Family: TK-like PP module

different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
   uperfamily
5. Family: TK-like PP module [88760]
   different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Protein Domains:

1. Transketolase (TK), PP module [88761]
   1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [88762] (7)
      1. 1gpu
         complexed with ca, thd
         1. region a:3-337 [65454]
         2. region b:3-337 [65457]
      2. 1trk
         complexed with ca, tpp
         1. region a:3-337 [31803]
         2. region b:3-337 [31805]
      3. 1tkb
         complexed with ca, n1t
         1. region a:3-337 [31807]
         2. region b:3-337 [31809]
      4. 1tkc
         complexed with ca, m6t
         1. region a:3-337 [31811]
         2. region b:3-337 [31813]
      5. 1ngs
         complexed with ca, e4p, tpp
         1. region a:3-337 [31819]
         2. region b:3-337 [31821]
      6. 1tka
         complexed with ca, n3t
         1. region a:3-337 [31815]
         2. region b:3-337 [31817]
      7. 1ay0
         complexed with ca, tpp; mutant
         1. region a:3-337 [31823]
         2. region b:3-337 [31825]
   2. Maize (Zea mays) [TaxId: 4577] [88763] (1)
      1. 1itz
         complexed with mg, tpp
         1. region a:10-347 [76797]
         2. region b:10-347 [76800]
         3. region c:10-347 [76803]
   3. Escherichia coli [TaxId: 562] [89656] (7)
      1. 2r8o
         automatically matched to d1qgda2
         complexed with ca, edo, t5x
         1. region a:2-332 [151732]
      2. 2r8o
         automatically matched to d1qgda2
         complexed with ca, edo, t5x
         1. region b:2-332 [151735]
      3. 2r5n
         automatically matched to d1qgda2
         complexed with ca, edo, r5p, rp5, tpp
         1. region a:2-332 [151592]
      4. 2r5n
         automatically matched to d1qgda2
         complexed with ca, edo, r5p, rp5, tpp
         1. region b:2-332 [151595]
      5. 2r8p
         automatically matched to d1qgda2
         complexed with ca, edo, t6f
         1. region a:2-332 [151738]
      6. 2r8p
         automatically matched to d1qgda2
         complexed with ca, edo, t6f
         1. region b:2-332 [151741]
      7. 1qgd
         complexed with ca, so4, tpp
         1. region a:2-332 [88368]
         2. region b:2-332 [88371]
   4. Leishmania mexicana mexicana [TaxId: 44270] [117524] (1)
      SQ Q8MPM3
      1. 1r9j
         complexed with ca, tpp
         1. region a:1-336 [111723]
         2. region b:1-336 [111726]
2. Pyruvate dehydrogenase E1 component, PP module [88764]
   E1A and E1B fused together in a single-chain protein
   1. Escherichia coli [TaxId: 562] [88765] (14)
      1. 2iea
         automatically matched to d1l8aa1
         complexed with mg, tdp
         1. region a:56-470 [137295]
      2. 2iea
         automatically matched to d1l8aa1
         complexed with mg, tdp
         1. region b:56-470 [137298]
      3. 2qta
         automatically matched to d1l8aa1
         complexed with mg, tdp; mutant
         1. region a:56-470 [151334]
      4. 2qta
         automatically matched to d1l8aa1
         complexed with mg, tdp; mutant
         1. region b:56-470 [151337]
      5. 2qtc
         automatically matched to d1l8aa1
         complexed with mg, tdk; mutant
         1. region a:56-470 [151344]
      6. 2qtc
         automatically matched to d1l8aa1
         complexed with mg, tdk; mutant
         1. region b:56-470 [151347]
      7. 1l8a
         complexed with mg, tdp
         1. region a:56-470 [73677]
         2. region b:56-470 [73680]
      8. 2g28
         automatically matched to d1l8aa1
         complexed with mg, tdk
         1. region a:56-470 [134530]
      9. 2g28
         automatically matched to d1l8aa1
         complexed with mg, tdk
         1. region b:56-470 [134533]
      10. 2g25
          automatically matched to d1l8aa1
          complexed with mg, po4, tdk
          1. region a:56-470 [134524]
      11. 2g25
          automatically matched to d1l8aa1
          complexed with mg, po4, tdk
          1. region b:56-470 [134527]
      12. 1rp7
          complexed with mg, tzd
          1. region a:56-470 [97703]
          2. region b:56-470 [97706]
      13. 2g67
          automatically matched to d1l8aa1
          1. region a:56-470 [134696]
      14. 2g67
          automatically matched to d1l8aa1
          1. region b:56-470 [134699]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk