Structural Classification of Proteins
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Family: Branched-chain alpha-keto acid dehydrogenase Pyr module

parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
    link to SUPERFAMILY database - Superfamily
  5. Family: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741]
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Protein Domains:

  1. Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742]
    1. Human (Homo sapiens) [TaxId: 9606] [88743] (21)
      SQ P21953 52-392
      1. 2bfd picpicxrefxref
        automatically matched to d1olsb1
        complexed with cl, gol, k, mn, mpd, tdp; mutant
        1. region b:2-204 [128419] picpiclink
      2. 2bff picpicxrefxref
        automatically matched to d1olsb1
        complexed with gol, k, mn, tzd
        1. region b:2-204 [128421] picpiclink
      3. 1x7y picpicxrefxref
        complexed with cl, gol, k, mn, tdp; mutant
        1. region b:14-204 [114945] picpiclink
      4. 2bfc picpicxrefxref
        automatically matched to d1olsb1
        complexed with gol, k, mn, tzd; mutant
        1. region b:2-204 [128417] picpiclink
      5. 1x7z picpicxrefxref
        complexed with cl, gol, k, mn, tdp; mutant
        1. region b:14-204 [114948] picpiclink
      6. 1x7w picpicxrefxref
        complexed with cl, gol, k, mn, tdp; mutant
        1. region b:14-204 [114939] picpiclink
      7. 2bev picpicxrefxref
        automatically matched to d1olsb1
        complexed with cl, gol, k, mn, thy
        1. region b:2-204 [128393] picpiclink
      8. 2bew picpicxrefxref
        automatically matched to d1olsb1
        complexed with cl, gol, k, mn, thw
        1. region b:2-204 [128396] picpiclink
      9. 1v16 picpicxrefxref
        complexed with bdn, cl, gol, k, mn, tdp; mutant
        1. region b:2-204 [108241] picpiclink
      10. 1wci picpicxrefxref
        automatically matched to d1olsb1
        complexed with cl, gol, k, mn, wwf
        1. region b:2-204 [120891] picpiclink
      11. 1u5b picpicxrefxref
        complexed with gol, k, mn, tdp
        1. region b:14-204 [113035] picpiclink
      12. 1v1r picpicxrefxref
        complexed with cl, gol, k, na, so4
        1. region b:2-204 [108273] picpiclink
      13. 1olu picpicxrefxref
        complexed with gol, k, mg, tdp; mutant
        1. region b:2-204 [93336] picpiclink
      14. 1v11 picpicxrefxref
        complexed with bdn, cl, gol, k, mn, tdp; mutant
        1. region b:2-204 [108228] picpiclink
      15. 1ols picpicxrefxref
        complexed with gol, k, mn, tdp
        1. region b:2-204 [93332] picpiclink
      16. 1v1m picpicxrefxref
        complexed with bdn, cl, gol, k, mn, tdp; mutant
        1. region b:2-204 [108262] picpiclink
      17. 2beu picpicxrefxref
        automatically matched to d1olsb1
        complexed with cl, gol, k, mn, so4, thv
        1. region b:2-204 [128390] picpiclink
      18. 1x80 picpicxrefxref
        complexed with cl, gol, k, mn, tdp
        1. region b:14-204 [114951] picpiclink
      19. 1x7x picpicxrefxref
        complexed with cl, gol, k, mn, tdp; mutant
        1. region b:14-204 [114942] picpiclink
      20. 1olx picpicxrefxref
        complexed with gol, k, mn, tdp; mutant
        1. region b:2-204 [93339] picpiclink
      21. 1dtw picpicxrefxref
        complexed with k, mg, tdp
        1. region b:17-204 [31828] picpiclink
    2. Thermus thermophilus [TaxId: 274] [102332] (4)
      1. 1umd picpicxrefxref
        complexed with coi, mg, tdp
        1. region b:2-187 [99600] picpiclink
        2. region d:2-187 [99603] picpiclink
      2. 1umb picpicxrefxref
        complexed with mg, tdp
        1. region b:2-187 [99588] picpiclink
        2. region d:2-187 [99591] picpiclink
      3. 1um9 picpicxrefxref
        complexed with so4
        1. region b:2-187 [99582] picpiclink
        2. region d:2-187 [99585] picpiclink
      4. 1umc picpicxrefxref
        complexed with 4mv, mg, tdp
        1. region b:2-187 [99594] picpiclink
        2. region d:2-187 [99597] picpiclink
  2. 2-oxoisovalerate dehydrogenase (E1B), Pyr module [88744]
    chain A is alpha-subunit and chain B is beta-subunit
    1. Pseudomonas putida [TaxId: 303] [88745] (5)
      1. 1qs0 picpicxrefxref
        complexed with hri, mg, tdp
        1. region b:2-205 [31830] picpiclink
      2. 2bp7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1qs0b1
        1. region b:2-205 [128927] picpiclink
      3. 2bp7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1qs0b1
        1. region d:2-205 [128930] picpiclink
      4. 2bp7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1qs0b1
        1. region f:2-205 [128933] picpiclink
      5. 2bp7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1qs0b1
        1. region h:2-205 [128936] picpiclink
  3. E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472]
    1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [69473] (1)
      1. 1ik6 picpicxref
        structure determined on its own rather in the complex with E1-alpha
        1. region a:1-191 [66174] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [89653] (3)
      1. 2ozl picpicxrefxrefxrefxref
        automatically matched to d1ni4b1
        complexed with k, mg, tpp; mutant
        1. region b:0-191 [139447] picpiclink
      2. 2ozl picpicxrefxrefxrefxref
        automatically matched to d1ni4b1
        complexed with k, mg, tpp; mutant
        1. region d:0-191 [139449] picpiclink
      3. 1ni4 picpicxrefxref
        complexed with k, mg, mse, tpp; mutant
        1. region b:0-191 [85729] picpiclink
        2. region d:0-191 [85732] picpiclink
  4. Pyruvate dehydrogenase E1-beta, PdhB, N-terminal domain [117522]
    1. Bacillus stearothermophilus [TaxId: 1422] [117523] (2)
      SQ P21874
      1. 1w85 picpicxrefxrefxref
        complexed with k, mg, peg, tdp
        1. region b:1-192 [114336] picpiclink
        2. region d:1-192 [114339] picpiclink
        3. region f:1-192 [114342] picpiclink
        4. region h:1-192 [114345] picpiclink
      2. 1w88 picpicxrefxrefxref
        complexed with mg, tdp; mutant
        1. region b:1-192 [114350] picpiclink
        2. region d:1-192 [114353] picpiclink
        3. region f:1-192 [114356] picpiclink
        4. region h:1-192 [114359] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk