Structural Classification of Proteins

Superfamily: Cysteine proteinases

: the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Cysteine proteinases [54000]
consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
Superfamily: Cysteine proteinases [54001]
the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
uperfamily

Families:

Papain-like [54002] (30)
1. Actinidin [54003]
  1. Chinese gooseberry or kiwifruit (Actinidia chinensis) [TaxId: 3625] [54004] (2)
    1. 2act
      complexed with cya, nh4
      1. chain a [37002]
    2. 1aec
      complexed with e64
      1. chain a [37003]
2. Papain [54005]
  1. Papaya (Carica papaya) [TaxId: 3649] [54006] (18)
    1. 1khq
      complexed with glm
      1. chain a [90964]
    2. 1ppn
      complexed with moh, o o
      1. chain a [37004]
    3. 1cvz
      complexed with c48
      1. chain a [37005]
    4. 9pap
      complexed with cyo, moh
      1. chain a [37006]
    5. 1pip
      complexed with nit, sin
      1. chain a [37007]
    6. 1ppd
      complexed with seo
      1. chain a [37008]
    7. 1khp
      complexed with glm
      1. chain a [90963]
    8. 1ppp
      complexed with e6c, moh
      1. chain a [37009]
    9. 1pe6
      complexed with e6c, moh
      1. chain a [37010]
    10. 1bp4
      complexed with ald
      1. chain a [37011]
    11. 1pop
      complexed with moh
      1. chain a [37013]
    12. 1stf
      complexed with cbm; mutant
      1. chain e [37012]
    13. 1bqi
      complexed with sba
      1. chain a [37014]
    14. 5pad
      complexed with bzo, glm
      1. chain a [37017]
    15. 1pad
      1. chain a [37016]
    16. 2pad
      1. chain a [37015]
    17. 4pad
      complexed with tos
      1. chain a [37018]
    18. 6pad
      complexed with bzo
      1. chain a [37019]
3. Caricain (protease omega) [54007]
  1. Papaya (Carica papaya) [TaxId: 3649] [54008] (3)
    1. 1ppo
      complexed with hg
      1. chain a [37020]
    2. 1meg
      complexed with e64, eoh; mutant
      1. chain a [37021]
    3. 1pci
      zymogen with propeptide
      CASP2
      mutant
      1. chain a [37022]
      2. chain b [37023]
      3. chain c [37024]
4. Chymopapain [54009]
  1. Papaya (Carica papaya) [TaxId: 3649] [54010] (1)
    1. 1yal
      1. chain a [37025]
5. Glycyl endopeptidase [54011]
  1. Papaya (Carica papaya) [TaxId: 3649] [54012] (1)
    1. 1gec
      complexed with cbz, gcm
      1. chain e [37026]
6. Proline-specific cysteine protease [54013]
  1. Ginger rhizome (Zingiber officinale) [TaxId: 94328] [54014] (1)
    1. 1cqd
      complexed with fuc, nag, thj
      1. chain a [37027]
      2. chain b [37028]
      3. chain c [37029]
      4. chain d [37030]
7. Ervatamin B [89803]
  1. Adam's apple (Ervatamia coronaria) [TaxId: 52861] [89804] (1)
    1. 1iwd
      complexed with thj
      1. chain a [83756]
8. Ervatamin C [102717]
  1. East indian rosebay (Ervatamia coronaria) [TaxId: 52861] [102718] (1)
    1. 1o0e
      complexed with thj
      1. chain a [92393]
      2. chain b [92394]
9. Vignain (bean endopeptidase) [102719]
  1. Castor bean (Ricinus communis) [TaxId: 3988] [102720] (1)
    1. 1s4v
      complexed with so4
      1. chain a [98511]
      2. chain b [98512]
10. Bleomycin hydrolase [54017]
  DNA-binding protease that has more insertions in the papain-like fold
  1. Baker's yeast (Saccharomyces cerevisiae), Gal6 [TaxId: 4932] [54018] (3)
    1. 3gcb
      complexed with gol, so4; mutant
      1. chain a [37032]
    2. 1a6r
      complexed with so4; mutant
      1. chain a [37033]
    3. 1gcb
      complexed with gol, hg, so4
      1. chain a [37034]
  2. Human (Homo sapiens) [TaxId: 9606] [54019] (2)
    1. 2cb5
      mutant
      1. chain a [37035]
      2. chain b [37036]
    2. 1cb5
      1. chain a [37037]
      2. chain b [37038]
      3. chain c [37039]
11. Cruzain [54020]
  1. Trypanosoma cruzi [TaxId: 5693] [54021] (17)
    1. 1me4
      complexed with t10
      1. chain a [79023]
    2. 1me3
      complexed with p10
      1. chain a [79022]
    3. 2efm
      automatically matched to d1ewla_
      complexed with 4mc, edo, so4
      1. region a:1-215 [146817]
    4. 2efm
      automatically matched to d1ewla_
      complexed with 4mc, edo, so4
      1. region c:1-215 [146818]
    5. 1f2a
      complexed with vs2
      1. chain a [37040]
    6. 1f2b
      complexed with vs3
      1. chain a [37042]
    7. 1ewp
      complexed with mor
      1. chain a [37041]
    8. 2oz2
      automatically matched to d1ewla_
      complexed with d1r, so4
      1. region a:1-215 [149097]
    9. 2oz2
      automatically matched to d1ewla_
      complexed with d1r, so4
      1. region c:1-215 [149098]
    10. 1f2c
      complexed with vs4
      1. chain a [37043]
    11. 1ewm
      complexed with rl2
      1. chain a [83194]
    12. 1ewl
      complexed with r99
      1. chain a [83193]
    13. 1f29
      complexed with vs1
      1. chain a [37045]
      2. chain b [37046]
      3. chain c [37047]
    14. 1aim
      complexed with zya; mutant
      1. chain a [37044]
    15. 1ewo
      complexed with vsc
      1. chain a [83195]
    16. 1u9q
      automatically matched to d1ewla_
      complexed with 186
      1. region x:1-212 [119650]
    17. 2aim
      complexed with zra; mutant
      1. chain a [37048]
12. (Pro)cathepsin B [54022]
  1. Human (Homo sapiens) [TaxId: 9606] [54023] (6)
    1. 1gmy
      complexed with aem, apd, dfa
      1. chain a [76236]
      2. chain b [76237]
      3. chain c [76238]
    2. 1huc
      1. chain a,b [37049]
      2. chain c,d [37050]
    3. 1csb
      complexed with eox, epo
      1. chain a,b [37051]
      2. chain d,e [37052]
    4. 3pbh
      1. chain a [37053]
    5. 1pbh
      1. chain a [37054]
    6. 2pbh
      1. chain a [37055]
  2. Rat (Rattus norvegicus) [TaxId: 10116] [54024] (4)
    1. 1the
      complexed with cbz, sem; mutant
      1. chain a [37056]
      2. chain b [37057]
    2. 1cte
      complexed with pys; mutant
      1. chain a [37058]
      2. chain b [37059]
    3. 1cpj
      mutant
      1. chain a [37060]
      2. chain b [37061]
    4. 1mir
      zymogen
      mutant
      1. chain a [37062]
      2. chain b [37063]
  3. Cow (Bos taurus) [TaxId: 9913] [54025] (11)
    1. 2dcc
      automatically matched to d1itoa_
      complexed with 77b, gol, po4
      1. region a:1-253 [131371]
    2. 2dc9
      automatically matched to d1itoa_
      complexed with 74m, gol, po4
      1. region a:1-253 [131368]
    3. 2dc8
      automatically matched to d1itoa_
      complexed with 59a, gol, po4
      1. region a:1-253 [131367]
    4. 2dcb
      automatically matched to d1itoa_
      complexed with 76v, gol, po4
      1. region a:1-253 [131370]
    5. 2dc7
      automatically matched to d1itoa_
      complexed with 042, gol, po4
      1. region a:1-253 [131366]
    6. 2dca
      automatically matched to d1itoa_
      complexed with 75v, gol, po4
      1. region a:1-253 [131369]
    7. 1qdq
      complexed with 074
      1. chain a [37064]
    8. 1ito
      complexed with e6c
      1. chain a [76787]
    9. 2dc6
      automatically matched to d1itoa_
      complexed with 73v, gol, po4
      1. region a:1-253 [131365]
    10. 1sp4
      complexed with epo, leu, meu, pro
      1. chain a,b [98956]
    11. 2dcd
      automatically matched to d1itoa_
      complexed with 78a, gol, po4
      1. region a:1-253 [131372]
13. Cathepsin C (dipeptidyl peptidase I), catalytic domain [75330]
  1. Human (Homo sapiens) [TaxId: 9606] [75331] (1)
    1. 1k3b
      complexed with cl, nag, so4
      1. chain b,c [72015]
  2. Rat (Rattus norvegicus) [TaxId: 10116] [82565] (1)
    1. 1jqp
      complexed with cl, nag, so4
      1. region a:204-438 [77163]
14. Cathepsin F [89805]
  1. Human (Homo sapiens) [TaxId: 9606] [89806] (1)
    1. 1m6d
      complexed with myp; mutant
      1. chain a [84849]
      2. chain b [84850]
15. Cathepsin H [81637]
  also contains a disulfide-bound minicathepsin H chain
  1. Pig (Sus scrofa) [TaxId: 9823] [81636] (3)
    1. 8pch
      complexed with bma, nag
      1. chain p,a [76086]
    2. 1nb5
      complexed with bma, nag
      1. chain p,a [80377]
      2. chain r,b [80378]
      3. chain s,c [80379]
      4. chain t,d [80380]
    3. 1nb3
      complexed with bma, nag
      1. chain p,a [80369]
      2. chain r,b [80370]
      3. chain s,c [80371]
      4. chain t,d [80372]
16. (Pro)cathepsin K [54028]
  1. Human (Homo sapiens) [TaxId: 9606] [54029] (32)
    SQ P43235 116-329 ! SQ P43235 115-329
    1. 2r6n
      automatically matched to d1atka_
      complexed with cke
      1. region a:1-215 [151620]
    2. 1tu6
      complexed with fsp, so4
      1. chain a [107318]
      2. chain b [107319]
    3. 3c9e
      automatically matched to d1atka_
      complexed with asg, bdp, ca, e64
      1. region a:1-215 [156124]
    4. 1mem
      complexed with bns, bzp, nfp
      1. chain a [37069]
    5. 2ato
      automatically matched to d1atk__
      complexed with myq, so4
      1. region a:1-215 [127300]
    6. 2bdl
      automatically matched to d1atk__
      complexed with 4pr
      1. region a:1-215 [128339]
    7. 1vsn
      complexed with nft
      1. region a:1-211 [145790]
    8. 1u9x
      automatically matched to d1atk__
      complexed with ihj
      1. region a:1-215 [119654]
    9. 1q6k
      complexed with so4, tco
      1. chain a [95980]
    10. 1yt7
      automatically matched to d1atk__
      complexed with 3fc, so4
      1. region a:2-215 [123995]
    11. 1u9v
      automatically matched to d1atk__
      complexed with ihe
      1. region a:1-215 [119652]
    12. 2auz
      automatically matched to d1atk__
      complexed with ct2, so4
      1. region a:1-215 [127346]
    13. 1yk7
      automatically matched to d1atk__
      complexed with nbl
      1. region a:1-215 [123501]
    14. 2aux
      automatically matched to d1atk__
      complexed with ct1
      1. region a:3-215 [127343]
    15. 1ayu
      complexed with ina
      1. chain a [37070]
    16. 1u9w
      automatically matched to d1atk__
      complexed with ihi
      1. region a:1-215 [119653]
    17. 1atk
      complexed with e64
      1. chain a [37071]
    18. 1snk
      complexed with mye, so4
      1. chain a [105819]
    19. 1ayv
      complexed with in6
      1. chain a [37072]
    20. 1au3
      complexed with pcm
      1. chain a [37073]
    21. 1bgo
      complexed with i10
      1. chain a [37074]
    22. 1yk8
      automatically matched to d1atk__
      complexed with t2m
      1. region a:117-329 [123502]
    23. 2ftd
      automatically matched to d1atk__
      complexed with ili
      1. region a:1-215 [134058]
    24. 2ftd
      automatically matched to d1atk__
      complexed with ili
      1. region b:1-215 [134059]
    25. 1nlj
      complexed with 2ca
      1. chain a [80626]
      2. chain b [80627]
    26. 1ayw
      complexed with in3
      1. chain a [37075]
    27. 1au4
      complexed with inp
      1. chain a [37076]
    28. 7pck
      contains propeptide
      1. chain a [37079]
      2. chain b [37080]
      3. chain c [37081]
      4. chain d [37082]
    29. 1au0
      complexed with sdk
      1. chain a [37077]
    30. 1au2
      complexed with pos
      1. chain a [37078]
    31. 1nl6
      complexed with 750
      1. chain a [80619]
      2. chain b [80620]
    32. 1by8
      contains propeptide
      1. chain a [37083]
  2. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [142845] (1)
    SQ P43236 115-329
    1. 2f7d
      complexed with noq; mutant
      1. region a:1-211 [133086]
17. (Pro)cathepsin L [54026]
  1. Human (Homo sapiens) [TaxId: 9606] [54027] (4)
    1. 1cs8
      contains propeptide
      mutant
      1. chain a [37065]
    2. 1mhw
      complexed with bp4, csw, dar, pea
      1. chain a,c [79132]
      2. chain b,d [79133]
    3. 1cjl
      contains propeptide
      mutant
      1. chain a [37066]
    4. 1icf
      1. chain a,b [37067]
      2. chain c,d [37068]
18. (Pro)cathepsin S [82566]
  1. Human (Homo sapiens) [TaxId: 9606] [82567] (36)
    1. 2h7j
      automatically matched to d1ms6a_
      complexed with h7j, p15
      1. region a:1-217 [136216]
    2. 2h7j
      automatically matched to d1ms6a_
      complexed with h7j, p15
      1. region b:1-217 [136217]
    3. 2hhn
      automatically matched to d1ms6a_
      complexed with gnq, so4
      1. region a:1-217 [136501]
    4. 2hhn
      automatically matched to d1ms6a_
      complexed with gnq, so4
      1. region b:1-217 [136502]
    5. 2op3
      automatically matched to d1ms6a_
      complexed with peu, so4, tf5
      1. region a:1-217 [139203]
    6. 2op3
      automatically matched to d1ms6a_
      complexed with peu, so4, tf5
      1. region b:1-217 [139204]
    7. 2frq
      automatically matched to d1ms6a_
      complexed with c71
      1. region a:1-218 [133999]
    8. 2frq
      automatically matched to d1ms6a_
      complexed with c71
      1. region b:1-218 [134000]
    9. 2fq9
      automatically matched to d1ms6a_
      complexed with crj
      1. region a:1-218 [133941]
    10. 2fq9
      automatically matched to d1ms6a_
      complexed with crj
      1. region b:1-218 [133942]
    11. 2ft2
      automatically matched to d1ms6a_
      complexed with c28
      1. region a:1-218 [134054]
    12. 2ft2
      automatically matched to d1ms6a_
      complexed with c28
      1. region b:1-218 [134055]
    13. 1ms6
      complexed with bln
      1. chain a [85080]
    14. 2hh5
      automatically matched to d1ms6a_
      complexed with cl, gnq, zn
      1. region a:1-217 [136468]
    15. 2hh5
      automatically matched to d1ms6a_
      complexed with cl, gnq, zn
      1. region b:1-217 [136469]
    16. 1nqc
      complexed with c4p
      1. chain a [86024]
    17. 2f1g
      automatically matched to d1ms6a_
      complexed with gnf, gol
      1. region a:1-217 [132764]
    18. 2f1g
      automatically matched to d1ms6a_
      complexed with gnf, gol
      1. region b:1-217 [132765]
    19. 2fud
      automatically matched to d1ms6a_
      complexed with crl
      1. region a:1-218 [134117]
    20. 2fud
      automatically matched to d1ms6a_
      complexed with crl
      1. region b:1-218 [134118]
    21. 2r9m
      automatically matched to d1ms6a_
      complexed with y11
      1. region a:1-217 [151792]
    22. 2r9m
      automatically matched to d1ms6a_
      complexed with y11
      1. region b:1-217 [151793]
    23. 2hxz
      automatically matched to d1ms6a_
      complexed with h7j, so4
      1. region a:1-217 [136861]
    24. 2hxz
      automatically matched to d1ms6a_
      complexed with h7j, so4
      1. region b:1-217 [136862]
    25. 2hxz
      automatically matched to d1ms6a_
      complexed with h7j, so4
      1. region c:1-217 [136863]
    26. 1npz
      complexed with c1p
      1. chain a [86003]
      2. chain b [86004]
    27. 2fra
      automatically matched to d1ms6a_
      complexed with crv
      1. region a:1-218 [133978]
    28. 2fra
      automatically matched to d1ms6a_
      complexed with crv
      1. region b:1-218 [133979]
    29. 2g7y
      automatically matched to d1ms6a_
      complexed with mo9
      1. region a:1-218 [134739]
    30. 2g7y
      automatically matched to d1ms6a_
      complexed with mo9
      1. region b:1-218 [134740]
    31. 2r9n
      automatically matched to d1ms6a_
      complexed with y14
      1. region a:1-217 [151794]
    32. 2r9n
      automatically matched to d1ms6a_
      complexed with y14
      1. region b:1-217 [151795]
    33. 2r9o
      automatically matched to d1ms6a_
      complexed with y15
      1. region a:1-217 [151796]
    34. 2r9o
      automatically matched to d1ms6a_
      complexed with y15
      1. region b:1-217 [151797]
    35. 1glo
      mutant
      1. chain a [76230]
    36. 2g6d
      complexed with mqq; mutant
      1. region a:1-211 [134702]
19. (Pro)cathepsin V [64202]
  1. Human (Homo sapiens) [TaxId: 9606] [64203] (1)
    1. 1fh0
      complexed with bns, nfp, ods, so4; mutant
      1. chain a [59832]
      2. chain b [59833]
20. (Pro)cathepsin X [54031]
  1. Human (Homo sapiens) [TaxId: 9606] [54032] (2)
    1. 1deu
      contains propeptide
      1. chain a [37085]
      2. chain b [37086]
    2. 1ef7
      1. chain a [37087]
      2. chain b [37088]
21. Staphopain StpA [54033]
  1. Staphylococcus aureus [TaxId: 1280] [54034] (1)
    1. 1cv8
      complexed with act, e64
      1. chain a [37089]
22. Staphopain SspB [102721]
  1. Staphylococcus aureus [TaxId: 1280] [102722] (4)
    SQ Q70UQ9 41-393
    1. 1pxv
      complexed with staphostatin B
      complexed with gai, so4; mutant
      1. chain a [95301]
      2. chain b [95302]
    2. 1y4h
      complexed with cl, so4
      1. region a:221-393 [122615]
    3. 1y4h
      automatically matched to 1Y4H A:221-393
      complexed with cl, so4
      1. region b:221-393 [122616]
    4. 1x9y
      1. region a:223-393 [115011]
      2. region b:223-393 [115013]
      3. region c:223-393 [115015]
      4. region d:223-393 [115017]
23. Streptococcal pyrogenic exotoxin B [54035]
  1. Streptococcus pyogenes [TaxId: 1314] [54036] (2)
    SQ P00788 31-398
    1. 1dki
      zymogen
      complexed with so4; mutant
      1. chain a [37090]
      2. chain b [37091]
      3. chain c [37092]
      4. chain d [37093]
    2. 1pvj
      complexed with zfb
      1. chain a [104325]
      2. chain b [104326]
      3. chain c [104327]
      4. chain d [104328]
24. Falcipain 2 [142846]
  1. Plasmodium falciparum [TaxId: 5833] [142847] (6)
    SQ Q9N6S8 244-484
    1. 2oul
      automatically matched to d1yvba1
      1. region a:-16-224 [149025]
    2. 1yvb
      complexed with gol
      1. region a:0-212 [124092]
    3. 2ghu
      automatically matched to 1YVB A:0-212
      1. region a:1-241 [135210]
    4. 2ghu
      automatically matched to 1YVB A:0-212
      1. region b:1-241 [135211]
    5. 2ghu
      automatically matched to 1YVB A:0-212
      1. region c:1-241 [135212]
    6. 2ghu
      automatically matched to 1YVB A:0-212
      1. region d:1-241 [135213]
25. Major mite fecal allergen der p 1 [142848]
  1. House-dust mite (Dermatophagoides pteronyssinus) [TaxId: 6956] [142849] (3)
    SQ P08176 19-320! SQ P08176 99-320
    1. 1xkg
      complexed with gol, so4, yt3; mutant
      1. region a:4-305 [122081]
    2. 2as8
      complexed with mg; mutant
      1. region a:1-222 [127242]
    3. 2as8
      automatically matched to 2AS8 A:1-222
      complexed with mg; mutant
      1. region b:1-222 [127243]
Avirulence protein Avrpph3 [102723] (1)
1. Avirulence protein Avrpph3 [102724]
  1. Pseudomonas syringae pv. phaseolicola [TaxId: 319] [102725] (1)
    1. 1ukf
      1. chain a [99488]
FMDV leader protease [54037] (1)
1. FMDV leader protease [54038]
  1. Foot-and-mouth disease virus [TaxId: 12110] [54039] (5)
    1. 1qmy
      complexed with edo; mutant
      1. chain a [37094]
      2. chain b [37095]
      3. chain c [37096]
    2. 1qol
      complexed with cl, edo; mutant
      1. chain a [37097]
      2. chain b [37098]
      3. chain c [37099]
      4. chain d [37100]
      5. chain e [37101]
      6. chain f [37102]
      7. chain g [37103]
      8. chain h [37104]
    3. 2jqf
      automatically matched to d1qola_
      mutant
      1. region r:29-201 [148174]
    4. 2jqf
      automatically matched to d1qola_
      mutant
      1. region s:229-401 [148175]
    5. 2jqg
      automatically matched to d1qola_
      mutant
      1. region r:29-195 [148176]
Calpain large subunit, catalytic domain (domain II) [54040] (5)
1. Calpain large subunit, catalytic domain (domain II) [54041]
  includes the N-terminal 'sequence' domain I
  1. Human (Homo sapiens), M-type [TaxId: 9606] [54042] (2)
    1. 1kfu
      1. region l:2-355 [68573]
    2. 1kfx
      1. region l:2-355 [68577]
  2. Rat (Rattus norvegicus), M-type [TaxId: 10116] [54043] (3)
    1. 1mdw
      calcium-bound protease core
      complexed with ca; mutant
      1. chain a [84934]
      2. chain b [84935]
    2. 1df0
      mutant
      1. region a:2-355 [37106]
    3. 1u5i
      automatically matched to d1df0a3
      mutant
      1. region a:2-355 [119549]
  3. Rat (Rattus norvegicus), mu-type [TaxId: 10116] [75332] (10)
    SQ P97571 33-353
    1. 2r9f
      automatically matched to d1tloa_
      complexed with ca, cl, gol, k2z
      1. region a:33-354 [151767]
    2. 2g8j
      automatically matched to d1tloa_
      complexed with ca, d7g
      1. region a:33-354 [134773]
    3. 2r9c
      automatically matched to d1tloa_
      complexed with ca, cl, gol, grd
      1. region a:33-354 [151766]
    4. 1tl9
      complexed with ace, ca
      1. chain a [112505]
    5. 1tlo
      complexed with ca, e64
      1. chain a [112508]
    6. 1kxr
      calcium-bound protease core
      complexed with ca; mutant
      1. chain a [73175]
      2. chain b [73176]
    7. 2nqg
      automatically matched to d1tloa_
      complexed with ca, nqg
      1. region a:33-354 [138453]
    8. 2nqi
      automatically matched to d1tloa_
      complexed with ca, nqi
      1. region a:33-354 [138454]
    9. 2g8e
      automatically matched to d1tloa_
      complexed with ca, d5g, mes
      1. region a:33-354 [134769]
    10. 1qxp
      mu-like isoform with the large and small subunits fused in a single chain
      mutant
      1. region a:2-355 [96546]
      2. region b:2-355 [96550]
  4. Human (Homo sapiens), calpain 9 [TaxId: 9606] [142850] (1)
    SQ O14815 28-337
    1. 1ziv
      complexed with bme, ca
      1. region a:28-337 [125139]
  5. Human(Homo sapiens), mu type [TaxId: 9606] [142851] (3)
    SQ P07384 33-353! SQ P07384 33-354
    1. 1zcm
      complexed with c1n, ca; mutant
      1. region a:33-353 [124909]
    2. 2ary
      complexed with bme, ca
      1. region a:33-354 [127223]
    3. 2ary
      automatically matched to 2ARY A:33-354
      complexed with bme, ca
      1. region b:33-354 [127224]
Transglutaminase core [54044] (6)
1. Transglutaminase catalytic domain [54045]
  1. Human (Homo sapiens), blood isozyme [TaxId: 9606] [54046] (8)
    Coagulation factor XIII
    1. 1ex0
      complexed with ca, pgo, po4; mutant
      1. region a:191-510 [90468]
      2. region b:191-511 [90472]
    2. 1f13
      1. region a:191-515 [37107]
      2. region b:191-515 [37108]
    3. 1evu
      complexed with ca, pgo
      1. region a:191-508 [37113]
      2. region b:191-508 [37114]
    4. 1ggu
      complexed with ca
      1. region a:191-508 [37115]
      2. region b:191-508 [37116]
    5. 1fie
      1. region a:191-515 [37109]
      2. region b:191-515 [37110]
    6. 1qrk
      complexed with sr
      1. region a:191-511 [37119]
      2. region b:191-507 [37120]
    7. 1ggy
      complexed with yb
      1. region a:191-508 [37117]
      2. region b:191-508 [37118]
    8. 1ggt
      1. region a:191-515 [37111]
      2. region b:191-515 [37112]
  2. Human (Homo sapiens), tissue isozyme [TaxId: 9606] [75333] (2)
    GDP-binding protein
    1. 2q3z
      automatically matched to d1kv3a4
      complexed with ace, nh2, onl, so4
      1. region a:146-461 [150040]
    2. 1kv3
      complexed with gdp
      1. region a:146-468 [73030]
      2. region b:146-468 [73034]
      3. region c:146-468 [73038]
      4. region d:146-468 [73042]
      5. region e:146-468 [73046]
      6. region f:146-468 [73050]
  3. Human (Homo sapiens), TGase E3 [TaxId: 9606] [75334] (8)
    1. 1vjj
      complexed with ca, cl, gdp, mg; mutant
      1. region a:141-461 [100817]
      2. region b:141-459 [100821]
    2. 1sgx
      complexed with 5gp, ca, mg; mutant
      1. region a:141-461 [98865]
      2. region b:141-459 [98869]
    3. 1l9n
      complexed with bgl, ca, cl; mutant
      1. region a:141-460 [73743]
      2. region b:141-460 [73747]
    4. 1rle
      complexed with ca, gsp, mg; mutant
      1. region a:141-461 [97641]
      2. region b:141-459 [97645]
    5. 1l9m
      complexed with br, ca, cl; mutant
      1. region a:141-461 [73735]
      2. region b:141-460 [73739]
    6. 1nug
      complexed with ca, cl, mg; mutant
      1. region a:141-461 [86189]
      2. region b:141-459 [86193]
    7. 1nuf
      complexed with br, ca, cl; mutant
      1. region a:141-461 [86185]
    8. 1nud
      complexed with br, ca, cl; mutant
      1. region a:141-460 [86177]
      2. region b:141-460 [86181]
  4. Red sea bream (Chrysophrys major) [TaxId: 143350] [64204] (1)
    1. 1g0d
      complexed with so4
      1. region a:141-461 [60169]
2. Peptide:N-glycanase 1, PNG1 [142852]
  1. Baker's yeast(Saccharomyces cerevisiae) [TaxId: 4932] [142853] (2)
    SQ Q02890 8-327
    1. 1x3z
      automatically matched to 1X3W A:8-327
      complexed with suc, zn
      1. region a:8-327 [121673]
    2. 1x3w
      complexed with suc, zn
      1. region a:8-327 [121671]
  2. Mouse (Mus musculus) [TaxId: 10090] [159840] (2)
    SQ Q9JI78 164-450
    1. 2f4m
      complexed with cl, zn
      1. region a:164-450 [145135]
    2. 2f4o
      automatically matched to 2F4M A:164-450
      complexed with cl, phq, zn
      1. region a:164-447 [145136]
Arylamine N-acetyltransferase [54047] (4)
fold similar to that of the factor XIII catalytic domain
1. Arylamine N-acetyltransferase [54048]
  1. Salmonella typhimurium [TaxId: 90371] [54049] (1)
    1. 1e2t
      1. chain a [37121]
      2. chain b [37122]
      3. chain c [37123]
      4. chain d [37124]
      5. chain e [37125]
      6. chain f [37126]
      7. chain g [37127]
      8. chain h [37128]
  2. Mycobacterium smegmatis [TaxId: 1772] [75335] (7)
    1. 1w5r
      mutant
      1. region a:3-275 [120643]
    2. 1w5r
      automatically matched to 1W5R A:3-275
      mutant
      1. region b:3-275 [120644]
    3. 1gx3
      1. chain a [70678]
      2. chain b [70679]
      3. chain c [70680]
      4. chain d [70681]
    4. 1w6f
      automatically matched to d1gx3a_
      complexed with isz
      1. region a:3-275 [120656]
    5. 1w6f
      automatically matched to d1gx3a_
      complexed with isz
      1. region b:7-275 [120657]
    6. 1w6f
      automatically matched to d1gx3a_
      complexed with isz
      1. region c:4-275 [120658]
    7. 1w6f
      automatically matched to d1gx3a_
      complexed with isz
      1. region d:6-274 [120659]
  3. Rhizobium loti [TaxId: 381] [142854] (2)
    SQ Q98D42 6-275
    1. 2bsz
      1. region a:6-275 [129131]
    2. 2bsz
      automatically matched to 2BSZ A:6-275
      1. region b:7-274 [129132]
  4. Pseudomonas aeruginosa [TaxId: 287] [142855] (1)
    SQ Q9HUY3 1-277
    1. 1w4t
      complexed with so4
      1. region a:1-277 [120639]
Ubiquitin carboxyl-terminal hydrolase UCH-L [54050] (3)
1. Ubiquitin carboxyl-terminal hydrolase UCH-l3 [54051]
  1. Human (Homo sapiens) [TaxId: 9606] [54052] (2)
    SQ P15374
    1. 1xd3
      complexed with gve, mg
      1. chain a [115145]
      2. chain c [115147]
    2. 1uch
      1. chain a [37129]
  2. Synthetic, based on Saccharomyces cerevisiae sequence [54053] (1)
    1. 1cmx
      1. chain a [37130]
      2. chain c [37131]
2. Ubiquitin carboxyl-terminal hydrolase isozyme l1 [142856]
  1. Human (Homo sapiens) [TaxId: 9606] [142857] (2)
    SQ P09936 1-223
    1. 2etl
      complexed with cl
      1. region a:1-223 [132361]
    2. 2etl
      automatically matched to 2ETL A:1-223
      complexed with cl
      1. region b:1-223 [132362]
Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (5)
Pfam 00443
1. Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) [82569]
  1. Human (Homo sapiens) [TaxId: 9606] [82570] (2)
    1. 1nbf
      complex with ubiquitin aldehyde
      complexed with glz
      1. chain a [80387]
      2. chain b [80388]
      3. chain e [80391]
    2. 1nb8
      complexed with mse
      1. chain a [80385]
      2. chain b [80386]
2. Ubiquitin carboxyl-terminal hydrolase 6 [110769]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110770] (1)
    SQ P43593 103-499
    1. 1vjv
      1. chain a [108632]
3. Ubiquitin carboxyl-terminal hydrolase 8 [142858]
  1. Human (Homo sapiens) [TaxId: 9606] [142859] (1)
    SQ P40818 762-1109
    1. 2gfo
      complexed with zn
      1. region a:762-1109 [135105]
4. Ubiquitin carboxyl-terminal hydrolase 14 [142860]
  1. Human (Homo sapiens) [TaxId: 9606] [142861] (4)
    SQ P54578 100-482
    1. 2ayn
      1. region a:100-482 [127563]
    2. 2ayn
      automatically matched to 2AYN A:100-482
      1. region b:100-482 [127564]
    3. 2ayn
      automatically matched to 2AYN A:100-482
      1. region c:100-482 [127565]
    4. 2ayo
      automatically matched to 2AYN A:100-482
      1. region a:100-482 [127566]
5. Ubiquitin carboxyl-terminal hydrolase 2, USP2 [159841]
  1. Human (Homo sapiens) [TaxId: 9606] [159842] (2)
    SQ O75604 263-600! SQ O75604 264-599
    1. 2hd5
      complexed with zn
      1. region a:211-521 [145293]
    2. 2ibi
      complexed with neh, zn; mutant
      1. region a:263-600 [145520]
Adenain-like [54054] (5)
Pfam 02902; Ulp1 protease family
1. Human adenovirus 2 proteinase, adenain [54055]
  1. Mastadenovirus H2 [TaxId: 10515] [54056] (2)
    1. 1nln
      complexed with peptide cofactor, chain B
      complexed with acy
      1. chain a [91962]
    2. 1avp
      complexed with peptide cofactor, chain B
      1. chain a [37132]
2. Ulp1 protease C-terminal domain [54057]
  1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [54058] (4)
    1. 1euv
      1. chain a [37133]
    2. 2hl9
      automatically matched to d1euva_
      1. region a:402-621 [147308]
    3. 2hl8
      automatically matched to d1euva_
      1. region a:401-621 [147307]
    4. 2hkp
      automatically matched to d1euva_
      1. region a:401-621 [147301]
3. Sentrin-specific protease 2, SENP2 [110771]
  1. Human (Homo sapiens) [TaxId: 9606] [110772] (8)
    SQ Q9HC62 366-589
    1. 1th0
      1. chain a [106903]
      2. chain b [106904]
    2. 2io0
      complexed with so4; mutant
      1. region a:364-589 [145530]
    3. 2io1
      automatically matched to 2IO0 A:364-589
      mutant
      1. region a:367-589 [145531]
    4. 2io1
      automatically matched to 2IO0 A:364-589
      mutant
      1. region c:366-589 [145532]
    5. 2io1
      automatically matched to 2IO0 A:364-589
      mutant
      1. region e:367-589 [145533]
    6. 1tgz
      complexed with so4
      1. chain a [106901]
    7. 2io2
      automatically matched to 2IO0 A:364-589
      mutant
      1. region a:365-589 [145534]
    8. 2io3
      automatically matched to 2IO0 A:364-589
      mutant
      1. region a:366-589 [145536]
4. Sentrin-specific protease 8, SENP8 [117760]
  1. Human (Homo sapiens) [TaxId: 9606] [117761] (6)
    SQ Q96LD8
    1. 2bkr
      automatically matched to 2BKQ A:1-212
      1. region a:1-212 [128710]
    2. 2bkq
      1. region a:1-212 [128706]
    3. 2bkq
      automatically matched to 2BKQ A:1-212
      1. region b:1-212 [128707]
    4. 2bkq
      automatically matched to 2BKQ A:1-212
      1. region c:1-212 [128708]
    5. 2bkq
      automatically matched to 2BKQ A:1-212
      1. region d:2-212 [128709]
    6. 1xt9
      1. chain a [116013]
5. Sentrin-specific protease 1 [142862]
  1. Human (Homo sapiens) [TaxId: 9606] [142863] (6)
    SQ Q9P0U3 419-643
    1. 2iy1
      automatically matched to 2IY0 A:419-643
      mutant
      1. region a:419-643 [145553]
    2. 2iy1
      automatically matched to 2IY0 A:419-643
      mutant
      1. region c:419-643 [145554]
    3. 2iy0
      mutant
      1. region a:419-643 [145551]
    4. 2g4d
      mutant
      1. region a:440-643 [145184]
    5. 2g4d
      automatically matched to 2G4D A:440-643
      mutant
      1. region c:440-643 [145185]
    6. 2ckh
      1. region a:419-643 [130565]
Microbial transglutaminase [75336] (1)
inverted positions of the catalytic triad Asp and His residues
1. Microbial transglutaminase [75337]
  1. Streptoverticillium mobaraense [TaxId: 35621] [75338] (1)
    1. 1iu4
      1. chain a [71430]
      2. chain b [71431]
      3. chain c [71432]
      4. chain d [71433]
Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [110773] (1)
probably the same as Pfam 02338, OTU-like cysteine protease, but 1TFF (SQ Q96DC9) was not detected by the Pfam model
1. Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [110774]
  1. Human (Homo sapiens) [TaxId: 9606] [110775] (1)
    SQ Q96DC9
    1. 1tff
      mutant
      1. chain a [106854]
IgG-specific endopeptidase IdeS (Sib38) [117762] (1)
1. IgG-specific endopeptidase IdeS (Sib38) [117763]
  1. Streptococcus pyogenes [TaxId: 1314] [117764] (1)
    SQ Q9F1R7 38-339 # SPy0861
    1. 1y08
      complexed with so4; mutant
      1. chain a [116280]
Lpg0564-like [142864] (1)
Pfam 07313, DUF1460; contains new PDB entry 2p1g, annotated as putative xylanase
1. Hypothetical protein Lpg0564 [142865]
  1. Legionella pneumophila [TaxId: 446] [142866] (1)
    SQ Q5ZY11 49-352
    1. 2im9
      1. region a:49-352 [137508]
Phytochelatin synthase [142867] (1)
Pfam 05023; assosiated Pfam 09328 (DUF1984) is a part of the same functional unit
1. Primitive phytochelatin synthase [142868]
  1. Nostoc sp. pcc 7120 [TaxId: 103690] [142869] (4)
    SQ Q8YY76 29-238
    1. 2bu3
      automatically matched to 2BTW A:29-238
      complexed with 3gc, ca, cl
      1. region a:29-238 [129167]
    2. 2bu3
      automatically matched to 2BTW A:29-238
      complexed with 3gc, ca, cl
      1. region b:32-238 [129168]
    3. 2btw
      complexed with ca
      1. region b:29-238 [129160]
    4. 2btw
      complexed with ca
      1. region a:29-238 [129159]
CHAP domain [142870] (1)
Pfam 05257
1. Glutathionylspermidine synthase, amidase domain [142871]
  1. Escherichia coli [TaxId: 562] [142872] (10)
    SQ P0AES0 10-200
    1. 2io8
      automatically matched to 2IO7 A:10-200
      complexed with adp, cys, mg
      1. region a:10-200 [137550]
    2. 2io8
      automatically matched to 2IO7 A:10-200
      complexed with adp, cys, mg
      1. region b:10-200 [137553]
    3. 2io9
      automatically matched to 2IO7 A:10-200
      complexed with adp, gsh, mg
      1. region a:10-200 [137556]
    4. 2io9
      automatically matched to 2IO7 A:10-200
      complexed with adp, gsh, mg
      1. region b:10-200 [137559]
    5. 2iob
      automatically matched to 2IO7 A:10-200
      1. region a:12-200 [137568]
    6. 2iob
      automatically matched to 2IO7 A:10-200
      1. region b:13-200 [137571]
    7. 2ioa
      automatically matched to 2IO7 A:10-200
      complexed with adp, gga, mg
      1. region a:10-200 [137562]
    8. 2ioa
      automatically matched to 2IO7 A:10-200
      complexed with adp, gga, mg
      1. region b:12-200 [137565]
    9. 2io7
      complexed with anp, mg
      1. region a:10-200 [137544]
    10. 2io7
      automatically matched to 2IO7 A:10-200
      complexed with anp, mg
      1. region b:12-200 [137547]
NlpC/P60 [142873] (1)
Pfam 00877
1. Cell wall-associated hydrolase Spr C-terminal domain [142874]
  1. Nostoc punctiforme [TaxId: 272131] [142875] (3)
    SQ Q8YRR4 87-234
    1. 2evr
      complexed with cl, edo, na
      1. region a:87-234 [132441]
    2. 2fg0
      automatically matched to 2EVR A:87-234
      complexed with gol
      1. region a:87-234 [133397]
    3. 2fg0
      automatically matched to 2EVR A:87-234
      complexed with gol
      1. region b:87-234 [133399]
PMT C-terminal domain like [159843] (1)
displays a minimal thiol-protease fold and its catalytic triad; potential redox regulation: the catalytic cysteine can form a disulfide bond with an N-terminal cysteine
1. Dermonecrotic toxin, ToxA [159844]
  Synonym: Mitogenic toxin PMT
  1. Pasteurella multocida [TaxId: 747] [159845] (4)
    SQ P17452 1094-1285
    1. 2ebf
      complexed with 2po, tre
      1. region x:1094-1285 [146768]
    2. 2ebh
      complexed with tre; mutant
      1. region x:1094-1285 [146771]
    3. 2ec5
      mutant
      1. region a:1094-1285 [146780]
    4. 2ec5
      automatically matched to 2EC5 A:1094-1285
      mutant
      1. region b:1094-1285 [146783]
MOA C-terminal domain-like [159846] (1)
PfamB 070855
1. Agglutinin MOA [159847]
  1. Fairy-ring mushroom (Marasmius oreades) [TaxId: 181124] [159848] (1)
    SQ Q8X123 156-293
    1. 2iho
      complexed with gal, nag
      1. region a:156-293 [147682]
Atu2299-like [159849] (1)
Pfam 09641; DUF2026; putative Cys/Ser-His-Asp catalytic triad
1. Hypothetical protein Atu2299 [159850]
  Serine catalytic nucleophile
  1. Agrobacterium tumefaciens [TaxId: 358] [159851] (1)
    SQ Q8UD29 1-202
    1. 2hly
      1. region a:5-206 [147310]
M48USP-like [159852] (1)
Pfam 04843; Herpesvirus tegument protein, N-terminal conserved region
1. Tegument protein M48; N-terminal domain [159853]
  1. Murine cytomegalovirus (MCMV) [TaxId: 10366] [159854] (2)
    SQ A8E1C4 1-232
    1. 2j7q
      complexed with gol, gve, mg, pg4
      1. region a:1-232 [145673]
    2. 2j7q
      complexed with gol, gve, mg, pg4
      1. region c:1-232 [145674]
YiiX-like [159855] (1)
Pfam 06520; DUF1105; circularly permuted active site residues compare to papain
1. Hypothetical protein YiiX [159856]
  1. Escherichia coli [TaxId: 562] [159857] (2)
    SQ Q8X778 19-200
    1. 2if6
      complexed with unx
      1. region a:19-200 [147651]
    2. 2if6
      automatically matched to 2IF6 A:19-200
      complexed with unx
      1. region b:19-198 [147652]
Autophagin-like [159858] (2)
Pfam 03416
1. Cysteine protease ATG4A [159859]
  Autophagin-2
  1. Human (Homo sapiens) [TaxId: 9606] [159860] (4)
    SQ Q8WYN0 26-359
    1. 2p82
      complexed with cl, edo
      1. region a:26-359 [149300]
    2. 2p82
      automatically matched to 2P82 A:26-359
      complexed with cl, edo
      1. region b:26-359 [149301]
    3. 2p82
      automatically matched to 2P82 A:26-359
      complexed with cl, edo
      1. region c:26-359 [149302]
    4. 2p82
      automatically matched to 2P82 A:26-359
      complexed with cl, edo
      1. region d:26-357 [149303]
2. Cysteine protease ATG4B [159861]
  Autophagin-1
  1. Human (Homo sapiens) [TaxId: 9606] [159862] (5)
    SQ Q9Y4P1 10-373! SQ Q9Y4P1 5-354
    1. 2z0d
      mutant
      1. region a:5-354 [145769]
    2. 2z0e
      automatically matched to 2Z0D A:5-354
      mutant
      1. region a:5-354 [145770]
    3. 2cy7
      automatically matched to 2D1I A:10-373
      1. region a:10-373 [146431]
    4. 2d1i
      1. region a:10-373 [146447]
    5. 2d1i
      automatically matched to 2D1I A:10-373
      1. region b:10-373 [146448]