Structural Classification of Proteins
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Family: Sir2 family of transcriptional regulators

silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: DHS-like NAD/FAD-binding domain [52466]
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
  4. Superfamily: DHS-like NAD/FAD-binding domain [52467]
    binds cofactor molecules in the opposite direction than classical Rossmann fold
    link to SUPERFAMILY database - Superfamily
  5. Family: Sir2 family of transcriptional regulators [63984]
    silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

Protein Domains:

  1. AF1676, Sir2 homolog (Sir2-AF1?) [63985]
    1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [63986] (6)
      1. 1m2k picpic
        complexed with apr, zn; mutant
        1. chain a [84754] picpiclink
      2. 1m2j picpic
        complexed with apr, zn; mutant
        1. chain a [84753] picpiclink
      3. 1m2g picpic
        complexed with apr, zn
        1. chain a [84750] picpiclink
      4. 1m2h picpic
        complexed with apr, zn; mutant
        1. chain a [84751] picpiclink
      5. 1ici picpic
        complexed with nad, zn
        1. chain a [62266] picpiclink
        2. chain b [62267] picpiclink
      6. 1m2n picpic
        complexed with oad, zn; mutant
        1. chain a [84756] picpiclink
        2. chain b [84757] picpiclink
  2. AF0112, Sir2 homolog (Sir2-AF2) [82380]
    1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [82381] (7)
      1. 1ma3 picpic
        complexed with an acetylated p53 peptide, chain B
        complexed with aly, mes, zn
        1. chain a [78883] picpiclink
      2. 1s7g picpic
        complexed with 1pe, 2pe, apr, egl, nad, p6g, pg4, so4, zn
        1. chain a [98642] picpiclink
        2. chain b [98643] picpiclink
        3. chain c [98644] picpiclink
        4. chain d [98645] picpiclink
        5. chain e [98646] picpiclink
      3. 1yc2 picpic
        automatically matched to d1ma3a_
        complexed with 2pe, apr, edo, nad, nca, pg4, pge, so4, zn
        1. region a:1-252 [122903] picpiclink
      4. 1yc2 picpic
        automatically matched to d1ma3a_
        complexed with 2pe, apr, edo, nad, nca, pg4, pge, so4, zn
        1. region b:1-252 [122904] picpiclink
      5. 1yc2 picpic
        automatically matched to d1ma3a_
        complexed with 2pe, apr, edo, nad, nca, pg4, pge, so4, zn
        1. region c:1-252 [122905] picpiclink
      6. 1yc2 picpic
        automatically matched to d1ma3a_
        complexed with 2pe, apr, edo, nad, nca, pg4, pge, so4, zn
        1. region d:2-252 [122906] picpiclink
      7. 1yc2 picpic
        automatically matched to d1ma3a_
        complexed with 2pe, apr, edo, nad, nca, pg4, pge, so4, zn
        1. region e:1-250 [122907] picpiclink
  3. NAD-dependent deacetylase CobB [102292]
    1. Escherichia coli [TaxId: 562] [102293] (1)
      1. 1s5p picpic
        complex with a acetylated substrate peptide, chain B
        complexed with zn
        1. chain a [98569] picpiclink
  4. Sirt2 histone deacetylase [63987]
    1. Human (Homo sapiens) [TaxId: 9606] [63988] (1)
      1. 1j8f picpic
        complexed with zn
        1. chain a [62738] picpiclink
        2. chain b [62739] picpiclink
        3. chain c [62740] picpiclink
  5. Hst2 [102294]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [102295] (5)
      SQ P53686 1-293
      1. 1q1a picpic
        complexed with histone H4 peptide, chain B
        complexed with oad, zn2
        1. chain a [95561] picpiclink
      2. 1szd picpic
        complexed with apr, cl, gol, zn
        1. chain a [106150] picpiclink
      3. 1szc picpic
        complexed with cl, cna, gol, zn
        1. chain a [106149] picpiclink
      4. 1q14 picpic
        complexed with cl, zn2
        1. chain a [95537] picpiclink
      5. 1q17 picpic
        complexed with apr, cl, zn
        1. chain a [95550] picpiclink
        2. chain b [95551] picpiclink
        3. chain c [95552] picpiclink
  6. NAD-dependent deacetylase NpdA [142126]
    1. Thermotoga maritima [TaxId: 2336] [142127] (10)
      SQ Q9WYW0 1-245
      1. 1yc5 picpic
        complexed with nca, zn
        1. region a:1-245 [122910] picpiclink
      2. 2h2g picpic
        automatically matched to 1YC5 A:1-245
        complexed with zn
        1. region a:1-245 [136005] picpiclink
      3. 2h2d picpic
        automatically matched to 1YC5 A:1-245
        complexed with zn
        1. region a:1-245 [135997] picpiclink
      4. 2h2i picpic
        automatically matched to 1YC5 A:1-245
        complexed with zn, zpg
        1. region a:1-244 [136007] picpiclink
      5. 3d4b picpic
        automatically matched to d1yc5a1
        complexed with dzd, zn
        1. region a:1-245 [157291] picpiclink
      6. 2h4f picpic
        automatically matched to 1YC5 A:1-245
        complexed with nad, zn
        1. region a:1-245 [136073] picpiclink
      7. 2h2h picpic
        automatically matched to 1YC5 A:1-245
        complexed with zn
        1. region a:1-245 [136006] picpiclink
      8. 2h4j picpic
        automatically matched to 1YC5 A:1-245
        complexed with nca, oad, zn
        1. region a:1-245 [136076] picpiclink
      9. 2h2f picpic
        automatically matched to 1YC5 A:1-245
        complexed with zn
        1. region a:1-245 [136004] picpiclink
      10. 3d81 picpic
        automatically matched to d1yc5a1
        complexed with fzn, zn
        1. region a:1-245 [157437] picpiclink
  7. NAD-dependent deacetylase sirtuin-5 [142128]
    1. Human (Homo sapiens) [TaxId: 9606] [142129] (6)
      SQ Q9NXA8 36-302
      1. 2b4y picpic
        complexed with apr, epe, zn
        1. region a:36-302 [127868] picpiclink
      2. 2b4y picpic
        automatically matched to 2B4Y A:36-302
        complexed with apr, epe, zn
        1. region b:36-302 [127869] picpiclink
      3. 2b4y picpic
        automatically matched to 2B4Y A:36-302
        complexed with apr, epe, zn
        1. region c:36-302 [127870] picpiclink
      4. 2b4y picpic
        automatically matched to 2B4Y A:36-302
        complexed with apr, epe, zn
        1. region d:36-302 [127871] picpiclink
      5. 2nyr picpic
        automatically matched to 2B4Y A:36-302
        complexed with svr, zn
        1. region a:36-302 [138827] picpiclink
      6. 2nyr picpic
        automatically matched to 2B4Y A:36-302
        complexed with svr, zn
        1. region b:36-302 [138828] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk