Structural Classification of Proteins
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Superfamily: NAD(P)-binding Rossmann-fold domains

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: NAD(P)-binding Rossmann-fold domains [51734]
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. Superfamily: NAD(P)-binding Rossmann-fold domains [51735]
    link to SUPERFAMILY database - Superfamily

Families:

  1. Alcohol dehydrogenase-like, C-terminal domain [51736] (28)
    N-terminal all-beta domain defines family
    1. Alcohol dehydrogenase [51737]
      1. Horse (Equus caballus) [TaxId: 9796] [51738] (38) picpic
        SQ P00327
      2. Human (Homo sapiens), different isozymes [TaxId: 9606] [51739] (26) picpic
        SQ P00326 ! SQ P00325 ! SQ P07327
      3. Mouse (Mus musculus), class II [TaxId: 10090] [51740] (3) picpic
      4. Frog (Rana perezi) [TaxId: 8403] [89511] (2) picpic
      5. Cod (Gadus callarias) [TaxId: 8053] [51741] (1) picpic
      6. Archaeon Sulfolobus solfataricus [TaxId: 2287] [82286] (4) picpic
      7. Archaeon Aeropyrum pernix [TaxId: 56636] [102121] (1) picpic
      8. Pseudomonas aeruginosa [TaxId: 287] [102122] (1) picpic
      9. Bacillus stearothermophilus [TaxId: 1422] [102123] (1) picpic
    2. Hypothetical protein TM0436 [102124]
      1. Thermotoga maritima [TaxId: 2336] [102125] (1) picpic
    3. Hypothetical protein YhdH [102126]
      1. Escherichia coli [TaxId: 562] [102127] (2) picpic
        SQ P26646
    4. Hypothetical protein YahK [102128]
      1. Escherichia coli [TaxId: 562] [102129] (1) picpic
    5. Benzyl alcohol dehydrogenase [89512]
      1. Acinetobacter calcoaceticus [TaxId: 471] [89513] (1) picpic
    6. Bacterial secondary alcohol dehydrogenase [51742]
      1. Clostridium beijerinckii [TaxId: 1520] [51743] (3) picpic
      2. Thermoanaerobacter brockii [TaxId: 29323] [51744] (10) picpic
    7. Ketose reductase (sorbitol dehydrogenase) [51745]
      1. Silverleaf whitefly (Bemisia argentifolii) [TaxId: 77855] [51746] (1) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [102130] (3) picpic
    8. Formaldehyde dehydrogenase [82287]
      1. Pseudomonas putida [TaxId: 303] [82288] (1) picpic
    9. Quinone oxidoreductase [51747]
      1. Escherichia coli [TaxId: 562] [51748] (1) picpic
      2. Thermus thermophilus [TaxId: 274] [89514] (2) picpic
      3. Human (Homo sapiens) [TaxId: 9606] [117402] (1) picpic
        SQ Q08257
    10. Putative enoyl reductase domain of polyketide synthase [89515]
      1. Mycobacterium tuberculosis [TaxId: 1773] [89516] (1) picpic
    11. 2,4-dienoyl-CoA reductase [89517]
      1. Yeast (Candida tropicalis) [TaxId: 5482] [89518] (5) picpic
    12. Putative zinc-binding alcohol dehydrogenase [102131]
      1. Mouse (Mus musculus) [TaxId: 10090] [102132] (1) picpic
    13. Cinnamyl alcohol dehydrogenase, ADH6 [110403]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110404] (3) picpic
        SQ Q04894
    14. Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase [110405]
      1. Guinea pig (Cavia porcellus) [TaxId: 10141] [110406] (5) picpic
        SQ Q9EQZ5
    15. B. subtilis YhfP homologue [117403]
      1. Bacillus stearothermophilus [TaxId: 1422] [117404] (1) picpic
        SQ Q5L022; 96% sequence identity; Geobacillus kaustophilus TaxID:1462
    16. Hypothetical protein YhfP [117405]
      1. Bacillus subtilis [TaxId: 1423] [117406] (2) picpic
        SQ O07615
  2. Tyrosine-dependent oxidoreductases [51751] (108)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
    1. Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752]
      1. Escherichia coli [TaxId: 562] [51753] (17) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [51754] (7) picpic
      3. Trypanosoma brucei [TaxId: 5691] [89519] (5) picpic
      4. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141872] (1) picpic
        SQ P04397 11-357
        N-terminal domain of bifunctional Gal10 protein
    2. dTDP-glucose 4,6-dehydratase (RmlB) [51755]
      1. Escherichia coli [TaxId: 562] [51756] (1) picpic
      2. Salmonella enterica [TaxId: 28901] [63925] (1) picpic
      3. Streptococcus suis, serotype 2 [TaxId: 1307] [69406] (6) picpic
      4. Streptomyces venezuelae [TaxId: 54571] [102133] (2) picpic
    3. dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102]
      1. Salmonella enterica serovar typhimurium [TaxId: 90371] [75103] (4) picpic
    4. GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757]
      1. Escherichia coli [TaxId: 562] [51758] (8) picpic
    5. GDP-mannose 4,6-dehydratase [51759]
      1. Escherichia coli [TaxId: 562] [51760] (1) picpic
      2. Pseudomonas aeruginosa [TaxId: 287] [102134] (1) picpic
      3. Human (Homo sapiens) [TaxId: 9606] [102135] (1) picpic
      4. Thale-cress (Arabidopsis thaliana) [TaxId: 3702] [82289] (2) picpic
    6. ADP-L-glycero-D-mannoheptose 6-epimerase [51761]
      1. Escherichia coli [TaxId: 562] [51762] (1) picpic
    7. CDP-glucose-4,6-dehydratase [102136]
      1. Yersinia pseudotuberculosis [TaxId: 633] [102137] (1) picpic
      2. Salmonella typhimurium [TaxId: 90371] [141873] (2) picpic
        SQ P26397 2-356
    8. CDP-tyvelose-2-epimerase [102138]
      1. Salmonella typhi [TaxId: 90370] [102139] (1) picpic
    9. Phenylcoumaran benzylic ether reductase [102140]
      1. Loblolly pine (Pinus taeda) [TaxId: 3352] [102141] (1) picpic
    10. Pinoresinol-lariciresinol reductase [102142]
      1. Giant arborvitae (Thuja plicata) [TaxId: 3316] [102143] (1) picpic
    11. Sulfolipid biosynthesis protein SQD1 [51763]
      1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [51764] (4) picpic
    12. Negative transcriptional regulator NmrA [69407]
      has an UDP-galactose 4-epimerase-like structure but evolved a different function
      1. Aspergillus nidulans [TaxId: 162425] [69408] (29) picpic
        SQ O59919
    13. Carbonyl reductase [51765]
      1. Mouse (Mus musculus) [TaxId: 10090] [51766] (1) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [102144] (5) picpic
        dicarbonyl/L-xylulose reductase
    14. Sepiapterin reductase [51767]
      1. Mouse (Mus musculus) [TaxId: 10090] [51768] (3) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [141874] (6) picpic
        SQ P35270 5-261
    15. Dihydropteridin reductase (pteridine reductase) [51769]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [51770] (2) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [51771] (1) picpic
      3. Leishmania major [TaxId: 5664] [63926] (35) picpic
        SQ Q01782
      4. Leishmania tarentolae [TaxId: 5689] [102145] (1) picpic
      5. Trypanosoma cruzi [TaxId: 5693] [102146] (2) picpic
      6. Nematode (Caenorhabditis elegans) [TaxId: 6239] [89520] (1) picpic
    16. Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772]
      1. Human (Homo sapiens) [TaxId: 9606] [51773] (16) picpic
        SQ P14061
    17. 7-alpha-hydroxysteroid dehydrogenase [51774]
      1. Escherichia coli [TaxId: 562] [51775] (3) picpic
    18. 3-alpha,20-beta-hydroxysteroid dehydrogenase [51776]
      1. Streptomyces hydrogenans [TaxId: 1905] [51777] (2) picpic
    19. 3-alpha-hydroxysteroid dehydrogenase [51778]
      1. Comamonas testosteroni [TaxId: 285] [51779] (2) picpic
    20. 3beta/17beta hydroxysteroid dehydrogenase [82290]
      1. Comamonas testosteroni [TaxId: 285] [82291] (1) picpic
    21. Putative oxidoreductase Rv2002 [82292]
      1. Mycobacterium tuberculosis [TaxId: 1773] [82293] (3) picpic
    22. R-specific alcohol dehydrogenase [89521]
      1. Lactobacillus brevis [TaxId: 1580] [89522] (15) picpic
    23. Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780]
      1. Pseudomonas sp., lb400 [TaxId: 306] [51781] (1) picpic
    24. Drosophila alcohol dehydrogenase [51782]
      1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [102147] (1) picpic
      2. Fly (Drosophila lebanonensis) [TaxId: 7225] [51783] (7) picpic
    25. Glucose dehydrogenase [51784]
      1. Bacillus megaterium [TaxId: 1404] [51785] (4) picpic
    26. Sorbitol dehydrogenase [102148]
      1. Rhodobacter sphaeroides [TaxId: 1063] [102149] (1) picpic
    27. meso-2,3-butanediol dehydrogenase [51786]
      1. Klebsiella pneumoniae [TaxId: 573] [51787] (1) picpic
    28. Levodione reductase [89523]
      1. Corynebacterium aquaticum [TaxId: 144185] [89524] (1) picpic
    29. Mannitol dehydrogenase [63927]
      1. Mushroom (Agaricus bisporus) [TaxId: 5341] [63928] (1) picpic
    30. (3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294]
      peroxisomal multifunctional enzyme type 2
      segment swapping involving a C-terminal extension to the family fold
      1. Rat (Rattus norvegicus) [TaxId: 10116] [82295] (1) picpic
    31. beta-keto acyl carrier protein reductase [51788]
      1. Oil seed rape (Brassica napus) [TaxId: 3708] [51789] (7) picpic
      2. Escherichia coli [TaxId: 562] [51790] (3) picpic
      3. Thermotoga maritima [TaxId: 2336] [102150] (1) picpic
        TM1169
      4. Thermus thermophilus [TaxId: 274] [117407] (1) picpic
        SQ Q5SK98
      5. Streptomyces coelicolor [TaxId: 1902] [117408] (9) picpic
        SQ P16544 #SP
      6. Mycobacterium tuberculosis [TaxId: 1773] [141875] (6) picpic
        SQ P0A5Y4 9-245! SQ P0A5Y4 9-247
      7. Thermus thermophilus, TTHB020 [TaxId: 274] [141876] (2) picpic
        SQ Q53WH2 2-242
      8. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [141877] (1) picpic
        SQ Q86RB1 54-304
    32. Enoyl-ACP reductase [51791]
      1. Oil seed rape (Brassica napus) [TaxId: 3708] [51792] (4) picpic
      2. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [82296] (27) picpic
        SQ Q9BJJ9 96-424 # fragment
      3. Mycobacterium tuberculosis, TB, gene InhA [TaxId: 1773] [51793] (44) picpic
      4. Escherichia coli [TaxId: 562] [51794] (14) picpic
      5. Helicobacter pylori [TaxId: 210] [102151] (8) picpic
      6. Thermus thermophilus [TaxId: 274] [117409] (9) picpic
        SQ Q5SLI9
    33. Tropinone reductase [51795]
      1. Jimsonweed (Datura stramonium), I [TaxId: 4076] [51796] (1) picpic
      2. Jimsonweed (Datura stramonium), II [TaxId: 4076] [51797] (4) picpic
      3. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117410] (2) picpic
        SQ Q9ASX2
    34. 1,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798]
      1. Rice blast fungus (Magnaporthe grisea) [TaxId: 148305] [51799] (4) picpic
    35. 1,3,6,8-tetrahydroxynaphthalene reductase [63929]
      1. Rice blast fungus (Magnaporthe grisea) [TaxId: 148305] [63930] (1) picpic
    36. Biliverdin IX beta reductase [63931]
      Histidine in the active site instead of the Tyr-Lys dyad
      1. Human (Homo sapiens) [TaxId: 9606] [63932] (5) picpic
    37. Type II 3-hydroxyacyl-CoA dehydrogenase [63933]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [63934] (3) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [102152] (4) picpic
        SQ Q99714
      3. Thermus thermophilus [TaxId: 274] [89525] (1) picpic
    38. Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935]
      1. Pig (Sus scrofa) [TaxId: 9823] [63936] (1) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [141878] (4) picpic
        SQ P16152 2-276
    39. Halohydrin dehalogenase HheC [102153]
      haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
      1. Agrobacterium tumefaciens [TaxId: 358] [102154] (23) picpic
    40. Glucose dehydrogenase (5l265) [102155]
      1. Nematode (Caenorhabditis elegans) [TaxId: 6239] [102156] (1) picpic
    41. UDP-N-acetylglucosamine 4-epimerase WbpP [110407]
      1. Pseudomonas aeruginosa [TaxId: 287] [110408] (2) picpic
        SQ Q8KN66 # list: Q8GGB8 Q9RHD6 99% identity
    42. DTDP-4-dehydrorhamnose reductase RfbD [110409]
      1. Clostridium acetobutylicum [TaxId: 1488] [110410] (1) picpic
        SQ Q97GQ1
    43. Gluconate 5-dehydrogenase [110411]
      1. Thermotoga maritima [TaxId: 2336] [110412] (1) picpic
        SQ Q9WYS2
    44. Carbonyl reductase sniffer [110413]
      1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [110414] (1) picpic
        SQ Q9W3H4 # cg10964-pa
    45. Hypothetical protein F25D1.5 [110415]
      1. Caenorhabditis elegans [TaxId: 6239] [110416] (1) picpic
        SQ Q19774
    46. Putative dehydrogenase ARPG836 (MGC4172) [117411]
      1. Human (Homo sapiens) [TaxId: 9606] [117412] (1) picpic
        SQ Q6UWP2
    47. Aldehyde reductase II [117413]
      1. Sporobolomyces salmonicolor [TaxId: 5005] [117414] (5) picpic
        SQ Q9UUN9
    48. Hypothetical protein R05D8.7 [117415]
      1. Caenorhabditis elegans [TaxId: 6239] [117416] (1) picpic
        SQ Q9N5G4
    49. Hypothetical protein At5g02240 (T7H20_290) [117417]
      1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117418] (7) picpic
        SQ Q94EG6
    50. Polymyxin resistance protein ArnA (PrmI) [117419]
      evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
      1. Escherichia coli [TaxId: 562] [117420] (12) picpic
        SQ P77398
    51. 2,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421]
      1. Human (Homo sapiens), [TaxId: 9606] [117422] (3) picpic
        SQ Q16698 35-328
    52. 11-beta-hydroxysteroid dehydrogenase 1 [117423]
      1. Human (Homo sapiens) [TaxId: 9606] [117424] (37) picpic
        SQ P28845
      2. Guinea pig (Cavia porcellus) [TaxId: 10141] [117425] (1) picpic
        SQ Q6QLL4 23-296
      3. Mouse (Mus musculus) [TaxId: 10090] [141879] (4) picpic
        SQ P50172 24-298
    53. 17-beta-hydroxysteroid dehydrogenase type XI [117426]
      1. Human (Homo sapiens) [TaxId: 9606] [117427] (1) picpic
        SQ Q8NBQ5 30-273
    54. UDP-glucuronate decarboxylase 1 [141880]
      1. Human (Homo sapiens) [TaxId: 9606] [141881] (1) picpic
        SQ Q8NBZ7 87-398
    55. Xylitol dehydrogenase [141882]
      1. Gluconobacter oxydans [TaxId: 442] [141883] (8) picpic
        SQ Q8GR61 3-262
    56. Peroxisomal trans 2-enoyl CoA reductase [141884]
      1. Human (Homo sapiens) [TaxId: 9606] [141885] (4) picpic
        SQ Q9BY49 7-303
    57. D(-)-3-hydroxybutyrate dehydrogenase [141886]
      1. Pseudomonas fragi [TaxId: 296] [141887] (3) picpic
        SQ Q5KST5 1-260
    58. 15-hydroxyprostaglandin dehydrogenase, PGDH [141888]
      1. Human (Homo sapiens) [TaxId: 9606] [141889] (1) picpic
        SQ P15428 3-256
    59. GDP-mannose-3', 5'-epimerase [141890]
      1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [141891] (8) picpic
        SQ Q93VR3 13-374! SQ Q93VR3 13-375
    60. Bacterial sepiapterin reductase [141892]
      1. Chlorobium tepidum [TaxId: 1097] [141893] (4) picpic
        SQ Q8KES3 2-241
        CT0609
    61. Dehydrogenase/reductase SDR family member 6, DHRS6 [141894]
      Oxidoreductase UCPA
      1. Human (Homo sapiens) [TaxId: 9606] [141895] (4) picpic
        SQ Q9BUT1 1-245
    62. Hypothetical protein TTHA0369 [141896]
      TT0321
      1. Thermus thermophilus [TaxId: 274] [141897] (4) picpic
        SQ Q5SLC4 2-249
    63. Rhizome secoisolariciresinol dehydrogenase [141898]
      1. Mayapple (Podophyllum peltatum) [TaxId: 35933] [141899] (4) picpic
        SQ Q94KL8 11-278
    64. Peroxisomal multifunctional enzyme type 2 [141900]
      17-beta-hydroxysteroid dehydrogenase 4
      1. Human (Homo sapiens) [TaxId: 9606] [141901] (6) picpic
        SQ P51659 2-303
        the structure of C-terminal domain is also known, PDB entry 1S9C
    65. (s)-1-phenylethanol dehydrogenase [141902]
      1. Azoarcus sp. ebn1 [TaxId: 76114] [141903] (6) picpic
        SQ Q5P5I4 3-249
    66. TAT-interacting protein TIP30 [141904]
      1. Human (Homo sapiens) [TaxId: 9606] [141905] (1) picpic
        SQ Q9BUP3 5-236
      2. Mouse (Mus musculus) [TaxId: 10090] [141906] (1) picpic
        SQ Q9Z2G9 7-236
    67. Retinal dehydrogenase/reductase 3 [141907]
      1. Human (Homo sapiens) [TaxId: 9606] [141908] (16) picpic
        SQ Q9BPX1 4-253
    68. Erythromycin synthase, eryAI, 1st ketoreductase module [141909]
      tandem repeat of two SDR-like modules resembling a dimer commonly founf in the family; only the second module retains the coenzyme-binding site
      1. Saccharopolyspora erythraea [TaxId: 1836] [141910] (4) picpic
        SQ Q5UNP6 1448-1656! SQ Q5UNP6 1657-1915
    69. Hypothetical protein PA4017 [141911]
      unknown function; the active site region is blocked by a loop; strong sequence similarity to mammalian TAT-interacting protein TIP30
      1. Pseudomonas aeruginosa [TaxId: 287] [141912] (2) picpic
        SQ Q9HX10 4-215
    70. Putative carbonyl reductase sniffer [141913]
      1. Caenorhabditis elegans [TaxId: 6239] [141914] (6) picpic
        SQ P90780 1-250
  3. Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (52)
    family members also share a common alpha+beta fold in C-terminal domain
    1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) [51801]
      1. Escherichia coli [TaxId: 562] [51802] (13) picpic
        SQ P06977
      2. Bacillus stearothermophilus, nca 1503 [TaxId: 1422] [51803] (14) picpic
      3. Achromobacter xylosoxidans [TaxId: 85698] [89526] (1) picpic
        formerly Alcaligenes xylosoxidans
      4. Thermus aquaticus [TaxId: 271] [51804] (13) picpic
      5. Thermus thermophilus [TaxId: 274] [102157] (1) picpic
      6. Thermotoga maritima [TaxId: 2336] [51805] (1) picpic
      7. Archaeon Sulfolobus solfataricus [TaxId: 2287] [51806] (1) picpic
      8. Archaeon Methanothermus fervidus [TaxId: 2180] [51807] (1) picpic
      9. Trypanosoma brucei brucei, glycosome [TaxId: 5702] [51808] (1) picpic
      10. Trypanosoma cruzi [TaxId: 5693] [75104] (7) picpic
      11. Leishmania mexicana [TaxId: 5665] [51809] (5) picpic
      12. American lobster (Homarus americanus) [TaxId: 6706] [51810] (2) picpic
      13. South China Sea lobster (Palinurus versicolor) [TaxId: 150436] [51811] (5) picpic
      14. Human (Homo sapiens) [TaxId: 9606] [51812] (1) picpic
      15. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [102158] (1) picpic
      16. Spinach (Spinacia oleracea) [TaxId: 3562] [69409] (24) picpic
        SQ P19866
      17. Human(Homo sapiens), liver isoform [TaxId: 9606] [141915] (8) picpic
        SQ P04406 2-150,315-334
      18. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [141916] (12) picpic
        SQ Q8IKK7 4-152,319-335! SQ Q8T6B1 1-152,319-337
      19. Archaeon Pyrococcus horikoshii [TaxId: 53953] [159423] (4) picpic
        SQ O59494 1-139,302-334
    2. Aspartate beta-semialdehyde dehydrogenase [51813]
      1. Escherichia coli [TaxId: 562] [51814] (4) picpic
        SQ P00353
      2. Vibrio cholerae [TaxId: 666] [82297] (2) picpic
      3. Haemophilus influenzae [TaxId: 727] [102159] (12) picpic
        SQ P44801
      4. Streptococcus pneumoniae [TaxId: 1313] [141917] (11) picpic
        SQ Q8DQ00 2-127,330-357
    3. Acetaldehyde dehydrogenase (acylating) [89527]
      1. Pseudomonas sp. [TaxId: 306] [89528] (1) picpic
    4. Homoserine dehydrogenase [51815]
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [51816] (4) picpic
        SQ P31116
    5. Saccharopine reductase [51817]
      1. Rice blast fungus (Magnaporthe grisea) [TaxId: 148305] [51818] (3) picpic
    6. Diaminopimelic acid dehydrogenase (DAPDH) [51819]
      1. Corynebacterium glutamicum [TaxId: 1718] [51820] (4) picpic
    7. Dihydrodipicolinate reductase [51821]
      1. Escherichia coli [TaxId: 562] [51822] (5) picpic
      2. Mycobacterium tuberculosis [TaxId: 1773] [102160] (14) picpic
      3. Thermotoga maritima [TaxId: 2336] [110417] (1) picpic
        SQ Q9X1K8
    8. Myo-inositol 1-phosphate synthase [75105]
      1. Mycobacterium tuberculosis [TaxId: 1773] [75106] (1) picpic
      2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [75107] (9) picpic
        SQ P11986
      3. Archaeoglobus fulgidus [TaxId: 2234] [110418] (1) picpic
        SQ O28480
      4. Caenorhabditis elegans [TaxId: 6239] [110419] (1) picpic
        SQ Q18664
    9. Hypothetical protein TM1419 [102161]
      myo-inositol 1-phosphate synthase-related protein
      1. Thermotoga maritima [TaxId: 2336] [102162] (1) picpic
    10. Hypothetical protein TM1643 [75108]
      1. Thermotoga maritima [TaxId: 2336] [75109] (2) picpic
    11. 1-deoxy-D-xylulose-5-phosphate reductoisomerase [69410]
      1. Escherichia coli [TaxId: 562] [69411] (12) picpic
        SQ P45568
      2. Zymomonas mobilis [TaxId: 542] [110420] (2) picpic
        SQ Q9X5F2
    12. Biliverdin reductase [51823]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [51824] (3) picpic
    13. Glucose-fructose oxidoreductase, N-terminal domain [51825]
      1. Zymomonas mobilis [TaxId: 542] [51826] (12) picpic
    14. Glucose 6-phosphate dehydrogenase, N-terminal domain [51827]
      1. Leuconostoc mesenteroides [TaxId: 1245] [51828] (9) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [51829] (1) picpic
    15. Virulence factor MviM [110421]
      1. Escherichia coli [TaxId: 562] [110422] (1) picpic
        SQ P75931
    16. N-acetyl-gamma-glutamyl-phosphate reductase ArgC [110423]
      1. Thermotoga maritima [TaxId: 2336] [110424] (1) picpic
        SQ Q9X2A2
      2. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117428] (5) picpic
        SQ O82187 15-359
      3. Salmonella typhimurium [TaxId: 90371] [141918] (1) picpic
        SQ Q8ZKL8 1-153,309-334
    17. Putative oxidoreductase VCA1048 [110425]
      1. Vibrio cholerae [TaxId: 666] [110426] (1) picpic
        SQ Q9KKQ4
    18. Probable oxidoreductase At4g09670 [117429]
      1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117430] (1) picpic
        SQ Q9SZ83
    19. Putative semialdehyde dehydrogenase [141919]
      1. Rice (Oryza sativa) [TaxId: 4530] [141920] (4) picpic
        SQ Q6AV34 68-218,384-415
    20. Galactose/lactose metabolism regulatory protein GAL80 [141921]
      1. Yeast (Kluyveromyces lactis) [TaxId: 28985] [141922] (9) picpic
        SQ Q06433 2-154,374-457
    21. Usg-1 protein homolog PA3116 [141923]
      1. Pseudomonas aeruginosa [TaxId: 287] [141924] (1) picpic
        SQ O87014 3-129,320-336
    22. Hypothetical protein TM0312 [141925]
      1. Thermotoga maritima [TaxId: 2336] [141926] (2) picpic
        SQ Q9WYE8 4-131,276-328
  4. Formate/glycerate dehydrogenases, NAD-domain [51830] (14)
    this domain interrupts the other domain which defines family
    1. Formate dehydrogenase [51831]
      1. Pseudomonas sp., strain 101 [TaxId: 306] [51832] (2) picpic
    2. Putative formate dehydrogenase [51833]
      1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [51834] (1) picpic
    3. Transcription corepressor CtbP [82298]
      C-terminal binding protein 1; a dehydrogenase
      1. Human (Homo sapiens), Ctbp1 [TaxId: 9606] [82299] (1) picpic
      2. Rat (Rattus norvegicus), Ctbp3 [TaxId: 10116] [89529] (2) picpic
    4. D-2-hydroxyisocaproate dehydrogenase [51835]
      1. Lactobacillus casei [TaxId: 1582] [51836] (1) picpic
    5. D-glycerate dehydrogenase [51837]
      1. Hyphomicrobium methylovorum [TaxId: 84] [51838] (1) picpic
    6. Phosphoglycerate dehydrogenase [51839]
      has additional C-terminal domain of the ferredoxin fold
      1. Escherichia coli [TaxId: 562] [51840] (18) picpic
      2. Mycobacterium tuberculosis [TaxId: 1773] [141927] (2) picpic
        SQ P0A544 98-281
    7. D-lactate dehydrogenase [51841]
      1. Lactobacillus helveticus [TaxId: 1587] [51842] (3) picpic
    8. L-alanine dehydrogenase [51843]
      1. Phormidium lapideum [TaxId: 32060] [51844] (3) picpic
    9. Nicotinamide nucleotide transhydrogenase dI component [63937]
      L-alanine dehydrogenase homologue
      1. Rhodospirillum rubrum [TaxId: 1085] [63938] (28) picpic
    10. S-adenosylhomocystein hydrolase [51845]
      1. Human (Homo sapiens) [TaxId: 9606] [51846] (2) picpic
      2. Rat (Rattus norvegicus) [TaxId: 10116] [51847] (17) picpic
      3. Plasmodium falciparum, isolate 3D7 [TaxId: 5833] [117431] (1) picpic
        SQ P50250
  5. Siroheme synthase N-terminal domain-like [75110] (2)
    1. Siroheme synthase CysG, domain 1 [102163]
      1. Salmonella typhimurium [TaxId: 90371] [102164] (3) picpic
    2. Bifunctional dehydrogenase/ferrochelatase Met8p, N-terminal domain [75111]
      involved in siroheme synthesis
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [75112] (1) picpic
  6. LDH N-terminal domain-like [51848] (33)
    1. Malate dehydrogenase [51849]
      1. Pig (Sus scrofa) [TaxId: 9823] [51850] (3) picpic
      2. Sorghum (Sorghum vulgare), chloroplast [TaxId: 4558] [51851] (1) picpic
      3. Flaveria bidentis, chloroplast [TaxId: 4224] [51852] (1) picpic
      4. Escherichia coli [TaxId: 562] [51853] (8) picpic
      5. Thermus flavus [TaxId: 274] [51854] (2) picpic
      6. Thermus thermophilus [TaxId: 274] [82300] (9) picpic
        identical sequence to that from the Thermus flavus enzyme
      7. Archaeon Haloarcula marismortui [TaxId: 2238] [51855] (17) picpic
      8. Aquaspirillum arcticum [TaxId: 87645] [51856] (3) picpic
      9. Chloroflexus aurantiacus [TaxId: 1108] [69415] (7) picpic
        SQ P80040
      10. Chlorobium tepidum [TaxId: 1097] [69416] (1) picpic
      11. Chlorobium vibrioforme [TaxId: 1098] [69417] (2) picpic
      12. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [110427] (2) picpic
        SQ O08349
    2. L-2-hydroxyisocapronate dehydrogenase, L-HICDH [51857]
      1. Lactobacillus confusus [TaxId: 1583] [51858] (1) picpic
    3. Lactate dehydrogenase [51859]
      1. Pig (Sus scrofa) [TaxId: 9823] [51860] (3) picpic
      2. Human (Homo sapiens), heart isoform (H chain) [TaxId: 9606] [63939] (2) picpic
      3. Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] [63940] (1) picpic
      4. Mouse (Mus musculus) [TaxId: 10090] [51861] (4) picpic
      5. Dogfish (Squalus acanthias) [TaxId: 7797] [51862] (3) picpic
      6. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [51863] (9) picpic
      7. Plasmodium berghei [TaxId: 5821] [102165] (7) picpic
      8. Toxoplasma gondii [TaxId: 5811] [102166] (4) picpic
      9. Bacillus stearothermophilus [TaxId: 1422] [51864] (9) picpic
      10. Lactobacillus casei [TaxId: 1582] [51865] (1) picpic
      11. Lactobacillus pentosus [TaxId: 1589] [69418] (1) picpic
      12. Bifidobacterium longum, strain am101-2 [TaxId: 216816] [51866] (2) picpic
      13. Thermotoga maritima [TaxId: 2336] [51867] (1) picpic
      14. Clostridium thermocellum [TaxId: 1515] [117432] (1) picpic
        SQ Q4CDK5
    4. MJ0490, lactate/malate dehydrogenase [63941]
      1. Archaeon Methanococcus jannaschii [TaxId: 2190] [63942] (2) picpic
    5. Alpha-glucosidase AglA [89530]
      1. Thermotoga maritima [TaxId: 2336] [89531] (1) picpic
        TM1834
    6. Putative alpha-glucosidase TM0752 [102167]
      1. Thermotoga maritima [TaxId: 2336] [102168] (1) picpic
    7. Maltose-6'-phosphate glucosidase GlvA [102169]
      1. Bacillus subtilis [TaxId: 1423] [102170] (1) picpic
        SQ P54716
    8. 6-phospho-beta-glucosidase [110428]
      1. Bacillus stearothermophilus [TaxId: 1422] [110429] (1) picpic
        SQ P84135
      2. Thermotoga maritima [TaxId: 2336] [110430] (3) picpic
        SQ Q9X108
  7. 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (26)
    the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
    C-terminal domains also show some similarity
    1. Class I ketol-acid reductoisomerase (KARI) [89532]
      1. Pseudomonas aeruginosa [TaxId: 287] [89533] (1) picpic
    2. Class II ketol-acid reductoisomerase (KARI) [51869]
      contains additional subdomain at the N-terminus, partly ordered
      1. Spinach (Spinacia oleracea) [TaxId: 3562] [51870] (2) picpic
    3. 6-phosphogluconate dehydrogenase [51871]
      1. Sheep (Ovis orientalis aries) [TaxId: 9940] [51872] (5) picpic
      2. Trypanosoma brucei [TaxId: 5691] [51873] (1) picpic
    4. Hydroxyisobutyrate dehydrogenase [102171]
      1. Thermus thermophilus [TaxId: 274] [102172] (8) picpic
        structural genomics
      2. Salmonella typhimurium [TaxId: 90371] [110431] (1) picpic
        SQ Q8ZLV8
      3. Pseudomonas aeruginosa [TaxId: 287] [159424] (1) picpic
        SQ Q9I5I6 1-162
    5. Mannitol 2-dehydrogenase [82301]
      1. Pseudomonas fluorescens [TaxId: 294] [82302] (2) picpic
    6. Short chain L-3-hydroxyacyl CoA dehydrogenase [51874]
      1. Human (Homo sapiens) [TaxId: 9606] [51875] (11) picpic
      2. Pig (Sus scrofa) [TaxId: 9823] [51876] (1) picpic
    7. Conserved hypothetical protein MTH1747 [75113]
      1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [75114] (1) picpic
    8. UDP-glucose dehydrogenase (UDPGDH) [51877]
      1. Streptococcus pyogenes [TaxId: 1314] [51878] (2) picpic
    9. GDP-mannose 6-dehydrogenase [89534]
      1. Pseudomonas aeruginosa [TaxId: 287] [89535] (3) picpic
    10. N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [51879]
      1. Arthrobacter, strain 1c [TaxId: 1663] [51880] (1) picpic
    11. Glycerol-3- phosphate dehydrogenase [51881]
      1. Trypanosome (Leishmania mexicana) [TaxId: 5665] [51882] (7) picpic
      2. Archaeoglobus fulgidus [TaxId: 2234] [117433] (1) picpic
        SQ O29390
    12. Ketopantoate reductase PanE [69419]
      1. Escherichia coli [TaxId: 562] [69420] (5) picpic
    13. Coenzyme F420H2:NADP+ oxidoreductase (FNO) [69421]
      lacks all but the first helix of the C-terminal all-alpha domain
      1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [69422] (2) picpic
    14. Fatty oxidation complex alpha subunit, middle domain [110432]
      1. Pseudomonas fragi [TaxId: 296] [110433] (4) picpic
        SQ P28793
    15. Pyrroline-5-carboxylate reductase ProC [117434]
      1. Neisseria meningitidis, serogroup B [TaxId: 487] [117435] (2) picpic
        SQ Q9K1N1
      2. Streptococcus pyogenes [TaxId: 1314] [141928] (10) picpic
        SQ Q9A1S9 1-152
    16. Prephenate dehydrogenase TyrA [141929]
      1. Aquifex aeolicus [TaxId: 63363] [141930] (4) picpic
        SQ O67636 30-200
      2. Synechocystis sp. pcc 6803 [TaxId: 1148] [141931] (4) picpic
        SQ P73906 1-165
      3. Haemophilus influenzae [TaxId: 727] [159425] (2) picpic
        SQ P43902 92-243
    17. 5,10-methenyltetrahydromethanopterin hydrogenase, HMD [141932]
      1. Archaeon Methanocaldococcus jannaschii [TaxId: 2190] [141933] (1) picpic
        SQ Q58194 1-242
    18. Hypothetical protein TM1727 [159426]
      ProC structural homologue
      1. Thermotoga maritima [TaxId: 2336] [159427] (2) picpic
        SQ Q9X250 2-154
  8. Aminoacid dehydrogenase-like, C-terminal domain [51883] (24)
    extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site
    1. Glutamate dehydrogenase [51884]
      1. Clostridium symbiosum [TaxId: 1512] [51885] (4) picpic
      2. Archaeon Pyrococcus furiosus [TaxId: 2261] [51886] (1) picpic
      3. Archaeon Thermococcus profundus [TaxId: 49899] [63943] (1) picpic
      4. Archaeon Thermococcus litoralis [TaxId: 2265] [51887] (1) picpic
      5. Thermotoga maritima [TaxId: 2336] [51888] (3) picpic
      6. Cow (Bos taurus) [TaxId: 9913] [51889] (5) picpic
      7. Human (Homo sapiens) [TaxId: 9606] [75115] (2) picpic
      8. Pyrobaculum islandicum [TaxId: 2277] [117436] (1) picpic
        SQ Q9Y8I4
    2. Leucine dehydrogenase [51890]
      1. Bacillus sphaericus [TaxId: 1421] [51891] (1) picpic
    3. Phenylalanine dehydrogenase [51892]
      1. Rhodococcus sp., M4 [TaxId: 1831] [51893] (4) picpic
    4. Methylenetetrahydrofolate dehydrogenase/cyclohydrolase [51894]
      the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated
      1. Human (Homo sapiens) [TaxId: 9606] [51895] (4) picpic
      2. Escherichia coli [TaxId: 562] [51896] (1) picpic
      3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [51897] (2) picpic
    5. Methylene-tetrahydromethanopterin dehydrogenase [82303]
      1. Methylobacterium extorquens [TaxId: 408] [82304] (2) picpic
    6. Putative shikimate dehydrogenase YdiB [82305]
      1. Escherichia coli [TaxId: 562] [82306] (3) picpic
    7. Shikimate 5-dehydrogenase-like protein HI0607 [89536]
      1. Haemophilus influenzae [TaxId: 727] [89537] (1) picpic
    8. Shikimate 5-dehydrogenase AroE [89538]
      1. Escherichia coli [TaxId: 562] [89539] (1) picpic
      2. Haemophilus influenzae [TaxId: 727] [102173] (2) picpic
      3. Archaeon Methanococcus jannaschii [TaxId: 2190] [89540] (1) picpic
        MJ1084
    9. Glutamyl tRNA-reductase middle domain [69413]
      other domains of this protein are distinct from those usually associated with the family domain
      1. Archaeon Methanopyrus kandleri [TaxId: 2320] [69414] (1) picpic
    10. Mitochondrial NAD(P)-dependent malic enzyme [51898]
      includes C-terminal additional subdomains
      1. Human (Homo sapiens) [TaxId: 9606] [51899] (10) picpic
      2. Domestic pigeon (Columba livia) [TaxId: 8932] [75116] (1) picpic
      3. Pig roundworm (Ascaris suum) [TaxId: 6253] [75117] (2) picpic
    11. Malate oxidoreductase (malic enzyme) [110434]
      1. Thermotoga maritima [TaxId: 2336] [110435] (5) picpic
        SQ Q9WZ12
  9. Potassium channel NAD-binding domain [63944] (4)
    1. Rck domain from putative potassium channel Kch [63945]
      1. Escherichia coli [TaxId: 562] [63946] (1) picpic
    2. Ktn bsu222 [75118]
      1. Bacillus subtilis [TaxId: 1423] [75119] (13) picpic
    3. Ktn Mja218 [75120]
      1. Archaeon Methanococcus jannaschii [TaxId: 2190] [75121] (1) picpic
    4. Potassium channel-related protein MthK [75122]
      1. Archaeon Methanothermobacter thermautotrophicus [TaxId: 145262] [75123] (9) picpic
  10. Transcriptional repressor Rex, C-terminal domain [102174] (1)
    1. Transcriptional repressor Rex, C-terminal domain [102175]
      forms swapped dimer with C-terminal helices
      1. Thermus aquaticus [TaxId: 271] [102176] (3) picpic
        SQ Q9X2V5
        CASP5
  11. CoA-binding domain [51900] (7)
    1. Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain [51901]
      1. Escherichia coli [TaxId: 562] [51902] (18) picpic
      2. Thermus thermophilus [TaxId: 274] [89541] (1) picpic
      3. Pig (Sus scrofa) [TaxId: 9823] [51903] (6) picpic
    2. Hypothetical protein TT1466 [89542]
      putative CoA-binding protein
      1. Thermus thermophilus [TaxId: 274] [89543] (2) picpic
    3. Hypothetical protein PH1109 [141934]
      1. Pyrococcus horikoshii [TaxId: 53953] [141935] (3) picpic
        SQ O58836 1-142
    4. Acetate-CoA ligase alpha chain, AcdA, N-terminal domain [141936]
      1. Pyrococcus horikoshii [TaxId: 53953] [141937] (2) picpic
        SQ O58493 1-129
    5. Hypothetical protein PF0725 [141938]
      1. Pyrococcus furiosus [TaxId: 2261] [141939] (1) picpic
        SQ Q8U2V3 6-121
  12. Ornithine cyclodeaminase-like [110436] (2)
    Pfam 02423; contains additional alpha+beta dimerisation subdomain mostly formed by the N-terminal meander beta-sheet
    1. Archaeal alanine dehydrogenase [110437]
      1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [110438] (2) picpic
        SQ O28608 # Rossmann-fold core (101-292) begins with an N-terminal helix and ends with a beta-strand
    2. Ornithine cyclodeaminase [117437]
      1. Pseudomonas putida [TaxId: 303] [117438] (2) picpic
        SQ Q88H32
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk