fold
4. Archaeon Thermococcus gorgonarius [TaxId: 71997] [53128] (3)
  additional N-terminal subdomain contains rudimental OB-fold but complete ferredoxin-like fold
5. Archaeon Thermococcus sp., 9on-7 [TaxId: 35749] [53129] (1)
  additional N-terminal subdomain contains rudimental OB-fold but complete ferredoxin-like fold
6. Archaeon Desulfurococcus tok [TaxId: 108142] [53130] (2)
  additional N-terminal subdomain contains rudimental OB-fold but complete ferredoxin-like fold
7. Archaeon Pyrococcus kodakaraensis [TaxId: 311400] [53131] (2)
  SQ P56689 1-758 # 93% sequence identity; Thermococcus kodakarensis KOD1 TaxID: 69014
  additional N-terminal subdomain contains rudimental OB-fold but complete ferredoxin-like fold
8. Sulfolobus solfataricus [TaxId: 2287] [117647] (1)
  SQ P26811 40-864
N-terminal exonuclease domain of the epsilon subunit of DNA polymerase III [82444]
1. Escherichia coli [TaxId: 562] [82445] (5)
Exonuclease I [53132]
also includes an alpha+beta domain with SH3-like like motif and non-globular C-terminal all-alpha region
1. Escherichia coli [TaxId: 562] [53133] (1)
2. Escherichia coli K12 (Escherichia coli K-12) [TaxId: 83333] [159630] (3)
Oligoribonuclease [89719]
1. Haemophilus influenzae [TaxId: 727] [89720] (1)
  HI1715
2. Escherichia coli [TaxId: 562] [142492] (6)
  SQ P0A784 1-180
Hypothetical protein AT5G06450 [102483]
forms a ring-shaped hexamer; function unknown
1. Thale-cress (Arabidopsis thaliana) [TaxId: 3702] [102484] (7)
Exonuclease ERI1 [117648]
1. Human (Homo sapiens) [TaxId: 9606] [117649] (1)
  SQ Q8IV48 122-321
Exonuclease domain of phi29 DNA polymerase [117650]
1. Bacteriophage phi-29 [TaxId: 10756] [117651] (18)
  SQ P03680
Interferon-stimulated gene 20 kDa protein, ISG20 [117652]
1. Human (Homo sapiens) [TaxId: 9606] [117653] (1)
  SQ Q96AZ6 6-178
Exosome complex exonuclease RRP6 [142493]
1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [142494] (4)
  SQ Q12149 129-420
Ribonuclease D, catalytic domain [142495]
1. Escherichia coli [TaxId: 562] [142496] (1)
  SQ P09155 1-193
Ribonuclease T [142497]
1. Pseudomonas aeruginosa [TaxId: 287] [142498] (2)
  SQ Q9HY82 19-220
Three prime repair exonuclease 2, TREX2 [142499]
1. Human (Homo sapiens) [TaxId: 9606] [142500] (2)
  SQ Q9BQ50 44-271
Three prime repair exonuclease 1, TREX1 [159631]
1. Mouse (Mus musculus) [TaxId: 10090] [159632] (18)
  SQ Q91XB0 5-234! SQ Q91XB0 9-234