Superfamily: SH2 domain

uperfamily

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b) [53931]
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: SH2-like [55549]
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices
4. Superfamily: SH2 domain [55550]
   uperfamily

Families:

1. SH2 domain [55551] (39)
   Pfam 00017
   1. p56-lck tyrosine kinase [55552]
      1. Human (Homo sapiens) [TaxId: 9606] [55553] (16)
         1. 1lkk
            complexed with phs
            1. chain a [40412]
         2. 1lkl
            complexed with phs
            1. chain a [40413]
         3. 1lcj
            complexed with phs; mutant
            1. chain a [40414]
         4. 1bhf
            complexed with 1pa, ace
            1. chain a [40415]
         5. 1bhh
            1. chain a [40416]
            2. chain b [40417]
         6. 1cwe
            complexed with ppm
            1. chain a [40419]
            2. chain c [40420]
         7. 1ijr
            complexed with cc0
            1. chain a [71238]
         8. 1cwd
            complexed with ppm
            1. chain l [40418]
         9. 1lck
            complexed with phs; mutant
            1. region a:117-226 [40421]
         10. 1fbz
             complexed with cc1
             1. chain a [40422]
             2. chain b [40423]
         11. 1x27
             automatically matched to d1lcka2
             complexed with na
             1. region a:119-226 [121622]
         12. 1x27
             automatically matched to d1lcka2
             complexed with na
             1. region b:119-226 [121624]
         13. 1x27
             automatically matched to d1lcka2
             complexed with na
             1. region c:119-226 [121626]
         14. 1x27
             automatically matched to d1lcka2
             complexed with na
             1. region d:119-226 [121628]
         15. 1x27
             automatically matched to d1lcka2
             complexed with na
             1. region e:119-226 [121630]
         16. 1x27
             automatically matched to d1lcka2
             complexed with na
             1. region f:119-226 [121632]
   2. Carboxyl-terminal src kinase (csk) [75498]
      1. Human (Homo sapiens) [TaxId: 9606] [75499] (1)
         1. 1k9a
            1. region a:77-177 [72189]
            2. region b:77-177 [72192]
            3. region c:77-177 [72195]
            4. region d:77-177 [72198]
            5. region e:77-177 [72201]
            6. region f:77-177 [72204]
   3. c-src tyrosine kinase [55556]
      1. Human (Homo sapiens) [TaxId: 9606] [55557] (42)
         1. 1o4r
            complexed with 787
            1. chain a [92469]
         2. 1o4k
            complexed with psn
            1. chain a [92462]
         3. 1o48
            complexed with 853
            1. chain a [92450]
         4. 1o4a
            complexed with 197
            1. chain a [92452]
         5. 1o4g
            complexed with i59
            1. chain a [92458]
         6. 1o43
            complexed with 821
            1. chain a [92445]
         7. 1o4m
            complexed with mla
            1. chain a [92464]
         8. 1o4q
            complexed with 256
            1. chain a [92468]
         9. 1fmk
            1. region a:146-248 [40436]
         10. 1o4n
             complexed with oxd
             1. chain a [92465]
         11. 1o4j
             complexed with is2
             1. chain a [92461]
         12. 1o44
             complexed with 852
             1. chain a [92446]
         13. 1o41
             complexed with 300
             1. chain a [92443]
         14. 1o4l
             complexed with cit
             1. chain a [92463]
         15. 1o49
             complexed with 493
             1. chain a [92451]
         16. 1o42
             complexed with 843
             1. chain a [92444]
         17. 1o4d
             complexed with 262
             1. chain a [92455]
         18. 1o4p
             complexed with 791
             1. chain a [92467]
         19. 1o4b
             complexed with 876
             1. chain a [92453]
         20. 1y57
             automatically matched to d1hcsb_
             complexed with mpz, so4
             1. region a:141-246 [145904]
         21. 1o4i
             complexed with 219
             1. chain a [92460]
         22. 1o47
             complexed with 822
             1. chain a [92449]
         23. 1o4c
             complexed with po4
             1. chain a [92454]
         24. 1o4f
             complexed with 790
             1. chain a [92457]
         25. 1o45
             complexed with 687
             1. chain a [92447]
         26. 2src
             complexed with anp
             1. region a:146-248 [40437]
         27. 1o4o
             complexed with hps
             1. chain a [92466]
         28. 1a09
             complexed with ace, dip, pth
             1. chain a [40438]
             2. chain b [40439]
         29. 1a1a
             complexed with ace, dip, pth; mutant
             1. chain a [40449]
             2. chain b [40450]
         30. 1o4e
             complexed with 299
             1. chain a [92456]
         31. 1a1b
             complexed with ace, dip
             1. chain a [40441]
             2. chain b [40442]
         32. 1a1e
             complexed with ace, diy
             1. chain a [40445]
             2. chain b [40446]
         33. 1shd
             complexed with po3
             1. chain a [40440]
         34. 1a07
             complexed with ace, dip
             1. chain a [40443]
             2. chain b [40444]
         35. 1o46
             complexed with 903
             1. chain a [92448]
         36. 1o4h
             complexed with 772
             1. chain a [92459]
         37. 1a08
             complexed with ace, dip, fty
             1. chain a [40447]
             2. chain b [40448]
         38. 1a1c
             complexed with ace, dix
             1. chain a [40451]
             2. chain b [40452]
         39. 2h8h
             automatically matched to d1hcsb_
             complexed with h8h
             1. region a:141-246 [147241]
         40. 1ksw
             complexed with nbs; mutant
             1. region a:146-248 [68861]
         41. 1hct
             complexed with po3
             1. chain b [40454]
         42. 1hcs
             complexed with po3
             1. chain b [40453]
      2. Chicken (Gallus gallus) [TaxId: 9031] [55558] (3)
         1. 1f2f
            complexed with po4; mutant
            1. chain a [40455]
         2. 1f1w
            mutant
            1. chain a [40456]
         3. 2ptk
            1. region a:146-248 [40457]
      3. Rous sarcoma virus [TaxId: 11886] [69782] (13)
         1. 1sha
            complexed with po4
            1. chain a [40424]
         2. 1p13
            complexed with peptide, chains C and D
            complexed with cac
            1. chain a [93892]
            2. chain b [93893]
         3. 1nzl
            complexed with doubly phosphorylated peptide, chain C
            complexed with cl, pg4, ptr
            1. chain a [86453]
            2. chain b [86454]
         4. 1is0
            complexed with ptc
            1. chain a [66299]
            2. chain b [66300]
         5. 1shb
            complexed with po4
            1. chain a [40425]
         6. 1kc2
            complexed with co, ptr; mutant
            1. chain a [72291]
         7. 1nzv
            complexed with doubly phosphorylated peptide, chain C
            complexed with cl, pg4, ptr
            1. chain a [86457]
            2. chain b [86458]
         8. 1bkm
            complexed with 1c5; mutant
            1. chain a [40426]
         9. 1skj
            complexed with ur2; mutant
            1. chain a [40427]
         10. 1bkl
             mutant
             1. chain a [40428]
         11. 1spr
             complexed with po4
             1. chain a [40429]
             2. chain b [40430]
             3. chain c [40431]
             4. chain d [40432]
         12. 1sps
             complexed with po3
             1. chain a [40433]
             2. chain b [40434]
             3. chain c [40435]
         13. 2jyq
             automatically matched to d1sprb_
             1. region a:1-104 [148242]
   4. Tyrosine kinase Fyn [55559]
      1. Human (Homo sapiens) [TaxId: 9606] [55560] (3)
         1. 1g83
            mutant
            1. region a:142-245 [60342]
            2. region b:142-245 [60344]
         2. 1aou
            mutant
            1. chain f [40459]
         3. 1aot
            mutant
            1. chain f [40458]
   5. Tyrosine phosphatase Syp [55561]
      1. Mouse (Mus musculus) [TaxId: 10090] [55562] (4)
         1. 1aya
            complexed with phs
            1. chain a [40460]
            2. chain b [40461]
         2. 1ayd
            1. chain a [40462]
         3. 1ayc
            complexed with phs
            1. chain a [40463]
         4. 1ayb
            complexed with phs
            1. chain a [40464]
   6. Growth factor receptor-bound protein 2 (GRB2) [55563]
      1. Human (Homo sapiens) [TaxId: 9606] [55564] (25)
         1. 1jyr
            complexed with ptr
            1. chain a [71969]
         2. 3c7i
            automatically matched to d1fhsa_
            complexed with fmt, tvn
            1. region a:55-155 [156013]
         3. 1zfp
            complexed with be2, nh2, zn
            1. chain e [40465]
         4. 1bmb
            1. chain a [40466]
         5. 2huw
            automatically matched to d1fhs__
            complexed with po4, yvn
            1. region a:55-152 [136779]
         6. 2huw
            automatically matched to d1fhs__
            complexed with po4, yvn
            1. region b:56-152 [136780]
         7. 2h46
            automatically matched to d1fhs__
            complexed with gol
            1. region e:55-152 [136070]
         8. 1jyq
            complexed with maz, ptm, ptr
            1. chain a [71967]
            2. chain b [71968]
         9. 2aob
            automatically matched to d1fhs__
            complexed with s1s
            1. region a:60-151 [127076]
         10. 2aob
             automatically matched to d1fhs__
             complexed with s1s
             1. region b:60-151 [127077]
         11. 2aob
             automatically matched to d1fhs__
             complexed with s1s
             1. region c:60-151 [127078]
         12. 2aob
             automatically matched to d1fhs__
             complexed with s1s
             1. region d:60-151 [127079]
         13. 1bm2
             complexed with ace, slz
             1. chain a [40467]
         14. 1tze
             complexed with nh2
             1. chain e [40468]
         15. 1fyr
             complexed with ace
             1. chain a [40469]
             2. chain b [40470]
             3. chain c [40471]
             4. chain d [40472]
         16. 2aoa
             automatically matched to d1fhs__
             complexed with p33, s1s
             1. region a:60-150 [127075]
         17. 1jyu
             1. chain a [71970]
         18. 2h5k
             automatically matched to d1fhs__
             complexed with ace, cac, nh2
             1. region a:57-152 [136149]
         19. 2h5k
             automatically matched to d1fhs__
             complexed with ace, cac, nh2
             1. region b:57-152 [136150]
         20. 1gri
             1. region a:57-156 [40473]
             2. region b:57-156 [40474]
         21. 1cj1
             complexed with c78
             1. chain a [40476]
             2. chain b [40477]
             3. chain c [40478]
             4. chain d [40479]
             5. chain e [40480]
             6. chain f [40481]
             7. chain g [40482]
             8. chain h [40483]
             9. chain i [40484]
             10. chain j [40485]
             11. chain k [40486]
             12. chain l [40487]
         22. 1ghu
             mutant
             1. chain a [40475]
         23. 1fhs
             1. chain a [40488]
         24. 1x0n
             automatically matched to d1fhs__
             complexed with dtf
             1. region a:60-159 [121551]
         25. 1qg1
             1. chain e [40489]
   7. Hemopoetic cell kinase Hck [55565]
      1. Human (Homo sapiens) [TaxId: 9606] [55566] (4)
         1. 1qcf
            complexed with pp1; mutant
            1. region a:146-248 [40490]
         2. 1ad5
            complexed with anp, ca
            1. region a:146-248 [40491]
            2. region b:146-248 [40492]
         3. 2hck
            complexed with ca, que
            1. region a:146-248 [40493]
            2. region b:146-248 [40494]
         4. 3hck
            1. chain a [40495]
   8. Crk proto-oncogen [82741]
      1. Human (Homo sapiens) [TaxId: 9606] [82742] (3)
         1. 2eyv
            automatically matched to d1ju5a_
            1. region a:12-120 [132602]
         2. 1ju5
            complex with the Crk-derived phophopeptide and Abl SH3 domain
            complexed with phs; mutant
            1. chain a [77173]
         3. 2eyy
            automatically matched to d1ju5a_
            1. region a:12-120 [132605]
   9. Shc adaptor protein [55567]
      1. Human (Homo sapiens) [TaxId: 9606] [55568] (2)
         1. 1mil
            1. chain a [40496]
         2. 1tce
            1. chain a [40497]
   10. Phosphatidylinositol 3-kinase, p85-alpha subunit [55569]
       1. Cow (Bos taurus) [TaxId: 9913] [55570] (7)
          1. 1qad
             C-terminal SH2 domain
             1. chain a [40498]
          2. 1bfj
             C-terminal SH2 domain
             1. chain a [40500]
          3. 1bfi
             C-terminal SH2 domain
             1. chain a [40499]
          4. 1oo4
             N-terminal SH2 domain; complexed to a peptide derived from PDGFR (chain B)
             complexed with ptr; mutant
             1. chain a [87185]
          5. 1oo3
             N-terminal SH2 domain
             mutant
             1. chain a [87184]
          6. 2pna
             N-terminal SH2 domain
             1. chain a [40501]
          7. 2pnb
             N-terminal SH2 domain
             1. chain a [40502]
       2. Human (Homo sapiens) [TaxId: 9606] [55571] (2)
          1. 1h9o
             complexed with a tyr751 phosphopeptide from the pdgf receptor
             1. chain a [60837]
          2. 1pic
             complexed with ace
             1. chain a [40503]
       3. Rat (Rattus norvegicus) [TaxId: 10116] [55572] (2)
          1. 1fu6
             1. chain a [40504]
          2. 1fu5
             1. chain a [40505]
   11. Proto-oncogen tyrosine kinase [55573]
       1. Human (Homo sapiens) [TaxId: 9606] [55574] (2)
          1. 2fo0
             automatically matched to d1ab2__
             complexed with gol, myr, p16; mutant
             1. region a:139-239 [133863]
          2. 1ab2
             1. chain a [40506]
   12. Syk tyrosine kinase [55575]
       1. Human (Homo sapiens) [TaxId: 9606] [55576] (3)
          1. 1a81
             1. region a:9-137 [40507]
             2. region a:138-262 [40508]
             3. region c:9-137 [40509]
             4. region c:138-262 [40510]
             5. region e:9-117 [40511]
             6. region e:152-262 [40512]
             7. region g:9-117 [40513]
             8. region g:152-262 [40514]
             9. region i:9-137 [40515]
             10. region i:138-262 [40516]
             11. region k:9-117 [40517]
             12. region k:152-262 [40518]
          2. 1csy
             C-terminal SH2 domain
             complexed with ace, nh2
             1. chain a [40519]
          3. 1csz
             C-terminal SH2 domain
             complexed with ace, nh2
             1. chain a [40520]
   13. Growth factor receptor-bound protein 10, GRB10 [89994]
       1. Human (Homo sapiens) [TaxId: 9606] [89995] (1)
          1. 1nrv
             1. chain a [86126]
             2. chain b [86127]
   14. Growth factor receptor-bound protein 7 [103135]
       1. Human (Homo sapiens) [TaxId: 9606] [103136] (5)
          1. 2qms
             automatically matched to d1mw4a_
             complexed with so4
             1. region a:420-532 [150890]
          2. 2qms
             automatically matched to d1mw4a_
             complexed with so4
             1. region b:420-532 [150891]
          3. 2qms
             automatically matched to d1mw4a_
             complexed with so4
             1. region c:420-532 [150892]
          4. 2qms
             automatically matched to d1mw4a_
             complexed with so4
             1. region d:420-532 [150893]
          5. 1mw4
             1. chain a [91476]
   15. Tyrosine-protein kinase zap-70 [89996]
       1. Human (Homo sapiens) [TaxId: 9606] [89997] (3)
          1. 2oq1
             automatically matched to d1m61a1
             complexed with pb
             1. region a:5-134 [139220]
          2. 2oq1
             automatically matched to d1m61a2
             complexed with pb
             1. region a:135-258 [139221]
          3. 1m61
             complexed with po4
             1. region a:1-132 [90398]
             2. region a:133-256 [90399]
   16. Phospholipase C-gamma-1 [55577]
       1. Cow (Bos taurus) [TaxId: 9913] [55578] (3)
          1. 2pld
             complexed with po3
             1. chain a [40521]
          2. 2fci
             automatically matched to d2plda_
             complexed with ace
             1. region a:1-105 [133268]
          3. 2ple
             complexed with po3
             1. chain a [40522]
   17. P55 Blk protein tyrosine kinase [55579]
       1. Mouse (Mus musculus) [TaxId: 10090] [55580] (2)
          1. 1blj
             1. chain a [40524]
          2. 1blk
             1. chain a [40523]
   18. Itk/tsk protein tyrosine kinase [82743]
       1. Mouse (Mus musculus) [TaxId: 10090] [82744] (6)
          1. 1lui
             complexed with ace, nh2
             1. chain a [78224]
          2. 1lum
             complexed with ace, nh2
             1. chain a [78228]
          3. 1luk
             complexed with ace, nh2
             1. chain a [78227]
          4. 1lun
             complexed with ace, nh2
             1. chain a [78229]
          5. 2eu0
             automatically matched to d1luia_
             complexed with ace, nh2
             1. region a:4-111 [132376]
          6. 2etz
             automatically matched to d1luia_
             complexed with ace, nh2
             1. region a:4-111 [132375]
   19. Abl tyrosine kinase [55581]
       1. Human (Homo sapiens) [TaxId: 9606] [55582] (1)
          1. 2abl
             mutant
             1. region a:140-237 [40525]
       2. Mouse (Mus musculus) [TaxId: 10090] [89998] (2)
          1. 1opk
             complexed with gol, myr, p16; mutant
             1. region a:140-240 [87233]
          2. 1opl
             complexed with myr, p16; mutant
             1. region a:140-240 [87236]
             2. region b:140-237 [87238]
   20. Csk homologous kinase Chk [64345]
       1. Human (Homo sapiens) [TaxId: 9606] [64346] (1)
          1. 1jwo
             1. chain a [63310]
   21. STAT-1 [55583]
       1. Human (Homo sapiens) [TaxId: 9606] [55584] (1)
          1. 1bf5
             protein/DNA complex
             1. region a:569-710 [40526]
   22. STAT3b [55585]
       1. Mouse (Mus musculus) [TaxId: 10090] [55586] (1)
          1. 1bg1
             protein/DNA complex
             1. region a:576-716 [40527]
   23. STAT homologue [103137]
       1. Dictyostelium discoideum [TaxId: 44689] [103138] (2)
          1. 1uur
             1. region a:577-707 [100018]
          2. 1uus
             1. region a:577-707 [100021]
   24. Cbl [55587]
       1. Human (Homo sapiens) [TaxId: 9606] [55588] (12)
          1. 3bux
             automatically matched to d1fbva3
             1. region b:264-351 [155649]
          2. 3bux
             automatically matched to d1fbva3
             1. region d:264-351 [155652]
          3. 3buw
             automatically matched to d1fbva3
             1. region b:264-351 [155643]
          4. 3buw
             automatically matched to d1fbva3
             1. region d:264-351 [155646]
          5. 1yvh
             automatically matched to d1fbva3
             complexed with mg
             1. region a:264-351 [124098]
          6. 3bun
             automatically matched to d1fbva3
             1. region b:264-351 [155628]
          7. 3bum
             automatically matched to d1fbva3
             1. region b:264-351 [155625]
          8. 2cbl
             complexed with ca
             1. region a:264-351 [40528]
          9. 1b47
             complexed with ca
             1. region a:264-350 [40529]
             2. region b:264-350 [40530]
             3. region c:264-350 [40531]
          10. 3buo
              automatically matched to d1fbva3
              1. region b:264-351 [155631]
          11. 3buo
              automatically matched to d1fbva3
              1. region d:264-351 [155634]
          12. 1fbv
              complexed with so4, zn
              1. region a:264-355 [40532]
   25. Tyrosine phoshatase shp-2 [55589]
       1. Human (Homo sapiens) [TaxId: 9606] [55590] (1)
          1. 2shp
             complexed with cat; mutant
             1. region a:2-110 [40533]
             2. region a:111-218 [40534]
             3. region b:2-110 [40535]
             4. region b:111-218 [40536]
   26. The Xlp protein Sap [55591]
       1. Human (Homo sapiens) [TaxId: 9606] [55592] (6)
          1. 1d4t
             complex with a slam peptide
             1. chain a [40537]
          2. 1d1z
             complexed with sul
             1. chain a [40538]
             2. chain b [40539]
             3. chain c [40540]
             4. chain d [40541]
          3. 1d4w
             complex with slam phosphopeptide
             mutant
             1. chain a [40542]
             2. chain b [40543]
          4. 1m27
             complex with Fyn SH3 domain and slam peptide, chain B
             complexed with flc
             1. chain a [84748]
          5. 1ka6
             complexed with nh2; mutant
             1. chain a [68370]
          6. 1ka7
             complex with peptide
             mutant
             1. chain a [68371]
   27. Ews/fli1 activated transcript 2, Eat2 [89999]
       1. Mouse (Mus musculus) [TaxId: 10090] [90000] (1)
          1. 1i3z
             complex with slam phosphopeptide, chain B
             complexed with ptr
             1. chain a [83667]
   28. Adaptor protein Aps [103139]
       1. Rat (Rattus norvegicus) [TaxId: 10116] [103140] (2)
          1. 1rpy
             complexed with so4
             1. chain a [97718]
             2. chain b [97719]
          2. 1rqq
             complexed with insulin receptor kinase
             complexed with 112, mn; mutant
             1. chain c [97762]
             2. chain d [97763]
   29. Tyrosine-protein kinase 6 (Breast tumor kinase, Brk) [111084]
       1. Human (Homo sapiens) [TaxId: 9606] [111085] (1)
          SQ Q13882 75-174
          1. 1rja
             1. chain a [104962]
   30. GRB2-related adaptor protein 2 (MONA, GRID) [111086]
       1. Mouse (Mus musculus) [TaxId: 10090] [111087] (3)
          SQ O89100 53-147
          1. 1r1q
             complexed with ace, so4
             1. chain a [104763]
             2. chain b [104764]
          2. 1r1p
             complexed with ace, so4
             1. chain a [104759]
             2. chain b [104760]
             3. chain c [104761]
             4. chain d [104762]
          3. 1r1s
             complexed with ace, so4
             1. chain a [104765]
             2. chain c [104766]
             3. chain e [104767]
             4. chain g [104768]
   31. Beta-chimaerin, N-terminal domain [118052]
       includes N-terminal tail and the linker to the next domain
       1. Human (Homo sapiens) [TaxId: 9606] [118053] (1)
          SQ P52757 23-468
          1. 1xa6
             complexed with zn
             1. region a:21-161 [115031]
   32. Hematopoietic SH2 domain containing protein HSH2D [143623]
       1. Human (Homo sapiens) [TaxId: 9606] [143624] (1)
          SQ Q96JZ2 24-129
          1. 2cs0
             1. region a:8-113 [130744]
   33. Suppressor of cytokine signaling 2, SOCS-2 [160562]
       1. Human (Homo sapiens) [TaxId: 9606] [160563] (1)
          SQ O14508 32-134
          1. 2c9w
             complexed with ni, so4
             1. region a:32-134 [145024]
   34. Suppressor of cytokine signaling 4, SOCS-4 [160564]
       1. Human (Homo sapiens) [TaxId: 9606] [160565] (1)
          SQ Q8WXH5 274-385
          1. 2izv
             complexed with cl, edo, na
             1. region a:274-385 [145556]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk