Structural Classification of Proteins
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Family: Growth factor receptor domain

Lineage:

  1. Root: scop
  2. Class: Small proteins [56992]
    Usually dominated by metal ligand, heme, and/or disulfide bridges
  3. Fold: Knottins (small inhibitors, toxins, lectins) [57015]
    disulfide-bound fold; contains beta-hairpin with two adjacent disulfides
  4. Superfamily: Growth factor receptor domain [57184]
    link to SUPERFAMILY database - Superfamily
  5. Family: Growth factor receptor domain [57185]

Protein Domains:

  1. Insulin-like growth factor-binding protein-5 (IGFBP-5) [57186]
    1. Human (Homo sapiens) [TaxId: 9606] [57187] (2)
      1. 1h59 picpicxref
        complex with IGF
        1. chain b [70881] picpiclink
      2. 1boe picpic
        1. chain a [44187] picpiclink
  2. Type 1 insulin-like growth factor receptor Cys-rich domain [57188]
    contains 3 cystine-knot subdomains and 4 single-disulfide cystine knot-like subdomains
    1. Human (Homo sapiens) [TaxId: 9606] [57189] (1)
      1. 1igr picpicxref
        complexed with fuc, man, nag, so4
        1. region a:150-299 [44188] picpiclink
  3. Receptor protein-tyrosine kinase Erbb-3 Cys-rich domains [75668]
    1. Human (Homo sapiens) [TaxId: 9606] [75669] (1)
      1. 1m6b picpicxref
        complexed with nag, so4
        1. region a:166-310 [74523] picpiclink
        2. region a:480-580 [74524] picpiclink
        3. region b:166-310 [74527] picpiclink
        4. region b:480-611 [74528] picpiclink
  4. EGF receptor Cys-rich domains [82887]
    1. Human (Homo sapiens) [TaxId: 9606] [82888] (15)
      1. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ivoa4
        complexed with bma, man, nag, so4
        1. region a:481-502 [154771] picpiclink
      2. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ivoa4
        complexed with bma, man, nag, so4
        1. region b:481-502 [154773] picpiclink
      3. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ivoa4
        complexed with bma, man, nag, so4
        1. region e:481-502 [154777] picpiclink
      4. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ivoa4
        complexed with bma, man, nag, so4
        1. region i:481-502 [154783] picpiclink
      5. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ivoa4
        complexed with bma, man, nag, so4
        1. region m:481-502 [154787] picpiclink
      6. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ivoa4
        complexed with bma, man, nag, so4
        1. region p:481-502 [154791] picpiclink
      7. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ivoa4
        complexed with bma, man, nag, so4
        1. region s:481-502 [154795] picpiclink
      8. 3b2u picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ivoa4
        complexed with bma, man, nag, so4
        1. region v:481-502 [154799] picpiclink
      9. 1mox picpicxrefxref
        complexed with TGF-alpha
        complexed with cd, cl, fuc, man, nag, pt
        1. region a:163-311 [91374] picpiclink
        2. region a:481-500 [91375] picpiclink
        3. region b:163-311 [91378] picpiclink
        4. region b:481-501 [91379] picpiclink
      10. 1yy9 picpicxrefxref
        automatically matched to d1ivoa3
        complexed with bma, man, nag, ndg
        1. region a:163-311 [124209] picpiclink
      11. 1yy9 picpicxrefxref
        automatically matched to d1ivoa4
        complexed with bma, man, nag, ndg
        1. region a:481-512 [124210] picpiclink
      12. 1nql picpicxrefxref
        complexed with EGF
        complexed with aso, nag
        1. region a:163-311 [86035] picpiclink
        2. region a:481-614 [86036] picpiclink
      13. 3c09 picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1ivoa4
        complexed with bma, man, nag
        1. region a:481-500 [155812] picpiclink
      14. 3c09 picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1ivoa4
        complexed with bma, man, nag
        1. region d:481-500 [155816] picpiclink
      15. 1ivo picpicxrefxref
        complexed with EGF
        complexed with nag
        1. region a:163-311 [76847] picpiclink
        2. region a:481-512 [76848] picpiclink
        3. region b:163-311 [76851] picpiclink
        4. region b:481-512 [76852] picpiclink
  5. Protooncoprotein Her2 extracellular domain [82889]
    1. Human (Homo sapiens) [TaxId: 9606] [82890] (2)
      1. 1n8z picpicxrefxrefxrefxrefxref
        complexed with nag, so4
        1. region c:166-322 [80324] picpiclink
        2. region c:489-607 [80325] picpiclink
      2. 1s78 picpicxrefxrefxrefxrefxref
        complexed with man, nag
        1. region a:166-322 [98618] picpiclink
        2. region a:489-564 [98619] picpiclink
        3. region b:166-322 [98622] picpiclink
        4. region b:489-577 [98623] picpiclink
    2. Rat (Rattus norvegicus) [TaxId: 10116] [82891] (1)
      1. 1n8y picpicxref
        complexed with nag
        1. region c:166-322 [80316] picpiclink
        2. region c:489-608 [80317] picpiclink
  6. Insulin-like growth factor-binding protein 4 [161120]
    1. Human (Homo sapiens) [TaxId: 9606] [161121] (2)
      SQ P22692 24-103
      1. 1wqj picpicxref
        1. region b:3-82 [144560] picpiclink
      2. 2dsr picpicxrefxref
        automatically matched to 1WQJ B:3-82
        1. region b:3-82 [145093] picpiclink
  7. Insulin receptor [161122]
    1. Human (Homo sapiens) [TaxId: 9606] [161123] (1)
      SQ P06213 184-338
      1. 2dtg picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        mutant
        1. region e:157-311 [145105] picpiclink
  8. Insulin-like growth factor-binding protein 4, IGFBP4 [161124]
    1. Human (Homo sapiens) [TaxId: 9606] [161125] (3)
      SQ P22692 22-113
      1. 2dsp picpicxref
        1. region b:1-92 [145088] picpiclink
      2. 2dsq picpicxrefxrefxrefxref
        automatically matched to 2DSP B:1-92
        1. region a:2-92 [145089] picpiclink
      3. 2dsq picpicxrefxrefxrefxref
        automatically matched to 2DSP B:1-92
        1. region b:3-89 [145090] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk