Structural Classification of Proteins

Superfamily: LuxS/MPP-like metallohydrolase

: Share the same "active site motif" HxxEH located in the first core helix, but differ in one of the zinc-binding residues
uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: LuxS/MPP-like metallohydrolase [63410]
core: beta-alpha-beta(2)-alpha(2); 2 layers: alpha/beta
Superfamily: LuxS/MPP-like metallohydrolase [63411]
Share the same "active site motif" HxxEH located in the first core helix, but differ in one of the zinc-binding residues
uperfamily

Families:

Autoinducer-2 production protein LuxS [64294] (4)
contains additional N-terminal strand; possible relationships to the putative editing domain of ThrRS (d.67.1)
1. Autoinducer-2 production protein LuxS [64295]
  S-ribosylhomocysteinase
  1. Bacillus subtilis [TaxId: 1423] [64296] (6)
  2. Deinococcus radiodurans [TaxId: 1299] [64297] (5)
  3. Haemophilus influenzae [TaxId: 727] [64298] (2)
  4. Helicobacter pylori [TaxId: 210] [64299] (1)
MPP-like [63412] (10)
Common fold elaborated with many additional structures; duplication: each family member consists of two similar domains of beta(2)-alpha(2)-beta(2)-alpha(5)-beta structure, but only the N-terminal domain of MPP beta chain binds the catalytic metal
1. Mitochondrial processing peptidase (MPP) beta chain [64300]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [64301] (4)
2. Mitochondrial processing peptidase (MPP) alpha chain [64302]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [64303] (4)
3. Cytochrome bc1 core subunit 1 [63408]
  1. Cow (Bos taurus) [TaxId: 9913] [55997] (26)
    SQ P31800
  2. Chicken (Gallus gallus) [TaxId: 9031] [55998] (3)
  3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [64304] (14)
4. Cytochrome bc1 core subunit 2 [63409]
  1. Cow (Bos taurus) [TaxId: 9913] [56000] (12)
    SQ P23004
  2. Chicken (Gallus gallus) [TaxId: 9031] [56001] (17)
  3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [64305] (14)
5. Presequence protease 1, PREP1 [143498]
  duplication: comprises four domains of this fold; similar to the MPP alpha-beta heterodimer
  1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [143499] (8)
    SQ Q9LJL3 100-356! SQ Q9LJL3 357-624! SQ Q9LJL3 625-882! SQ Q9LJL3 883-1078
6. Protease III [143500]
  duplication: comprises four domains of this fold
  1. Escherichia coli [TaxId: 562] [143501] (4)
    SQ P05458 24-263! SQ P05458 264-503! SQ P05458 504-732! SQ P05458 733-960