Structural Classification of Proteins
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Family: Pyruvate oxidase and decarboxylase PP module

the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
    link to SUPERFAMILY database - Superfamily
  5. Family: Pyruvate oxidase and decarboxylase PP module [88749]
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology

Protein Domains:

  1. Pyruvate decarboxylase [88750]
    1. Brewer's yeast (Saccharomyces), uvarum strain [TaxId: 4932] [88751] (1)
      1. 1pyd picpicxrefxref
        complexed with mg, tdp
        1. region a:361-556 [31774] picpiclink
        2. region b:361-556 [31776] picpiclink
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [88752] (2)
      1. 1pvd picpicxrefxref
        complexed with mg, tpp
        1. region a:361-556 [31778] picpiclink
        2. region b:361-556 [31780] picpiclink
      2. 1qpb picpicxrefxref
        1. region a:361-556 [31782] picpiclink
        2. region b:361-556 [31784] picpiclink
    3. Zymomonas mobilis [TaxId: 542] [88753] (1)
      1. 1zpd picpicxrefxref
        complexed with cit, dpx, mg
        1. region a:363-566 [31786] picpiclink
        2. region b:363-566 [31788] picpiclink
        3. region e:363-566 [31790] picpiclink
        4. region f:363-566 [31792] picpiclink
  2. Indole-3-pyruvate decarboxylase [89654]
    1. Enterobacter cloacae [TaxId: 550] [89655] (1)
      1. 1ovm picpicxrefxref
        complexed with mg, tpp
        1. region a:356-551 [87463] picpiclink
        2. region b:356-551 [87466] picpiclink
        3. region c:356-551 [87469] picpiclink
        4. region d:356-551 [87472] picpiclink
  3. Pyruvate oxidase [88754]
    1. Lactobacillus plantarum [TaxId: 1590] [88755] (12)
      1. 2ez9 picpicxrefxrefxrefxref
        automatically matched to d1powa3
        complexed with fad, mg, na, tdk; mutant
        1. region a:366-593 [132629] picpiclink
      2. 2ez9 picpicxrefxrefxrefxref
        automatically matched to d1powa3
        complexed with fad, mg, na, tdk; mutant
        1. region b:366-593 [132632] picpiclink
      3. 2ez8 picpicxrefxrefxrefxref
        automatically matched to d1powa3
        complexed with fad, mg, na, pyr, tdl; mutant
        1. region a:366-593 [132623] picpiclink
      4. 2ez8 picpicxrefxrefxrefxref
        automatically matched to d1powa3
        complexed with fad, mg, na, pyr, tdl; mutant
        1. region b:366-593 [132626] picpiclink
      5. 2ez4 picpicxrefxrefxrefxref
        automatically matched to d1powa3
        complexed with fad, mg, na, po4, tpp; mutant
        1. region a:366-593 [132612] picpiclink
      6. 2ez4 picpicxrefxrefxrefxref
        automatically matched to d1powa3
        complexed with fad, mg, na, po4, tpp; mutant
        1. region b:366-593 [132615] picpiclink
      7. 2ezu picpicxrefxrefxrefxref
        automatically matched to d1powa3
        complexed with fad, htl, mg, na, pyr; mutant
        1. region a:366-593 [132641] picpiclink
      8. 2ezu picpicxrefxrefxrefxref
        automatically matched to d1powa3
        complexed with fad, htl, mg, na, pyr; mutant
        1. region b:366-593 [132644] picpiclink
      9. 1pox picpicxrefxref
        complexed with fad, gol, mg, na, tpp; mutant
        1. region a:366-593 [31794] picpiclink
        2. region b:366-593 [31796] picpiclink
      10. 2ezt picpicxrefxrefxrefxref
        automatically matched to d1powa3
        complexed with fad, mg, na, po4, pyr, tdm; mutant
        1. region a:366-593 [132635] picpiclink
      11. 2ezt picpicxrefxrefxrefxref
        automatically matched to d1powa3
        complexed with fad, mg, na, po4, pyr, tdm; mutant
        1. region b:366-593 [132638] picpiclink
      12. 1pow picpicxrefxref
        complexed with fad, mg, tpp
        1. region a:366-593 [31798] picpiclink
        2. region b:366-593 [31800] picpiclink
    2. Aerococcus viridans [TaxId: 1377] [142207] (4)
      1. 2dji picpicxrefxref
        automatically matched to 1V5E A:364-592
        complexed with fad, so4
        1. region a:364-592 [131546] picpiclink
      2. 1v5e picpicxrefxref
        complexed with fad, so4
        1. region a:364-592 [119846] picpiclink
      3. 1v5f picpicxrefxref
        automatically matched to 1V5E A:364-592
        complexed with fad, mg, so4, tpp
        1. region a:364-592 [119849] picpiclink
      4. 1v5g picpicxrefxref
        automatically matched to 1V5E A:364-592
        complexed with fad, htl, mg
        1. region a:364-592 [119852] picpiclink
  4. Benzoylformate decarboxylase [88756]
    1. Pseudomonas putida [TaxId: 303] [88757] (12)
      SQ P20906
      1. 1q6z picpicxrefxref
        complexed with ca, mg, tdp; mutant
        1. region a:342-524 [111657] picpiclink
      2. 2fn3 picpicxrefxref
        automatically matched to d1mcza3
        complexed with ca, mg, tzd; mutant
        1. region a:342-525 [133805] picpiclink
      3. 1pi3 picpicxrefxref
        complexed with ca, mg, tdp; mutant
        1. region a:342-524 [111635] picpiclink
      4. 1po7 picpicxrefxref
        complexed with ca, mg, tdp; mutant
        1. region a:342-524 [111638] picpiclink
      5. 1yno picpicxrefxref
        automatically matched to d1mcza3
        complexed with ca, mg, tzd
        1. region a:342-525 [123749] picpiclink
      6. 2fwn picpicxrefxref
        automatically matched to d1mcza3
        complexed with ca, mg, tdp
        1. region a:342-525 [134251] picpiclink
      7. 1bfd picpicxrefxref
        complexed with ca, mg, tpp
        1. region a:342-524 [31802] picpiclink
      8. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1mcza3
        complexed with mg, so4, tpp; mutant
        1. region a:342-525 [152467] picpiclink
      9. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1mcza3
        complexed with mg, so4, tpp; mutant
        1. region b:342-525 [152470] picpiclink
      10. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1mcza3
        complexed with mg, so4, tpp; mutant
        1. region c:342-525 [152473] picpiclink
      11. 2v3w picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1mcza3
        complexed with mg, so4, tpp; mutant
        1. region d:342-525 [152476] picpiclink
      12. 1mcz picpicxrefxref
        complexed with mg, rmn, tdp
        1. region a:342-525 [78954] picpiclink
        2. region b:342-525 [78957] picpiclink
        3. region c:342-525 [78960] picpiclink
        4. region d:342-525 [78963] picpiclink
        5. region e:342-525 [78966] picpiclink
        6. region f:342-525 [78969] picpiclink
        7. region g:342-525 [78972] picpiclink
        8. region h:342-525 [78975] picpiclink
        9. region i:342-525 [78978] picpiclink
        10. region j:342-525 [78981] picpiclink
        11. region k:342-525 [78984] picpiclink
        12. region l:342-525 [78987] picpiclink
        13. region m:342-525 [78990] picpiclink
        14. region n:342-525 [78993] picpiclink
        15. region o:342-525 [78996] picpiclink
        16. region p:342-525 [78999] picpiclink
  5. Acetohydroxyacid synthase catalytic subunit [88758]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [88759] (6)
      SQ P07342 84-687
      1. 1t9b picpicxrefxref
        complexed with 1cs, fad, k, mg, nsp, p22, p25, yf3
        1. region a:461-687 [112336] picpiclink
        2. region b:461-687 [112339] picpiclink
      2. 1t9c picpicxrefxref
        complexed with 1sm, fad, k, mg, p22, p23
        1. region a:461-687 [112342] picpiclink
        2. region b:461-687 [112345] picpiclink
      3. 1t9d picpicxrefxref
        complexed with 1mm, fad, k, mg, p22, p25, yf1
        1. region a:461-687 [112348] picpiclink
        2. region b:461-687 [112351] picpiclink
        3. region c:461-687 [112354] picpiclink
        4. region d:461-687 [112357] picpiclink
      4. 1t9a picpicxrefxref
        complexed with 1tb, fad, k, mg, p23, yf3, yf4
        1. region a:461-687 [112330] picpiclink
        2. region b:461-687 [112333] picpiclink
      5. 1jsc picpicxrefxref
        complexed with 2hp, fad, k, mg, tpp
        1. region a:461-648 [67226] picpiclink
        2. region b:464-649 [67229] picpiclink
      6. 1n0h picpicxrefxref
        complexed with ayd, cie, dtt, fad, k, mg, tpp
        1. region a:461-687 [79736] picpiclink
        2. region b:461-687 [79739] picpiclink
    2. Thale cress (Arabidopsis thaliana), chloroplast [TaxId: 3702] [142208] (6)
      SQ P17597 460-667
      1. 1ybh picpicxrefxref
        complexed with cie, fad, mg, nhe, p22
        1. region a:460-667 [122893] picpiclink
      2. 1yi0 picpicxrefxref
        automatically matched to 1YBH A:460-667
        complexed with 1sm, fad, mg, nhe, p22
        1. region a:460-667 [123223] picpiclink
      3. 1yhz picpicxrefxref
        automatically matched to 1YBH A:460-667
        complexed with 1cs, fad, mg, nhe, p22
        1. region a:460-667 [123220] picpiclink
      4. 1yhy picpicxrefxref
        automatically matched to 1YBH A:460-667
        complexed with 1mm, fad, mg, nhe, p22
        1. region a:460-667 [123217] picpiclink
      5. 1yi1 picpicxrefxref
        automatically matched to 1YBH A:460-667
        complexed with 1tb, fad, mg, nhe, p22
        1. region a:460-667 [123226] picpiclink
      6. 1z8n picpicxrefxref
        automatically matched to 1YBH A:460-667
        complexed with 1iq, fad, mg, nhe, tpp
        1. region a:460-667 [124721] picpiclink
  6. Catabolic acetolactate synthase [102333]
    1. Klebsiella pneumoniae [TaxId: 573] [102334] (3)
      1. 1ozh picpicxrefxref
        complexed with he3, mg, peg, pig, po4
        1. region a:367-558 [93835] picpiclink
        2. region b:367-559 [93838] picpiclink
        3. region c:367-558 [93841] picpiclink
        4. region d:367-555 [93844] picpiclink
      2. 1ozf picpicxrefxref
        complexed with mg, peg, po4, tpp
        1. region a:367-554 [93823] picpiclink
        2. region b:367-554 [93826] picpiclink
      3. 1ozg picpicxrefxref
        complexed with he3, mg, peg, po4
        1. region a:367-554 [93829] picpiclink
        2. region b:367-554 [93832] picpiclink
  7. Carboxyethylarginine synthase [102335]
    1. Streptomyces clavuligerus [TaxId: 1901] [102336] (11)
      1. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa3
        complexed with gol, mg, so4, tpp
        1. region a:375-572 [147687] picpiclink
      2. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa3
        complexed with gol, mg, so4, tpp
        1. region b:375-572 [147690] picpiclink
      3. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa3
        complexed with gol, mg, so4, tpp
        1. region c:375-572 [147693] picpiclink
      4. 2iht picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa3
        complexed with gol, mg, so4, tpp
        1. region d:375-572 [147696] picpiclink
      5. 2ihu picpicxrefxref
        automatically matched to d1upaa3
        complexed with gol, k, mg, tar, tp8, tp9
        1. region a:375-572 [147699] picpiclink
      6. 2ihv picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa3
        complexed with gva, k, mg, tpp
        1. region a:375-572 [147702] picpiclink
      7. 2ihv picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa3
        complexed with gva, k, mg, tpp
        1. region b:375-572 [147705] picpiclink
      8. 2ihv picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1upaa3
        complexed with gva, k, mg, tpp
        1. region d:375-572 [147708] picpiclink
      9. 1upa picpicxrefxref
        complexed with mg, so4, tpp
        1. region a:375-572 [99716] picpiclink
        2. region b:375-572 [99719] picpiclink
        3. region c:375-563 [99722] picpiclink
        4. region d:375-572 [99725] picpiclink
      10. 1upb picpicxrefxref
        complexed with mg, so4, tpp
        1. region a:375-572 [99728] picpiclink
        2. region b:375-572 [99731] picpiclink
        3. region c:375-563 [99734] picpiclink
        4. region d:375-572 [99737] picpiclink
      11. 1upc picpicxrefxref
        complexed with mg, so4, tpp
        1. region a:375-572 [99740] picpiclink
        2. region b:375-572 [99743] picpiclink
        3. region c:375-572 [99746] picpiclink
        4. region d:375-572 [99749] picpiclink
        5. region e:375-572 [99752] picpiclink
        6. region f:375-572 [99755] picpiclink
  8. Oxalyl-CoA decarboxylase [142209]
    1. Oxalobacter formigenes [TaxId: 847] [142210] (12)
      SQ P40149 370-552
      1. 2ji7 picpicxrefxrefxrefxref
        automatically matched to d2c31a3
        complexed with adp, b3p, mg, oxt, pge
        1. region a:370-552 [148064] picpiclink
      2. 2ji7 picpicxrefxrefxrefxref
        automatically matched to d2c31a3
        complexed with adp, b3p, mg, oxt, pge
        1. region b:370-552 [148067] picpiclink
      3. 2c31 picpicxrefxrefxrefxref
        complexed with adp, mg, tzd
        1. region a:370-552 [129706] picpiclink
      4. 2c31 picpicxrefxrefxrefxref
        automatically matched to 2C31 A:370-552
        complexed with adp, mg, tzd
        1. region b:370-552 [129709] picpiclink
      5. 2ji6 picpicxrefxrefxrefxref
        automatically matched to d2c31a3
        complexed with adp, b3p, mg, oxk, pge, tpw
        1. region a:370-552 [148058] picpiclink
      6. 2ji6 picpicxrefxrefxrefxref
        automatically matched to d2c31a3
        complexed with adp, b3p, mg, oxk, pge, tpw
        1. region b:370-552 [148061] picpiclink
      7. 2ji9 picpicxrefxrefxrefxref
        automatically matched to d2c31a3
        complexed with adp, b3p, mg, tpw
        1. region a:370-552 [148076] picpiclink
      8. 2ji9 picpicxrefxrefxrefxref
        automatically matched to d2c31a3
        complexed with adp, b3p, mg, tpw
        1. region b:370-552 [148079] picpiclink
      9. 2ji8 picpicxrefxrefxrefxref
        automatically matched to d2c31a3
        complexed with adp, fyn, mg, pge, tpp
        1. region a:370-552 [148070] picpiclink
      10. 2ji8 picpicxrefxrefxrefxref
        automatically matched to d2c31a3
        complexed with adp, fyn, mg, pge, tpp
        1. region b:370-552 [148073] picpiclink
      11. 2jib picpicxrefxrefxrefxref
        automatically matched to d2c31a3
        complexed with adp, coa, mg, pge, tpp
        1. region a:370-552 [148082] picpiclink
      12. 2jib picpicxrefxrefxrefxref
        automatically matched to d2c31a3
        complexed with adp, coa, mg, pge, tpp
        1. region b:370-552 [148085] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
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