Family: TK-like Pyr module

different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: Thiamin diphosphate-binding fold (THDP-binding) [52517]
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
4. Superfamily: Thiamin diphosphate-binding fold (THDP-binding) [52518]
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
   uperfamily
5. Family: TK-like Pyr module [88735]
   different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

Protein Domains:

1. Transketolase (TK), Pyr module [88736]
   1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [88737] (7)
      1. 1gpu
         complexed with ca, thd
         1. region a:338-534 [65455]
         2. region b:338-534 [65458]
      2. 1trk
         complexed with ca, tpp
         1. region a:338-534 [31804]
         2. region b:338-534 [31806]
      3. 1tkb
         complexed with ca, n1t
         1. region a:338-534 [31808]
         2. region b:338-534 [31810]
      4. 1tkc
         complexed with ca, m6t
         1. region a:338-534 [31812]
         2. region b:338-534 [31814]
      5. 1ngs
         complexed with ca, e4p, tpp
         1. region a:338-534 [31820]
         2. region b:338-534 [31822]
      6. 1tka
         complexed with ca, n3t
         1. region a:338-534 [31816]
         2. region b:338-534 [31818]
      7. 1ay0
         complexed with ca, tpp; mutant
         1. region a:338-534 [31824]
         2. region b:338-534 [31826]
   2. Maize (Zea mays) [TaxId: 4577] [88738] (1)
      1. 1itz
         complexed with mg, tpp
         1. region a:348-539 [76798]
         2. region b:348-539 [76801]
         3. region c:348-539 [76804]
   3. Escherichia coli [TaxId: 562] [89650] (7)
      1. 2r8o
         automatically matched to d1qgda1
         complexed with ca, edo, t5x
         1. region a:333-527 [151731]
      2. 2r8o
         automatically matched to d1qgda1
         complexed with ca, edo, t5x
         1. region b:333-527 [151734]
      3. 2r5n
         automatically matched to d1qgda1
         complexed with ca, edo, r5p, rp5, tpp
         1. region a:333-527 [151591]
      4. 2r5n
         automatically matched to d1qgda1
         complexed with ca, edo, r5p, rp5, tpp
         1. region b:333-527 [151594]
      5. 2r8p
         automatically matched to d1qgda1
         complexed with ca, edo, t6f
         1. region a:333-527 [151737]
      6. 2r8p
         automatically matched to d1qgda1
         complexed with ca, edo, t6f
         1. region b:333-527 [151740]
      7. 1qgd
         complexed with ca, so4, tpp
         1. region a:333-527 [88367]
         2. region b:333-527 [88370]
   4. Leishmania mexicana mexicana [TaxId: 44270] [117521] (1)
      SQ Q8MPM3
      1. 1r9j
         complexed with ca, tpp
         1. region a:337-526 [111722]
         2. region b:337-526 [111725]
2. Pyruvate dehydrogenase E1 component, Pyr module [88739]
   E1A and E1B fused together in a single-chain protein
   1. Escherichia coli [TaxId: 562] [88740] (14)
      1. 2iea
         automatically matched to d1l8aa2
         complexed with mg, tdp
         1. region a:471-700 [137294]
      2. 2iea
         automatically matched to d1l8aa2
         complexed with mg, tdp
         1. region b:471-700 [137297]
      3. 2qta
         automatically matched to d1l8aa2
         complexed with mg, tdp; mutant
         1. region a:471-700 [151333]
      4. 2qta
         automatically matched to d1l8aa2
         complexed with mg, tdp; mutant
         1. region b:471-700 [151336]
      5. 2qtc
         automatically matched to d1l8aa2
         complexed with mg, tdk; mutant
         1. region a:471-700 [151343]
      6. 2qtc
         automatically matched to d1l8aa2
         complexed with mg, tdk; mutant
         1. region b:471-700 [151346]
      7. 1l8a
         complexed with mg, tdp
         1. region a:471-700 [73678]
         2. region b:471-700 [73681]
      8. 2g28
         automatically matched to d1l8aa2
         complexed with mg, tdk
         1. region a:471-700 [134529]
      9. 2g28
         automatically matched to d1l8aa2
         complexed with mg, tdk
         1. region b:471-700 [134532]
      10. 2g25
          automatically matched to d1l8aa2
          complexed with mg, po4, tdk
          1. region a:471-700 [134523]
      11. 2g25
          automatically matched to d1l8aa2
          complexed with mg, po4, tdk
          1. region b:471-700 [134526]
      12. 1rp7
          complexed with mg, tzd
          1. region a:471-700 [97702]
          2. region b:471-700 [97705]
      13. 2g67
          automatically matched to d1l8aa2
          1. region a:471-700 [134695]
      14. 2g67
          automatically matched to d1l8aa2
          1. region b:471-700 [134698]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk