Structural Classification of Proteins
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Family: Pyruvate oxidase and decarboxylase, middle domain

N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: DHS-like NAD/FAD-binding domain [52466]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
  4. Superfamily: DHS-like NAD/FAD-binding domain [52467]
    binds cofactor molecules in the opposite direction than classical Rossmann fold
    link to SUPERFAMILY database - Superfamily
  5. Family: Pyruvate oxidase and decarboxylase, middle domain [52475]
    N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold

Protein Domains:

  1. Pyruvate oxidase [52476]
    binds FAD
    1. Lactobacillus plantarum [TaxId: 1590] [52477] (12)
      1. 2ez9 picpicxrefxrefxrefxref
        automatically matched to d1powa1
        complexed with fad, mg, na, tdk; mutant
        1. region a:183-365 [132627] picpiclink
      2. 2ez9 picpicxrefxrefxrefxref
        automatically matched to d1powa1
        complexed with fad, mg, na, tdk; mutant
        1. region b:183-365 [132630] picpiclink
      3. 2ez8 picpicxrefxrefxrefxref
        automatically matched to d1powa1
        complexed with fad, mg, na, pyr, tdl; mutant
        1. region a:183-365 [132621] picpiclink
      4. 2ez8 picpicxrefxrefxrefxref
        automatically matched to d1powa1
        complexed with fad, mg, na, pyr, tdl; mutant
        1. region b:183-365 [132624] picpiclink
      5. 2ez4 picpicxrefxrefxrefxref
        automatically matched to d1powa1
        complexed with fad, mg, na, po4, tpp; mutant
        1. region a:183-365 [132610] picpiclink
      6. 2ez4 picpicxrefxrefxrefxref
        automatically matched to d1powa1
        complexed with fad, mg, na, po4, tpp; mutant
        1. region b:183-365 [132613] picpiclink
      7. 2ezu picpicxrefxrefxrefxref
        automatically matched to d1powa1
        complexed with fad, htl, mg, na, pyr; mutant
        1. region a:183-365 [132639] picpiclink
      8. 2ezu picpicxrefxrefxrefxref
        automatically matched to d1powa1
        complexed with fad, htl, mg, na, pyr; mutant
        1. region b:183-365 [132642] picpiclink
      9. 1pox picpicxrefxref
        complexed with fad, gol, mg, na, tpp; mutant
        1. region a:183-365 [31731] picpiclink
        2. region b:183-365 [31732] picpiclink
      10. 2ezt picpicxrefxrefxrefxref
        automatically matched to d1powa1
        complexed with fad, mg, na, po4, pyr, tdm; mutant
        1. region a:183-365 [132633] picpiclink
      11. 2ezt picpicxrefxrefxrefxref
        automatically matched to d1powa1
        complexed with fad, mg, na, po4, pyr, tdm; mutant
        1. region b:183-365 [132636] picpiclink
      12. 1pow picpicxrefxref
        complexed with fad, mg, tpp
        1. region a:183-365 [31733] picpiclink
        2. region b:183-365 [31734] picpiclink
    2. Aerococcus viridans [TaxId: 1377] [142122] (4)
      1. 2dji picpicxrefxref
        automatically matched to 1V5E A:187-363
        complexed with fad, so4
        1. region a:187-363 [131544] picpiclink
      2. 1v5e picpicxrefxref
        complexed with fad, so4
        1. region a:187-363 [119844] picpiclink
      3. 1v5f picpicxrefxref
        automatically matched to 1V5E A:187-363
        complexed with fad, mg, so4, tpp
        1. region a:187-363 [119847] picpiclink
      4. 1v5g picpicxrefxref
        automatically matched to 1V5E A:187-363
        complexed with fad, htl, mg
        1. region a:187-363 [119850] picpiclink
  2. Pyruvate decarboxylase [52478]
    rudiment domain with a variant fold, lacks FAD-binding
    1. Brewer's yeast (Saccharomyces), uvarum strain [TaxId: 4932] [52479] (1)
      1. 1pyd picpicxrefxref
        complexed with mg, tdp
        1. region a:182-360 [31735] picpiclink
        2. region b:182-360 [31736] picpiclink
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52480] (2)
      1. 1pvd picpicxrefxref
        complexed with mg, tpp
        1. region a:182-360 [31737] picpiclink
        2. region b:182-360 [31738] picpiclink
      2. 1qpb picpicxrefxref
        1. region a:182-360 [31739] picpiclink
        2. region b:182-360 [31740] picpiclink
    3. Zymomonas mobilis [TaxId: 542] [52481] (1)
      1. 1zpd picpicxrefxref
        complexed with cit, dpx, mg
        1. region a:188-362 [31741] picpiclink
        2. region b:188-362 [31742] picpiclink
        3. region e:188-362 [31743] picpiclink
        4. region f:188-362 [31744] picpiclink
  3. Indole-3-pyruvate decarboxylase [89637]
    1. Enterobacter cloacae [TaxId: 550] [89638] (1)
      1. 1ovm picpicxrefxref
        complexed with mg, tpp
        1. region a:181-341 [87461] picpiclink
        2. region b:181-341 [87464] picpiclink
        3. region c:181-341 [87467] picpiclink
        4. region d:181-341 [87470] picpiclink
  4. Benzoylformate decarboxylase [52482]
    1. Pseudomonas putida [TaxId: 303] [52483] (12)
      SQ P20906
      1. 1q6z picpicxrefxref
        complexed with ca, mg, tdp; mutant
        1. region a:182-341 [111655] picpiclink
      2. 2fn3 picpicxrefxref
        automatically matched to d1bfd_1
        complexed with ca, mg, tzd; mutant
        1. region a:182-341 [133803] picpiclink
      3. 1pi3 picpicxrefxref
        complexed with ca, mg, tdp; mutant
        1. region a:182-341 [111633] picpiclink
      4. 1po7 picpicxrefxref
        complexed with ca, mg, tdp; mutant
        1. region a:182-341 [111636] picpiclink
      5. 1yno picpicxrefxref
        automatically matched to d1bfd_1
        complexed with ca, mg, tzd
        1. region a:182-341 [123747] picpiclink
      6. 2fwn picpicxrefxref
        automatically matched to d1bfd_1
        complexed with ca, mg, tdp
        1. region a:182-341 [134249] picpiclink
      7. 1bfd picpicxrefxref
        complexed with ca, mg, tpp
        1. region a:182-341 [31745] picpiclink
      8. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1bfda1
        complexed with mg, so4, tpp; mutant
        1. region a:182-341 [152465] picpiclink
      9. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1bfda1
        complexed with mg, so4, tpp; mutant
        1. region b:182-341 [152468] picpiclink
      10. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1bfda1
        complexed with mg, so4, tpp; mutant
        1. region c:182-341 [152471] picpiclink
      11. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1bfda1
        complexed with mg, so4, tpp; mutant
        1. region d:182-341 [152474] picpiclink
      12. 1mcz picpicxrefxref
        complexed with mg, rmn, tdp
        1. region a:182-341 [78952] picpiclink
        2. region b:182-341 [78955] picpiclink
        3. region c:182-341 [78958] picpiclink
        4. region d:182-341 [78961] picpiclink
        5. region e:182-341 [78964] picpiclink
        6. region f:182-341 [78967] picpiclink
        7. region g:182-341 [78970] picpiclink
        8. region h:182-341 [78973] picpiclink
        9. region i:182-341 [78976] picpiclink
        10. region j:182-341 [78979] picpiclink
        11. region k:182-341 [78982] picpiclink
        12. region l:182-341 [78985] picpiclink
        13. region m:182-341 [78988] picpiclink
        14. region n:182-341 [78991] picpiclink
        15. region o:182-341 [78994] picpiclink
        16. region p:182-341 [78997] picpiclink
  5. Acetohydroxyacid synthase catalytic subunit [69463]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [69464] (6)
      SQ P07342 84-687
      1. 1t9b picpicxrefxref
        complexed with 1cs, fad, k, mg, nsp, p22, p25, yf3
        1. region a:290-460 [112334] picpiclink
        2. region b:290-460 [112337] picpiclink
      2. 1t9c picpicxrefxref
        complexed with 1sm, fad, k, mg, p22, p23
        1. region a:290-460 [112340] picpiclink
        2. region b:290-460 [112343] picpiclink
      3. 1t9d picpicxrefxref
        complexed with 1mm, fad, k, mg, p22, p25, yf1
        1. region a:290-460 [112346] picpiclink
        2. region b:290-460 [112349] picpiclink
        3. region c:290-460 [112352] picpiclink
        4. region d:290-460 [112355] picpiclink
      4. 1t9a picpicxrefxref
        complexed with 1tb, fad, k, mg, p23, yf3, yf4
        1. region a:290-460 [112328] picpiclink
        2. region b:290-460 [112331] picpiclink
      5. 1jsc picpicxrefxref
        complexed with 2hp, fad, k, mg, tpp
        1. region a:280-460 [67224] picpiclink
        2. region b:276-458 [67227] picpiclink
      6. 1n0h picpicxrefxref
        complexed with ayd, cie, dtt, fad, k, mg, tpp
        1. region a:277-460 [79734] picpiclink
        2. region b:278-460 [79737] picpiclink
    2. Thale cress (Arabidopsis thaliana), chloroplast [TaxId: 3702] [142123] (6)
      SQ P17597 281-459
      1. 1ybh picpicxrefxref
        complexed with cie, fad, mg, nhe, p22
        1. region a:281-459 [122891] picpiclink
      2. 1yi0 picpicxrefxref
        automatically matched to 1YBH A:281-459
        complexed with 1sm, fad, mg, nhe, p22
        1. region a:281-459 [123221] picpiclink
      3. 1yhz picpicxrefxref
        automatically matched to 1YBH A:281-459
        complexed with 1cs, fad, mg, nhe, p22
        1. region a:281-459 [123218] picpiclink
      4. 1yhy picpicxrefxref
        automatically matched to 1YBH A:281-459
        complexed with 1mm, fad, mg, nhe, p22
        1. region a:281-459 [123215] picpiclink
      5. 1yi1 picpicxrefxref
        automatically matched to 1YBH A:281-459
        complexed with 1tb, fad, mg, nhe, p22
        1. region a:281-459 [123224] picpiclink
      6. 1z8n picpicxrefxref
        automatically matched to 1YBH A:281-459
        complexed with 1iq, fad, mg, nhe, tpp
        1. region a:281-459 [124719] picpiclink
  6. Catabolic acetolactate synthase [102288]
    1. Klebsiella pneumoniae [TaxId: 573] [102289] (3)
      1. 1ozh picpicxrefxref
        complexed with he3, mg, peg, pig, po4
        1. region a:188-366 [93833] picpiclink
        2. region b:188-366 [93836] picpiclink
        3. region c:189-366 [93839] picpiclink
        4. region d:188-366 [93842] picpiclink
      2. 1ozf picpicxrefxref
        complexed with mg, peg, po4, tpp
        1. region a:188-366 [93821] picpiclink
        2. region b:188-366 [93824] picpiclink
      3. 1ozg picpicxrefxref
        complexed with he3, mg, peg, po4
        1. region a:188-366 [93827] picpiclink
        2. region b:188-366 [93830] picpiclink
  7. Carboxyethylarginine synthase [102290]
    1. Streptomyces clavuligerus [TaxId: 1901] [102291] (11)
      1. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa1
        complexed with gol, mg, so4, tpp
        1. region a:198-374 [147685] picpiclink
      2. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa1
        complexed with gol, mg, so4, tpp
        1. region b:198-374 [147688] picpiclink
      3. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa1
        complexed with gol, mg, so4, tpp
        1. region c:198-374 [147691] picpiclink
      4. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa1
        complexed with gol, mg, so4, tpp
        1. region d:198-374 [147694] picpiclink
      5. 2ihu picpicxrefxref
        automatically matched to d1upaa1
        complexed with gol, k, mg, tar, tp8, tp9
        1. region a:198-374 [147697] picpiclink
      6. 2ihv picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa1
        complexed with gva, k, mg, tpp
        1. region a:198-374 [147700] picpiclink
      7. 2ihv picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa1
        complexed with gva, k, mg, tpp
        1. region b:198-374 [147703] picpiclink
      8. 2ihv picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa1
        complexed with gva, k, mg, tpp
        1. region d:198-374 [147706] picpiclink
      9. 1upa picpicxrefxref
        complexed with mg, so4, tpp
        1. region a:198-374 [99714] picpiclink
        2. region b:198-374 [99717] picpiclink
        3. region c:198-374 [99720] picpiclink
        4. region d:198-374 [99723] picpiclink
      10. 1upb picpicxrefxref
        complexed with mg, so4, tpp
        1. region a:198-374 [99726] picpiclink
        2. region b:198-374 [99729] picpiclink
        3. region c:198-374 [99732] picpiclink
        4. region d:198-374 [99735] picpiclink
      11. 1upc picpicxrefxref
        complexed with mg, so4, tpp
        1. region a:198-374 [99738] picpiclink
        2. region b:198-374 [99741] picpiclink
        3. region c:198-374 [99744] picpiclink
        4. region d:198-374 [99747] picpiclink
        5. region e:198-374 [99750] picpiclink
        6. region f:198-374 [99753] picpiclink
  8. Oxalyl-CoA decarboxylase [142124]
    1. Oxalobacter formigenes [TaxId: 847] [142125] (12)
      SQ P40149 195-369
      1. 2ji7 picpicxrefxrefxrefxref
        automatically matched to d2c31a1
        complexed with adp, b3p, mg, oxt, pge
        1. region a:195-369 [148062] picpiclink
      2. 2ji7 picpicxrefxrefxrefxref
        automatically matched to d2c31a1
        complexed with adp, b3p, mg, oxt, pge
        1. region b:195-369 [148065] picpiclink
      3. 2c31 picpicxrefxrefxrefxref
        complexed with adp, mg, tzd
        1. region a:195-369 [129704] picpiclink
      4. 2c31 picpicxrefxrefxrefxref
        automatically matched to 2C31 A:195-369
        complexed with adp, mg, tzd
        1. region b:195-369 [129707] picpiclink
      5. 2ji6 picpicxrefxrefxrefxref
        automatically matched to d2c31a1
        complexed with adp, b3p, mg, oxk, pge, tpw
        1. region a:195-369 [148056] picpiclink
      6. 2ji6 picpicxrefxrefxrefxref
        automatically matched to d2c31a1
        complexed with adp, b3p, mg, oxk, pge, tpw
        1. region b:195-369 [148059] picpiclink
      7. 2ji9 picpicxrefxrefxrefxref
        automatically matched to d2c31a1
        complexed with adp, b3p, mg, tpw
        1. region a:195-369 [148074] picpiclink
      8. 2ji9 picpicxrefxrefxrefxref
        automatically matched to d2c31a1
        complexed with adp, b3p, mg, tpw
        1. region b:195-369 [148077] picpiclink
      9. 2ji8 picpicxrefxrefxrefxref
        automatically matched to d2c31a1
        complexed with adp, fyn, mg, pge, tpp
        1. region a:195-369 [148068] picpiclink
      10. 2ji8 picpicxrefxrefxrefxref
        automatically matched to d2c31a1
        complexed with adp, fyn, mg, pge, tpp
        1. region b:195-369 [148071] picpiclink
      11. 2jib picpicxrefxrefxrefxref
        automatically matched to d2c31a1
        complexed with adp, coa, mg, pge, tpp
        1. region a:195-369 [148080] picpiclink
      12. 2jib picpicxrefxrefxrefxref
        automatically matched to d2c31a1
        complexed with adp, coa, mg, pge, tpp
        1. region b:195-369 [148083] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
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