Structural Classification of Proteins
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Family: Protein kinases, catalytic subunit

members organized in the groups and subfamiles specified by the comments

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Protein kinase-like (PK-like) [56111]
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. Superfamily: Protein kinase-like (PK-like) [56112]
    shares functional and structural similarities with the ATP-grasp fold and PIPK
    link to SUPERFAMILY database - Superfamily
  5. Family: Protein kinases, catalytic subunit [88854]
    members organized in the groups and subfamiles specified by the comments

Protein Domains:

  1. Cyclin-dependent PK, CDK2 [88855]
    CMGC group; CDKs subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [88856] (146) picpic
      SQ P24941
    2. (Plasmodium falciparum) [TaxId: 5833] [103289] (4) picpic
      CDK2 homologue Pfpk5
  2. Cyclin-dependent PK, CDK5 [88857]
    CMGC group; CDKs subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [88858] (4) picpic
      SQ Q00535
  3. Cyclin-dependent PK, CDK6 [88859]
    CMGC group; CDKs subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [88860] (8) picpic
  4. MAP kinase p38 [56129]
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56130] (65) picpic
    2. Mouse (Mus musculus) [TaxId: 10090] [56131] (3) picpic
  5. MAP kinase p38-gamma [56132]
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56133] (1) picpic
  6. MAP kinase Erk2 [56134]
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56135] (1) picpic
    2. Rat (Rattus norvegicus) [TaxId: 10116] [56136] (10) picpic
  7. c-jun N-terminal kinase (jnk3s) [56137]
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56138] (17) picpic
  8. Glycogen synthase kinase-3 beta (Gsk3b) [69823]
    CMGC group; GSK3 subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [69824] (17) picpic
      SQ P49841 35-383 ! SQ P49841 35-384
  9. Protein kinase CK2, alpha subunit [56142]
    CMGC group; CK2 subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [75559] (4) picpic
    2. Maize (Zea mays) [TaxId: 4577] [56143] (21) picpic
    3. Rattus norvegicus [TaxId: 10116] [160809] (8) picpic
  10. Sky1p [56148]
    CMGC group; Clk subfamily; serine/threonine kinase
    1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [56149] (5) picpic
  11. cAMP-dependent PK, catalytic subunit [56116]
    AGC group; PKA subfamily; serine/threonine kinase
    1. Pig (Sus scrofa) [TaxId: 9823] [56117] (3) picpic
    2. Cow (Bos taurus) [TaxId: 9913] [56118] (32) picpic
      SQ P00517
    3. Mouse (Mus musculus) [TaxId: 10090] [56119] (17) picpic
    4. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [64403] (1) picpic
  12. Pkb kinase (Akt-2) [82791]
    AGC group; RAC/Akt subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [82792] (18) picpic
  13. G-protein coupled receptor kinase 2 [90034]
    AGC group; GRKs subfamily; serine/threonine kinase
    1. Cow (Bos taurus) [TaxId: 9913] [90035] (6) picpic
  14. 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036]
    AGC group; PBK subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [90037] (13) picpic
      SQ O15530 75-363
  15. Calmodulin-dependent protein kinase [56120]
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. Rat (Rattus norvegicus) [TaxId: 10116] [56121] (1) picpic
  16. Titin, kinase domain [56124]
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56125] (1) picpic
  17. Twitchin, kinase domain [56126]
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. California sea hare (Aplysia californica), twk43 [TaxId: 6500] [56127] (1) picpic
    2. Caenorhabditis elegans, pjk4 [TaxId: 6239] [56128] (1) picpic
  18. Death-associated protein kinase, Dap [75560]
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [75561] (6) picpic
      SQ P53355 2-285
  19. gamma-subunit of glycogen phosphorylase kinase (Phk) [56122]
    CaMK group; CAMKI subfamily; serine/threonine kinase
    1. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [56123] (3) picpic
  20. MAP kinase activated protein kinase 2, mapkap2 [82789]
    CaMK group; MAPKAPK subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [82790] (6) picpic
  21. Cell cycle checkpoint kinase chk1 [64404]
    CaMK group; CAMKL subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [64405] (36) picpic
  22. pak1 [56146]
    OPK group; PAK/STE20 subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56147] (2) picpic
  23. Mycobacterial protein kinase PknB, catalytic domain [82793]
    OPK group; PKN subfamily; serine/threonine kinase
    1. Mycobacterium tuberculosis [TaxId: 1773] [82794] (6) picpic
  24. Casein kinase-1, CK1 [56139]
    OPK group; CKI subfamily; serine/threonine kinase
    1. Rat (Rattus norvegicus) [TaxId: 10116] [56140] (2) picpic
    2. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [56141] (3) picpic
  25. Aurora-related kinase 1 (aurora-2) [90038]
    OPK group; AIRK subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [90039] (10) picpic
  26. B-Raf kinase [103290]
    OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
    1. Human (Homo sapiens) [TaxId: 9606] [103291] (2) picpic
  27. Type I TGF-beta receptor R4 [56144]
    TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases
    1. Human (Homo sapiens) [TaxId: 9606] [56145] (4) picpic
      SQ P36897 200-500 ! SQ P36897 201-503
  28. c-src tyrosine kinase [56155]
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56156] (10) picpic
    2. Chicken (Gallus gallus) [TaxId: 9031] [56157] (1) picpic
  29. Haemopoetic cell kinase Hck [56151]
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56152] (4) picpic
  30. Lymphocyte kinase (lck) [56153]
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56154] (19) picpic
  31. Bruton's tyrosine kinase (Btk) [75564]
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [75565] (1) picpic
  32. Carboxyl-terminal src kinase (csk) [56164]
    PTK group; CSK subfamily; non-membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56165] (4) picpic
  33. Abelsone tyrosine kinase (abl) [56166]
    PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase
    1. Mouse (Mus musculus) [TaxId: 10090] [56167] (10) picpic
  34. Musk tyrosine kinase [82797]
    PTK group; MUSK subfamily; non-membrane spanning protein tyrosine kinase
    1. Rat (Rattus norvegicus) [TaxId: 10116] [82798] (1) picpic
  35. Focal adhesion kinase 1 (fak) [103292]
    PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [103293] (6) picpic
  36. EGF receptor tyrosine kinase, Erbb-1 [82795]
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [82796] (10) picpic
      SQ P00533 702-1018
  37. ephb2 receptor tyrosine kinase [69827]
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
    1. Mouse (Mus musculus) [TaxId: 10090] [69828] (1) picpic
  38. epha2 receptor tyrosine kinase [103294]
    PTK group; Eph/Elk/Eck subfamily; membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [103295] (1) picpic
  39. Tie2 kinase [64406]
    PTK group; Tie/Tck subfamily; membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [64407] (1) picpic
  40. Fibroblast growth factor receptor 1 [56158]
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56159] (4) picpic
  41. Fibroblast growth factor receptor 2 [75562]
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [75563] (4) picpic
      SQ P21802 467-765
  42. Vascular endothelial growth factor receptor 2 (kdr) [56160]
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56161] (4) picpic
  43. c-KIT receptor [103296]
    PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [103297] (3) picpic
      SQ P10721 547-935
  44. Fl cytokine receptor [103298]
    PTK group; CSF-1/PDGF receptor subfamily; membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [103299] (1) picpic
  45. Insulin receptor [56162]
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [56163] (13) picpic
  46. Insulin-like growth factor 1 receptor [69825]
    PTK group; InsR subfamily; membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [69826] (9) picpic
  47. Hepatocyte growth factor receptor, c-MET [103300]
    PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [103301] (6) picpic
  48. Ribosomal protein S6 kinase alpha 5, Msk1 [111192]
    AGC group (?); S6 kinase subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [111193] (1) picpic
      SQ O75582 24-345
  49. Tyrosine-protein kinase Itk/Tsk [111194]
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [111195] (3) picpic
      SQ Q08881 357-619
  50. Protein kinase wnk1 [111196]
    OPK group; WNK subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [111197] (1) picpic
      SQ Q9JIH7 211-480
  51. Tyrosine-protein kinase ZAP-70 [111198]
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [111199] (1) picpic
      SQ P43403 328-606 # structure of the N-terminal SH2 domains (1-132;133-256) is also known: 1m61 (scop_sp 89997)
  52. Activated CDC42 kinase 1, ACK1 [111200]
    PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [111201] (3) picpic
      SQ Q07912 117-389
  53. Mitogen-activated protein kinase 8 (jnk1) [111202]
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [111203] (2) picpic
      SQ P45983 9-363
  54. Serine/threonine protein kinase TAO2 [118127]
    OPK group; serine/threonine kinase
    1. Rat (Rattus norvegicus) [TaxId: 10116] [118128] (4) picpic
      SQ Q9JLS3 12-320
  55. Protein kinase C, theta type [118129]
    AGC group; PKC subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [118130] (1) picpic
      SQ Q04759 377-696
  56. Tyrosine-protein kinase SYK [118131]
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [118132] (3) picpic
      SQ P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (scop_sp 55576)
  57. Proto-oncogene serine/threonine-protein kinase Pim-1 [118133]
    OPK group(?); PIM subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [118134] (8) picpic
      SQ P11309 33-305 ! SQ P11309 32-308
  58. Dual specificity mitogen-activated protein kinase kinase 2, Mek2 [118135]
    OPK group (?); MAPKK subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [118136] (1) picpic
      SQ P36507 60-393
  59. Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137]
    OPK group (?); MAPKK subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [118138] (2) picpic
      SQ Q02750 61-381
  60. Cell division protein kinase 7, CDK7 [118139]
    CMGC group; CDKs subfamily; serine/threonine kinase
    1. Human (Homo sapiens) [TaxId: 9606] [118140] (1) picpic
      SQ P50613 13-311
  61. Serine/threonine-protein kinase Nek2 [143893]
    NIMA subfamily (NimA-related protein kinase 2)
    1. Human (Homo sapiens) [TaxId: 9606] [143894] (1) picpic
      SQ P51955 3-271
  62. Cell division protein kinase 9, CDK9 [160810]
    1. Human (Homo sapiens) [TaxId: 9606] [160811] (3) picpic
      SQ P50750 8-325
  63. STE20-like serine/threonine-protein kinase, SLK [160812]
    1. Human (Homo sapiens) [TaxId: 9606] [160813] (3) picpic
      SQ Q9H2G2 21-308
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
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