Class: All beta proteins

Lineage:

1. Root: scop
2. Class: All beta proteins [48724]

Folds:

1. Immunoglobulin-like beta-sandwich [48725] (28)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands
   1. Immunoglobulin [48726] (4)
      uperfamily
   2. E set domains [81296] (23)
      "Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies
      uperfamily
   3. Fibronectin type III [49265] (1)
      uperfamily
   4. PKD domain [49299] (1)
      uperfamily
   5. beta-Galactosidase/glucuronidase domain [49303] (1)
      uperfamily
   6. Transglutaminase, two C-terminal domains [49309] (1)
      uperfamily
   7. Cadherin-like [49313] (2)
      uperfamily
   8. Actinoxanthin-like [49319] (1)
      uperfamily
   9. Cu,Zn superoxide dismutase-like [49329] (1)
      has additional strand at N-terminus
      uperfamily
   10. CBD9-like [49344] (3)
       has additional strand at N-terminus; the active site in a similar topological location as the Cu,Zn SOD site
       uperfamily
   11. Lamin A/C globular tail domain [74853] (1)
       uperfamily
   12. Clathrin adaptor appendage domain [49348] (3)
       contains an additional N-terminal strand
       uperfamily
   13. Integrin domains [69179] (1)
       uperfamily
   14. PapD-like [49354] (2)
       contains PP switch between strands D and C'
       uperfamily
   15. Purple acid phosphatase, N-terminal domain [49363] (1)
       uperfamily
   16. Fungal immunomodulatory protein, FIP [101542] (1)
       uperfamily
   17. Superoxide reductase-like [49367] (1)
       uperfamily
   18. Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) [74863] (1)
       uperfamily
   19. Invasin/intimin cell-adhesion fragments [49373] (1)
       uperfamily
   20. Antigen MPT63/MPB63 (immunoprotective extracellular protein) [81982] (1)
       uperfamily
   21. Tp47 lipoprotein, middle and C-terminal domains [81986] (1)
       uperfamily
   22. ASF1-like [101546] (1)
       contains extra C-terminal strand
       uperfamily
   23. ApaG-like [110069] (1)
       uperfamily
   24. Accessory protein X4 (ORF8, ORF7a) [117066] (1)
       uperfamily
   25. LEA14-like [117070] (1)
       uperfamily
   26. ICP-like [141066] (1)
       topological variant with similarity to the Cupredoxin-like fold (scop_cf 49502) in the N-terminal region
       uperfamily
   27. CalX-like [141072] (1)
       uperfamily
   28. NEAT domain-like [158911] (1)
2. Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (10)
   sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
   1. Diphtheria toxin, C-terminal domain [49380] (1)
      uperfamily
   2. Carbohydrate-binding domain [49384] (3)
      uperfamily
   3. Bacterial adhesins [49401] (6)
      uperfamily
   4. Alpha-macroglobulin receptor domain [49410] (1)
      uperfamily
   5. p53-like transcription factors [49417] (7)
      uperfamily
   6. Cytochrome f, large domain [49441] (1)
      uperfamily
   7. beta-sandwich domain of Sec23/24 [81995] (1)
      uperfamily
   8. Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor [49447] (1)
      duplication: one domain of this fold is inserted into another domain of the same fold
      uperfamily
   9. Peptidylarginine deiminase Pad4, middle domain [110083] (1)
      uperfamily
   10. DR1885-like metal-binding protein [110087] (1)
       uperfamily
3. Prealbumin-like [49451] (7)
   sandwich; 7 strands in 2 sheets, greek-key
   variations: some members have additional 1-2 strands to common fold
   1. Starch-binding domain-like [49452] (3)
      uperfamily
   2. Carboxypeptidase regulatory domain-like [49464] (2)
      uperfamily
   3. VHL [49468] (1)
      uperfamily
   4. Transthyretin (synonym: prealbumin) [49472] (1)
      uperfamily
   5. Cna protein B-type domain [49478] (1)
      uperfamily
   6. Aromatic compound dioxygenase [49482] (1)
      uperfamily
   7. Hypothetical protein PA1324 [117074] (1)
      uperfamily
4. HSP40/DnaJ peptide-binding domain [49492] (1)
   sandwich; 6 strands in 2 sheets
   1. HSP40/DnaJ peptide-binding domain [49493] (1)
      uperfamily
5. Penicillin-binding protein associated domain [69188] (1)
   sandwich; 6 strands in 2 sheets
   1. Penicillin-binding protein associated domain [69189] (2)
      uperfamily
6. alpha-Amylase inhibitor tendamistat [49497] (1)
   sandwich; 6 strands in 2 sheets
   1. alpha-Amylase inhibitor tendamistat [49498] (1)
      uperfamily
7. C-terminal domain of mollusc hemocyanin [81278] (1)
   six-stranded beta-sandwich, jelly-roll/greek-key topology
   1. C-terminal domain of mollusc hemocyanin [81277] (1)
      analogous to the Ig-like domain of arthropod hemocyanin; similar sequential but different spatial position relative the shared domain
      uperfamily
8. HPA-like [141085] (1)
   sandwich, 6 strands in 2 sheets; jelly-roll (truncated); also includes the pending PCSK9 V domain-like superfamily (the C-terminal domains of 2p4e and 2pmw)
   1. Agglutinin HPA-like [141086] (1)
      forms similar trimers to the PCSK9 V domain; strand directions of the subunit beta-sheets are parallel to the three-fold symmetry axis;
      uperfamily
9. L21p-like [141090] (1)
   core: sandwich, 6 strands in 2 sheets
   1. L21p-like [141091] (1)
      uperfamily
10. Cupredoxin-like [49502] (2)
    sandwich; 7 strands in 2 sheets, greek-key
    variations: some members have additional 1-2 strands
    1. Cupredoxins [49503] (7)
       contains copper-binding site
       uperfamily
    2. Major surface antigen p30, SAG1 [74877] (1)
       SS-crosslinked beta-sandwich of distinct geometry but topologically similar to cupredoxins
       uperfamily
11. Ctag/Cox11 [110110] (1)
    sandwich; 7 strands in 2 sheets, greek-key; permutation of the immunoglobulin-like fold
    1. Ctag/Cox11 [110111] (1)
       uperfamily
12. Atu1913-like [141098] (1)
    sandwich; 7 strands in two sheets, greek-key/jelly-roll; forms segment swapped dimers, swapping is probably facilitated by the helix insertion after strand 3
    1. Atu1913-like [141099] (1)
       uperfamily
13. C2 domain-like [49561] (5)
    sandwich; 8 strands in 2 sheets; greek-key
    1. C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (2)
       two constituent families are related by circular permutation
       uperfamily
    2. Periplasmic chaperone C-domain [49584] (1)
       uperfamily
    3. PHL pollen allergen [49590] (1)
       uperfamily
    4. Rab geranylgeranyltransferase alpha-subunit, insert domain [49594] (1)
       uperfamily
    5. Smr-associated domain-like [158949] (1)
14. TRAF domain-like [49598] (1)
    sandwich; 8 strands in 2 sheets; greek-key
    1. TRAF domain-like [49599] (2)
       has a circularly permuted immunoglobulin-fold topology with extra strand
       uperfamily
15. Neurophysin II [49605] (1)
    sandwich; 8 strands in 2 sheets; meander
    1. Neurophysin II [49606] (1)
       duplication: composed of two structural repeats
       uperfamily
16. N-utilization substance G protein NusG, insert domain [82003] (1)
    sandwich; 8 strands in 2 sheets; meander
    1. N-utilization substance G protein NusG, insert domain [82004] (1)
       uperfamily
17. Nucleoplasmin-like/VP (viral coat and capsid proteins) [88632] (7)
    sandwich; 8 strands in 2 sheets; jelly-roll; some members can have additional 1-2 strands
    characteristic interaction between the domains of this fold allows the formation of five-fold and pseudo six-fold assemblies
    1. Nucleoplasmin-like core domain [69203] (1)
       oligomerizes into a pentameric ring structure
       uperfamily
    2. Positive stranded ssRNA viruses [88633] (9)
       uperfamily
    3. ssDNA viruses [88645] (3)
       uperfamily
    4. Group I dsDNA viruses [88648] (1)
       uperfamily
    5. Group II dsDNA viruses VP [49749] (3)
       duplication: consists of two domains of this fold packed together like the nucleoplasmin subunits
       trimeric; in the trimers, the domains are arranged around pseudo six-fold axis
       uperfamily
    6. Satellite viruses [88650] (1)
       uperfamily
    7. PHM/PNGase F [49742] (2)
       members of this superfamily bind peptide substrates
       duplication: consists of two domains of this fold packed together like the adjacent nucleoplasmin subunits
       uperfamily
18. gamma-Crystallin-like [49694] (1)
    sandwich; 8 strands in 2 sheets; greek-key
    duplication: has internal pseudo twofold symmetry
    1. gamma-Crystallin-like [49695] (6)
       uperfamily
19. Lipase/lipooxygenase domain (PLAT/LH2 domain) [49722] (1)
    sandwich; 8 strands in 2 sheets; complex topology
    duplication: has weak internal pseudo twofold symmetry
    1. Lipase/lipooxygenase domain (PLAT/LH2 domain) [49723] (3)
       uperfamily
20. Calpain large subunit, middle domain (domain III) [49757] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll
    1. Calpain large subunit, middle domain (domain III) [49758] (1)
       uperfamily
21. Supernatant protein factor (SPF), C-terminal domain [101575] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll; similarity to the Nucleoplasmin-like/VP fold
    1. Supernatant protein factor (SPF), C-terminal domain [101576] (1)
       uperfamily
22. Hypothetical protein TM1070 [89231] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll
    1. Hypothetical protein TM1070 [89232] (1)
       uperfamily
23. Olfactory marker protein [63696] (1)
    sandwich; 8 strands in 2 sheets; jelly-roll
    1. Olfactory marker protein [63697] (1)
       uperfamily
24. HSP20-like chaperones [49763] (1)
    sandwich; 8 strands in 2 sheets; greek-key
    1. HSP20-like chaperones [49764] (4)
       uperfamily
25. Heat shock protein 70kD (HSP70), peptide-binding domain [100919] (1)
    beta-sandwich: 8 strands in 2 sheets
    1. Heat shock protein 70kD (HSP70), peptide-binding domain [100920] (1)
       uperfamily
26. Ecotin, trypsin inhibitor [49771] (1)
    sandwich; 8 strands in 2 sheets; complex topology with the crossing loops
    1. Ecotin, trypsin inhibitor [49772] (1)
       uperfamily
27. PEBP-like [49776] (1)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
    1. PEBP-like [49777] (2)
       uperfamily
28. Ganglioside M2 (gm2) activator [63706] (1)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
    1. Ganglioside M2 (gm2) activator [63707] (1)
       uperfamily
29. Nicotinic receptor ligand binding domain-like [63711] (1)
    sandwich; 8 strands in 2 sheets; greek-key: partial topological similarity to immunoglobulin-like folds
    1. Nicotinic receptor ligand binding domain-like [63712] (1)
       uperfamily
30. Beta-galactosidase LacA, domain 3 [117099] (1)
    sandwich; 8 strands in 2 sheets
    1. Beta-galactosidase LacA, domain 3 [117100] (1)
       uperfamily
31. Galactose-binding domain-like [49784] (1)
    sandwich; 9 strands in 2 sheets; jelly-roll
    1. Galactose-binding domain-like [49785] (32)
       uperfamily
32. Viral protein domain [49817] (1)
    sandwich; 9 strands in 2 sheets; jelly-roll; form trimers
    1. Viral protein domain [49818] (3)
       forms homotrimers
       uperfamily
33. Calcium-mediated lectin [82025] (1)
    sandwich; 9 strands in 2 sheets; greek-key
    1. Calcium-mediated lectin [82026] (1)
       uperfamily
34. Dextranase, N-terminal domain [101595] (1)
    sandwich; 9 strands in 2 sheets; greek-key
    1. Dextranase, N-terminal domain [101596] (1)
       uperfamily
35. Smp-1-like [101600] (1)
    sandwich; 9 strands in 2 sheets; greek-key/jelly-roll
    1. Smp-1-like [101601] (1)
       uperfamily
36. Superantigen (mitogen) Ypm [101605] (1)
    sandwich; 9 strands in 2 sheets; jelly-roll
    1. Superantigen (mitogen) Ypm [101606] (1)
       uperfamily
37. ENV polyprotein, receptor-binding domain [49829] (1)
    sandwich; 9 strands in 2 sheets; greek-key; contains a few helices in loop regions
    1. ENV polyprotein, receptor-binding domain [49830] (1)
       uperfamily
38. BTV NS2-like ssRNA-binding domain [110131] (1)
    sandwich; 9 strands in 2 sheets; unusual topology with 2 crossover loops
    1. BTV NS2-like ssRNA-binding domain [110132] (1)
       uperfamily
39. WSSV envelope protein-like [158973] (1)
    beta-sandwich; 9 strands in 2 sheets; greek-key
    1. WSSV envelope protein-like [158974] (1)
40. Virus attachment protein globular domain [49834] (1)
    sandwich, 10 strands in 2 sheets; greek-key
    1. Virus attachment protein globular domain [49835] (3)
       uperfamily
41. TNF-like [49841] (1)
    sandwich, 10 strands in 2 sheets; jelly-roll
    1. TNF-like [49842] (1)
       uperfamily
42. CUB-like [49853] (3)
    sandwich, 10 strands in 2 sheets; jelly-roll
    1. Spermadhesin, CUB domain [49854] (1)
       uperfamily
    2. Collagen-binding domain [89260] (1)
       N-terminal strand appears only in calcium-free form
       uperfamily
    3. Acetamidase/Formamidase-like [141130] (1)
       decorated fold with additional structures; contains extra C-terminal alpha+beta subdomain: beta(2)-alpha(2)-beta(2): antiparallel beta-sheet, order 1243
       uperfamily
43. Hyaluronate lyase-like, C-terminal domain [49862] (1)
    sandwich, 10 strands in 2 sheets; "folded meander"
    1. Hyaluronate lyase-like, C-terminal domain [49863] (1)
       uperfamily
44. Cytolysin/lectin [63723] (1)
    sandwich, 10 strands in 2 sheets;
    1. Cytolysin/lectin [63724] (2)
       some topological similarity to osmotin
       uperfamily
45. Putative glucosidase YicI, C-terminal domain [117124] (1)
    sandwich; 10 strands in two sheets
    1. Putative glucosidase YicI, C-terminal domain [117125] (1)
       uperfamily
46. CsrA-like [117129] (1)
    sandwich; 10 strands in 2 sheets; intertwined dimer (segment-swapped, 5-stranded greek-key sandwich?)
    1. CsrA-like [117130] (1)
       uperfamily
47. Osmotin, thaumatin-like protein [49869] (1)
    sandwich; 11 strands in 2 sheets
    1. Osmotin, thaumatin-like protein [49870] (1)
       has two smaller insertion domains
       uperfamily
48. SMAD/FHA domain [49878] (1)
    sandwich; 11 strands in 2 sheets; greek-key
    1. SMAD/FHA domain [49879] (4)
       has a few short helices inserted in loops
       uperfamily
49. Soluble secreted chemokine inhibitor, VCCI [49888] (1)
    sandwich; 11 strands in 2 sheets; greek-key
    1. Soluble secreted chemokine inhibitor, VCCI [49889] (1)
       uperfamily
50. Baculovirus p35 protein [49893] (1)
    sandwich; 14 strands in 2 sheets; greek-key
    1. Baculovirus p35 protein [49894] (1)
       has a few helices inserted in loops
       uperfamily
51. Concanavalin A-like lectins/glucanases [49898] (1)
    sandwich; 12-14 strands in 2 sheets; complex topology
    1. Concanavalin A-like lectins/glucanases [49899] (25)
       uperfamily
52. Supersandwich [49993] (3)
    sandwich; 18 strands in 2 sheets
    1. Galactose mutarotase-like [74650] (11)
       probable carbohydrate-binding domain in enzymes acting on sugars
       uperfamily
    2. V-region of surface antigen I/II (SA I/II, PAC) [74914] (1)
       uperfamily
    3. Amine oxidase catalytic domain [49998] (1)
       uperfamily
53. Leukotriene A4 hydrolase N-terminal domain [63736] (1)
    duplication: two beta-sandwiches of similar topologies are fused together in a single three beta-sheet domain
    1. Leukotriene A4 hydrolase N-terminal domain [63737] (1)
       uperfamily
54. EV matrix protein [50011] (1)
    consists of two beta-sandwich domains of similar topologies
    1. EV matrix protein [50012] (1)
       uperfamily
55. Viral chemokine binding protein m3 [82045] (1)
    consists of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds
    1. Viral chemokine binding protein m3 [82046] (1)
       uperfamily
56. gp9 [50016] (1)
    consists of two different beta-sandwich domains unrelated to other beta-sandwich folds
    1. gp9 [50017] (1)
       uperfamily
57. Flagellar hook protein flgE [117142] (1)
    consists of two different domains; d1: [complex fold made of bifurcated beta-sheets]; d2 (inserted into d1): [beta-sandwich; 8 strands in 2 sheets]
    1. Flagellar hook protein flgE [117143] (1)
       uperfamily
58. ISP domain [50021] (1)
    consists of two all-beta subdomains: conserved small domain has a rubredoxin-like fold; larger domain consists of 6 beta-stands packed in either sandwich of two 3-stranded sheets or closed barrel (n=6; S=8)
    1. ISP domain [50022] (3)
       uperfamily
59. Trm112p-like [158996] (1)
    similar to the small domain of the ISP (scop_cf 50021)
    1. Trm112p-like [158997] (1)
       possibly have evolved from a metal ion (or cofactor)-binding protein of a rubredoxin-like fold; in the known members, from one to three of the four metal-binding positions are occupied by cysteine residues
60. YopX-like [159005] (1)
    consists of two domains: the N-terminal dimerisation domain of variable structure and the C-terminal domain with similarity to the SH3-like fold
    1. YopX-like [159006] (1)
       conmrises proteins of plasmid and phage origins
61. Obg-fold [82050] (1)
    this fold is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich
    these regions form six left-handed collagen-like helices packed and H-bonded together
    1. Obg GTP-binding protein N-terminal domain [82051] (1)
       uperfamily
62. SH3-like barrel [50036] (21)
    barrel, partly opened; n*=4, S*=8; meander
    the last strand is interrupted by a turn of 3-10 helix
    1. C-terminal domain of transcriptional repressors [50037] (3)
       the N-terminal domains of these repressors bind DNA
       uperfamily
    2. SH3-domain [50044] (1)
       uperfamily
    3. Prokaryotic SH3-related domain [82057] (4)
       uperfamily
    4. Myosin S1 fragment, N-terminal domain [50084] (1)
       uperfamily
    5. Tudor/PWWP/MBT [63748] (4)
       uperfamily
    6. Chromo domain-like [54160] (3)
       SH3-like barrel is capped by a C-terminal helix
       uperfamily
    7. BAH domain [82061] (1)
       uperfamily
    8. PAZ domain [101690] (1)
       uperfamily
    9. Cap-Gly domain [74924] (1)
       uperfamily
    10. Electron transport accessory proteins [50090] (4)
        uperfamily
    11. Translation proteins SH3-like domain [50104] (7)
        many known members contain KOW motif
        uperfamily
    12. Cell growth inhibitor/plasmid maintenance toxic component [50118] (3)
        contains insert beta-sheet subdomain and C-terminal helix
        uperfamily
    13. Fumarylacetoacetate hydrolase, FAH, N-terminal domain [63433] (1)
        uperfamily
    14. DNA-binding domain of retroviral integrase [50122] (1)
        uperfamily
    15. Hypothetical protein YfhH [101697] (1)
        contains extra N-terminal all-alpha subdomain
        uperfamily
    16. Kinase-associated protein B-like [141251] (1)
        contains extra C-terminal alpha-hairpin
        uperfamily
    17. YccV-like [141255] (1)
        contains extra C-terminal helix packed against barrel
        uperfamily
    18. CarD-like [141259] (1)
        uperfamily
    19. Mib/herc2 domain-like [159034] (1)
    20. YorP-like [159038] (1)
    21. Plus3-like [159042] (1)
63. GroES-like [50128] (2)
    contains barrel, partly opened; n*=4, S*=8; meander
    1. GroES-like [50129] (2)
       uperfamily
    2. SacY-like RNA-binding domain [50151] (1)
       uperfamily
64. PDZ domain-like [50155] (1)
    contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
    1. PDZ domain-like [50156] (6)
       peptide-binding domain
       uperfamily
65. N-terminal domains of the minor coat protein g3p [50175] (1)
    core: barrel, in some members open; n*=4, S*=8; meander
    1. N-terminal domains of the minor coat protein g3p [50176] (1)
       uperfamily
66. Sm-like fold [50181] (5)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology
    1. Sm-like ribonucleoproteins [50182] (6)
       uperfamily
    2. YhbC-like, C-terminal domain [74942] (1)
       uperfamily
    3. GatD N-terminal domain-like [141300] (1)
       uperfamily
    4. Dom34/Pelota N-terminal domain-like [159065] (1)
    5. TrmB C-terminal domain-like [159071] (1)
       sugar-binding domain; permuted OB-fold?
67. SspB-like [101737] (1)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
    1. SspB-like [101738] (2)
       uperfamily
68. Rof/RNase P subunit-like [101743] (1)
    core: barrel, open; n*=4, S*=8; meander; SH3-like topology; some similarity to the Sm-like fold
    1. Rof/RNase P subunit-like [101744] (2)
       uperfamily
69. Hydrophobin II, HfbII [101750] (1)
    core: barrel, closed; n=4, S=8; complex topology; helix-containing crossover connection
    1. Hydrophobin II, HfbII [101751] (1)
       uperfamily
70. Ribosomal protein L14 [50192] (1)
    barrel, closed; n=5, S=8, meander
    1. Ribosomal protein L14 [50193] (1)
       uperfamily
71. OB-fold [50198] (16)
    barrel, closed or partly opened n=5, S=10 or S=8; greek-key
    1. Staphylococcal nuclease [50199] (1)
       uperfamily
    2. Bacterial enterotoxins [50203] (2)
       uperfamily
    3. TIMP-like [50242] (3)
       uperfamily
    4. Heme chaperone CcmE [82093] (1)
       uperfamily
    5. gp5 N-terminal domain-like [69255] (1)
       uperfamily
    6. Hypothetical protein YgiW [101756] (1)
       uperfamily
    7. Nucleic acid-binding proteins [50249] (16)
       uperfamily
    8. Inorganic pyrophosphatase [50324] (1)
       uperfamily
    9. MOP-like [50331] (3)
       uperfamily
    10. CheW-like [50341] (1)
        uperfamily
    11. TM0957-like [141318] (1)
        extra N-terminal region and large insertion after strand 3 together form an alpha-helical subdomain
        uperfamily
    12. NfeD domain-like [141322] (1)
        close structural similarity to some members of the Nucleic acid-binding OB-fold proteins, possibly related to this superfamily
        uperfamily
    13. BC4932-like [159121] (1)
    14. HupF/HypC-like [159127] (1)
        contains extra C-terminal helix packed against the beta-barrel side
    15. EutN/CcmL-like [159133] (1)
        homohexameric unit
    16. HIN-2000 domain-like [159141] (1)
        duplication: tandem repeat of two OB-fold domains
72. PRC-barrel domain [50345] (1)
    core: barrel, partly opened; n*=5, S*=8; meander
    1. PRC-barrel domain [50346] (4)
       uperfamily
73. beta-Trefoil [50352] (8)
    barrel, closed; n=6, S=12; and a hairpin triplet; meander
    duplication: has internal pseudo threefold symmetry
    1. Cytokine [50353] (2)
       uperfamily
    2. MIR domain [82109] (1)
       uperfamily
    3. Ricin B-like lectins [50370] (3)
       uperfamily
    4. Agglutinin [50382] (1)
       this superfamily is distinct from the ricin B-like lectin superfamily
       uperfamily
    5. STI-like [50386] (2)
       uperfamily
    6. Actin-crosslinking proteins [50405] (2)
       uperfamily
    7. DNA-binding protein LAG-1 (CSL) [110217] (1)
       contains rudiment hairpin triplet lacking one hairpin
       uperfamily
    8. AbfB domain [110221] (1)
       uperfamily
74. Reductase/isomerase/elongation factor common domain [50412] (4)
    barrel, closed; n=6, S=10; greek-key
    1. Riboflavin synthase domain-like [63380] (3)
       uperfamily
    2. Riboflavin kinase-like [82114] (2)
       uperfamily
    3. FucI/AraA C-terminal domain-like [50443] (2)
       uperfamily
    4. Translation proteins [50447] (6)
       uperfamily
75. Elongation factor/aminomethyltransferase common domain [50464] (2)
    barrel, closed; n=6, S=10; greek-key
    1. EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain [50465] (1)
       probably related to the second domain and its superfamiy by a circular permutation
       uperfamily
    2. Aminomethyltransferase beta-barrel domain [101790] (1)
       uperfamily
76. Split barrel-like [50474] (3)
    barrel; n=6, S=10; greek-key
    1. FMN-binding split barrel [50475] (4)
       related to the ferredoxin reductase-like FAD-binding domain
       uperfamily
    2. PilZ domain-like [141371] (2)
       uperfamily
    3. YkvR-like [159173] (1)
       provisional classification, pending better resolution structures
77. Phage tail proteins [69278] (1)
    core: barrel; n=6, S=10; greek-key; topologically similar to the FMN-binding split barrel
    1. Phage tail proteins [69279] (3)
       uperfamily
78. Surface presentation of antigens (SPOA) [101800] (1)
    segment-swapped dimer forming two identical conjoint barrels (n=6, S=10) topologically similar to the FMN-binding split barrel
    1. Surface presentation of antigens (SPOA) [101801] (1)
       uperfamily
79. FMT C-terminal domain-like [50485] (1)
    barrel, open; n*=6, S*=10; greek-key
    1. FMT C-terminal domain-like [50486] (2)
       uperfamily
80. Trypsin-like serine proteases [50493] (1)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
    1. Trypsin-like serine proteases [50494] (4)
       uperfamily
81. Replicase NSP9 [101815] (1)
    barrel; n=6, S=8, greek-key; similar to one trypsin-like protease barrel
    1. Replicase NSP9 [101816] (1)
       uperfamily
82. mu transposase, C-terminal domain [50609] (1)
    barrel; n=6, S=8, greek-key
    1. mu transposase, C-terminal domain [50610] (1)
       uperfamily
83. Domain of alpha and beta subunits of F1 ATP synthase-like [50614] (3)
    barrel, closed; n=6, S=8; greek-key
    1. N-terminal domain of alpha and beta subunits of F1 ATP synthase [50615] (1)
       uperfamily
    2. Alanine racemase C-terminal domain-like [50621] (2)
       the barrel is decorated with additional structures
       uperfamily
    3. Aminopeptidase/glucanase lid domain [101821] (1)
       uperfamily
84. Small protein B (SmpB) [74981] (1)
    barrel, closed; n=6, S=8, greek-key, partial similarity to the OB-fold
    1. Small protein B (SmpB) [74982] (1)
       uperfamily
85. Acid proteases [50629] (1)
    barrel, closed; n=6, S=10, complex topology
    1. Acid proteases [50630] (3)
       uperfamily
86. ValRS/IleRS/LeuRS editing domain [50676] (1)
    core: barrel, closed; n=6, S=8; topology is similar to that of the acid proteases barrel
    1. ValRS/IleRS/LeuRS editing domain [50677] (1)
       uperfamily
87. Urease metallochaperone UreE, N-terminal domain [69286] (1)
    barrel, closed; n=6, S=8; a crossover loop topology
    1. Urease metallochaperone UreE, N-terminal domain [69287] (1)
       uperfamily
88. Double psi beta-barrel [50684] (2)
    barrel, closed; n=6, S=10; complex topology with crossover (psi) loops
    1. Barwin-like endoglucanases [50685] (4)
       uperfamily
    2. ADC-like [50692] (3)
       uperfamily
89. Ribosomal protein L25-like [50714] (1)
    barrel, closed; n=6, S=10; complex topology
    1. Ribosomal protein L25-like [50715] (2)
       uperfamily
90. Core binding factor beta, CBF [50722] (1)
    barrel, closed; n=6, S=10; meander; capped at both ends by alpha-helices
    1. Core binding factor beta, CBF [50723] (1)
       uperfamily
91. NifT/FixU barrel-like [159202] (1)
    barrel, closed, n=6, S=10; meander
    1. NifT/FixU-like [159203] (1)
92. PH domain-like barrel [50728] (2)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
    1. PH domain-like [50729] (13)
       uperfamily
    2. PA2021-like [141447] (1)
       prokaryotiic proteins of PH domain-like fold lacking the N-terminal strand
       uperfamily
93. Transcription factor IIA (TFIIA), beta-barrel domain [50783] (1)
    barrel, closed; n=6, S=12; mixed beta-sheet
    1. Transcription factor IIA (TFIIA), beta-barrel domain [50784] (1)
       dimer of non-identical beta-sheet domains
       uperfamily
94. Hcp1-like [141451] (1)
    barrel, closed; n=6, S=12; contains extra, non-barrel strand 7 at the C-terminus
    1. Hcp1-like [141452] (1)
       probable biological unit is a ring-like hexamer containing a 24-stranded beta-barrel made of the subunit beta-sheets
       uperfamily
95. YopT-like [159221] (1)
    beta-sheet barrel, closed, n=6, S=12, capped at both ends by helices; intertwined dimer of beta-alpha-beta(2) subinits;
    1. YopT-like [159222] (1)
96. Herpes virus serine proteinase, assemblin [50788] (1)
    core: barrel, closed; n=7, S=8; complex topology
    1. Herpes virus serine proteinase, assemblin [50789] (1)
       uperfamily
97. PK beta-barrel domain-like [50799] (1)
    barrel, closed; n=7, S=10; complex topology
    1. PK beta-barrel domain-like [50800] (2)
       uperfamily
98. XRCC4, N-terminal domain [50808] (1)
    barrel, closed; n=7, S=10; order: 1234765; strands 1 and 5 are parallel to each other
    1. XRCC4, N-terminal domain [50809] (1)
       an HTH motif connects strands 4 and 5
       uperfamily
99. HesB-like domain [89359] (1)
    barrel, closed; n=7, S=10; complex topology
    1. HesB-like domain [89360] (1)
       uperfamily
100. Bacterial fluorinating enzyme, C-terminal domain [101851] (1)
     barrel, closed; n=7, S=10; greek-key topology; one overside connection
     1. Bacterial fluorinating enzyme, C-terminal domain [101852] (1)
        uperfamily
101. SPOC domain-like [100938] (1)
     barrel, closed; n=7, S=10; complex topology
     1. SPOC domain-like [100939] (3)
        uperfamily
102. BH3618-like [141456] (1)
     barrel, closed; n=7, S=10; meander
     1. BH3618-like [141457] (1)
        uperfamily
103. FAS1 domain [82152] (1)
     core: barrel, closed; n=7, S=12; meander
     1. FAS1 domain [82153] (1)
        uperfamily
104. Lipocalins [50813] (1)
     barrel, closed or opened; n=8, S=12; meander
     1. Lipocalins [50814] (9)
        bind hydrophobic ligands in their interior
        uperfamily
105. Streptavidin-like [50875] (8)
     barrel, closed; n=8, S=10; meander
     1. Avidin/streptavidin [50876] (1)
        uperfamily
     2. beta-Barrel protease inhibitors [50882] (2)
        uperfamily
     3. D-aminopeptidase, middle and C-terminal domains [50886] (1)
        uperfamily
     4. Quinohemoprotein amine dehydrogenase A chain, domain 3 [69298] (1)
        uperfamily
     5. Dipeptidyl peptidase I (cathepsin C), exclusion domain [75001] (1)
        uperfamily
     6. YceI-like [101874] (1)
        uperfamily
     7. Extracellular hemoglobin linker subunit, receptor domain [141480] (1)
        uperfamily
     8. YdhA-like [141488] (1)
        uperfamily
106. FomD barrel-like [159233] (1)
     barrel, closed; n=8, S=12; meander; similar topology to the AOC barrel-like fold (reversed to the lipocalin barrel topology)
     1. FomD-like [159234] (1)
107. AOC barrel-like [141492] (2)
     barrel, closed; n=8, S=10; meander; mirrored (reversed) topology to the Spreptavidin-like and Lipocalin-like folds
     1. Allene oxide cyclase-like [141493] (1)
        uperfamily
     2. SO1590-like [159238] (1)
108. AttH-like [159244] (1)
     duplication: two flattened beta-barrels of lipocalin-like topology are orthogonally packed with a pseudo twofold symmetry
     1. AttH-like [159245] (1)
109. Cyclophilin-like [50890] (1)
     barrel, closed; n=8, S=10; complex topology
     1. Cyclophilin-like [50891] (4)
        uperfamily
110. Oncogene products [50903] (1)
     barrel, closed; n=8, S=10; one overside connection
     1. Oncogene products [50904] (1)
        duplication: N- and C-terminal halves are related by pseudo dyad
        uperfamily
111. L,D-transpeptidase catalytic domain-like [141522] (1)
     barrel, closed; n=8, S=10; one overside connection
     1. L,D-transpeptidase catalytic domain-like [141523] (1)
        uperfamily
112. Sortase [63816] (1)
     barrel, closed; n=8, S=10; mixed sheet; two overside connections
     1. Sortase [63817] (1)
        uperfamily
113. PTSIIA/GutA-like [141529] (1)
     barrel, closed; n=8, S=12; mixed sheet; two overside connections; duplication: consists of two intertwinned structural repeats
     1. PTSIIA/GutA-like [141530] (1)
        uperfamily
114. Mannose 6-phosphate receptor domain [50910] (1)
     barrel, partly open; n*=8, S*=10; one psi loop
     1. Mannose 6-phosphate receptor domain [50911] (1)
        uperfamily
115. triple barrel [50915] (1)
     dimer of two non-identical subunits; forms two similar barrels, n=8, S=10 each, that are fused together with the formation of third barrel, n=6, S=8
     1. Rap30/74 interaction domains [50916] (1)
        uperfamily
116. 4-bladed beta-propeller [50922] (1)
     consists of four 4-stranded beta-sheet motifs; meander
     1. Hemopexin-like domain [50923] (1)
        uperfamily
117. 5-bladed beta-propeller [50933] (3)
     consists of five 4-stranded beta-sheet motifs; meander
     1. Tachylectin-2 [50934] (1)
        uperfamily
     2. Arabinanase/levansucrase/invertase [75005] (5)
        uperfamily
     3. Apyrase [101887] (1)
        distorted propeller with an alpha helix inserted between the second and third blades
        uperfamily
118. 6-bladed beta-propeller [50938] (11)
     consists of six 4-stranded beta-sheet motifs; meander
     1. Sialidases [50939] (2)
        uperfamily
     2. Soluble quinoprotein glucose dehydrogenase [50952] (1)
        uperfamily
     3. Thermostable phytase (3-phytase) [50956] (1)
        uperfamily
     4. TolB, C-terminal domain [50960] (1)
        uperfamily
     5. YWTD domain [63825] (1)
        uperfamily
     6. Calcium-dependent phosphotriesterase [63829] (3)
        uperfamily
     7. Tricorn protease N-terminal domain [69304] (1)
        possibly related to the second domain of tricorn protease (a distorted 7-bladed beta-propeller)
        uperfamily
     8. Fucose-specific lectin [89372] (1)
        uperfamily
     9. NHL repeat [101898] (1)
        uperfamily
     10. GyrA/ParC C-terminal domain-like [101904] (1)
         beta-pinwheel, a variant of beta-propeller fold; unlike an canonical beta-propeller, strands 1 and 4 of each four-strand repeat unit are in one blade whereas strands 2 and 3 are in the next blade
         uperfamily
     11. Kelch motif [117281] (1)
         uperfamily
119. 7-bladed beta-propeller [50964] (14)
     consists of seven 4-stranded beta-sheet motifs; meander
     1. Galactose oxidase, central domain [50965] (1)
        uperfamily
     2. YVTN repeat-like/Quinoprotein amine dehydrogenase [50969] (3)
        uperfamily
     3. Nitrous oxide reductase, N-terminal domain [50974] (1)
        uperfamily
     4. WD40 repeat-like [50978] (2)
        also contains 8-bladed propellers
        uperfamily
     5. RCC1/BLIP-II [50985] (2)
        two families are clearly related but differ by the number of strands per blade
        uperfamily
     6. Clathrin heavy-chain terminal domain [50989] (1)
        uperfamily
     7. Integrin alpha N-terminal domain [69318] (1)
        uperfamily
     8. Peptidase/esterase 'gauge' domain [50993] (2)
        uperfamily
     9. Tricorn protease domain 2 [69322] (1)
        distorted 7-bladed beta-propeller fold; possibly related to the N-terminal domain of tricorn protease (a 6-bladed beta-propeller)
        uperfamily
     10. 3-carboxy-cis,cis-mucoante lactonizing enzyme [75011] (1)
         uperfamily
     11. Putative isomerase YbhE [101908] (1)
         uperfamily
     12. Sema domain [101912] (1)
         irregular 7-bladed beta-propeller with a large insertion in the fifth blade
         uperfamily
     13. Oligoxyloglucan reducing end-specific cellobiohydrolase [110296] (1)
         duplication: # two beta-propeller domains are swapped with the N-terminal strands; similar domain arrangment to the Actin interacting protein 1 (scop_pr 89378)
         uperfamily
     14. Nucleoporin domain [117289] (1)
         uperfamily
120. 8-bladed beta-propeller [50997] (3)
     consists of eight 4-stranded beta-sheet motifs; meander
     also found in some members of the WD40-repeat superfamily
     1. Quinoprotein alcohol dehydrogenase-like [50998] (1)
        uperfamily
     2. C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase [51004] (1)
        uperfamily
     3. DPP6 N-terminal domain-like [82171] (1)
        uperfamily
121. Glycosyl hydrolase domain [51010] (1)
     folded sheet; greek-key
     1. Glycosyl hydrolase domain [51011] (5)
        this domain is C-terminal to the catalytic beta/alpha barrel domain
        uperfamily
122. WW domain-like [51044] (3)
     core: 3-stranded meander beta-sheet
     1. WW domain [51045] (1)
        uperfamily
     2. Carbohydrate binding domain [51055] (1)
        uperfamily
     3. Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain [101931] (1)
        uperfamily
123. Head domain of nucleotide exchange factor GrpE [51063] (1)
     small mixed beta-sheet, 4 "generalized" strands
     1. Head domain of nucleotide exchange factor GrpE [51064] (1)
        uperfamily
124. Coronavirus RNA-binding domain [110303] (1)
     coiled antiparallel beta-sheet of 5 strands, order 51324; complex topology, crossing loops
     1. Coronavirus RNA-binding domain [110304] (1)
        uperfamily
125. Ribonuclease domain of colicin E3 [63839] (1)
     twisted meander beta-sheet of 6 strands
     1. Ribonuclease domain of colicin E3 [63840] (1)
        uperfamily
126. NAC domain [101940] (1)
     core: twisted 7-stranded beta-sheet (half-barrel)
     1. NAC domain [101941] (1)
        uperfamily
127. At5g01610-like [141561] (1)
     contains large meander beta-sheet bent into a scoop-like shape
     1. At5g01610-like [141562] (1)
        uperfamily
128. Carbonic anhydrase [51068] (1)
     single sheet; 10 strands
     1. Carbonic anhydrase [51069] (1)
        uperfamily
129. LolA-like prokaryotic lipoproteins and lipoprotein localization factors [89391] (1)
     11 stranded sheet partly folded in a corner-like structure filled with a few short helices
     1. Prokaryotic lipoproteins and lipoprotein localization factors [89392] (3)
        uperfamily
130. YmcC-like [159269] (1)
     12-stranded meander beta-sheet, folded into a deformed beta-barrel; topological similarity to the LolA-like fold (scop_cf 89391)
     1. YmcC-like [159270] (1)
131. Spiral beta-roll [159274] (1)
     a large 15-stranded beta-sheet rolled about a single helix core; overlapping edges form a sandwich-like structure; topological similarity to the LolA-like fold (scop_cf 89391)
     1. PA1994-like [159275] (1)
132. Bacteriochlorophyll A protein [51080] (1)
     single sheet; 16 strands; meander
     1. Bacteriochlorophyll A protein [51081] (1)
        uperfamily
133. open-sided beta-meander [51086] (2)
     single sheet formed by beta-hairpin repeats; exposed on both sides in the middle
     1. Outer surface protein [51087] (1)
        21 stranded sheet partly folded upon itself at the ends
        uperfamily
     2. Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [82185] (1)
        11+ stranded sheet partly folded upon itself at the C-end
        uperfamily
134. beta-Prism I [51091] (3)
     consists of 3 4-stranded sheets; strands are parallel to the 3-fold axis
     duplication: has internal pseudo threefold symmetry
     1. Vitelline membrane outer protein-I (VMO-I) [51092] (1)
        uperfamily
     2. delta-Endotoxin (insectocide), middle domain [51096] (1)
        uperfamily
     3. Mannose-binding lectins [51101] (1)
        uperfamily
135. beta-Prism II [51109] (1)
     consists of 3 4-stranded sheets; strands are perpendicular to the 3-fold axis
     duplication: consists of two domains of this fold
     1. alpha-D-mannose-specific plant lectins [51110] (1)
        uperfamily
136. Single-stranded right-handed beta-helix [51125] (8)
     superhelix turns are made of parallel beta-strands and (short) turns
     1. beta-Roll [51120] (1)
        superhelix turns are made of two short strands each
        uperfamily
     2. Pectin lyase-like [51126] (11)
        superhelix turns are made of 3 strands each
        uperfamily
     3. Insect cysteine-rich antifreeze protein [51156] (1)
        superhelix turns are made of two short strands each
        uperfamily
     4. Cell-division inhibitor MinC, C-terminal domain [63848] (1)
        superhelix turns are made of three short strands each
        uperfamily
     5. Alpha subunit of glutamate synthase, C-terminal domain [69336] (1)
        uperfamily
     6. C-terminal domain of adenylylcyclase associated protein [69340] (1)
        superhelix turns are made of two strands each
        uperfamily
     7. Stabilizer of iron transporter SufD [101960] (1)
        superhelix turns are made of two very long strands each
        uperfamily
     8. Pentapeptide repeat-like [141571] (1)
        superhelix turns are made of four short strands each; duplication: the sequence pentapeptide repeats correspond to individual strands
        uperfamily
137. Single-stranded left-handed beta-helix [51160] (4)
     superhelix turns are made of parallel beta-strands and (short) turns
     1. Trimeric LpxA-like enzymes [51161] (8)
        superhelical turns are made of three short strands; duplication: the sequence hexapeptide repeats correspond to individual strands
        uperfamily
     2. An insect antifreeze protein [51177] (1)
        superhelical turns are made of three short strands
        uperfamily
     3. Adhesin YadA, collagen-binding domain [101967] (1)
        superhelical turns are made of two short strands
        uperfamily
     4. Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain [159283] (1)
        probable rudiment form of the LpxA-like hexapeptide domain
138. Double-stranded beta-helix [51181] (7)
     one turn of helix is made by two pairs of antiparallel strands linked with short turns
     has appearance of a sandwich of distinct architecture and jelly-roll topology
     1. RmlC-like cupins [51182] (24)
        uperfamily
     2. Clavaminate synthase-like [51197] (13)
        Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold
        uperfamily
     3. cAMP-binding domain-like [51206] (3)
        uperfamily
     4. Regulatory protein AraC [51215] (1)
        uperfamily
     5. Thiamin pyrophosphokinase, substrate-binding domain [63862] (1)
        uperfamily
     6. Calcium ATPase, transduction domain A [81653] (1)
        a distorted variant of double-helix
        uperfamily
     7. TRAP-like [51219] (2)
        shorter variant of double-helix; assembles in large ring-like structures containing from 9 to 11 domains
        uperfamily
139. Triple-stranded beta-helix [69348] (1)
     (homo)trimer; each chain donates 3 beta-strands per turn of the helix
     1. Phage fibre proteins [69349] (5)
        uperfamily
140. Triple beta-spiral [51224] (1)
     trimer formed by the interlocking beta-hairpin repeat units
     1. Fibre shaft of virus attachment proteins [51225] (2)
        uperfamily
141. Trimeric adhesin [101998] (1)
     trimer; contains two different beta-prism-like domains connected by an linker subdomain of less regular structure
     1. Trimeric adhesin [101999] (1)
        uperfamily
142. beta-hairpin stack [69359] (1)
     Trp-rich beta-hairpin repeat units form helical structures of 3 units per turn
     1. Cell wall binding repeat [69360] (1)
        uperfamily
143. Barrel-sandwich hybrid [51229] (4)
     sandwich of half-barrel shaped beta-sheets
     1. Single hybrid motif [51230] (1)
        7 to 8 strands in 2 beta-sheets
        uperfamily
     2. Rudiment single hybrid motif [51246] (2)
        uperfamily
     3. Duplicated hybrid motif [51261] (2)
        half-barrel sheet of 8 strands sandwiched with two 3-stranded sheets
        uperfamily
     4. Ribosomal L27 protein-like [110324] (2)
        rudiment single hybrid fold with a permuted topology
        uperfamily
144. beta-clip [51268] (7)
     double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll
     1. AFP III-like domain [51269] (1)
        duplication: consists of two structural repeats related by pseudo dyad
        uperfamily
     2. SET domain [82199] (3)
        duplication: the core is composed of two structural repeats similar to (circularly permuted) repeats of AFPIII
        also contains a substrate-binding alpha+beta subdomain inserted in the core
        uperfamily
     3. Head decoration protein D (gpD, major capsid protein D) [51274] (1)
        uperfamily
     4. Urease, beta-subunit [51278] (1)
        uperfamily
     5. MoeA C-terminal domain-like [63867] (1)
        uperfamily
     6. dUTPase-like [51283] (1)
        forms tight trimer through an additional beta-sheet in each subunit
        subunit beta-sheets are orthogonally packed around the three-fold axis
        uperfamily
     7. Tlp20, baculovirus telokin-like protein [51289] (1)
        similar to dUTPase in fold and trimeric assembly
        uperfamily
145. PheT/TilS domain [56036] (1)
     core: 3 layers; contains beta-sandwich of unusual topology
     1. PheT/TilS domain [56037] (2)
        contains putative tRNA-binding structural motif
        uperfamily
146. C-terminal autoproteolytic domain of nucleoporin nup98 [82214] (1)
     multisheet protein with a mixture of beta-sandwich and beta-prism features
     1. C-terminal autoproteolytic domain of nucleoporin nup98 [82215] (1)
        uperfamily
147. Pseudo beta-prism [141657] (1)
     beta-sandwich with one regular beta-sheet and the other beta-sheet bent in the middle with a set of aligned beta-bulges
     1. Bacteriophage trimeric proteins domain [141658] (2)
        found in phage proteins that form trimers, but is not involved in the trimerisation
        uperfamily
148. SARS ORF9b-like [141665] (1)
     complex dimeric fold with three intersubunit beta-sheets packed around a single core
     1. 'SARS ORF9b-like [141666] (1)
        uperfamily
149. Adsorption protein p2 [89427] (1)
     multisheet protein containing partial beta-propeller and beta-sandwich regions
     1. Adsorption protein p2 [89428] (1)
        uperfamily
150. Baseplate structural protein gp8 [89432] (1)
     multisheet protein with a mixture of beta-sandwich and beta-barrel features
     1. Baseplate structural protein gp8 [89433] (1)
        uperfamily
151. Hedgehog/intein (Hint) domain [51293] (1)
     complex fold made of five beta-hairpin units and a b-ribbon arc
     1. Hedgehog/intein (Hint) domain [51294] (2)
        duplication: contains two intertwined structural repeats
        uperfamily
152. LexA/Signal peptidase [51305] (1)
     complex fold made of several coiled beta-sheets; contains an SH3-like barrel
     1. LexA/Signal peptidase [51306] (2)
        uperfamily
153. Cloacin translocation domain [69368] (1)
     complex fold made of several coiled beta-sheets
     1. Cloacin translocation domain [69369] (1)
        uperfamily
154. Mss4-like [51315] (1)
     complex fold made of several coiled beta-sheets
     1. Mss4-like [51316] (4)
        duplication: tandem repeat of two similar structural motifs
        uperfamily
155. Cyanovirin-N [51321] (1)
     complex fold
     1. Cyanovirin-N [51322] (1)
        duplication: tandem repeat of two homologous motifs made three stranded beta-sheet and beta-hairpins
        uperfamily
156. Tp47 lipoprotein, N-terminal domain [82219] (1)
     complex fold; consists of two intertwined subdomains
     1. Tp47 lipoprotein, N-terminal domain [82220] (1)
        uperfamily
157. Methuselah ectodomain [63876] (1)
     complex fold
     1. Methuselah ectodomain [63877] (1)
        duplication: contains two similar sub domains connected by a structured linker
        uperfamily
158. Head-binding domain of phage P22 tailspike protein [51326] (1)
     complex fold made of bifurcated and partly folded beta-sheet
     1. Head-binding domain of phage P22 tailspike protein [51327] (1)
        uperfamily
159. E2 regulatory, transactivation domain [51331] (1)
     complex fold made of bifurcated and coiled beta-sheets
     1. E2 regulatory, transactivation domain [51332] (1)
        uperfamily
160. MoeA N-terminal region -like [63881] (1)
     complex fold made of bifurcated and coiled b-sheets
     1. MoeA N-terminal region -like [63882] (1)
        uperfamily
161. MOSC N-terminal domain-like [141672] (1)
     complex fold; comprises a beta-hairpin and a meander 3-stranded sheet packed against beta-barrel: closed, n=5, S=8; contains three short helices
     1. MOSC N-terminal domain-like [141673] (1)
        uperfamily
162. MAL13P1.257-like [141677] (1)
     complex fold; duplication: consists of two intertwinned structural repeats related by pseudo dyad
     1. MAL13P1.257-like [141678] (1)
        uperfamily
163. Composite domain of metallo-dependent hydrolases [51337] (1)
     pseudobarrel; mixed sheet of 7 strand folded upon itself and "buckled" by two beta-turns
     1. Composite domain of metallo-dependent hydrolases [51338] (11)
        this domain is interrupted by the catalytic beta/alpha barrel domain
        uperfamily
164. Epsilon subunit of F1F0-ATP synthase N-terminal domain [51343] (1)
     pseudobarrel: sandwich of two sheets packed at a positive interstrand angle and interconnected with many short turns
     1. Epsilon subunit of F1F0-ATP synthase N-terminal domain [51344] (1)
        uperfamily
165. N-terminal domain of MutM-like DNA repair proteins [81625] (1)
     pseudobarrel; capped on both ends by alpha-helices
     1. N-terminal domain of MutM-like DNA repair proteins [81624] (1)
        uperfamily
166. Hypothetical protein YojF [89441] (1)
     pseudobarrel; capped at one end by an alpha-helix
     1. Hypothetical protein YojF [89442] (1)
        uperfamily
167. DNA-binding pseudobarrel domain [101935] (1)
     core: barrel, open; n=7, S*=10; capped with helices at both ends; partial similarity to the AbrB/MazE/MraZ-like fold (scop_cf 89446)
     1. DNA-binding pseudobarrel domain [101936] (2)
        uperfamily
168. Double-split beta-barrel [89446] (2)
     pseudobarrel; capped on both ends by alpha-helices
     1. AbrB/MazE/MraZ-like [89447] (3)
        members of this superfamily are known or predicted to have DNA-binding function
        uperfamily
     2. AF2212/PG0164-like [141694] (2)
        six-stranded barrel, topologically similar to the Reductase/isomerase/elongation factor domain fold (scop_cf 50412)
        uperfamily
169. PUA domain-like [88696] (1)
     pseudobarrel; mixed folded sheet of 5 strands; order 13452; strand 1 and 3 are parallel to each other
     1. PUA domain-like [88697] (13)
        uperfamily
170. AXH domain [102030] (1)
     pseudobarrel; some similarity to OB-fold
     1. AXH domain [102031] (1)
        uperfamily
171. FimD N-terminal domain-like [141728] (1)
     pseudo barrel, capped by an alpha-helix; some topological similarity to the PRC-barrel domain (scop_sf 50346) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
     1. FimD N-terminal domain-like [141729] (1)
        uperfamily
172. HisI-like [141733] (1)
     pseudo barrel, capped by an alpha-helix; contains a beta-triangle structure on one side; some topological similarity to the Ribosomal protein L25-like fold (scop_cf 50714) and the N-terminal domain of Glutamine synthetase (scop_sf 54368)
     1. HisI-like [141734] (1)
        uperfamily
173. MFPT repeat-like [141738] (1)
     consists of two similar pseudo barrel subdomains with structural similarity to a circularly permuted SAND domain (scop_fa 63764)
     1. MFPT repeat-like [141739] (1)
        uperfamily
174. P-domain of calnexin/calreticulin [63886] (1)
     non-globular proline-rich hairpin
     1. P-domain of calnexin/calreticulin [63887] (1)
        uperfamily

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk