Structural Classification of Proteins
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Family: Pyruvate oxidase and decarboxylase Pyr module

the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
    link to SUPERFAMILY database - Superfamily
  5. Family: Pyruvate oxidase and decarboxylase Pyr module [88724]
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology

Protein Domains:

  1. Pyruvate decarboxylase [88725]
    1. Brewer's yeast (Saccharomyces), uvarum strain [TaxId: 4932] [88726] (1)
      1. 1pyd picpicxrefxref
        complexed with mg, tdp
        1. region a:2-181 [31773] picpiclink
        2. region b:2-181 [31775] picpiclink
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [88727] (2)
      1. 1pvd picpicxrefxref
        complexed with mg, tpp
        1. region a:2-181 [31777] picpiclink
        2. region b:2-181 [31779] picpiclink
      2. 1qpb picpicxrefxref
        1. region a:2-181 [31781] picpiclink
        2. region b:2-181 [31783] picpiclink
    3. Zymomonas mobilis [TaxId: 542] [88728] (1)
      1. 1zpd picpicxrefxref
        complexed with cit, dpx, mg
        1. region a:2-187 [31785] picpiclink
        2. region b:2-187 [31787] picpiclink
        3. region e:2-187 [31789] picpiclink
        4. region f:2-187 [31791] picpiclink
  2. Indole-3-pyruvate decarboxylase [89648]
    1. Enterobacter cloacae [TaxId: 550] [89649] (1)
      1. 1ovm picpicxrefxref
        complexed with mg, tpp
        1. region a:3-180 [87462] picpiclink
        2. region b:3-180 [87465] picpiclink
        3. region c:3-180 [87468] picpiclink
        4. region d:3-180 [87471] picpiclink
  3. Pyruvate oxidase [88729]
    1. Lactobacillus plantarum [TaxId: 1590] [88730] (12)
      1. 2ez9 picpicxrefxrefxrefxref
        automatically matched to d1powa2
        complexed with fad, mg, na, tdk; mutant
        1. region a:9-182 [132628] picpiclink
      2. 2ez9 picpicxrefxrefxrefxref
        automatically matched to d1powa2
        complexed with fad, mg, na, tdk; mutant
        1. region b:9-182 [132631] picpiclink
      3. 2ez8 picpicxrefxrefxrefxref
        automatically matched to d1powa2
        complexed with fad, mg, na, pyr, tdl; mutant
        1. region a:9-182 [132622] picpiclink
      4. 2ez8 picpicxrefxrefxrefxref
        automatically matched to d1powa2
        complexed with fad, mg, na, pyr, tdl; mutant
        1. region b:9-182 [132625] picpiclink
      5. 2ez4 picpicxrefxrefxrefxref
        automatically matched to d1powa2
        complexed with fad, mg, na, po4, tpp; mutant
        1. region a:9-182 [132611] picpiclink
      6. 2ez4 picpicxrefxrefxrefxref
        automatically matched to d1powa2
        complexed with fad, mg, na, po4, tpp; mutant
        1. region b:9-182 [132614] picpiclink
      7. 2ezu picpicxrefxrefxrefxref
        automatically matched to d1powa2
        complexed with fad, htl, mg, na, pyr; mutant
        1. region a:9-182 [132640] picpiclink
      8. 2ezu picpicxrefxrefxrefxref
        automatically matched to d1powa2
        complexed with fad, htl, mg, na, pyr; mutant
        1. region b:9-182 [132643] picpiclink
      9. 1pox picpicxrefxref
        complexed with fad, gol, mg, na, tpp; mutant
        1. region a:9-182 [31793] picpiclink
        2. region b:9-182 [31795] picpiclink
      10. 2ezt picpicxrefxrefxrefxref
        automatically matched to d1powa2
        complexed with fad, mg, na, po4, pyr, tdm; mutant
        1. region a:9-182 [132634] picpiclink
      11. 2ezt picpicxrefxrefxrefxref
        automatically matched to d1powa2
        complexed with fad, mg, na, po4, pyr, tdm; mutant
        1. region b:9-182 [132637] picpiclink
      12. 1pow picpicxrefxref
        complexed with fad, mg, tpp
        1. region a:9-182 [31797] picpiclink
        2. region b:9-182 [31799] picpiclink
    2. Aerococcus viridans [TaxId: 1377] [142203] (4)
      1. 2dji picpicxrefxref
        automatically matched to 1V5E A:3-186
        complexed with fad, so4
        1. region a:3-186 [131545] picpiclink
      2. 1v5e picpicxrefxref
        complexed with fad, so4
        1. region a:3-186 [119845] picpiclink
      3. 1v5f picpicxrefxref
        automatically matched to 1V5E A:3-186
        complexed with fad, mg, so4, tpp
        1. region a:4-186 [119848] picpiclink
      4. 1v5g picpicxrefxref
        automatically matched to 1V5E A:3-186
        complexed with fad, htl, mg
        1. region a:4-186 [119851] picpiclink
  4. Benzoylformate decarboxylase [88731]
    1. Pseudomonas putida [TaxId: 303] [88732] (12)
      SQ P20906
      1. 1q6z picpicxrefxref
        complexed with ca, mg, tdp; mutant
        1. region a:2-181 [111656] picpiclink
      2. 2fn3 picpicxrefxref
        automatically matched to d1bfd_2
        complexed with ca, mg, tzd; mutant
        1. region a:2-181 [133804] picpiclink
      3. 1pi3 picpicxrefxref
        complexed with ca, mg, tdp; mutant
        1. region a:2-181 [111634] picpiclink
      4. 1po7 picpicxrefxref
        complexed with ca, mg, tdp; mutant
        1. region a:2-181 [111637] picpiclink
      5. 1yno picpicxrefxref
        automatically matched to d1bfd_2
        complexed with ca, mg, tzd
        1. region a:2-181 [123748] picpiclink
      6. 2fwn picpicxrefxref
        automatically matched to d1bfd_2
        complexed with ca, mg, tdp
        1. region a:2-181 [134250] picpiclink
      7. 1bfd picpicxrefxref
        complexed with ca, mg, tpp
        1. region a:2-181 [31801] picpiclink
      8. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1bfda2
        complexed with mg, so4, tpp; mutant
        1. region a:2-181 [152466] picpiclink
      9. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1bfda2
        complexed with mg, so4, tpp; mutant
        1. region b:2-181 [152469] picpiclink
      10. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1bfda2
        complexed with mg, so4, tpp; mutant
        1. region c:2-181 [152472] picpiclink
      11. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1bfda2
        complexed with mg, so4, tpp; mutant
        1. region d:2-181 [152475] picpiclink
      12. 1mcz picpicxrefxref
        complexed with mg, rmn, tdp
        1. region a:2-181 [78953] picpiclink
        2. region b:2-181 [78956] picpiclink
        3. region c:2-181 [78959] picpiclink
        4. region d:2-181 [78962] picpiclink
        5. region e:2-181 [78965] picpiclink
        6. region f:2-181 [78968] picpiclink
        7. region g:2-181 [78971] picpiclink
        8. region h:2-181 [78974] picpiclink
        9. region i:2-181 [78977] picpiclink
        10. region j:2-181 [78980] picpiclink
        11. region k:2-181 [78983] picpiclink
        12. region l:2-181 [78986] picpiclink
        13. region m:2-181 [78989] picpiclink
        14. region n:2-181 [78992] picpiclink
        15. region o:2-181 [78995] picpiclink
        16. region p:2-181 [78998] picpiclink
  5. Acetohydroxyacid synthase catalytic subunit [88733]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [88734] (6)
      SQ P07342 84-687
      1. 1t9b picpicxrefxref
        complexed with 1cs, fad, k, mg, nsp, p22, p25, yf3
        1. region a:89-263 [112335] picpiclink
        2. region b:89-263 [112338] picpiclink
      2. 1t9c picpicxrefxref
        complexed with 1sm, fad, k, mg, p22, p23
        1. region a:89-263 [112341] picpiclink
        2. region b:89-263 [112344] picpiclink
      3. 1t9d picpicxrefxref
        complexed with 1mm, fad, k, mg, p22, p25, yf1
        1. region a:89-263 [112347] picpiclink
        2. region b:89-263 [112350] picpiclink
        3. region c:89-263 [112353] picpiclink
        4. region d:89-263 [112356] picpiclink
      4. 1t9a picpicxrefxref
        complexed with 1tb, fad, k, mg, p23, yf3, yf4
        1. region a:89-263 [112329] picpiclink
        2. region b:89-263 [112332] picpiclink
      5. 1jsc picpicxrefxref
        complexed with 2hp, fad, k, mg, tpp
        1. region a:83-270 [67225] picpiclink
        2. region b:82-272 [67228] picpiclink
      6. 1n0h picpicxrefxref
        complexed with ayd, cie, dtt, fad, k, mg, tpp
        1. region a:83-270 [79735] picpiclink
        2. region b:83-270 [79738] picpiclink
    2. Thale cress (Arabidopsis thaliana), chloroplast [TaxId: 3702] [142204] (6)
      SQ P17597 86-280
      1. 1ybh picpicxrefxref
        complexed with cie, fad, mg, nhe, p22
        1. region a:86-280 [122892] picpiclink
      2. 1yi0 picpicxrefxref
        automatically matched to 1YBH A:86-280
        complexed with 1sm, fad, mg, nhe, p22
        1. region a:86-280 [123222] picpiclink
      3. 1yhz picpicxrefxref
        automatically matched to 1YBH A:86-280
        complexed with 1cs, fad, mg, nhe, p22
        1. region a:86-280 [123219] picpiclink
      4. 1yhy picpicxrefxref
        automatically matched to 1YBH A:86-280
        complexed with 1mm, fad, mg, nhe, p22
        1. region a:86-280 [123216] picpiclink
      5. 1yi1 picpicxrefxref
        automatically matched to 1YBH A:86-280
        complexed with 1tb, fad, mg, nhe, p22
        1. region a:86-280 [123225] picpiclink
      6. 1z8n picpicxrefxref
        automatically matched to 1YBH A:86-280
        complexed with 1iq, fad, mg, nhe, tpp
        1. region a:86-280 [124720] picpiclink
  6. Catabolic acetolactate synthase [102328]
    1. Klebsiella pneumoniae [TaxId: 573] [102329] (3)
      1. 1ozh picpicxrefxref
        complexed with he3, mg, peg, pig, po4
        1. region a:7-187 [93834] picpiclink
        2. region b:7-187 [93837] picpiclink
        3. region c:7-186 [93840] picpiclink
        4. region d:7-187 [93843] picpiclink
      2. 1ozf picpicxrefxref
        complexed with mg, peg, po4, tpp
        1. region a:7-187 [93822] picpiclink
        2. region b:5-187 [93825] picpiclink
      3. 1ozg picpicxrefxref
        complexed with he3, mg, peg, po4
        1. region a:6-187 [93828] picpiclink
        2. region b:5-187 [93831] picpiclink
  7. Carboxyethylarginine synthase [102330]
    1. Streptomyces clavuligerus [TaxId: 1901] [102331] (11)
      1. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa2
        complexed with gol, mg, so4, tpp
        1. region a:12-197 [147686] picpiclink
      2. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa2
        complexed with gol, mg, so4, tpp
        1. region b:12-197 [147689] picpiclink
      3. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa2
        complexed with gol, mg, so4, tpp
        1. region c:12-197 [147692] picpiclink
      4. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa2
        complexed with gol, mg, so4, tpp
        1. region d:12-197 [147695] picpiclink
      5. 2ihu picpicxrefxref
        automatically matched to d1upaa2
        complexed with gol, k, mg, tar, tp8, tp9
        1. region a:12-197 [147698] picpiclink
      6. 2ihv picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa2
        complexed with gva, k, mg, tpp
        1. region a:12-197 [147701] picpiclink
      7. 2ihv picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa2
        complexed with gva, k, mg, tpp
        1. region b:12-197 [147704] picpiclink
      8. 2ihv picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa2
        complexed with gva, k, mg, tpp
        1. region d:12-197 [147707] picpiclink
      9. 1upa picpicxrefxref
        complexed with mg, so4, tpp
        1. region a:12-197 [99715] picpiclink
        2. region b:12-197 [99718] picpiclink
        3. region c:12-197 [99721] picpiclink
        4. region d:12-197 [99724] picpiclink
      10. 1upb picpicxrefxref
        complexed with mg, so4, tpp
        1. region a:12-197 [99727] picpiclink
        2. region b:12-197 [99730] picpiclink
        3. region c:12-197 [99733] picpiclink
        4. region d:12-197 [99736] picpiclink
      11. 1upc picpicxrefxref
        complexed with mg, so4, tpp
        1. region a:12-197 [99739] picpiclink
        2. region b:12-197 [99742] picpiclink
        3. region c:12-197 [99745] picpiclink
        4. region d:12-197 [99748] picpiclink
        5. region e:12-197 [99751] picpiclink
        6. region f:12-197 [99754] picpiclink
  8. Oxalyl-CoA decarboxylase [142205]
    1. Oxalobacter formigenes [TaxId: 847] [142206] (12)
      SQ P40149 7-194
      1. 2ji7 picpicxrefxrefxrefxref
        automatically matched to d2c31a2
        complexed with adp, b3p, mg, oxt, pge
        1. region a:7-194 [148063] picpiclink
      2. 2ji7 picpicxrefxrefxrefxref
        automatically matched to d2c31a2
        complexed with adp, b3p, mg, oxt, pge
        1. region b:7-194 [148066] picpiclink
      3. 2c31 picpicxrefxrefxrefxref
        complexed with adp, mg, tzd
        1. region a:7-194 [129705] picpiclink
      4. 2c31 picpicxrefxrefxrefxref
        automatically matched to 2C31 A:7-194
        complexed with adp, mg, tzd
        1. region b:7-194 [129708] picpiclink
      5. 2ji6 picpicxrefxrefxrefxref
        automatically matched to d2c31a2
        complexed with adp, b3p, mg, oxk, pge, tpw
        1. region a:7-194 [148057] picpiclink
      6. 2ji6 picpicxrefxrefxrefxref
        automatically matched to d2c31a2
        complexed with adp, b3p, mg, oxk, pge, tpw
        1. region b:7-194 [148060] picpiclink
      7. 2ji9 picpicxrefxrefxrefxref
        automatically matched to d2c31a2
        complexed with adp, b3p, mg, tpw
        1. region a:7-194 [148075] picpiclink
      8. 2ji9 picpicxrefxrefxrefxref
        automatically matched to d2c31a2
        complexed with adp, b3p, mg, tpw
        1. region b:7-194 [148078] picpiclink
      9. 2ji8 picpicxrefxrefxrefxref
        automatically matched to d2c31a2
        complexed with adp, fyn, mg, pge, tpp
        1. region a:7-194 [148069] picpiclink
      10. 2ji8 picpicxrefxrefxrefxref
        automatically matched to d2c31a2
        complexed with adp, fyn, mg, pge, tpp
        1. region b:7-194 [148072] picpiclink
      11. 2jib picpicxrefxrefxrefxref
        automatically matched to d2c31a2
        complexed with adp, coa, mg, pge, tpp
        1. region a:7-194 [148081] picpiclink
      12. 2jib picpicxrefxrefxrefxref
        automatically matched to d2c31a2
        complexed with adp, coa, mg, pge, tpp
        1. region b:7-194 [148084] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
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