Structural Classification of Proteins
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Fold: (Phosphotyrosine protein) phosphatases II

core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: (Phosphotyrosine protein) phosphatases II [52798]
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

Superfamilies:

  1. (Phosphotyrosine protein) phosphatases II [52799] (5)
    share with the family I the common active site structure with a circularly permuted topology
    link to SUPERFAMILY database - Superfamily
    1. Dual specificity phosphatase-like [52800] (10)
      1. VH1-related dual-specificity phosphatase, VHR [52801]
        1. Human (Homo sapiens) [TaxId: 9606] [52802] (2) picpic
      2. Mapk phosphatase [52803]
        1. Human (Homo sapiens), pyst1 (mkp3) [TaxId: 9606] [52804] (1) picpic
        2. Human (Homo sapiens), pac-1 [TaxId: 9606] [75232] (1) picpic
      3. Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain [52818]
        1. Human (Homo sapiens) [TaxId: 9606] [52819] (1) picpic
      4. Proline directed phosphatase CDC14b2 [89698]
        duplication: consists of two structurally similar domains with the catalytic site being in the C-terminal domain
        1. Human (Homo sapiens) [TaxId: 9606] [89699] (3) picpic
      5. Protein tyrosine phosphatase type IVa [102418]
        1. Human (Homo sapiens), pr-3 [TaxId: 9606] [102419] (2) picpic
          SQ O75365 1-162 # 99% sequence identity
        2. Human (Homo sapiens), pr-1 [TaxId: 9606] [117578] (1) picpic
          SQ Q93096 9-160
      6. mRNA capping enzyme, triphosphatase domain [64047]
        1. Mouse (Mus musculus) [TaxId: 10090] [64048] (2) picpic
      7. Kinase associated phosphatase (kap) [64049]
        1. Human (Homo sapiens) [TaxId: 9606] [64050] (2) picpic
      8. Putative phosphatase At1g05000 [117579]
        1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117580] (3) picpic
          SQ Q9ZVN4 52-201
    2. Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (12)
      has an extension to the beta-sheet of 3 antiparallel strands before strand 4
      1. Tyrosine phosphatase [52806]
        1. Human (Homo sapiens), 1B [TaxId: 9606] [52807] (92) picpic
          SQ P18031 2-300 ! SQ P18031 1-298 ! SQ P18031 2-299
        2. Human (Homo sapiens), mu [TaxId: 9606] [52808] (1) picpic
          receptor protein tyrosine phosphatase mu, domain 1
        3. Mouse (Mus musculus) [TaxId: 10090] [52809] (1) picpic
          receptor protein tyrosine phosphatase alpha, domain 1
        4. Human (Homo sapiens), shp-2 [TaxId: 9606] [52810] (1) picpic
        5. Human (Homo sapiens), shp-1 [TaxId: 9606] [52811] (2) picpic
        6. Mouse (Mus musculus), ptp-sl/br7 [TaxId: 10090] [64051] (1) picpic
        7. Human (Homo sapiens), T-cell [TaxId: 9606] [75233] (1) picpic
          non-receptor type 2
      2. Protein-tyrosine phosphatase YopH, catalytic domain [100952]
        1. Yersinia enterocolitica [TaxId: 630] [52812] (13) picpic
      3. SptP tyrosine phosphatase, catalytic domain [52813]
        1. Salmonella typhimurium [TaxId: 90371] [52814] (2) picpic
      4. RPTP Lar [52815]
        duplication: tandem repeat of the phosphatase domain
        1. Human (Homo sapiens) [TaxId: 9606] [52816] (1) picpic
      5. Protein-tyrosine phosphatase alpha [102420]
        1. Mouse (Mus musculus) [TaxId: 10090] [102421] (1) picpic
      6. Tyrosine-protein phosphatase, non-receptor type 13 (PTPL1) [117581]
        1. Human (Homo sapiens) [TaxId: 9606] [117582] (1) picpic
          SQ Q12923 2170-2477 # structure of a PDZ domain (1361-1456) is also known (scop_sp 50169)
    3. Myotubularin-like phosphatases [102422] (1)
      common fold is decorated with additional structures
      1. Myotubularin-related protein 2, C-terminal domain [102423]
        1. Human (Homo sapiens) [TaxId: 9606] [102424] (4) picpic
    4. Myo-inositol hexaphosphate phosphohydrolase (phytase) PhyA [117583] (1)
      1. Myo-inositol hexaphosphate phosphohydrolase (phytase) PhyA [117584]
        1. Selenomonas ruminantium [TaxId: 971] [117585] (13) picpic
          SQ Q7WUJ1 34-346
    5. Mycobacterial PtpB-like [142348] (1)
      1. Phosphotyrosine protein phosphatase PtpB [142349]
        1. Mycobacterium tuberculosis [TaxId: 1773] [142350] (3) picpic
          SQ P96830 4-275
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk