Structural Classification of Proteins

Fold: NAD(P)-binding Rossmann-fold domains

: core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Lineage:

Root: scop
Class: Alpha and beta proteins (a/b) [51349]
Mainly parallel beta sheets (beta-alpha-beta units)
Fold: NAD(P)-binding Rossmann-fold domains [51734]
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamilies:

NAD(P)-binding Rossmann-fold domains [51735] (12)
uperfamily
1. Alcohol dehydrogenase-like, C-terminal domain [51736] (28)
  N-terminal all-beta domain defines family
  1. Alcohol dehydrogenase [51737]
    1. Horse (Equus caballus) [TaxId: 9796] [51738] (38)
      SQ P00327
    2. Human (Homo sapiens), different isozymes [TaxId: 9606] [51739] (26)
      SQ P00326 ! SQ P00325 ! SQ P07327
    3. Mouse (Mus musculus), class II [TaxId: 10090] [51740] (3)
    4. Frog (Rana perezi) [TaxId: 8403] [89511] (2)
    5. Cod (Gadus callarias) [TaxId: 8053] [51741] (1)
    6. Archaeon Sulfolobus solfataricus [TaxId: 2287] [82286] (4)
    7. Archaeon Aeropyrum pernix [TaxId: 56636] [102121] (1)
    8. Pseudomonas aeruginosa [TaxId: 287] [102122] (1)
    9. Bacillus stearothermophilus [TaxId: 1422] [102123] (1)
  2. Hypothetical protein TM0436 [102124]
    1. Thermotoga maritima [TaxId: 2336] [102125] (1)
  3. Hypothetical protein YhdH [102126]
    1. Escherichia coli [TaxId: 562] [102127] (2)
      SQ P26646
  4. Hypothetical protein YahK [102128]
    1. Escherichia coli [TaxId: 562] [102129] (1)
  5. Benzyl alcohol dehydrogenase [89512]
    1. Acinetobacter calcoaceticus [TaxId: 471] [89513] (1)
  6. Bacterial secondary alcohol dehydrogenase [51742]
    1. Clostridium beijerinckii [TaxId: 1520] [51743] (3)
    2. Thermoanaerobacter brockii [TaxId: 29323] [51744] (10)
  7. Ketose reductase (sorbitol dehydrogenase) [51745]
    1. Silverleaf whitefly (Bemisia argentifolii) [TaxId: 77855] [51746] (1)
    2. Human (Homo sapiens) [TaxId: 9606] [102130] (3)
  8. Formaldehyde dehydrogenase [82287]
    1. Pseudomonas putida [TaxId: 303] [82288] (1)
  9. Quinone oxidoreductase [51747]
    1. Escherichia coli [TaxId: 562] [51748] (1)
    2. Thermus thermophilus [TaxId: 274] [89514] (2)
    3. Human (Homo sapiens) [TaxId: 9606] [117402] (1)
      SQ Q08257
  10. Putative enoyl reductase domain of polyketide synthase [89515]
    1. Mycobacterium tuberculosis [TaxId: 1773] [89516] (1)
  11. 2,4-dienoyl-CoA reductase [89517]
    1. Yeast (Candida tropicalis) [TaxId: 5482] [89518] (5)
  12. Putative zinc-binding alcohol dehydrogenase [102131]
    1. Mouse (Mus musculus) [TaxId: 10090] [102132] (1)
  13. Cinnamyl alcohol dehydrogenase, ADH6 [110403]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110404] (3)
      SQ Q04894
  14. Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase [110405]
    1. Guinea pig (Cavia porcellus) [TaxId: 10141] [110406] (5)
      SQ Q9EQZ5
  15. B. subtilis YhfP homologue [117403]
    1. Bacillus stearothermophilus [TaxId: 1422] [117404] (1)
      SQ Q5L022; 96% sequence identity; Geobacillus kaustophilus TaxID:1462
  16. Hypothetical protein YhfP [117405]
    1. Bacillus subtilis [TaxId: 1423] [117406] (2)
      SQ O07615
2. Tyrosine-dependent oxidoreductases [51751] (108)
  also known as short-chain dehydrogenases and SDR family
  parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  1. Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752]
    1. Escherichia coli [TaxId: 562] [51753] (17)
    2. Human (Homo sapiens) [TaxId: 9606] [51754] (7)
    3. Trypanosoma brucei [TaxId: 5691] [89519] (5)
    4. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [141872] (1)
      SQ P04397 11-357
      N-terminal domain of bifunctional Gal10 protein
  2. dTDP-glucose 4,6-dehydratase (RmlB) [51755]
    1. Escherichia coli [TaxId: 562] [51756] (1)
    2. Salmonella enterica [TaxId: 28901] [63925] (1)
    3. Streptococcus suis, serotype 2 [TaxId: 1307] [69406] (6)
    4. Streptomyces venezuelae [TaxId: 54571] [102133] (2)
  3. dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102]
    1. Salmonella enterica serovar typhimurium [TaxId: 90371] [75103] (4)
  4. GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757]
    1. Escherichia coli [TaxId: 562] [51758] (8)
  5. GDP-mannose 4,6-dehydratase [51759]
    1. Escherichia coli [TaxId: 562] [51760] (1)
    2. Pseudomonas aeruginosa [TaxId: 287] [102134] (1)
    3. Human (Homo sapiens) [TaxId: 9606] [102135] (1)
    4. Thale-cress (Arabidopsis thaliana) [TaxId: 3702] [82289] (2)
  6. ADP-L-glycero-D-mannoheptose 6-epimerase [51761]
    1. Escherichia coli [TaxId: 562] [51762] (1)
  7. CDP-glucose-4,6-dehydratase [102136]
    1. Yersinia pseudotuberculosis [TaxId: 633] [102137] (1)
    2. Salmonella typhimurium [TaxId: 90371] [141873] (2)
      SQ P26397 2-356
  8. CDP-tyvelose-2-epimerase [102138]
    1. Salmonella typhi [TaxId: 90370] [102139] (1)
  9. Phenylcoumaran benzylic ether reductase [102140]
    1. Loblolly pine (Pinus taeda) [TaxId: 3352] [102141] (1)
  10. Pinoresinol-lariciresinol reductase [102142]
    1. Giant arborvitae (Thuja plicata) [TaxId: 3316] [102143] (1)
  11. Sulfolipid biosynthesis protein SQD1 [51763]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [51764] (4)
  12. Negative transcriptional regulator NmrA [69407]
    has an UDP-galactose 4-epimerase-like structure but evolved a different function
    1. Aspergillus nidulans [TaxId: 162425] [69408] (29)
      SQ O59919
  13. Carbonyl reductase [51765]
    1. Mouse (Mus musculus) [TaxId: 10090] [51766] (1)
    2. Human (Homo sapiens) [TaxId: 9606] [102144] (5)
      dicarbonyl/L-xylulose reductase
  14. Sepiapterin reductase [51767]
    1. Mouse (Mus musculus) [TaxId: 10090] [51768] (3)
    2. Human (Homo sapiens) [TaxId: 9606] [141874] (6)
      SQ P35270 5-261
  15. Dihydropteridin reductase (pteridine reductase) [51769]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [51770] (2)
    2. Human (Homo sapiens) [TaxId: 9606] [51771] (1)
    3. Leishmania major [TaxId: 5664] [63926] (35)
      SQ Q01782
    4. Leishmania tarentolae [TaxId: 5689] [102145] (1)
    5. Trypanosoma cruzi [TaxId: 5693] [102146] (2)
    6. Nematode (Caenorhabditis elegans) [TaxId: 6239] [89520] (1)
  16. Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772]
    1. Human (Homo sapiens) [TaxId: 9606] [51773] (16)
      SQ P14061
  17. 7-alpha-hydroxysteroid dehydrogenase [51774]
    1. Escherichia coli [TaxId: 562] [51775] (3)
  18. 3-alpha,20-beta-hydroxysteroid dehydrogenase [51776]
    1. Streptomyces hydrogenans [TaxId: 1905] [51777] (2)
  19. 3-alpha-hydroxysteroid dehydrogenase [51778]
    1. Comamonas testosteroni [TaxId: 285] [51779] (2)
  20. 3beta/17beta hydroxysteroid dehydrogenase [82290]
    1. Comamonas testosteroni [TaxId: 285] [82291] (1)
  21. Putative oxidoreductase Rv2002 [82292]
    1. Mycobacterium tuberculosis [TaxId: 1773] [82293] (3)
  22. R-specific alcohol dehydrogenase [89521]
    1. Lactobacillus brevis [TaxId: 1580] [89522] (15)
  23. Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780]
    1. Pseudomonas sp., lb400 [TaxId: 306] [51781] (1)
  24. Drosophila alcohol dehydrogenase [51782]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [102147] (1)
    2. Fly (Drosophila lebanonensis) [TaxId: 7225] [51783] (7)
  25. Glucose dehydrogenase [51784]
    1. Bacillus megaterium [TaxId: 1404] [51785] (4)
  26. Sorbitol dehydrogenase [102148]
    1. Rhodobacter sphaeroides [TaxId: 1063] [102149] (1)
  27. meso-2,3-butanediol dehydrogenase [51786]
    1. Klebsiella pneumoniae [TaxId: 573] [51787] (1)
  28. Levodione reductase [89523]
    1. Corynebacterium aquaticum [TaxId: 144185] [89524] (1)
  29. Mannitol dehydrogenase [63927]
    1. Mushroom (Agaricus bisporus) [TaxId: 5341] [63928] (1)
  30. (3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294]
    peroxisomal multifunctional enzyme type 2
    segment swapping involving a C-terminal extension to the family fold
    1. Rat (Rattus norvegicus) [TaxId: 10116] [82295] (1)
  31. beta-keto acyl carrier protein reductase [51788]
    1. Oil seed rape (Brassica napus) [TaxId: 3708] [51789] (7)
    2. Escherichia coli [TaxId: 562] [51790] (3)
    3. Thermotoga maritima [TaxId: 2336] [102150] (1)
      TM1169
    4. Thermus thermophilus [TaxId: 274] [117407] (1)
      SQ Q5SK98
    5. Streptomyces coelicolor [TaxId: 1902] [117408] (9)
      SQ P16544 #SP
    6. Mycobacterium tuberculosis [TaxId: 1773] [141875] (6)
      SQ P0A5Y4 9-245! SQ P0A5Y4 9-247
    7. Thermus thermophilus, TTHB020 [TaxId: 274] [141876] (2)
      SQ Q53WH2 2-242
    8. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [141877] (1)
      SQ Q86RB1 54-304
  32. Enoyl-ACP reductase [51791]
    1. Oil seed rape (Brassica napus) [TaxId: 3708] [51792] (4)
    2. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [82296] (27)
      SQ Q9BJJ9 96-424 # fragment
    3. Mycobacterium tuberculosis, TB, gene InhA [TaxId: 1773] [51793] (44)
    4. Escherichia coli [TaxId: 562] [51794] (14)
    5. Helicobacter pylori [TaxId: 210] [102151] (8)
    6. Thermus thermophilus [TaxId: 274] [117409] (9)
      SQ Q5SLI9
  33. Tropinone reductase [51795]
    1. Jimsonweed (Datura stramonium), I [TaxId: 4076] [51796] (1)
    2. Jimsonweed (Datura stramonium), II [TaxId: 4076] [51797] (4)
    3. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117410] (2)
      SQ Q9ASX2
  34. 1,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798]
    1. Rice blast fungus (Magnaporthe grisea) [TaxId: 148305] [51799] (4)
  35. 1,3,6,8-tetrahydroxynaphthalene reductase [63929]
    1. Rice blast fungus (Magnaporthe grisea) [TaxId: 148305] [63930] (1)
  36. Biliverdin IX beta reductase [63931]
    Histidine in the active site instead of the Tyr-Lys dyad
    1. Human (Homo sapiens) [TaxId: 9606] [63932] (5)
  37. Type II 3-hydroxyacyl-CoA dehydrogenase [63933]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [63934] (3)
    2. Human (Homo sapiens) [TaxId: 9606] [102152] (4)
      SQ Q99714
    3. Thermus thermophilus [TaxId: 274] [89525] (1)
  38. Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935]
    1. Pig (Sus scrofa) [TaxId: 9823] [63936] (1)
    2. Human (Homo sapiens) [TaxId: 9606] [141878] (4)
      SQ P16152 2-276
  39. Halohydrin dehalogenase HheC [102153]
    haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
    1. Agrobacterium tumefaciens [TaxId: 358] [102154] (23)
  40. Glucose dehydrogenase (5l265) [102155]
    1. Nematode (Caenorhabditis elegans) [TaxId: 6239] [102156] (1)
  41. UDP-N-acetylglucosamine 4-epimerase WbpP [110407]
    1. Pseudomonas aeruginosa [TaxId: 287] [110408] (2)
      SQ Q8KN66 # list: Q8GGB8 Q9RHD6 99% identity
  42. DTDP-4-dehydrorhamnose reductase RfbD [110409]
    1. Clostridium acetobutylicum [TaxId: 1488] [110410] (1)
      SQ Q97GQ1
  43. Gluconate 5-dehydrogenase [110411]
    1. Thermotoga maritima [TaxId: 2336] [110412] (1)
      SQ Q9WYS2
  44. Carbonyl reductase sniffer [110413]
    1. Fruit fly (Drosophila melanogaster) [TaxId: 7227] [110414] (1)
      SQ Q9W3H4 # cg10964-pa
  45. Hypothetical protein F25D1.5 [110415]
    1. Caenorhabditis elegans [TaxId: 6239] [110416] (1)
      SQ Q19774
  46. Putative dehydrogenase ARPG836 (MGC4172) [117411]
    1. Human (Homo sapiens) [TaxId: 9606] [117412] (1)
      SQ Q6UWP2
  47. Aldehyde reductase II [117413]
    1. Sporobolomyces salmonicolor [TaxId: 5005] [117414] (5)
      SQ Q9UUN9
  48. Hypothetical protein R05D8.7 [117415]
    1. Caenorhabditis elegans [TaxId: 6239] [117416] (1)
      SQ Q9N5G4
  49. Hypothetical protein At5g02240 (T7H20_290) [117417]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117418] (7)
      SQ Q94EG6
  50. Polymyxin resistance protein ArnA (PrmI) [117419]
    evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
    1. Escherichia coli [TaxId: 562] [117420] (12)
      SQ P77398
  51. 2,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421]
    1. Human (Homo sapiens), [TaxId: 9606] [117422] (3)
      SQ Q16698 35-328
  52. 11-beta-hydroxysteroid dehydrogenase 1 [117423]
    1. Human (Homo sapiens) [TaxId: 9606] [117424] (37)
      SQ P28845
    2. Guinea pig (Cavia porcellus) [TaxId: 10141] [117425] (1)
      SQ Q6QLL4 23-296
    3. Mouse (Mus musculus) [TaxId: 10090] [141879] (4)
      SQ P50172 24-298
  53. 17-beta-hydroxysteroid dehydrogenase type XI [117426]
    1. Human (Homo sapiens) [TaxId: 9606] [117427] (1)
      SQ Q8NBQ5 30-273
  54. UDP-glucuronate decarboxylase 1 [141880]
    1. Human (Homo sapiens) [TaxId: 9606] [141881] (1)
      SQ Q8NBZ7 87-398
  55. Xylitol dehydrogenase [141882]
    1. Gluconobacter oxydans [TaxId: 442] [141883] (8)
      SQ Q8GR61 3-262
  56. Peroxisomal trans 2-enoyl CoA reductase [141884]
    1. Human (Homo sapiens) [TaxId: 9606] [141885] (4)
      SQ Q9BY49 7-303
  57. D(-)-3-hydroxybutyrate dehydrogenase [141886]
    1. Pseudomonas fragi [TaxId: 296] [141887] (3)
      SQ Q5KST5 1-260
  58. 15-hydroxyprostaglandin dehydrogenase, PGDH [141888]
    1. Human (Homo sapiens) [TaxId: 9606] [141889] (1)
      SQ P15428 3-256
  59. GDP-mannose-3', 5'-epimerase [141890]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [141891] (8)
      SQ Q93VR3 13-374! SQ Q93VR3 13-375
  60. Bacterial sepiapterin reductase [141892]
    1. Chlorobium tepidum [TaxId: 1097] [141893] (4)
      SQ Q8KES3 2-241
      CT0609
  61. Dehydrogenase/reductase SDR family member 6, DHRS6 [141894]
    Oxidoreductase UCPA
    1. Human (Homo sapiens) [TaxId: 9606] [141895] (4)
      SQ Q9BUT1 1-245
  62. Hypothetical protein TTHA0369 [141896]
    TT0321
    1. Thermus thermophilus [TaxId: 274] [141897] (4)
      SQ Q5SLC4 2-249
  63. Rhizome secoisolariciresinol dehydrogenase [141898]
    1. Mayapple (Podophyllum peltatum) [TaxId: 35933] [141899] (4)
      SQ Q94KL8 11-278
  64. Peroxisomal multifunctional enzyme type 2 [141900]
    17-beta-hydroxysteroid dehydrogenase 4
    1. Human (Homo sapiens) [TaxId: 9606] [141901] (6)
      SQ P51659 2-303
      the structure of C-terminal domain is also known, PDB entry 1S9C
  65. (s)-1-phenylethanol dehydrogenase [141902]
    1. Azoarcus sp. ebn1 [TaxId: 76114] [141903] (6)
      SQ Q5P5I4 3-249
  66. TAT-interacting protein TIP30 [141904]
    1. Human (Homo sapiens) [TaxId: 9606] [141905] (1)
      SQ Q9BUP3 5-236
    2. Mouse (Mus musculus) [TaxId: 10090] [141906] (1)
      SQ Q9Z2G9 7-236
  67. Retinal dehydrogenase/reductase 3 [141907]
    1. Human (Homo sapiens) [TaxId: 9606] [141908] (16)
      SQ Q9BPX1 4-253
  68. Erythromycin synthase, eryAI, 1st ketoreductase module [141909]
    tandem repeat of two SDR-like modules resembling a dimer commonly founf in the family; only the second module retains the coenzyme-binding site
    1. Saccharopolyspora erythraea [TaxId: 1836] [141910] (4)
      SQ Q5UNP6 1448-1656! SQ Q5UNP6 1657-1915
  69. Hypothetical protein PA4017 [141911]
    unknown function; the active site region is blocked by a loop; strong sequence similarity to mammalian TAT-interacting protein TIP30
    1. Pseudomonas aeruginosa [TaxId: 287] [141912] (2)
      SQ Q9HX10 4-215
  70. Putative carbonyl reductase sniffer [141913]
    1. Caenorhabditis elegans [TaxId: 6239] [141914] (6)
      SQ P90780 1-250
3. Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (52)
  family members also share a common alpha+beta fold in C-terminal domain
  1. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) [51801]
    1. Escherichia coli [TaxId: 562] [51802] (13)
      SQ P06977
    2. Bacillus stearothermophilus, nca 1503 [TaxId: 1422] [51803] (14)
    3. Achromobacter xylosoxidans [TaxId: 85698] [89526] (1)
      formerly Alcaligenes xylosoxidans
    4. Thermus aquaticus [TaxId: 271] [51804] (13)
    5. Thermus thermophilus [TaxId: 274] [102157] (1)
    6. Thermotoga maritima [TaxId: 2336] [51805] (1)
    7. Archaeon Sulfolobus solfataricus [TaxId: 2287] [51806] (1)
    8. Archaeon Methanothermus fervidus [TaxId: 2180] [51807] (1)
    9. Trypanosoma brucei brucei, glycosome [TaxId: 5702] [51808] (1)
    10. Trypanosoma cruzi [TaxId: 5693] [75104] (7)
    11. Leishmania mexicana [TaxId: 5665] [51809] (5)
    12. American lobster (Homarus americanus) [TaxId: 6706] [51810] (2)
    13. South China Sea lobster (Palinurus versicolor) [TaxId: 150436] [51811] (5)
    14. Human (Homo sapiens) [TaxId: 9606] [51812] (1)
    15. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [102158] (1)
    16. Spinach (Spinacia oleracea) [TaxId: 3562] [69409] (24)
      SQ P19866
    17. Human(Homo sapiens), liver isoform [TaxId: 9606] [141915] (8)
      SQ P04406 2-150,315-334
    18. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [141916] (12)
      SQ Q8IKK7 4-152,319-335! SQ Q8T6B1 1-152,319-337
    19. Archaeon Pyrococcus horikoshii [TaxId: 53953] [159423] (4)
      SQ O59494 1-139,302-334
  2. Aspartate beta-semialdehyde dehydrogenase [51813]
    1. Escherichia coli [TaxId: 562] [51814] (4)
      SQ P00353
    2. Vibrio cholerae [TaxId: 666] [82297] (2)
    3. Haemophilus influenzae [TaxId: 727] [102159] (12)
      SQ P44801
    4. Streptococcus pneumoniae [TaxId: 1313] [141917] (11)
      SQ Q8DQ00 2-127,330-357
  3. Acetaldehyde dehydrogenase (acylating) [89527]
    1. Pseudomonas sp. [TaxId: 306] [89528] (1)
  4. Homoserine dehydrogenase [51815]
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [51816] (4)
      SQ P31116
  5. Saccharopine reductase [51817]
    1. Rice blast fungus (Magnaporthe grisea) [TaxId: 148305] [51818] (3)
  6. Diaminopimelic acid dehydrogenase (DAPDH) [51819]
    1. Corynebacterium glutamicum [TaxId: 1718] [51820] (4)
  7. Dihydrodipicolinate reductase [51821]
    1. Escherichia coli [TaxId: 562] [51822] (5)
    2. Mycobacterium tuberculosis [TaxId: 1773] [102160] (14)
    3. Thermotoga maritima [TaxId: 2336] [110417] (1)
      SQ Q9X1K8
  8. Myo-inositol 1-phosphate synthase [75105]
    1. Mycobacterium tuberculosis [TaxId: 1773] [75106] (1)
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [75107] (9)
      SQ P11986
    3. Archaeoglobus fulgidus [TaxId: 2234] [110418] (1)
      SQ O28480
    4. Caenorhabditis elegans [TaxId: 6239] [110419] (1)
      SQ Q18664
  9. Hypothetical protein TM1419 [102161]
    myo-inositol 1-phosphate synthase-related protein
    1. Thermotoga maritima [TaxId: 2336] [102162] (1)
  10. Hypothetical protein TM1643 [75108]
    1. Thermotoga maritima [TaxId: 2336] [75109] (2)
  11. 1-deoxy-D-xylulose-5-phosphate reductoisomerase [69410]
    1. Escherichia coli [TaxId: 562] [69411] (12)
      SQ P45568
    2. Zymomonas mobilis [TaxId: 542] [110420] (2)
      SQ Q9X5F2
  12. Biliverdin reductase [51823]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [51824] (3)
  13. Glucose-fructose oxidoreductase, N-terminal domain [51825]
    1. Zymomonas mobilis [TaxId: 542] [51826] (12)
  14. Glucose 6-phosphate dehydrogenase, N-terminal domain [51827]
    1. Leuconostoc mesenteroides [TaxId: 1245] [51828] (9)
    2. Human (Homo sapiens) [TaxId: 9606] [51829] (1)
  15. Virulence factor MviM [110421]
    1. Escherichia coli [TaxId: 562] [110422] (1)
      SQ P75931
  16. N-acetyl-gamma-glutamyl-phosphate reductase ArgC [110423]
    1. Thermotoga maritima [TaxId: 2336] [110424] (1)
      SQ Q9X2A2
    2. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117428] (5)
      SQ O82187 15-359
    3. Salmonella typhimurium [TaxId: 90371] [141918] (1)
      SQ Q8ZKL8 1-153,309-334
  17. Putative oxidoreductase VCA1048 [110425]
    1. Vibrio cholerae [TaxId: 666] [110426] (1)
      SQ Q9KKQ4
  18. Probable oxidoreductase At4g09670 [117429]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117430] (1)
      SQ Q9SZ83
  19. Putative semialdehyde dehydrogenase [141919]
    1. Rice (Oryza sativa) [TaxId: 4530] [141920] (4)
      SQ Q6AV34 68-218,384-415
  20. Galactose/lactose metabolism regulatory protein GAL80 [141921]
    1. Yeast (Kluyveromyces lactis) [TaxId: 28985] [141922] (9)
      SQ Q06433 2-154,374-457
  21. Usg-1 protein homolog PA3116 [141923]
    1. Pseudomonas aeruginosa [TaxId: 287] [141924] (1)
      SQ O87014 3-129,320-336
  22. Hypothetical protein TM0312 [141925]
    1. Thermotoga maritima [TaxId: 2336] [141926] (2)
      SQ Q9WYE8 4-131,276-328
4. Formate/glycerate dehydrogenases, NAD-domain [51830] (14)
  this domain interrupts the other domain which defines family
  1. Formate dehydrogenase [51831]
    1. Pseudomonas sp., strain 101 [TaxId: 306] [51832] (2)
  2. Putative formate dehydrogenase [51833]
    1. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [51834] (1)
  3. Transcription corepressor CtbP [82298]
    C-terminal binding protein 1; a dehydrogenase
    1. Human (Homo sapiens), Ctbp1 [TaxId: 9606] [82299] (1)
    2. Rat (Rattus norvegicus), Ctbp3 [TaxId: 10116] [89529] (2)
  4. D-2-hydroxyisocaproate dehydrogenase [51835]
    1. Lactobacillus casei [TaxId: 1582] [51836] (1)
  5. D-glycerate dehydrogenase [51837]
    1. Hyphomicrobium methylovorum [TaxId: 84] [51838] (1)
  6. Phosphoglycerate dehydrogenase [51839]
    has additional C-terminal domain of the ferredoxin fold
    1. Escherichia coli [TaxId: 562] [51840] (18)
    2. Mycobacterium tuberculosis [TaxId: 1773] [141927] (2)
      SQ P0A544 98-281
  7. D-lactate dehydrogenase [51841]
    1. Lactobacillus helveticus [TaxId: 1587] [51842] (3)
  8. L-alanine dehydrogenase [51843]
    1. Phormidium lapideum [TaxId: 32060] [51844] (3)
  9. Nicotinamide nucleotide transhydrogenase dI component [63937]
    L-alanine dehydrogenase homologue
    1. Rhodospirillum rubrum [TaxId: 1085] [63938] (28)
  10. S-adenosylhomocystein hydrolase [51845]
    1. Human (Homo sapiens) [TaxId: 9606] [51846] (2)
    2. Rat (Rattus norvegicus) [TaxId: 10116] [51847] (17)
    3. Plasmodium falciparum, isolate 3D7 [TaxId: 5833] [117431] (1)
      SQ P50250
5. Siroheme synthase N-terminal domain-like [75110] (2)
  1. Siroheme synthase CysG, domain 1 [102163]
    1. Salmonella typhimurium [TaxId: 90371] [102164] (3)
  2. Bifunctional dehydrogenase/ferrochelatase Met8p, N-terminal domain [75111]
    involved in siroheme synthesis
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [75112] (1)
6. LDH N-terminal domain-like [51848] (33)
  1. Malate dehydrogenase [51849]
    1. Pig (Sus scrofa) [TaxId: 9823] [51850] (3)
    2. Sorghum (Sorghum vulgare), chloroplast [TaxId: 4558] [51851] (1)
    3. Flaveria bidentis, chloroplast [TaxId: 4224] [51852] (1)
    4. Escherichia coli [TaxId: 562] [51853] (8)
    5. Thermus flavus [TaxId: 274] [51854] (2)
    6. Thermus thermophilus [TaxId: 274] [82300] (9)
      identical sequence to that from the Thermus flavus enzyme
    7. Archaeon Haloarcula marismortui [TaxId: 2238] [51855] (17)
    8. Aquaspirillum arcticum [TaxId: 87645] [51856] (3)
    9. Chloroflexus aurantiacus [TaxId: 1108] [69415] (7)
      SQ P80040
    10. Chlorobium tepidum [TaxId: 1097] [69416] (1)
    11. Chlorobium vibrioforme [TaxId: 1098] [69417] (2)
    12. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [110427] (2)
      SQ O08349
  2. L-2-hydroxyisocapronate dehydrogenase, L-HICDH [51857]
    1. Lactobacillus confusus [TaxId: 1583] [51858] (1)
  3. Lactate dehydrogenase [51859]
    1. Pig (Sus scrofa) [TaxId: 9823] [51860] (3)
    2. Human (Homo sapiens), heart isoform (H chain) [TaxId: 9606] [63939] (2)
    3. Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606] [63940] (1)
    4. Mouse (Mus musculus) [TaxId: 10090] [51861] (4)
    5. Dogfish (Squalus acanthias) [TaxId: 7797] [51862] (3)
    6. Malaria parasite (Plasmodium falciparum) [TaxId: 5833] [51863] (9)
    7. Plasmodium berghei [TaxId: 5821] [102165] (7)
    8. Toxoplasma gondii [TaxId: 5811] [102166] (4)
    9. Bacillus stearothermophilus [TaxId: 1422] [51864] (9)
    10. Lactobacillus casei [TaxId: 1582] [51865] (1)
    11. Lactobacillus pentosus [TaxId: 1589] [69418] (1)
    12. Bifidobacterium longum, strain am101-2 [TaxId: 216816] [51866] (2)
    13. Thermotoga maritima [TaxId: 2336] [51867] (1)
    14. Clostridium thermocellum [TaxId: 1515] [117432] (1)
      SQ Q4CDK5
  4. MJ0490, lactate/malate dehydrogenase [63941]
    1. Archaeon Methanococcus jannaschii [TaxId: 2190] [63942] (2)
  5. Alpha-glucosidase AglA [89530]
    1. Thermotoga maritima [TaxId: 2336] [89531] (1)
      TM1834
  6. Putative alpha-glucosidase TM0752 [102167]
    1. Thermotoga maritima [TaxId: 2336] [102168] (1)
  7. Maltose-6'-phosphate glucosidase GlvA [102169]
    1. Bacillus subtilis [TaxId: 1423] [102170] (1)
      SQ P54716
  8. 6-phospho-beta-glucosidase [110428]
    1. Bacillus stearothermophilus [TaxId: 1422] [110429] (1)
      SQ P84135
    2. Thermotoga maritima [TaxId: 2336] [110430] (3)
      SQ Q9X108
7. 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (26)
  the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
  C-terminal domains also show some similarity
  1. Class I ketol-acid reductoisomerase (KARI) [89532]
    1. Pseudomonas aeruginosa [TaxId: 287] [89533] (1)
  2. Class II ketol-acid reductoisomerase (KARI) [51869]
    contains additional subdomain at the N-terminus, partly ordered
    1. Spinach (Spinacia oleracea) [TaxId: 3562] [51870] (2)
  3. 6-phosphogluconate dehydrogenase [51871]
    1. Sheep (Ovis orientalis aries) [TaxId: 9940] [51872] (5)
    2. Trypanosoma brucei [TaxId: 5691] [51873] (1)
  4. Hydroxyisobutyrate dehydrogenase [102171]
    1. Thermus thermophilus [TaxId: 274] [102172] (8)
      structural genomics
    2. Salmonella typhimurium [TaxId: 90371] [110431] (1)
      SQ Q8ZLV8
    3. Pseudomonas aeruginosa [TaxId: 287] [159424] (1)
      SQ Q9I5I6 1-162
  5. Mannitol 2-dehydrogenase [82301]
    1. Pseudomonas fluorescens [TaxId: 294] [82302] (2)
  6. Short chain L-3-hydroxyacyl CoA dehydrogenase [51874]
    1. Human (Homo sapiens) [TaxId: 9606] [51875] (11)
    2. Pig (Sus scrofa) [TaxId: 9823] [51876] (1)
  7. Conserved hypothetical protein MTH1747 [75113]
    1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [75114] (1)
  8. UDP-glucose dehydrogenase (UDPGDH) [51877]
    1. Streptococcus pyogenes [TaxId: 1314] [51878] (2)
  9. GDP-mannose 6-dehydrogenase [89534]
    1. Pseudomonas aeruginosa [TaxId: 287] [89535] (3)
  10. N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [51879]
    1. Arthrobacter, strain 1c [TaxId: 1663] [51880] (1)
  11. Glycerol-3- phosphate dehydrogenase [51881]
    1. Trypanosome (Leishmania mexicana) [TaxId: 5665] [51882] (7)
    2. Archaeoglobus fulgidus [TaxId: 2234] [117433] (1)
      SQ O29390
  12. Ketopantoate reductase PanE [69419]
    1. Escherichia coli [TaxId: 562] [69420] (5)
  13. Coenzyme F420H2:NADP+ oxidoreductase (FNO) [69421]
    lacks all but the first helix of the C-terminal all-alpha domain
    1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [69422] (2)
  14. Fatty oxidation complex alpha subunit, middle domain [110432]
    1. Pseudomonas fragi [TaxId: 296] [110433] (4)
      SQ P28793
  15. Pyrroline-5-carboxylate reductase ProC [117434]
    1. Neisseria meningitidis, serogroup B [TaxId: 487] [117435] (2)
      SQ Q9K1N1
    2. Streptococcus pyogenes [TaxId: 1314] [141928] (10)
      SQ Q9A1S9 1-152
  16. Prephenate dehydrogenase TyrA [141929]
    1. Aquifex aeolicus [TaxId: 63363] [141930] (4)
      SQ O67636 30-200
    2. Synechocystis sp. pcc 6803 [TaxId: 1148] [141931] (4)
      SQ P73906 1-165
    3. Haemophilus influenzae [TaxId: 727] [159425] (2)
      SQ P43902 92-243
  17. 5,10-methenyltetrahydromethanopterin hydrogenase, HMD [141932]
    1. Archaeon Methanocaldococcus jannaschii [TaxId: 2190] [141933] (1)
      SQ Q58194 1-242
  18. Hypothetical protein TM1727 [159426]
    ProC structural homologue
    1. Thermotoga maritima [TaxId: 2336] [159427] (2)
      SQ Q9X250 2-154
8. Aminoacid dehydrogenase-like, C-terminal domain [51883] (24)
  extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site
  1. Glutamate dehydrogenase [51884]
    1. Clostridium symbiosum [TaxId: 1512] [51885] (4)
    2. Archaeon Pyrococcus furiosus [TaxId: 2261] [51886] (1)
    3. Archaeon Thermococcus profundus [TaxId: 49899] [63943] (1)
    4. Archaeon Thermococcus litoralis [TaxId: 2265] [51887] (1)
    5. Thermotoga maritima [TaxId: 2336] [51888] (3)
    6. Cow (Bos taurus) [TaxId: 9913] [51889] (5)
    7. Human (Homo sapiens) [TaxId: 9606] [75115] (2)
    8. Pyrobaculum islandicum [TaxId: 2277] [117436] (1)
      SQ Q9Y8I4
  2. Leucine dehydrogenase [51890]
    1. Bacillus sphaericus [TaxId: 1421] [51891] (1)
  3. Phenylalanine dehydrogenase [51892]
    1. Rhodococcus sp., M4 [TaxId: 1831] [51893] (4)
  4. Methylenetetrahydrofolate dehydrogenase/cyclohydrolase [51894]
    the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated
    1. Human (Homo sapiens) [TaxId: 9606] [51895] (4)
    2. Escherichia coli [TaxId: 562] [51896] (1)
    3. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [51897] (2)
  5. Methylene-tetrahydromethanopterin dehydrogenase [82303]
    1. Methylobacterium extorquens [TaxId: 408] [82304] (2)
  6. Putative shikimate dehydrogenase YdiB [82305]
    1. Escherichia coli [TaxId: 562] [82306] (3)
  7. Shikimate 5-dehydrogenase-like protein HI0607 [89536]
    1. Haemophilus influenzae [TaxId: 727] [89537] (1)
  8. Shikimate 5-dehydrogenase AroE [89538]
    1. Escherichia coli [TaxId: 562] [89539] (1)
    2. Haemophilus influenzae [TaxId: 727] [102173] (2)
    3. Archaeon Methanococcus jannaschii [TaxId: 2190] [89540] (1)
      MJ1084
  9. Glutamyl tRNA-reductase middle domain [69413]
    other domains of this protein are distinct from those usually associated with the family domain
    1. Archaeon Methanopyrus kandleri [TaxId: 2320] [69414] (1)
  10. Mitochondrial NAD(P)-dependent malic enzyme [51898]
    includes C-terminal additional subdomains
    1. Human (Homo sapiens) [TaxId: 9606] [51899] (10)
    2. Domestic pigeon (Columba livia) [TaxId: 8932] [75116] (1)
    3. Pig roundworm (Ascaris suum) [TaxId: 6253] [75117] (2)
  11. Malate oxidoreductase (malic enzyme) [110434]
    1. Thermotoga maritima [TaxId: 2336] [110435] (5)
      SQ Q9WZ12
9. Potassium channel NAD-binding domain [63944] (4)
  1. Rck domain from putative potassium channel Kch [63945]
    1. Escherichia coli [TaxId: 562] [63946] (1)
  2. Ktn bsu222 [75118]
    1. Bacillus subtilis [TaxId: 1423] [75119] (13)
  3. Ktn Mja218 [75120]
    1. Archaeon Methanococcus jannaschii [TaxId: 2190] [75121] (1)
  4. Potassium channel-related protein MthK [75122]
    1. Archaeon Methanothermobacter thermautotrophicus [TaxId: 145262] [75123] (9)
10. Transcriptional repressor Rex, C-terminal domain [102174] (1)
  1. Transcriptional repressor Rex, C-terminal domain [102175]
    forms swapped dimer with C-terminal helices
    1. Thermus aquaticus [TaxId: 271] [102176] (3)
      SQ Q9X2V5
      CASP5
11. CoA-binding domain [51900] (7)
  1. Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain [51901]
    1. Escherichia coli [TaxId: 562] [51902] (18)
    2. Thermus thermophilus [TaxId: 274] [89541] (1)
    3. Pig (Sus scrofa) [TaxId: 9823] [51903] (6)
  2. Hypothetical protein TT1466 [89542]
    putative CoA-binding protein
    1. Thermus thermophilus [TaxId: 274] [89543] (2)
  3. Hypothetical protein PH1109 [141934]
    1. Pyrococcus horikoshii [TaxId: 53953] [141935] (3)
      SQ O58836 1-142
  4. Acetate-CoA ligase alpha chain, AcdA, N-terminal domain [141936]
    1. Pyrococcus horikoshii [TaxId: 53953] [141937] (2)
      SQ O58493 1-129
  5. Hypothetical protein PF0725 [141938]
    1. Pyrococcus furiosus [TaxId: 2261] [141939] (1)
      SQ Q8U2V3 6-121
12. Ornithine cyclodeaminase-like [110436] (2)
  Pfam 02423; contains additional alpha+beta dimerisation subdomain mostly formed by the N-terminal meander beta-sheet
  1. Archaeal alanine dehydrogenase [110437]
    1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [110438] (2)
      SQ O28608 # Rossmann-fold core (101-292) begins with an N-terminal helix and ends with a beta-strand
  2. Ornithine cyclodeaminase [117437]
    1. Pseudomonas putida [TaxId: 303] [117438] (2)
      SQ Q88H32