Fold: Cysteine proteinases

consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a+b) [53931]
   Mainly antiparallel beta sheets (segregated alpha and beta regions)
3. Fold: Cysteine proteinases [54000]
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

Superfamilies:

1. Cysteine proteinases [54001] (22)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
   uperfamily
   1. Papain-like [54002] (30)
      1. Actinidin [54003]
         1. Chinese gooseberry or kiwifruit (Actinidia chinensis) [TaxId: 3625] [54004] (2)
            1. 2act
               complexed with cya, nh4
               1. chain a [37002]
            2. 1aec
               complexed with e64
               1. chain a [37003]
      2. Papain [54005]
         1. Papaya (Carica papaya) [TaxId: 3649] [54006] (18)
            1. 1khq
               complexed with glm
               1. chain a [90964]
            2. 1ppn
               complexed with moh, o o
               1. chain a [37004]
            3. 1cvz
               complexed with c48
               1. chain a [37005]
            4. 9pap
               complexed with cyo, moh
               1. chain a [37006]
            5. 1pip
               complexed with nit, sin
               1. chain a [37007]
            6. 1ppd
               complexed with seo
               1. chain a [37008]
            7. 1khp
               complexed with glm
               1. chain a [90963]
            8. 1ppp
               complexed with e6c, moh
               1. chain a [37009]
            9. 1pe6
               complexed with e6c, moh
               1. chain a [37010]
            10. 1bp4
                complexed with ald
                1. chain a [37011]
            11. 1pop
                complexed with moh
                1. chain a [37013]
            12. 1stf
                complexed with cbm; mutant
                1. chain e [37012]
            13. 1bqi
                complexed with sba
                1. chain a [37014]
            14. 5pad
                complexed with bzo, glm
                1. chain a [37017]
            15. 1pad
                1. chain a [37016]
            16. 2pad
                1. chain a [37015]
            17. 4pad
                complexed with tos
                1. chain a [37018]
            18. 6pad
                complexed with bzo
                1. chain a [37019]
      3. Caricain (protease omega) [54007]
         1. Papaya (Carica papaya) [TaxId: 3649] [54008] (3)
            1. 1ppo
               complexed with hg
               1. chain a [37020]
            2. 1meg
               complexed with e64, eoh; mutant
               1. chain a [37021]
            3. 1pci
               zymogen with propeptide
               CASP2
               mutant
               1. chain a [37022]
               2. chain b [37023]
               3. chain c [37024]
      4. Chymopapain [54009]
         1. Papaya (Carica papaya) [TaxId: 3649] [54010] (1)
            1. 1yal
               1. chain a [37025]
      5. Glycyl endopeptidase [54011]
         1. Papaya (Carica papaya) [TaxId: 3649] [54012] (1)
            1. 1gec
               complexed with cbz, gcm
               1. chain e [37026]
      6. Proline-specific cysteine protease [54013]
         1. Ginger rhizome (Zingiber officinale) [TaxId: 94328] [54014] (1)
            1. 1cqd
               complexed with fuc, nag, thj
               1. chain a [37027]
               2. chain b [37028]
               3. chain c [37029]
               4. chain d [37030]
      7. Ervatamin B [89803]
         1. Adam's apple (Ervatamia coronaria) [TaxId: 52861] [89804] (1)
            1. 1iwd
               complexed with thj
               1. chain a [83756]
      8. Ervatamin C [102717]
         1. East indian rosebay (Ervatamia coronaria) [TaxId: 52861] [102718] (1)
            1. 1o0e
               complexed with thj
               1. chain a [92393]
               2. chain b [92394]
      9. Vignain (bean endopeptidase) [102719]
         1. Castor bean (Ricinus communis) [TaxId: 3988] [102720] (1)
            1. 1s4v
               complexed with so4
               1. chain a [98511]
               2. chain b [98512]
      10. Bleomycin hydrolase [54017]
          DNA-binding protease that has more insertions in the papain-like fold
          1. Baker's yeast (Saccharomyces cerevisiae), Gal6 [TaxId: 4932] [54018] (3)
             1. 3gcb
                complexed with gol, so4; mutant
                1. chain a [37032]
             2. 1a6r
                complexed with so4; mutant
                1. chain a [37033]
             3. 1gcb
                complexed with gol, hg, so4
                1. chain a [37034]
          2. Human (Homo sapiens) [TaxId: 9606] [54019] (2)
             1. 2cb5
                mutant
                1. chain a [37035]
                2. chain b [37036]
             2. 1cb5
                1. chain a [37037]
                2. chain b [37038]
                3. chain c [37039]
      11. Cruzain [54020]
          1. Trypanosoma cruzi [TaxId: 5693] [54021] (17)
             1. 1me4
                complexed with t10
                1. chain a [79023]
             2. 1me3
                complexed with p10
                1. chain a [79022]
             3. 2efm
                automatically matched to d1ewla_
                complexed with 4mc, edo, so4
                1. region a:1-215 [146817]
             4. 2efm
                automatically matched to d1ewla_
                complexed with 4mc, edo, so4
                1. region c:1-215 [146818]
             5. 1f2a
                complexed with vs2
                1. chain a [37040]
             6. 1f2b
                complexed with vs3
                1. chain a [37042]
             7. 1ewp
                complexed with mor
                1. chain a [37041]
             8. 2oz2
                automatically matched to d1ewla_
                complexed with d1r, so4
                1. region a:1-215 [149097]
             9. 2oz2
                automatically matched to d1ewla_
                complexed with d1r, so4
                1. region c:1-215 [149098]
             10. 1f2c
                 complexed with vs4
                 1. chain a [37043]
             11. 1ewm
                 complexed with rl2
                 1. chain a [83194]
             12. 1ewl
                 complexed with r99
                 1. chain a [83193]
             13. 1f29
                 complexed with vs1
                 1. chain a [37045]
                 2. chain b [37046]
                 3. chain c [37047]
             14. 1aim
                 complexed with zya; mutant
                 1. chain a [37044]
             15. 1ewo
                 complexed with vsc
                 1. chain a [83195]
             16. 1u9q
                 automatically matched to d1ewla_
                 complexed with 186
                 1. region x:1-212 [119650]
             17. 2aim
                 complexed with zra; mutant
                 1. chain a [37048]
      12. (Pro)cathepsin B [54022]
          1. Human (Homo sapiens) [TaxId: 9606] [54023] (6)
             1. 1gmy
                complexed with aem, apd, dfa
                1. chain a [76236]
                2. chain b [76237]
                3. chain c [76238]
             2. 1huc
                1. chain a,b [37049]
                2. chain c,d [37050]
             3. 1csb
                complexed with eox, epo
                1. chain a,b [37051]
                2. chain d,e [37052]
             4. 3pbh
                1. chain a [37053]
             5. 1pbh
                1. chain a [37054]
             6. 2pbh
                1. chain a [37055]
          2. Rat (Rattus norvegicus) [TaxId: 10116] [54024] (4)
             1. 1the
                complexed with cbz, sem; mutant
                1. chain a [37056]
                2. chain b [37057]
             2. 1cte
                complexed with pys; mutant
                1. chain a [37058]
                2. chain b [37059]
             3. 1cpj
                mutant
                1. chain a [37060]
                2. chain b [37061]
             4. 1mir
                zymogen
                mutant
                1. chain a [37062]
                2. chain b [37063]
          3. Cow (Bos taurus) [TaxId: 9913] [54025] (11)
             1. 2dcc
                automatically matched to d1itoa_
                complexed with 77b, gol, po4
                1. region a:1-253 [131371]
             2. 2dc9
                automatically matched to d1itoa_
                complexed with 74m, gol, po4
                1. region a:1-253 [131368]
             3. 2dc8
                automatically matched to d1itoa_
                complexed with 59a, gol, po4
                1. region a:1-253 [131367]
             4. 2dcb
                automatically matched to d1itoa_
                complexed with 76v, gol, po4
                1. region a:1-253 [131370]
             5. 2dc7
                automatically matched to d1itoa_
                complexed with 042, gol, po4
                1. region a:1-253 [131366]
             6. 2dca
                automatically matched to d1itoa_
                complexed with 75v, gol, po4
                1. region a:1-253 [131369]
             7. 1qdq
                complexed with 074
                1. chain a [37064]
             8. 1ito
                complexed with e6c
                1. chain a [76787]
             9. 2dc6
                automatically matched to d1itoa_
                complexed with 73v, gol, po4
                1. region a:1-253 [131365]
             10. 1sp4
                 complexed with epo, leu, meu, pro
                 1. chain a,b [98956]
             11. 2dcd
                 automatically matched to d1itoa_
                 complexed with 78a, gol, po4
                 1. region a:1-253 [131372]
      13. Cathepsin C (dipeptidyl peptidase I), catalytic domain [75330]
          1. Human (Homo sapiens) [TaxId: 9606] [75331] (1)
             1. 1k3b
                complexed with cl, nag, so4
                1. chain b,c [72015]
          2. Rat (Rattus norvegicus) [TaxId: 10116] [82565] (1)
             1. 1jqp
                complexed with cl, nag, so4
                1. region a:204-438 [77163]
      14. Cathepsin F [89805]
          1. Human (Homo sapiens) [TaxId: 9606] [89806] (1)
             1. 1m6d
                complexed with myp; mutant
                1. chain a [84849]
                2. chain b [84850]
      15. Cathepsin H [81637]
          also contains a disulfide-bound minicathepsin H chain
          1. Pig (Sus scrofa) [TaxId: 9823] [81636] (3)
             1. 8pch
                complexed with bma, nag
                1. chain p,a [76086]
             2. 1nb5
                complexed with bma, nag
                1. chain p,a [80377]
                2. chain r,b [80378]
                3. chain s,c [80379]
                4. chain t,d [80380]
             3. 1nb3
                complexed with bma, nag
                1. chain p,a [80369]
                2. chain r,b [80370]
                3. chain s,c [80371]
                4. chain t,d [80372]
      16. (Pro)cathepsin K [54028]
          1. Human (Homo sapiens) [TaxId: 9606] [54029] (32)
             SQ P43235 116-329 ! SQ P43235 115-329
             1. 2r6n
                automatically matched to d1atka_
                complexed with cke
                1. region a:1-215 [151620]
             2. 1tu6
                complexed with fsp, so4
                1. chain a [107318]
                2. chain b [107319]
             3. 3c9e
                automatically matched to d1atka_
                complexed with asg, bdp, ca, e64
                1. region a:1-215 [156124]
             4. 1mem
                complexed with bns, bzp, nfp
                1. chain a [37069]
             5. 2ato
                automatically matched to d1atk__
                complexed with myq, so4
                1. region a:1-215 [127300]
             6. 2bdl
                automatically matched to d1atk__
                complexed with 4pr
                1. region a:1-215 [128339]
             7. 1vsn
                complexed with nft
                1. region a:1-211 [145790]
             8. 1u9x
                automatically matched to d1atk__
                complexed with ihj
                1. region a:1-215 [119654]
             9. 1q6k
                complexed with so4, tco
                1. chain a [95980]
             10. 1yt7
                 automatically matched to d1atk__
                 complexed with 3fc, so4
                 1. region a:2-215 [123995]
             11. 1u9v
                 automatically matched to d1atk__
                 complexed with ihe
                 1. region a:1-215 [119652]
             12. 2auz
                 automatically matched to d1atk__
                 complexed with ct2, so4
                 1. region a:1-215 [127346]
             13. 1yk7
                 automatically matched to d1atk__
                 complexed with nbl
                 1. region a:1-215 [123501]
             14. 2aux
                 automatically matched to d1atk__
                 complexed with ct1
                 1. region a:3-215 [127343]
             15. 1ayu
                 complexed with ina
                 1. chain a [37070]
             16. 1u9w
                 automatically matched to d1atk__
                 complexed with ihi
                 1. region a:1-215 [119653]
             17. 1atk
                 complexed with e64
                 1. chain a [37071]
             18. 1snk
                 complexed with mye, so4
                 1. chain a [105819]
             19. 1ayv
                 complexed with in6
                 1. chain a [37072]
             20. 1au3
                 complexed with pcm
                 1. chain a [37073]
             21. 1bgo
                 complexed with i10
                 1. chain a [37074]
             22. 1yk8
                 automatically matched to d1atk__
                 complexed with t2m
                 1. region a:117-329 [123502]
             23. 2ftd
                 automatically matched to d1atk__
                 complexed with ili
                 1. region a:1-215 [134058]
             24. 2ftd
                 automatically matched to d1atk__
                 complexed with ili
                 1. region b:1-215 [134059]
             25. 1nlj
                 complexed with 2ca
                 1. chain a [80626]
                 2. chain b [80627]
             26. 1ayw
                 complexed with in3
                 1. chain a [37075]
             27. 1au4
                 complexed with inp
                 1. chain a [37076]
             28. 7pck
                 contains propeptide
                 1. chain a [37079]
                 2. chain b [37080]
                 3. chain c [37081]
                 4. chain d [37082]
             29. 1au0
                 complexed with sdk
                 1. chain a [37077]
             30. 1au2
                 complexed with pos
                 1. chain a [37078]
             31. 1nl6
                 complexed with 750
                 1. chain a [80619]
                 2. chain b [80620]
             32. 1by8
                 contains propeptide
                 1. chain a [37083]
          2. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [142845] (1)
             SQ P43236 115-329
             1. 2f7d
                complexed with noq; mutant
                1. region a:1-211 [133086]
      17. (Pro)cathepsin L [54026]
          1. Human (Homo sapiens) [TaxId: 9606] [54027] (4)
             1. 1cs8
                contains propeptide
                mutant
                1. chain a [37065]
             2. 1mhw
                complexed with bp4, csw, dar, pea
                1. chain a,c [79132]
                2. chain b,d [79133]
             3. 1cjl
                contains propeptide
                mutant
                1. chain a [37066]
             4. 1icf
                1. chain a,b [37067]
                2. chain c,d [37068]
      18. (Pro)cathepsin S [82566]
          1. Human (Homo sapiens) [TaxId: 9606] [82567] (36)
             1. 2h7j
                automatically matched to d1ms6a_
                complexed with h7j, p15
                1. region a:1-217 [136216]
             2. 2h7j
                automatically matched to d1ms6a_
                complexed with h7j, p15
                1. region b:1-217 [136217]
             3. 2hhn
                automatically matched to d1ms6a_
                complexed with gnq, so4
                1. region a:1-217 [136501]
             4. 2hhn
                automatically matched to d1ms6a_
                complexed with gnq, so4
                1. region b:1-217 [136502]
             5. 2op3
                automatically matched to d1ms6a_
                complexed with peu, so4, tf5
                1. region a:1-217 [139203]
             6. 2op3
                automatically matched to d1ms6a_
                complexed with peu, so4, tf5
                1. region b:1-217 [139204]
             7. 2frq
                automatically matched to d1ms6a_
                complexed with c71
                1. region a:1-218 [133999]
             8. 2frq
                automatically matched to d1ms6a_
                complexed with c71
                1. region b:1-218 [134000]
             9. 2fq9
                automatically matched to d1ms6a_
                complexed with crj
                1. region a:1-218 [133941]
             10. 2fq9
                 automatically matched to d1ms6a_
                 complexed with crj
                 1. region b:1-218 [133942]
             11. 2ft2
                 automatically matched to d1ms6a_
                 complexed with c28
                 1. region a:1-218 [134054]
             12. 2ft2
                 automatically matched to d1ms6a_
                 complexed with c28
                 1. region b:1-218 [134055]
             13. 1ms6
                 complexed with bln
                 1. chain a [85080]
             14. 2hh5
                 automatically matched to d1ms6a_
                 complexed with cl, gnq, zn
                 1. region a:1-217 [136468]
             15. 2hh5
                 automatically matched to d1ms6a_
                 complexed with cl, gnq, zn
                 1. region b:1-217 [136469]
             16. 1nqc
                 complexed with c4p
                 1. chain a [86024]
             17. 2f1g
                 automatically matched to d1ms6a_
                 complexed with gnf, gol
                 1. region a:1-217 [132764]
             18. 2f1g
                 automatically matched to d1ms6a_
                 complexed with gnf, gol
                 1. region b:1-217 [132765]
             19. 2fud
                 automatically matched to d1ms6a_
                 complexed with crl
                 1. region a:1-218 [134117]
             20. 2fud
                 automatically matched to d1ms6a_
                 complexed with crl
                 1. region b:1-218 [134118]
             21. 2r9m
                 automatically matched to d1ms6a_
                 complexed with y11
                 1. region a:1-217 [151792]
             22. 2r9m
                 automatically matched to d1ms6a_
                 complexed with y11
                 1. region b:1-217 [151793]
             23. 2hxz
                 automatically matched to d1ms6a_
                 complexed with h7j, so4
                 1. region a:1-217 [136861]
             24. 2hxz
                 automatically matched to d1ms6a_
                 complexed with h7j, so4
                 1. region b:1-217 [136862]
             25. 2hxz
                 automatically matched to d1ms6a_
                 complexed with h7j, so4
                 1. region c:1-217 [136863]
             26. 1npz
                 complexed with c1p
                 1. chain a [86003]
                 2. chain b [86004]
             27. 2fra
                 automatically matched to d1ms6a_
                 complexed with crv
                 1. region a:1-218 [133978]
             28. 2fra
                 automatically matched to d1ms6a_
                 complexed with crv
                 1. region b:1-218 [133979]
             29. 2g7y
                 automatically matched to d1ms6a_
                 complexed with mo9
                 1. region a:1-218 [134739]
             30. 2g7y
                 automatically matched to d1ms6a_
                 complexed with mo9
                 1. region b:1-218 [134740]
             31. 2r9n
                 automatically matched to d1ms6a_
                 complexed with y14
                 1. region a:1-217 [151794]
             32. 2r9n
                 automatically matched to d1ms6a_
                 complexed with y14
                 1. region b:1-217 [151795]
             33. 2r9o
                 automatically matched to d1ms6a_
                 complexed with y15
                 1. region a:1-217 [151796]
             34. 2r9o
                 automatically matched to d1ms6a_
                 complexed with y15
                 1. region b:1-217 [151797]
             35. 1glo
                 mutant
                 1. chain a [76230]
             36. 2g6d
                 complexed with mqq; mutant
                 1. region a:1-211 [134702]
      19. (Pro)cathepsin V [64202]
          1. Human (Homo sapiens) [TaxId: 9606] [64203] (1)
             1. 1fh0
                complexed with bns, nfp, ods, so4; mutant
                1. chain a [59832]
                2. chain b [59833]
      20. (Pro)cathepsin X [54031]
          1. Human (Homo sapiens) [TaxId: 9606] [54032] (2)
             1. 1deu
                contains propeptide
                1. chain a [37085]
                2. chain b [37086]
             2. 1ef7
                1. chain a [37087]
                2. chain b [37088]
      21. Staphopain StpA [54033]
          1. Staphylococcus aureus [TaxId: 1280] [54034] (1)
             1. 1cv8
                complexed with act, e64
                1. chain a [37089]
      22. Staphopain SspB [102721]
          1. Staphylococcus aureus [TaxId: 1280] [102722] (4)
             SQ Q70UQ9 41-393
             1. 1pxv
                complexed with staphostatin B
                complexed with gai, so4; mutant
                1. chain a [95301]
                2. chain b [95302]
             2. 1y4h
                complexed with cl, so4
                1. region a:221-393 [122615]
             3. 1y4h
                automatically matched to 1Y4H A:221-393
                complexed with cl, so4
                1. region b:221-393 [122616]
             4. 1x9y
                1. region a:223-393 [115011]
                2. region b:223-393 [115013]
                3. region c:223-393 [115015]
                4. region d:223-393 [115017]
      23. Streptococcal pyrogenic exotoxin B [54035]
          1. Streptococcus pyogenes [TaxId: 1314] [54036] (2)
             SQ P00788 31-398
             1. 1dki
                zymogen
                complexed with so4; mutant
                1. chain a [37090]
                2. chain b [37091]
                3. chain c [37092]
                4. chain d [37093]
             2. 1pvj
                complexed with zfb
                1. chain a [104325]
                2. chain b [104326]
                3. chain c [104327]
                4. chain d [104328]
      24. Falcipain 2 [142846]
          1. Plasmodium falciparum [TaxId: 5833] [142847] (6)
             SQ Q9N6S8 244-484
             1. 2oul
                automatically matched to d1yvba1
                1. region a:-16-224 [149025]
             2. 1yvb
                complexed with gol
                1. region a:0-212 [124092]
             3. 2ghu
                automatically matched to 1YVB A:0-212
                1. region a:1-241 [135210]
             4. 2ghu
                automatically matched to 1YVB A:0-212
                1. region b:1-241 [135211]
             5. 2ghu
                automatically matched to 1YVB A:0-212
                1. region c:1-241 [135212]
             6. 2ghu
                automatically matched to 1YVB A:0-212
                1. region d:1-241 [135213]
      25. Major mite fecal allergen der p 1 [142848]
          1. House-dust mite (Dermatophagoides pteronyssinus) [TaxId: 6956] [142849] (3)
             SQ P08176 19-320! SQ P08176 99-320
             1. 1xkg
                complexed with gol, so4, yt3; mutant
                1. region a:4-305 [122081]
             2. 2as8
                complexed with mg; mutant
                1. region a:1-222 [127242]
             3. 2as8
                automatically matched to 2AS8 A:1-222
                complexed with mg; mutant
                1. region b:1-222 [127243]
   2. Avirulence protein Avrpph3 [102723] (1)
      1. Avirulence protein Avrpph3 [102724]
         1. Pseudomonas syringae pv. phaseolicola [TaxId: 319] [102725] (1)
            1. 1ukf
               1. chain a [99488]
   3. FMDV leader protease [54037] (1)
      1. FMDV leader protease [54038]
         1. Foot-and-mouth disease virus [TaxId: 12110] [54039] (5)
            1. 1qmy
               complexed with edo; mutant
               1. chain a [37094]
               2. chain b [37095]
               3. chain c [37096]
            2. 1qol
               complexed with cl, edo; mutant
               1. chain a [37097]
               2. chain b [37098]
               3. chain c [37099]
               4. chain d [37100]
               5. chain e [37101]
               6. chain f [37102]
               7. chain g [37103]
               8. chain h [37104]
            3. 2jqf
               automatically matched to d1qola_
               mutant
               1. region r:29-201 [148174]
            4. 2jqf
               automatically matched to d1qola_
               mutant
               1. region s:229-401 [148175]
            5. 2jqg
               automatically matched to d1qola_
               mutant
               1. region r:29-195 [148176]
   4. Calpain large subunit, catalytic domain (domain II) [54040] (5)
      1. Calpain large subunit, catalytic domain (domain II) [54041]
         includes the N-terminal 'sequence' domain I
         1. Human (Homo sapiens), M-type [TaxId: 9606] [54042] (2)
            1. 1kfu
               1. region l:2-355 [68573]
            2. 1kfx
               1. region l:2-355 [68577]
         2. Rat (Rattus norvegicus), M-type [TaxId: 10116] [54043] (3)
            1. 1mdw
               calcium-bound protease core
               complexed with ca; mutant
               1. chain a [84934]
               2. chain b [84935]
            2. 1df0
               mutant
               1. region a:2-355 [37106]
            3. 1u5i
               automatically matched to d1df0a3
               mutant
               1. region a:2-355 [119549]
         3. Rat (Rattus norvegicus), mu-type [TaxId: 10116] [75332] (10)
            SQ P97571 33-353
            1. 2r9f
               automatically matched to d1tloa_
               complexed with ca, cl, gol, k2z
               1. region a:33-354 [151767]
            2. 2g8j
               automatically matched to d1tloa_
               complexed with ca, d7g
               1. region a:33-354 [134773]
            3. 2r9c
               automatically matched to d1tloa_
               complexed with ca, cl, gol, grd
               1. region a:33-354 [151766]
            4. 1tl9
               complexed with ace, ca
               1. chain a [112505]
            5. 1tlo
               complexed with ca, e64
               1. chain a [112508]
            6. 1kxr
               calcium-bound protease core
               complexed with ca; mutant
               1. chain a [73175]
               2. chain b [73176]
            7. 2nqg
               automatically matched to d1tloa_
               complexed with ca, nqg
               1. region a:33-354 [138453]
            8. 2nqi
               automatically matched to d1tloa_
               complexed with ca, nqi
               1. region a:33-354 [138454]
            9. 2g8e
               automatically matched to d1tloa_
               complexed with ca, d5g, mes
               1. region a:33-354 [134769]
            10. 1qxp
                mu-like isoform with the large and small subunits fused in a single chain
                mutant
                1. region a:2-355 [96546]
                2. region b:2-355 [96550]
         4. Human (Homo sapiens), calpain 9 [TaxId: 9606] [142850] (1)
            SQ O14815 28-337
            1. 1ziv
               complexed with bme, ca
               1. region a:28-337 [125139]
         5. Human(Homo sapiens), mu type [TaxId: 9606] [142851] (3)
            SQ P07384 33-353! SQ P07384 33-354
            1. 1zcm
               complexed with c1n, ca; mutant
               1. region a:33-353 [124909]
            2. 2ary
               complexed with bme, ca
               1. region a:33-354 [127223]
            3. 2ary
               automatically matched to 2ARY A:33-354
               complexed with bme, ca
               1. region b:33-354 [127224]
   5. Transglutaminase core [54044] (6)
      1. Transglutaminase catalytic domain [54045]
         1. Human (Homo sapiens), blood isozyme [TaxId: 9606] [54046] (8)
            Coagulation factor XIII
            1. 1ex0
               complexed with ca, pgo, po4; mutant
               1. region a:191-510 [90468]
               2. region b:191-511 [90472]
            2. 1f13
               1. region a:191-515 [37107]
               2. region b:191-515 [37108]
            3. 1evu
               complexed with ca, pgo
               1. region a:191-508 [37113]
               2. region b:191-508 [37114]
            4. 1ggu
               complexed with ca
               1. region a:191-508 [37115]
               2. region b:191-508 [37116]
            5. 1fie
               1. region a:191-515 [37109]
               2. region b:191-515 [37110]
            6. 1qrk
               complexed with sr
               1. region a:191-511 [37119]
               2. region b:191-507 [37120]
            7. 1ggy
               complexed with yb
               1. region a:191-508 [37117]
               2. region b:191-508 [37118]
            8. 1ggt
               1. region a:191-515 [37111]
               2. region b:191-515 [37112]
         2. Human (Homo sapiens), tissue isozyme [TaxId: 9606] [75333] (2)
            GDP-binding protein
            1. 2q3z
               automatically matched to d1kv3a4
               complexed with ace, nh2, onl, so4
               1. region a:146-461 [150040]
            2. 1kv3
               complexed with gdp
               1. region a:146-468 [73030]
               2. region b:146-468 [73034]
               3. region c:146-468 [73038]
               4. region d:146-468 [73042]
               5. region e:146-468 [73046]
               6. region f:146-468 [73050]
         3. Human (Homo sapiens), TGase E3 [TaxId: 9606] [75334] (8)
            1. 1vjj
               complexed with ca, cl, gdp, mg; mutant
               1. region a:141-461 [100817]
               2. region b:141-459 [100821]
            2. 1sgx
               complexed with 5gp, ca, mg; mutant
               1. region a:141-461 [98865]
               2. region b:141-459 [98869]
            3. 1l9n
               complexed with bgl, ca, cl; mutant
               1. region a:141-460 [73743]
               2. region b:141-460 [73747]
            4. 1rle
               complexed with ca, gsp, mg; mutant
               1. region a:141-461 [97641]
               2. region b:141-459 [97645]
            5. 1l9m
               complexed with br, ca, cl; mutant
               1. region a:141-461 [73735]
               2. region b:141-460 [73739]
            6. 1nug
               complexed with ca, cl, mg; mutant
               1. region a:141-461 [86189]
               2. region b:141-459 [86193]
            7. 1nuf
               complexed with br, ca, cl; mutant
               1. region a:141-461 [86185]
            8. 1nud
               complexed with br, ca, cl; mutant
               1. region a:141-460 [86177]
               2. region b:141-460 [86181]
         4. Red sea bream (Chrysophrys major) [TaxId: 143350] [64204] (1)
            1. 1g0d
               complexed with so4
               1. region a:141-461 [60169]
      2. Peptide:N-glycanase 1, PNG1 [142852]
         1. Baker's yeast(Saccharomyces cerevisiae) [TaxId: 4932] [142853] (2)
            SQ Q02890 8-327
            1. 1x3z
               automatically matched to 1X3W A:8-327
               complexed with suc, zn
               1. region a:8-327 [121673]
            2. 1x3w
               complexed with suc, zn
               1. region a:8-327 [121671]
         2. Mouse (Mus musculus) [TaxId: 10090] [159840] (2)
            SQ Q9JI78 164-450
            1. 2f4m
               complexed with cl, zn
               1. region a:164-450 [145135]
            2. 2f4o
               automatically matched to 2F4M A:164-450
               complexed with cl, phq, zn
               1. region a:164-447 [145136]
   6. Arylamine N-acetyltransferase [54047] (4)
      fold similar to that of the factor XIII catalytic domain
      1. Arylamine N-acetyltransferase [54048]
         1. Salmonella typhimurium [TaxId: 90371] [54049] (1)
            1. 1e2t
               1. chain a [37121]
               2. chain b [37122]
               3. chain c [37123]
               4. chain d [37124]
               5. chain e [37125]
               6. chain f [37126]
               7. chain g [37127]
               8. chain h [37128]
         2. Mycobacterium smegmatis [TaxId: 1772] [75335] (7)
            1. 1w5r
               mutant
               1. region a:3-275 [120643]
            2. 1w5r
               automatically matched to 1W5R A:3-275
               mutant
               1. region b:3-275 [120644]
            3. 1gx3
               1. chain a [70678]
               2. chain b [70679]
               3. chain c [70680]
               4. chain d [70681]
            4. 1w6f
               automatically matched to d1gx3a_
               complexed with isz
               1. region a:3-275 [120656]
            5. 1w6f
               automatically matched to d1gx3a_
               complexed with isz
               1. region b:7-275 [120657]
            6. 1w6f
               automatically matched to d1gx3a_
               complexed with isz
               1. region c:4-275 [120658]
            7. 1w6f
               automatically matched to d1gx3a_
               complexed with isz
               1. region d:6-274 [120659]
         3. Rhizobium loti [TaxId: 381] [142854] (2)
            SQ Q98D42 6-275
            1. 2bsz
               1. region a:6-275 [129131]
            2. 2bsz
               automatically matched to 2BSZ A:6-275
               1. region b:7-274 [129132]
         4. Pseudomonas aeruginosa [TaxId: 287] [142855] (1)
            SQ Q9HUY3 1-277
            1. 1w4t
               complexed with so4
               1. region a:1-277 [120639]
   7. Ubiquitin carboxyl-terminal hydrolase UCH-L [54050] (3)
      1. Ubiquitin carboxyl-terminal hydrolase UCH-l3 [54051]
         1. Human (Homo sapiens) [TaxId: 9606] [54052] (2)
            SQ P15374
            1. 1xd3
               complexed with gve, mg
               1. chain a [115145]
               2. chain c [115147]
            2. 1uch
               1. chain a [37129]
         2. Synthetic, based on Saccharomyces cerevisiae sequence [54053] (1)
            1. 1cmx
               1. chain a [37130]
               2. chain c [37131]
      2. Ubiquitin carboxyl-terminal hydrolase isozyme l1 [142856]
         1. Human (Homo sapiens) [TaxId: 9606] [142857] (2)
            SQ P09936 1-223
            1. 2etl
               complexed with cl
               1. region a:1-223 [132361]
            2. 2etl
               automatically matched to 2ETL A:1-223
               complexed with cl
               1. region b:1-223 [132362]
   8. Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (5)
      Pfam 00443
      1. Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP) [82569]
         1. Human (Homo sapiens) [TaxId: 9606] [82570] (2)
            1. 1nbf
               complex with ubiquitin aldehyde
               complexed with glz
               1. chain a [80387]
               2. chain b [80388]
               3. chain e [80391]
            2. 1nb8
               complexed with mse
               1. chain a [80385]
               2. chain b [80386]
      2. Ubiquitin carboxyl-terminal hydrolase 6 [110769]
         1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [110770] (1)
            SQ P43593 103-499
            1. 1vjv
               1. chain a [108632]
      3. Ubiquitin carboxyl-terminal hydrolase 8 [142858]
         1. Human (Homo sapiens) [TaxId: 9606] [142859] (1)
            SQ P40818 762-1109
            1. 2gfo
               complexed with zn
               1. region a:762-1109 [135105]
      4. Ubiquitin carboxyl-terminal hydrolase 14 [142860]
         1. Human (Homo sapiens) [TaxId: 9606] [142861] (4)
            SQ P54578 100-482
            1. 2ayn
               1. region a:100-482 [127563]
            2. 2ayn
               automatically matched to 2AYN A:100-482
               1. region b:100-482 [127564]
            3. 2ayn
               automatically matched to 2AYN A:100-482
               1. region c:100-482 [127565]
            4. 2ayo
               automatically matched to 2AYN A:100-482
               1. region a:100-482 [127566]
      5. Ubiquitin carboxyl-terminal hydrolase 2, USP2 [159841]
         1. Human (Homo sapiens) [TaxId: 9606] [159842] (2)
            SQ O75604 263-600! SQ O75604 264-599
            1. 2hd5
               complexed with zn
               1. region a:211-521 [145293]
            2. 2ibi
               complexed with neh, zn; mutant
               1. region a:263-600 [145520]
   9. Adenain-like [54054] (5)
      Pfam 02902; Ulp1 protease family
      1. Human adenovirus 2 proteinase, adenain [54055]
         1. Mastadenovirus H2 [TaxId: 10515] [54056] (2)
            1. 1nln
               complexed with peptide cofactor, chain B
               complexed with acy
               1. chain a [91962]
            2. 1avp
               complexed with peptide cofactor, chain B
               1. chain a [37132]
      2. Ulp1 protease C-terminal domain [54057]
         1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [54058] (4)
            1. 1euv
               1. chain a [37133]
            2. 2hl9
               automatically matched to d1euva_
               1. region a:402-621 [147308]
            3. 2hl8
               automatically matched to d1euva_
               1. region a:401-621 [147307]
            4. 2hkp
               automatically matched to d1euva_
               1. region a:401-621 [147301]
      3. Sentrin-specific protease 2, SENP2 [110771]
         1. Human (Homo sapiens) [TaxId: 9606] [110772] (8)
            SQ Q9HC62 366-589
            1. 1th0
               1. chain a [106903]
               2. chain b [106904]
            2. 2io0
               complexed with so4; mutant
               1. region a:364-589 [145530]
            3. 2io1
               automatically matched to 2IO0 A:364-589
               mutant
               1. region a:367-589 [145531]
            4. 2io1
               automatically matched to 2IO0 A:364-589
               mutant
               1. region c:366-589 [145532]
            5. 2io1
               automatically matched to 2IO0 A:364-589
               mutant
               1. region e:367-589 [145533]
            6. 1tgz
               complexed with so4
               1. chain a [106901]
            7. 2io2
               automatically matched to 2IO0 A:364-589
               mutant
               1. region a:365-589 [145534]
            8. 2io3
               automatically matched to 2IO0 A:364-589
               mutant
               1. region a:366-589 [145536]
      4. Sentrin-specific protease 8, SENP8 [117760]
         1. Human (Homo sapiens) [TaxId: 9606] [117761] (6)
            SQ Q96LD8
            1. 2bkr
               automatically matched to 2BKQ A:1-212
               1. region a:1-212 [128710]
            2. 2bkq
               1. region a:1-212 [128706]
            3. 2bkq
               automatically matched to 2BKQ A:1-212
               1. region b:1-212 [128707]
            4. 2bkq
               automatically matched to 2BKQ A:1-212
               1. region c:1-212 [128708]
            5. 2bkq
               automatically matched to 2BKQ A:1-212
               1. region d:2-212 [128709]
            6. 1xt9
               1. chain a [116013]
      5. Sentrin-specific protease 1 [142862]
         1. Human (Homo sapiens) [TaxId: 9606] [142863] (6)
            SQ Q9P0U3 419-643
            1. 2iy1
               automatically matched to 2IY0 A:419-643
               mutant
               1. region a:419-643 [145553]
            2. 2iy1
               automatically matched to 2IY0 A:419-643
               mutant
               1. region c:419-643 [145554]
            3. 2iy0
               mutant
               1. region a:419-643 [145551]
            4. 2g4d
               mutant
               1. region a:440-643 [145184]
            5. 2g4d
               automatically matched to 2G4D A:440-643
               mutant
               1. region c:440-643 [145185]
            6. 2ckh
               1. region a:419-643 [130565]
   10. Microbial transglutaminase [75336] (1)
       inverted positions of the catalytic triad Asp and His residues
       1. Microbial transglutaminase [75337]
          1. Streptoverticillium mobaraense [TaxId: 35621] [75338] (1)
             1. 1iu4
                1. chain a [71430]
                2. chain b [71431]
                3. chain c [71432]
                4. chain d [71433]
   11. Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [110773] (1)
       probably the same as Pfam 02338, OTU-like cysteine protease, but 1TFF (SQ Q96DC9) was not detected by the Pfam model
       1. Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [110774]
          1. Human (Homo sapiens) [TaxId: 9606] [110775] (1)
             SQ Q96DC9
             1. 1tff
                mutant
                1. chain a [106854]
   12. IgG-specific endopeptidase IdeS (Sib38) [117762] (1)
       1. IgG-specific endopeptidase IdeS (Sib38) [117763]
          1. Streptococcus pyogenes [TaxId: 1314] [117764] (1)
             SQ Q9F1R7 38-339 # SPy0861
             1. 1y08
                complexed with so4; mutant
                1. chain a [116280]
   13. Lpg0564-like [142864] (1)
       Pfam 07313, DUF1460; contains new PDB entry 2p1g, annotated as putative xylanase
       1. Hypothetical protein Lpg0564 [142865]
          1. Legionella pneumophila [TaxId: 446] [142866] (1)
             SQ Q5ZY11 49-352
             1. 2im9
                1. region a:49-352 [137508]
   14. Phytochelatin synthase [142867] (1)
       Pfam 05023; assosiated Pfam 09328 (DUF1984) is a part of the same functional unit
       1. Primitive phytochelatin synthase [142868]
          1. Nostoc sp. pcc 7120 [TaxId: 103690] [142869] (4)
             SQ Q8YY76 29-238
             1. 2bu3
                automatically matched to 2BTW A:29-238
                complexed with 3gc, ca, cl
                1. region a:29-238 [129167]
             2. 2bu3
                automatically matched to 2BTW A:29-238
                complexed with 3gc, ca, cl
                1. region b:32-238 [129168]
             3. 2btw
                complexed with ca
                1. region b:29-238 [129160]
             4. 2btw
                complexed with ca
                1. region a:29-238 [129159]
   15. CHAP domain [142870] (1)
       Pfam 05257
       1. Glutathionylspermidine synthase, amidase domain [142871]
          1. Escherichia coli [TaxId: 562] [142872] (10)
             SQ P0AES0 10-200
             1. 2io8
                automatically matched to 2IO7 A:10-200
                complexed with adp, cys, mg
                1. region a:10-200 [137550]
             2. 2io8
                automatically matched to 2IO7 A:10-200
                complexed with adp, cys, mg
                1. region b:10-200 [137553]
             3. 2io9
                automatically matched to 2IO7 A:10-200
                complexed with adp, gsh, mg
                1. region a:10-200 [137556]
             4. 2io9
                automatically matched to 2IO7 A:10-200
                complexed with adp, gsh, mg
                1. region b:10-200 [137559]
             5. 2iob
                automatically matched to 2IO7 A:10-200
                1. region a:12-200 [137568]
             6. 2iob
                automatically matched to 2IO7 A:10-200
                1. region b:13-200 [137571]
             7. 2ioa
                automatically matched to 2IO7 A:10-200
                complexed with adp, gga, mg
                1. region a:10-200 [137562]
             8. 2ioa
                automatically matched to 2IO7 A:10-200
                complexed with adp, gga, mg
                1. region b:12-200 [137565]
             9. 2io7
                complexed with anp, mg
                1. region a:10-200 [137544]
             10. 2io7
                 automatically matched to 2IO7 A:10-200
                 complexed with anp, mg
                 1. region b:12-200 [137547]
   16. NlpC/P60 [142873] (1)
       Pfam 00877
       1. Cell wall-associated hydrolase Spr C-terminal domain [142874]
          1. Nostoc punctiforme [TaxId: 272131] [142875] (3)
             SQ Q8YRR4 87-234
             1. 2evr
                complexed with cl, edo, na
                1. region a:87-234 [132441]
             2. 2fg0
                automatically matched to 2EVR A:87-234
                complexed with gol
                1. region a:87-234 [133397]
             3. 2fg0
                automatically matched to 2EVR A:87-234
                complexed with gol
                1. region b:87-234 [133399]
   17. PMT C-terminal domain like [159843] (1)
       displays a minimal thiol-protease fold and its catalytic triad; potential redox regulation: the catalytic cysteine can form a disulfide bond with an N-terminal cysteine
       1. Dermonecrotic toxin, ToxA [159844]
          Synonym: Mitogenic toxin PMT
          1. Pasteurella multocida [TaxId: 747] [159845] (4)
             SQ P17452 1094-1285
             1. 2ebf
                complexed with 2po, tre
                1. region x:1094-1285 [146768]
             2. 2ebh
                complexed with tre; mutant
                1. region x:1094-1285 [146771]
             3. 2ec5
                mutant
                1. region a:1094-1285 [146780]
             4. 2ec5
                automatically matched to 2EC5 A:1094-1285
                mutant
                1. region b:1094-1285 [146783]
   18. MOA C-terminal domain-like [159846] (1)
       PfamB 070855
       1. Agglutinin MOA [159847]
          1. Fairy-ring mushroom (Marasmius oreades) [TaxId: 181124] [159848] (1)
             SQ Q8X123 156-293
             1. 2iho
                complexed with gal, nag
                1. region a:156-293 [147682]
   19. Atu2299-like [159849] (1)
       Pfam 09641; DUF2026; putative Cys/Ser-His-Asp catalytic triad
       1. Hypothetical protein Atu2299 [159850]
          Serine catalytic nucleophile
          1. Agrobacterium tumefaciens [TaxId: 358] [159851] (1)
             SQ Q8UD29 1-202
             1. 2hly
                1. region a:5-206 [147310]
   20. M48USP-like [159852] (1)
       Pfam 04843; Herpesvirus tegument protein, N-terminal conserved region
       1. Tegument protein M48; N-terminal domain [159853]
          1. Murine cytomegalovirus (MCMV) [TaxId: 10366] [159854] (2)
             SQ A8E1C4 1-232
             1. 2j7q
                complexed with gol, gve, mg, pg4
                1. region a:1-232 [145673]
             2. 2j7q
                complexed with gol, gve, mg, pg4
                1. region c:1-232 [145674]
   21. YiiX-like [159855] (1)
       Pfam 06520; DUF1105; circularly permuted active site residues compare to papain
       1. Hypothetical protein YiiX [159856]
          1. Escherichia coli [TaxId: 562] [159857] (2)
             SQ Q8X778 19-200
             1. 2if6
                complexed with unx
                1. region a:19-200 [147651]
             2. 2if6
                automatically matched to 2IF6 A:19-200
                complexed with unx
                1. region b:19-198 [147652]
   22. Autophagin-like [159858] (2)
       Pfam 03416
       1. Cysteine protease ATG4A [159859]
          Autophagin-2
          1. Human (Homo sapiens) [TaxId: 9606] [159860] (4)
             SQ Q8WYN0 26-359
             1. 2p82
                complexed with cl, edo
                1. region a:26-359 [149300]
             2. 2p82
                automatically matched to 2P82 A:26-359
                complexed with cl, edo
                1. region b:26-359 [149301]
             3. 2p82
                automatically matched to 2P82 A:26-359
                complexed with cl, edo
                1. region c:26-359 [149302]
             4. 2p82
                automatically matched to 2P82 A:26-359
                complexed with cl, edo
                1. region d:26-357 [149303]
       2. Cysteine protease ATG4B [159861]
          Autophagin-1
          1. Human (Homo sapiens) [TaxId: 9606] [159862] (5)
             SQ Q9Y4P1 10-373! SQ Q9Y4P1 5-354
             1. 2z0d
                mutant
                1. region a:5-354 [145769]
             2. 2z0e
                automatically matched to 2Z0D A:5-354
                mutant
                1. region a:5-354 [145770]
             3. 2cy7
                automatically matched to 2D1I A:10-373
                1. region a:10-373 [146431]
             4. 2d1i
                1. region a:10-373 [146447]
             5. 2d1i
                automatically matched to 2D1I A:10-373
                1. region b:10-373 [146448]

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk