Structural Classification of Proteins
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Protein: E1-beta subunit of pyruvate dehydrogenase (PP module) from Human (Homo sapiens) [TaxId: 9606]

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
    link to SUPERFAMILY database - Superfamily
  5. Family: Branched-chain alpha-keto acid dehydrogenase PP module [88766]
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
  6. Protein: E1-beta subunit of pyruvate dehydrogenase (PP module) [89651]
  7. Species: Human (Homo sapiens) [TaxId: 9606] [89652]

PDB Entry Domains:

  1. 2ozl picpicxrefxrefxrefxref
    complexed with k, mg, tpp; mutant
    1. region a:1-361 [145744] picpiclink
  2. 2ozl picpicxrefxrefxrefxref
    automatically matched to 2OZL A:1-361
    complexed with k, mg, tpp; mutant
    1. region c:1-361 [145745] picpiclink
  3. 1ni4 picpicxrefxref
    complexed with k, mg, mse, tpp; mutant
    1. chain a [85728] picpiclink
    2. chain c [85731] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk