Structural Classification of Proteins
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Family: Interferons/interleukin-10 (IL-10)

contains an additional helix in one of the crossover connections

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: 4-helical cytokines [47265]
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. Superfamily: 4-helical cytokines [47266]
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
    link to SUPERFAMILY database - Superfamily
  5. Family: Interferons/interleukin-10 (IL-10) [47305]
    contains an additional helix in one of the crossover connections

Protein Domains:

  1. Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306]
    intertwined dimer, similar to interferon-gamma
    1. Human (Homo sapiens) [TaxId: 9606] [47307] (7)
      1. 2ilk picpic
        complexed with so4
        1. chain a [16885] picpiclink
      2. 1lk3 picpicxrefxrefxrefxref
        1. chain a [73950] picpiclink
        2. chain b [73951] picpiclink
      3. 1ilk picpic
        1. chain a [16886] picpiclink
      4. 2h24 picpic
        automatically matched to d2ilk__
        1. region a:18-159 [135988] picpiclink
      5. 1inr picpic
        1. chain a [16887] picpiclink
      6. 1y6k picpicxrefxref
        automatically matched to d2ilk__
        mutant
        1. region l:12-156 [122662] picpiclink
      7. 1j7v picpicxref
        complexed with IL-10 receptor 1 (IL-10R1)
        mutant
        1. chain l [62704] picpiclink
    2. Epstein-Barr virus [TaxId: 10376] [47308] (3)
      1. 1vlk picpic
        1. chain a [16888] picpiclink
      2. 1y6n picpicxrefxref
        mutant
        1. region l:12-157 [144600] picpiclink
      3. 1y6m picpicxrefxref
        automatically matched to d1vlk__
        mutant
        1. region l:12-157 [122665] picpiclink
    3. Human herpesvirus 5 [TaxId: 10359] [74708] (1)
      1. 1lqs picpicxref
        complexed with nag; mutant
        1. chain l [74192] picpiclink
        2. chain m [74193] picpiclink
  2. Interleukin-19 [81744]
    1. Human (Homo sapiens) [TaxId: 9606] [81745] (1)
      1. 1n1f picpic
        complexed with nag
        1. chain a [79803] picpiclink
  3. Interferon-beta [47309]
    1. Human (Homo sapiens) [TaxId: 9606] [47310] (1)
      1. 1au1 picpic
        complexed with fuc, gal, glc, man, zn
        1. chain a [16889] picpiclink
        2. chain b [16890] picpiclink
    2. Mouse (Mus musculus) [TaxId: 10090] [47311] (2)
      SQ P01575 22-182
      CA-atoms only
      1. 1wu3 picpic
        1. chain i [114890] picpiclink
      2. 1ifa picpic
        CA-atoms only
        1. chain a [16892] picpiclink
  4. Interleukin-22 (IL-22) [89036]
    1. Human (Homo sapiens) [TaxId: 9606] [89037] (8)
      1. 3dlq picpic
        automatically matched to d1m4ra_
        mutant
        1. region i:41-179 [157802] picpiclink
      2. 1m4r picpic
        1. chain a [84799] picpiclink
        2. chain b [84800] picpiclink
      3. 1ykb picpic
        automatically matched to d1m4ra_
        complexed with fuc, man, nag
        1. region a:39-179 [123503] picpiclink
      4. 1ykb picpic
        automatically matched to d1m4ra_
        complexed with fuc, man, nag
        1. region b:39-179 [123504] picpiclink
      5. 1ykb picpic
        automatically matched to d1m4ra_
        complexed with fuc, man, nag
        1. region c:39-179 [123505] picpiclink
      6. 1ykb picpic
        automatically matched to d1m4ra_
        complexed with fuc, man, nag
        1. region d:39-179 [123506] picpiclink
      7. 1ykb picpic
        automatically matched to d1m4ra_
        complexed with fuc, man, nag
        1. region e:39-179 [123507] picpiclink
      8. 1ykb picpic
        automatically matched to d1m4ra_
        complexed with fuc, man, nag
        1. region f:39-179 [123508] picpiclink
  5. Interferon-alpha 2b [47312]
    1. Human (Homo sapiens) [TaxId: 9606] [47313] (1)
      1. 1rh2 picpic
        CA-atoms only
        complexed with zn
        1. chain a [16893] picpiclink
        2. chain b [16894] picpiclink
        3. chain c [16895] picpiclink
        4. chain d [16896] picpiclink
        5. chain e [16897] picpiclink
        6. chain f [16898] picpiclink
  6. Interferon-alpha 2a [47314]
    1. Human (Homo sapiens) [TaxId: 9606] [47315] (2)
      1. 1itf picpic
        1. chain a [16899] picpiclink
      2. 2hym picpicxrefxref
        automatically matched to d1itf__
        1. region b:1-165 [136900] picpiclink
  7. Interferon-tau [47316]
    1. Sheep (Ovis aries) [TaxId: 9940] [47317] (1)
      1. 1b5l picpic
        complexed with so4
        1. chain a [16900] picpiclink
  8. Interferon-gamma [47318]
    intertwined dimer
    1. Cow (Bos taurus) [TaxId: 9913] [47319] (3)
      1. 1d9c picpic
        1. chain a [16901] picpiclink
        2. chain b [16902] picpiclink
      2. 1d9g picpic
        1. chain a [16903] picpiclink
        2. chain b [16904] picpiclink
      3. 1rfb picpic
        1. chain a [16905] picpiclink
        2. chain b [16906] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [47320] (5)
      1. 3bes picpic
        automatically matched to d1fg9a_
        complexed with bma, nag, po4
        1. region l:0-126 [155196] picpiclink
      2. 1fyh picpicxref
        a single-chain variant
        complexed with cl
        1. region a:0-124 [16907] picpiclink
        2. region a:201-324 [16908] picpiclink
        3. region d:0-124 [16909] picpiclink
        4. region d:201-324 [16910] picpiclink
      3. 1fg9 picpicxref
        1. chain a [16915] picpiclink
        2. chain b [16916] picpiclink
      4. 1hig picpic
        CA-atoms only
        1. chain a [16917] picpiclink
        2. chain b [16918] picpiclink
        3. chain c [16919] picpiclink
        4. chain d [16920] picpiclink
      5. 1eku picpic
        biologically active single chain mutant
        1. region a:0-121 [16911] picpiclink
        2. region a:123-242 [16912] picpiclink
        3. region b:0-121 [16913] picpiclink
        4. region b:123-241 [16914] picpiclink
    3. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [47321] (1)
      1. 2rig picpic
        CA-atoms only
        1. chain a [16921] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk