Structural Classification of Proteins
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Protein: Cyclin-dependent PK, CDK2 from Human (Homo sapiens) [TaxId: 9606]

SQ P24941

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: Protein kinase-like (PK-like) [56111]
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. Superfamily: Protein kinase-like (PK-like) [56112]
    shares functional and structural similarities with the ATP-grasp fold and PIPK
    link to SUPERFAMILY database - Superfamily
  5. Family: Protein kinases, catalytic subunit [88854]
    members organized in the groups and subfamiles specified by the comments
  6. Protein: Cyclin-dependent PK, CDK2 [88855]
    CMGC group; CDKs subfamily; serine/threonine kinase
  7. Species: Human (Homo sapiens) [TaxId: 9606] [88856]
    SQ P24941

PDB Entry Domains:

  1. 1gz8 picpic
    complexed with csw, mbp
    1. chain a [83405] picpiclink
  2. 2cch picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with atp, gol, so4
    1. region a:1-296 [130236] picpiclink
  3. 2cch picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with atp, gol, so4
    1. region c:1-296 [130239] picpiclink
  4. 1h00 picpic
    complexed with ace, fap, fcp
    1. chain a [83409] picpiclink
  5. 1urw picpic
    complexed with ace, i1p
    1. chain a [99836] picpiclink
  6. 1jvp picpic
    complexed with lig
    1. chain p [67371] picpiclink
  7. 1oit picpic
    complexed with hdt
    1. chain a [93075] picpiclink
  8. 1h01 picpic
    complexed with fal, fbl, gol, kcx
    1. chain a [83410] picpiclink
  9. 2fvd picpic
    automatically matched to d1vywa_
    complexed with lia
    1. region a:1-298 [134200] picpiclink
  10. 1h0v picpic
    complexed with un4
    1. chain a [83443] picpiclink
  11. 1h08 picpic
    complexed with ace, bwp, byp, gol
    1. chain a [83419] picpiclink
  12. 1h07 picpic
    complexed with ace, mfp, mfq
    1. chain a [83418] picpiclink
  13. 1ke6 picpic
    complexed with ls2
    1. chain a [72365] picpiclink
  14. 1ke7 picpic
    complexed with ls3
    1. chain a [72366] picpiclink
  15. 1oir picpic
    complexed with hdy
    1. chain a [93074] picpiclink
  16. 1ke8 picpic
    complexed with ls4
    1. chain a [72367] picpiclink
  17. 3bht picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with mfr, mg, sgm
    1. region a:1-298 [155276] picpiclink
  18. 1hcl picpic
    1. chain a [41593] picpiclink
  19. 2clx picpic
    automatically matched to d1vywa_
    complexed with f18
    1. region a:1-298 [130600] picpiclink
  20. 1ke9 picpic
    complexed with ls5
    1. chain a [72368] picpiclink
  21. 1hck picpic
    complexed with atp, mg
    1. chain a [41594] picpiclink
  22. 1ke5 picpic
    complexed with ls1
    1. chain a [72364] picpiclink
  23. 2exm picpic
    automatically matched to d1vywa_
    complexed with zip
    1. region a:1-298 [132561] picpiclink
  24. 2c6i picpic
    automatically matched to d1vywa_
    complexed with dt1
    1. region a:1-298 [129995] picpiclink
  25. 2c6k picpic
    automatically matched to d1vywa_
    complexed with dt2
    1. region a:1-298 [129997] picpiclink
  26. 1e1x picpic
    complexed with ace, nw1
    1. chain a [59157] picpiclink
  27. 1b38 picpic
    complexed with ace, atp, ium
    1. chain a [41595] picpiclink
  28. 1pxi picpic
    complexed with ck1
    1. chain a [95289] picpiclink
  29. 1pw2 picpic
    1. chain a [95197] picpiclink
  30. 1di8 picpic
    complexed with dtq
    1. chain a [41601] picpiclink
  31. 2c68 picpic
    automatically matched to d1vywa_
    complexed with ct6
    1. region a:1-297 [129985] picpiclink
  32. 2b55 picpic
    automatically matched to d1vywa_
    complexed with d31
    1. region a:1-298 [127877] picpiclink
  33. 2iw9 picpicxrefxrefxrefxref
    automatically matched to 2IW6 A:1-295
    complexed with 4sp, mg, sgm; mutant
    1. region a:1-295 [145546] picpiclink
  34. 2iw9 picpicxrefxrefxrefxref
    automatically matched to 2IW6 A:1-295
    complexed with 4sp, mg, sgm; mutant
    1. region c:1-295 [145547] picpiclink
  35. 1e1v picpic
    complexed with ace, cmg
    1. chain a [59156] picpiclink
  36. 1pye picpic
    complexed with pm1
    1. chain a [104390] picpiclink
  37. 2c6m picpic
    automatically matched to d1vywa_
    complexed with dt5
    1. region a:1-297 [129999] picpiclink
  38. 2btr picpic
    automatically matched to d1vywa_
    complexed with u73
    1. region a:1-298 [129157] picpiclink
  39. 1oiu picpicxref
    complexed with mg, n76, sgm
    1. chain a [103958] picpiclink
    2. chain c [103961] picpiclink
  40. 2b52 picpic
    automatically matched to d1vywa_
    complexed with d42
    1. region a:1-298 [127874] picpiclink
  41. 1w8c picpic
    automatically matched to d1vywa_
    complexed with ace, n69
    1. region a:1-298 [120718] picpiclink
  42. 1jsv picpic
    complexed with u55
    1. chain a [63278] picpiclink
  43. 1gii picpic
    complexed with 1pu; mutant
    1. chain a [65218] picpiclink
  44. 1ckp picpic
    complexed with edo, pvb
    1. chain a [41597] picpiclink
  45. 1pxo picpic
    complexed with ck7
    1. chain a [95295] picpiclink
  46. 1aq1 picpic
    complexed with stu
    1. chain a [41599] picpiclink
  47. 2a0c picpic
    automatically matched to d1vywa_
    complexed with ck9
    1. region x:1-298 [125945] picpiclink
  48. 1ykr picpic
    automatically matched to d1vywa_
    complexed with 628
    1. region a:1-298 [123560] picpiclink
  49. 1r78 picpic
    complexed with fmd
    1. chain a [97190] picpiclink
  50. 1fvt picpic
    complexed with 106
    1. chain a [41602] picpiclink
  51. 2c5n picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with ck8
    1. region a:1-296 [129926] picpiclink
  52. 2c5n picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with ck8
    1. region c:1-297 [129929] picpiclink
  53. 1w98 picpicxrefxref
    automatically matched to d1vywa_
    1. region a:1-297 [120776] picpiclink
  54. 2bts picpic
    automatically matched to d1vywa_
    complexed with u32
    1. region a:1-298 [129158] picpiclink
  55. 2ds1 picpic
    automatically matched to d1giia_
    complexed with 1cd; mutant
    1. region a:1-298 [131680] picpiclink
  56. 1wcc picpic
    automatically matched to d1vywa_
    complexed with cig
    1. region a:1-298 [120886] picpiclink
  57. 2b53 picpic
    automatically matched to d1vywa_
    complexed with d23
    1. region a:1-298 [127875] picpiclink
  58. 2b54 picpic
    automatically matched to d1vywa_
    complexed with d05
    1. region a:1-298 [127876] picpiclink
  59. 1y8y picpic
    automatically matched to d1vywa_
    complexed with ct7
    1. region a:1-298 [122770] picpiclink
  60. 2uue picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with gvc, mtz, nh2, pff
    1. region a:1-296 [139972] picpiclink
  61. 2uue picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with gvc, mtz, nh2, pff
    1. region c:1-297 [139975] picpiclink
  62. 1vyw picpicxref
    complexed with 292, so4
    1. chain a [108922] picpiclink
    2. chain c [108925] picpiclink
  63. 2bhe picpic
    automatically matched to d1vywa_
    complexed with bry
    1. region a:1-298 [128526] picpiclink
  64. 1b39 picpic
    complexed with ace, atp, ium
    1. chain a [41600] picpiclink
  65. 1h0w picpic
    complexed with 207
    1. chain a [83444] picpiclink
  66. 1h1p picpicxref
    complexed with cmg, tpo
    1. chain a [76477] picpiclink
    2. chain c [76480] picpiclink
  67. 1h27 picpicxref
    complex with cyclin and an 11-residue recruitment peptide from p27
    complexed with tpo
    1. chain a [76534] picpiclink
    2. chain c [76537] picpiclink
  68. 2c5o picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with ck2
    1. region a:1-296 [129932] picpiclink
  69. 2c5o picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with ck2
    1. region c:1-297 [129935] picpiclink
  70. 1dm2 picpic
    complexed with egl, hmd
    1. chain a [41598] picpiclink
  71. 1h1r picpicxref
    complexed with 6cp, tpo
    1. chain a [76489] picpiclink
    2. chain c [76492] picpiclink
  72. 1h1s picpicxref
    complexed with 4sp, tpo
    1. chain a [76495] picpiclink
    2. chain c [76498] picpiclink
  73. 1jsu picpicxrefxref
    complexed with so4; mutant
    1. chain a [41603] picpiclink
  74. 1w0x picpic
    automatically matched to d1vywa_
    complexed with olo
    1. region c:1-298 [120566] picpiclink
  75. 2c5p picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with ck7
    1. region a:1-296 [129938] picpiclink
  76. 2c5p picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with ck7
    1. region c:1-297 [129941] picpiclink
  77. 2bpm picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with 529, so4
    1. region a:-3-298 [128944] picpiclink
  78. 2bpm picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with 529, so4
    1. region c:0-298 [128947] picpiclink
  79. 1qmz picpicxref
    1. chain a [41604] picpiclink
    2. chain c [41605] picpiclink
  80. 1p5e picpicxref
    complexed with tbs, tpo
    1. chain a [87796] picpiclink
    2. chain c [87799] picpiclink
  81. 1oi9 picpicxref
    complexed with mg, n20, sgm
    1. chain a [103946] picpiclink
    2. chain c [103949] picpiclink
  82. 1vyz picpic
    complexed with n5b
    1. chain a [108928] picpiclink
  83. 2c69 picpic
    automatically matched to d1vywa_
    complexed with ct8
    1. region a:1-298 [129986] picpiclink
  84. 2cjm picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with atp, mg
    1. region a:1-292 [130541] picpiclink
  85. 2cjm picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with atp, mg
    1. region c:1-297 [130544] picpiclink
  86. 2iw8 picpicxrefxrefxrefxref
    complexed with 4sp, sgm; mutant
    1. region a:1-297 [145544] picpiclink
  87. 2iw8 picpicxrefxrefxrefxref
    automatically matched to 2IW8 A:1-297
    complexed with 4sp, sgm; mutant
    1. region c:1-296 [145545] picpiclink
  88. 1h26 picpicxref
    complex with cyclin and an 11-residue recruitment peptide from p53
    complexed with tpo
    1. chain a [76528] picpiclink
    2. chain c [76531] picpiclink
  89. 1gij picpic
    complexed with 2pu; mutant
    1. chain a [65219] picpiclink
  90. 1pxj picpic
    complexed with ck2
    1. chain a [95290] picpiclink
  91. 2c6l picpic
    automatically matched to d1vywa_
    complexed with dt4
    1. region a:1-298 [129998] picpiclink
  92. 2bkz picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with sbc, so4
    1. region a:-3-298 [128719] picpiclink
  93. 2bkz picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with sbc, so4
    1. region c:0-297 [128722] picpiclink
  94. 1v1k picpic
    complexed with 3fp, ace
    1. chain a [100255] picpiclink
  95. 1oiq picpic
    complexed with hdu
    1. chain a [93073] picpiclink
  96. 2i40 picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with blz
    1. region a:1-297 [137038] picpiclink
  97. 2i40 picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with blz
    1. region c:1-296 [137041] picpiclink
  98. 1pkd picpicxref
    complexed with tpo, ucn
    1. chain a [88141] picpiclink
    2. chain c [88144] picpiclink
  99. 1pxp picpic
    complexed with ck8
    1. chain a [95296] picpiclink
  100. 2c6o picpic
    automatically matched to d1vywa_
    complexed with 4sp
    1. region a:1-297 [130000] picpiclink
  101. 1p2a picpic
    complexed with 5bn
    1. chain a [87719] picpiclink
  102. 1y91 picpic
    automatically matched to d1vywa_
    complexed with ct9
    1. region a:1-298 [122771] picpiclink
  103. 2c4g picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with 514, so4
    1. region a:-3-297 [129809] picpiclink
  104. 2c4g picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with 514, so4
    1. region c:-1-298 [129812] picpiclink
  105. 2iw6 picpicxrefxrefxrefxref
    complexed with mg, qq2, sgm; mutant
    1. region a:1-295 [145542] picpiclink
  106. 2iw6 picpicxrefxrefxrefxref
    automatically matched to 2IW6 A:1-295
    complexed with mg, qq2, sgm; mutant
    1. region c:1-295 [145543] picpiclink
  107. 1okv picpicxref
    complex with cyclin
    complexed with nh2
    1. chain a [93282] picpiclink
    2. chain c [93285] picpiclink
  108. 1fin picpicxref
    complexed with atp
    1. chain a [41606] picpiclink
    2. chain c [41607] picpiclink
  109. 1okw picpicxref
    complex with cyclin
    complexed with ace, fcl, nh2
    1. chain a [93288] picpiclink
    2. chain c [93291] picpiclink
  110. 1pxl picpic
    complexed with ck4
    1. chain a [95292] picpiclink
  111. 2c5y picpic
    automatically matched to d1vywa_
    complexed with mtw
    1. region a:1-297 [129965] picpiclink
  112. 2duv picpic
    automatically matched to d1vywa_
    complexed with 371
    1. region a:1-298 [131752] picpiclink
  113. 2g9x picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with nu5
    1. region a:1-298 [134844] picpiclink
  114. 2g9x picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with nu5
    1. region c:1-298 [134847] picpiclink
  115. 1buh picpicxref
    1. chain a [41608] picpiclink
  116. 1ogu picpicxref
    complex with cyclin
    complexed with sgm, st8
    1. chain a [92942] picpiclink
    2. chain c [92945] picpiclink
  117. 1g5s picpic
    complexed with i17
    1. chain a [65167] picpiclink
  118. 1pxm picpic
    complexed with ck5
    1. chain a [95293] picpiclink
  119. 2a4l picpic
    automatically matched to d1vywa_
    complexed with rrc
    1. region a:1-298 [126158] picpiclink
  120. 1pf8 picpic
    complexed with su9
    1. chain a [94605] picpiclink
  121. 1f5q picpicxref
    complexed with cl
    1. chain a [41611] picpiclink
    2. chain c [41612] picpiclink
  122. 1ol2 picpicxref
    complex with cyclin
    complexed with nh2, pff
    1. chain a [93304] picpiclink
    2. chain c [93307] picpiclink
  123. 1gih picpic
    complexed with 1pu
    1. chain a [65217] picpiclink
  124. 1urc picpicxref
    complexed with ace
    1. chain a [113404] picpiclink
    2. chain c [113407] picpiclink
  125. 1jst picpicxref
    complexed with atp, mn
    1. chain a [41609] picpiclink
    2. chain c [41610] picpiclink
  126. 1h24 picpicxref
    complex with cyclin and a 9 residue recruitment peptide from E2F
    complexed with tpo
    1. chain a [76516] picpiclink
    2. chain c [76519] picpiclink
  127. 2c6t picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with dt5
    1. region a:1-296 [130004] picpiclink
  128. 2c6t picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with dt5
    1. region c:1-296 [130007] picpiclink
  129. 1e9h picpicxref
    complexed with inr
    1. chain a [64812] picpiclink
    2. chain c [64815] picpiclink
  130. 1pxn picpic
    complexed with ck6
    1. chain a [95294] picpiclink
  131. 2bhh picpic
    automatically matched to d1vywa_
    complexed with ryu
    1. region a:1-298 [128530] picpiclink
  132. 1h25 picpicxref
    complex with cyclin and an 11-residue recruitment peptide from retinoblastoma-associated protein
    complexed with tpo
    1. chain a [76522] picpiclink
    2. chain c [76525] picpiclink
  133. 1oiy picpicxref
    complexed with mg, n41, sgm
    1. chain a [103964] picpiclink
    2. chain c [103967] picpiclink
  134. 2cci picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with atp, mg; mutant
    1. region a:1-296 [130242] picpiclink
  135. 2cci picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with atp, mg; mutant
    1. region c:1-296 [130245] picpiclink
  136. 1fvv picpicxref
    complexed with 107
    1. chain a [41615] picpiclink
    2. chain c [41616] picpiclink
  137. 1pxk picpic
    complexed with ck3
    1. chain a [95291] picpiclink
  138. 1gy3 picpicxref
    complexed with atp, gol, mg, no3, tpo
    1. chain a [70728] picpiclink
    2. chain c [70731] picpiclink
  139. 1h1q picpicxref
    complexed with 2a6, tpo
    1. chain a [76483] picpiclink
    2. chain c [76486] picpiclink
  140. 2c5v picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with ab7, ck4, nh2, pff
    1. region a:1-296 [129952] picpiclink
  141. 2c5v picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with ab7, ck4, nh2, pff
    1. region c:1-296 [129955] picpiclink
  142. 1ol1 picpicxref
    complex with cyclin
    complexed with cir, nh2, pff
    1. chain a [93298] picpiclink
    2. chain c [93301] picpiclink
  143. 2c5x picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with mtw
    1. region a:1-296 [129959] picpiclink
  144. 2c5x picpicxrefxrefxrefxref
    automatically matched to d1vywa_
    complexed with mtw
    1. region c:1-296 [129962] picpiclink
  145. 1h28 picpicxref
    complex with cyclin and an 11-residue recruitment peptide from p107
    complexed with tpo
    1. chain a [76540] picpiclink
    2. chain c [76543] picpiclink
  146. 1fq1 picpicxref
    complexed with atp, mg; mutant
    1. chain b [59983] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk