Protein: Transketolase (TK), Pyr module from Escherichia coli [TaxId: 562]

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
   uperfamily
5. Family: TK-like Pyr module [88735]
   different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
6. Protein: Transketolase (TK), Pyr module [88736]
7. Species: Escherichia coli [TaxId: 562] [89650]

PDB Entry Domains:

1. 2r8o
   automatically matched to d1qgda1
   complexed with ca, edo, t5x
   1. region a:333-527 [151731]
2. 2r8o
   automatically matched to d1qgda1
   complexed with ca, edo, t5x
   1. region b:333-527 [151734]
3. 2r5n
   automatically matched to d1qgda1
   complexed with ca, edo, r5p, rp5, tpp
   1. region a:333-527 [151591]
4. 2r5n
   automatically matched to d1qgda1
   complexed with ca, edo, r5p, rp5, tpp
   1. region b:333-527 [151594]
5. 2r8p
   automatically matched to d1qgda1
   complexed with ca, edo, t6f
   1. region a:333-527 [151737]
6. 2r8p
   automatically matched to d1qgda1
   complexed with ca, edo, t6f
   1. region b:333-527 [151740]
7. 1qgd
   complexed with ca, so4, tpp
   1. region a:333-527 [88367]
   2. region b:333-527 [88370]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk