Structural Classification of Proteins
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Family: Branched-chain alpha-keto acid dehydrogenase PP module

parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
    link to SUPERFAMILY database - Superfamily
  5. Family: Branched-chain alpha-keto acid dehydrogenase PP module [88766]
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

Protein Domains:

  1. Branched-chain alpha-keto acid dehydrogenase, PP module [88767]
    1. Human (Homo sapiens) [TaxId: 9606] [88768] (23)
      SQ P12694 52-445
      1. 2bfd picpicxrefxref
        complexed with cl, gol, k, mn, mpd, tdp; mutant
        1. region a:6-400 [144988] picpiclink
      2. 2bff picpicxrefxref
        complexed with gol, k, mn, tzd
        1. region a:6-400 [144989] picpiclink
      3. 1x7y picpicxrefxref
        complexed with cl, gol, k, mn, tdp; mutant
        1. chain a [114944] picpiclink
      4. 2bfc picpicxrefxref
        complexed with gol, k, mn, tzd; mutant
        1. region a:6-400 [144987] picpiclink
      5. 2bfe picpic
        complexed with cl, gol, k, mn, mrd, tdp; mutant
        1. region a:6-400 [146140] picpiclink
      6. 1x7z picpicxrefxref
        complexed with cl, gol, k, mn, tdp; mutant
        1. chain a [114947] picpiclink
      7. 1x7w picpicxrefxref
        complexed with cl, gol, k, mn, tdp; mutant
        1. chain a [114938] picpiclink
      8. 2bfb picpic
        complexed with cl, gol, k, mn, mrd, tdp; mutant
        1. region a:6-400 [146139] picpiclink
      9. 2bev picpicxrefxref
        automatically matched to d1olxa_
        complexed with cl, gol, k, mn, thy
        1. region a:6-400 [128392] picpiclink
      10. 2bew picpicxrefxref
        automatically matched to d1olxa_
        complexed with cl, gol, k, mn, thw
        1. region a:6-400 [128395] picpiclink
      11. 1v16 picpicxrefxref
        complexed with bdn, cl, gol, k, mn, tdp; mutant
        1. chain a [108240] picpiclink
      12. 1wci picpicxrefxref
        automatically matched to d1olxa_
        complexed with cl, gol, k, mn, wwf
        1. region a:6-400 [120890] picpiclink
      13. 1u5b picpicxrefxref
        complexed with gol, k, mn, tdp
        1. chain a [113034] picpiclink
      14. 1v1r picpicxrefxref
        complexed with cl, gol, k, na, so4
        1. chain a [108272] picpiclink
      15. 1olu picpicxrefxref
        complexed with gol, k, mg, tdp; mutant
        1. chain a [93335] picpiclink
      16. 1v11 picpicxrefxref
        complexed with bdn, cl, gol, k, mn, tdp; mutant
        1. chain a [108227] picpiclink
      17. 1ols picpicxrefxref
        complexed with gol, k, mn, tdp
        1. chain a [93331] picpiclink
      18. 1v1m picpicxrefxref
        complexed with bdn, cl, gol, k, mn, tdp; mutant
        1. chain a [108261] picpiclink
      19. 2beu picpicxrefxref
        automatically matched to d1olxa_
        complexed with cl, gol, k, mn, so4, thv
        1. region a:6-400 [128389] picpiclink
      20. 1x80 picpicxrefxref
        complexed with cl, gol, k, mn, tdp
        1. chain a [114950] picpiclink
      21. 1x7x picpicxrefxref
        complexed with cl, gol, k, mn, tdp; mutant
        1. chain a [114941] picpiclink
      22. 1olx picpicxrefxref
        complexed with gol, k, mn, tdp; mutant
        1. chain a [93338] picpiclink
      23. 1dtw picpicxrefxref
        complexed with k, mg, tdp
        1. chain a [31827] picpiclink
    2. Thermus thermophilus [TaxId: 274] [102337] (4)
      1. 1umd picpicxrefxref
        complexed with coi, mg, tdp
        1. chain a [99599] picpiclink
        2. chain c [99602] picpiclink
      2. 1umb picpicxrefxref
        complexed with mg, tdp
        1. chain a [99587] picpiclink
        2. chain c [99590] picpiclink
      3. 1um9 picpicxrefxref
        complexed with so4
        1. chain a [99581] picpiclink
        2. chain c [99584] picpiclink
      4. 1umc picpicxrefxref
        complexed with 4mv, mg, tdp
        1. chain a [99593] picpiclink
        2. chain c [99596] picpiclink
  2. E1-beta subunit of pyruvate dehydrogenase (PP module) [89651]
    1. Human (Homo sapiens) [TaxId: 9606] [89652] (3)
      1. 2ozl picpicxrefxrefxrefxref
        complexed with k, mg, tpp; mutant
        1. region a:1-361 [145744] picpiclink
      2. 2ozl picpicxrefxrefxrefxref
        automatically matched to 2OZL A:1-361
        complexed with k, mg, tpp; mutant
        1. region c:1-361 [145745] picpiclink
      3. 1ni4 picpicxrefxref
        complexed with k, mg, mse, tpp; mutant
        1. chain a [85728] picpiclink
        2. chain c [85731] picpiclink
  3. 2-oxoisovalerate dehydrogenase (E1B), PP module [88769]
    chain A is alpha-subunit and chain B is beta-subunit
    1. Pseudomonas putida [TaxId: 303] [88770] (5)
      1. 1qs0 picpicxrefxref
        complexed with hri, mg, tdp
        1. chain a [31829] picpiclink
      2. 2bp7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1qs0a_
        1. region a:2-408 [128926] picpiclink
      3. 2bp7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1qs0a_
        1. region c:2-408 [128929] picpiclink
      4. 2bp7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1qs0a_
        1. region e:2-408 [128932] picpiclink
      5. 2bp7 picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1qs0a_
        1. region g:2-408 [128935] picpiclink
  4. Pyruvate dehydrogenase E1-alpha, PdhA [117525]
    1. Bacillus stearothermophilus [TaxId: 1422] [117526] (2)
      SQ P21873
      1. 1w85 picpicxrefxrefxref
        complexed with k, mg, peg, tdp
        1. chain a [114335] picpiclink
        2. chain c [114338] picpiclink
        3. chain e [114341] picpiclink
        4. chain g [114344] picpiclink
      2. 1w88 picpicxrefxrefxref
        complexed with mg, tdp; mutant
        1. chain a [114349] picpiclink
        2. chain c [114352] picpiclink
        3. chain e [114355] picpiclink
        4. chain g [114358] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk