Structural Classification of Proteins
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Family: Higher-molecular-weight phosphotyrosine protein phosphatases

has an extension to the beta-sheet of 3 antiparallel strands before strand 4

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: (Phosphotyrosine protein) phosphatases II [52798]
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
  4. Superfamily: (Phosphotyrosine protein) phosphatases II [52799]
    share with the family I the common active site structure with a circularly permuted topology
    link to SUPERFAMILY database - Superfamily
  5. Family: Higher-molecular-weight phosphotyrosine protein phosphatases [52805]
    has an extension to the beta-sheet of 3 antiparallel strands before strand 4

Protein Domains:

  1. Tyrosine phosphatase [52806]
    1. Human (Homo sapiens), 1B [TaxId: 9606] [52807] (92) picpic
      SQ P18031 2-300 ! SQ P18031 1-298 ! SQ P18031 2-299
    2. Human (Homo sapiens), mu [TaxId: 9606] [52808] (1) picpic
      receptor protein tyrosine phosphatase mu, domain 1
    3. Mouse (Mus musculus) [TaxId: 10090] [52809] (1) picpic
      receptor protein tyrosine phosphatase alpha, domain 1
    4. Human (Homo sapiens), shp-2 [TaxId: 9606] [52810] (1) picpic
    5. Human (Homo sapiens), shp-1 [TaxId: 9606] [52811] (2) picpic
    6. Mouse (Mus musculus), ptp-sl/br7 [TaxId: 10090] [64051] (1) picpic
    7. Human (Homo sapiens), T-cell [TaxId: 9606] [75233] (1) picpic
      non-receptor type 2
  2. Protein-tyrosine phosphatase YopH, catalytic domain [100952]
    1. Yersinia enterocolitica [TaxId: 630] [52812] (13) picpic
  3. SptP tyrosine phosphatase, catalytic domain [52813]
    1. Salmonella typhimurium [TaxId: 90371] [52814] (2) picpic
  4. RPTP Lar [52815]
    duplication: tandem repeat of the phosphatase domain
    1. Human (Homo sapiens) [TaxId: 9606] [52816] (1) picpic
  5. Protein-tyrosine phosphatase alpha [102420]
    1. Mouse (Mus musculus) [TaxId: 10090] [102421] (1) picpic
  6. Tyrosine-protein phosphatase, non-receptor type 13 (PTPL1) [117581]
    1. Human (Homo sapiens) [TaxId: 9606] [117582] (1) picpic
      SQ Q12923 2170-2477 # structure of a PDZ domain (1361-1456) is also known (scop_sp 50169)
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk