Structural Classification of Proteins
home mail help root up expand collapse

Protein: Transketolase (TK), Pyr module from Leishmania mexicana mexicana [TaxId: 44270]

SQ Q8MPM3

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
    link to SUPERFAMILY database - Superfamily
  5. Family: TK-like Pyr module [88735]
    different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
  6. Protein: Transketolase (TK), Pyr module [88736]
  7. Species: Leishmania mexicana mexicana [TaxId: 44270] [117521]
    SQ Q8MPM3

PDB Entry Domains:

  1. 1r9j picpicxrefxref
    complexed with ca, tpp
    1. region a:337-526 [111722] picpiclink
    2. region b:337-526 [111725] picpiclink
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk