Structural Classification of Proteins
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Superfamily: 4-helical cytokines

there are two different topoisomers of this fold with different entanglements of the two crossover connections
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: 4-helical cytokines [47265]
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. Superfamily: 4-helical cytokines [47266]
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
    link to SUPERFAMILY database - Superfamily

Families:

  1. Long-chain cytokines [47267] (14)
    1. Granulocyte-colony stimulating factor (G-CSF) [47268]
      1. Human (Homo sapiens) [TaxId: 9606] [47269] (5) picpic
      2. Cow (Bos taurus) [TaxId: 9913] [47270] (1) picpic
      3. Dog (Canis familiaris) [TaxId: 9615] [47271] (2) picpic
    2. Interleukin-6 [47272]
      1. Human (Homo sapiens) [TaxId: 9606] [47273] (4) picpic
      2. Human herpesvirus 8, Kaposi's sarcoma herpes-virus [TaxId: 37296] [63528] (1) picpic
    3. Leukemia inhibitory factor (LIF) [47274]
      1. Mouse (Mus musculus) [TaxId: 10090] [47275] (2) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [63529] (4) picpic
    4. Growth hormone, somatotropin [47276]
      1. Human (Homo sapiens) [TaxId: 9606] [47277] (9) picpic
    5. Prolactin (placental lactogen) [47278]
      1. Sheep (Ovis aries) [TaxId: 9940] [47279] (1) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [89035] (2) picpic
    6. Ciliary neurotrophic factor (CNTF) [47280]
      1. Human (Homo sapiens) [TaxId: 9606] [47281] (1) picpic
    7. Leptin (obesity protein) [47282]
      1. Human (Homo sapiens) [TaxId: 9606] [47283] (1) picpic
    8. Oncostatin M [47284]
      1. Human (Homo sapiens) [TaxId: 9606] [47285] (1) picpic
    9. Heterodimeric interleukin-12 alpha chain [63530]
      1. Human (Homo sapiens) [TaxId: 9606] [63531] (1) picpic
  2. Short-chain cytokines [47286] (14)
    1. Erythropoietin [47287]
      long chain cytokine with a short-chain cytokine topology
      1. Human (Homo sapiens) [TaxId: 9606] [47288] (3) picpic
    2. Thrombopoietin [101140]
      long chain cytokine with a short-chain cytokine topology
      1. Human (Homo sapiens) [TaxId: 9606] [101141] (2) picpic
    3. Granulocyte-macrophage colony-stimulating factor (GM-CSF) [47289]
      1. Human (Homo sapiens) [TaxId: 9606] [47290] (3) picpic
    4. Interleukin-4 (IL-4) [47291]
      1. Human (Homo sapiens) [TaxId: 9606] [47292] (16) picpic
    5. Interleukin-5 [47293]
      intertwined dimer
      1. Human (Homo sapiens) [TaxId: 9606] [47294] (1) picpic
    6. Macrophage colony-stimulating factor (M-CSF) [47295]
      forms dimer similar to the Flt3 ligand and SCF dimers
      1. Human (Homo sapiens) [TaxId: 9606] [47296] (1) picpic
    7. Flt3 ligand [47297]
      forms dimer similar to the M-CSF and SCF dimers
      1. Human (Homo sapiens) [TaxId: 9606] [47298] (1) picpic
    8. Stem cell factor, SCF [47299]
      forms dimer similar to the M-CSF and Flt3 ligand dimers
      1. Human (Homo sapiens) [TaxId: 9606] [47300] (3) picpic
    9. Interleukin-2 (IL-2) [47301]
      1. Human (Homo sapiens) [TaxId: 9606] [47302] (15) picpic
    10. Interleukin-3 (IL-3) [47303]
      1. Human (Homo sapiens) [TaxId: 9606] [47304] (1) picpic
    11. Interleukin-13 (IL-13) [63532]
      1. Human (Homo sapiens) [TaxId: 9606] [63533] (3) picpic
    12. Interleukin-15 (IL-15) [158422]
      1. Human (Homo sapiens) [TaxId: 9606] [158423] (10) picpic
        SQ P40933 49-162
      2. Mouse (Mus musculus) [TaxId: 10090] [158424] (2) picpic
        SQ P48346 49-162
    13. Interleukin-21 (IL-21) [158425]
      1. Human (Homo sapiens) [TaxId: 9606] [158426] (1) picpic
        SQ Q9HBE4 23-155
  3. Interferons/interleukin-10 (IL-10) [47305] (13)
    contains an additional helix in one of the crossover connections
    1. Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306]
      intertwined dimer, similar to interferon-gamma
      1. Human (Homo sapiens) [TaxId: 9606] [47307] (7) picpic
      2. Epstein-Barr virus [TaxId: 10376] [47308] (3) picpic
      3. Human herpesvirus 5 [TaxId: 10359] [74708] (1) picpic
    2. Interleukin-19 [81744]
      1. Human (Homo sapiens) [TaxId: 9606] [81745] (1) picpic
    3. Interferon-beta [47309]
      1. Human (Homo sapiens) [TaxId: 9606] [47310] (1) picpic
      2. Mouse (Mus musculus) [TaxId: 10090] [47311] (2) picpic
        SQ P01575 22-182
        CA-atoms only
    4. Interleukin-22 (IL-22) [89036]
      1. Human (Homo sapiens) [TaxId: 9606] [89037] (8) picpic
    5. Interferon-alpha 2b [47312]
      1. Human (Homo sapiens) [TaxId: 9606] [47313] (1) picpic
    6. Interferon-alpha 2a [47314]
      1. Human (Homo sapiens) [TaxId: 9606] [47315] (2) picpic
    7. Interferon-tau [47316]
      1. Sheep (Ovis aries) [TaxId: 9940] [47317] (1) picpic
    8. Interferon-gamma [47318]
      intertwined dimer
      1. Cow (Bos taurus) [TaxId: 9913] [47319] (3) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [47320] (5) picpic
      3. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [47321] (1) picpic
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk