Structural Classification of Proteins

Superfamily: DHS-like NAD/FAD-binding domain

: binds cofactor molecules in the opposite direction than classical Rossmann fold
uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: DHS-like NAD/FAD-binding domain [52466]
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
Superfamily: DHS-like NAD/FAD-binding domain [52467]
binds cofactor molecules in the opposite direction than classical Rossmann fold
uperfamily

Families:

Deoxyhypusine synthase, DHS [52468] (1)
1. Deoxyhypusine synthase, DHS [52469]
  1. Human (Homo sapiens) [TaxId: 9606] [52470] (4)
    SQ P49366
C-terminal domain of the electron transfer flavoprotein alpha subunit [52471] (3)
lacks strand 3; shares the FAD-binding mode with the pyruvate oxidase domain
1. C-terminal domain of the electron transfer flavoprotein alpha subunit [52472]
  1. Human (Homo sapiens) [TaxId: 9606] [52473] (3)
  2. Paracoccus denitrificans [TaxId: 266] [52474] (1)
  3. Methylophilus methylotrophus [TaxId: 17] [82379] (6)
Pyruvate oxidase and decarboxylase, middle domain [52475] (12)
N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold
1. Pyruvate oxidase [52476]
  binds FAD
  1. Lactobacillus plantarum [TaxId: 1590] [52477] (12)
  2. Aerococcus viridans [TaxId: 1377] [142122] (4)
2. Pyruvate decarboxylase [52478]
  rudiment domain with a variant fold, lacks FAD-binding
  1. Brewer's yeast (Saccharomyces), uvarum strain [TaxId: 4932] [52479] (1)
  2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [52480] (2)
  3. Zymomonas mobilis [TaxId: 542] [52481] (1)
3. Indole-3-pyruvate decarboxylase [89637]
  1. Enterobacter cloacae [TaxId: 550] [89638] (1)
4. Benzoylformate decarboxylase [52482]
  1. Pseudomonas putida [TaxId: 303] [52483] (12)
    SQ P20906
5. Acetohydroxyacid synthase catalytic subunit [69463]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [69464] (6)
    SQ P07342 84-687
  2. Thale cress (Arabidopsis thaliana), chloroplast [TaxId: 3702] [142123] (6)
    SQ P17597 281-459
6. Catabolic acetolactate synthase [102288]
  1. Klebsiella pneumoniae [TaxId: 573] [102289] (3)
7. Carboxyethylarginine synthase [102290]
  1. Streptomyces clavuligerus [TaxId: 1901] [102291] (11)
8. Oxalyl-CoA decarboxylase [142124]
  1. Oxalobacter formigenes [TaxId: 847] [142125] (12)
    SQ P40149 195-369
Transhydrogenase domain III (dIII) [52484] (3)
binds NADP, shares with the pyruvate oxidase FAD-binding domain a common ADP-binding mode
1. Transhydrogenase domain III (dIII) [52485]
  1. Human (Homo sapiens) [TaxId: 9606] [52486] (4)
  2. Cow (Bos taurus) [TaxId: 9913] [52487] (1)
  3. Rhodospirillum rubrum [TaxId: 1085] [52488] (17)
Sir2 family of transcriptional regulators [63984] (7)
silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain
1. AF1676, Sir2 homolog (Sir2-AF1?) [63985]
  1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [63986] (6)
2. AF0112, Sir2 homolog (Sir2-AF2) [82380]
  1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [82381] (7)
3. NAD-dependent deacetylase CobB [102292]
  1. Escherichia coli [TaxId: 562] [102293] (1)
4. Sirt2 histone deacetylase [63987]
  1. Human (Homo sapiens) [TaxId: 9606] [63988] (1)
5. Hst2 [102294]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [102295] (5)
    SQ P53686 1-293
6. NAD-dependent deacetylase NpdA [142126]
  1. Thermotoga maritima [TaxId: 2336] [142127] (10)
    SQ Q9WYW0 1-245
7. NAD-dependent deacetylase sirtuin-5 [142128]
  1. Human (Homo sapiens) [TaxId: 9606] [142129] (6)
    SQ Q9NXA8 36-302
ACDE2-like [142130] (1)
Pfam 02552
1. Acetyl-CoA decarbonylase/synthase complex epsilon subunit 2, ACDE2 [142131]
  1. Archaeoglobus fulgidus [TaxId: 2234] [142132] (4)
    SQ O30273 17-174