Structural Classification of Proteins
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Family: ABC transporter ATPase domain-like

there are two additional subdomains inserted into the central core that has a RecA-like topology

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a/b) [51349]
    Mainly parallel beta sheets (beta-alpha-beta units)
  3. Fold: P-loop containing nucleoside triphosphate hydrolases [52539]
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. Superfamily: P-loop containing nucleoside triphosphate hydrolases [52540]
    division into families based on beta-sheet topologies
    link to SUPERFAMILY database - Superfamily
  5. Family: ABC transporter ATPase domain-like [52686]
    there are two additional subdomains inserted into the central core that has a RecA-like topology

Protein Domains:

  1. ATP-binding subunit of the histidine permease [52687]
    1. Salmonella typhimurium [TaxId: 90371] [52688] (1)
      1. 1b0u picpic
        1. chain a [32370] picpiclink
  2. Branched chain aminoacid ABC transporter [75207]
    1. Thermotoga maritima, TM1139 [TaxId: 2336] [75208] (1)
      1. 1ji0 picpic
        complexed with atp, mse
        1. chain a [71665] picpiclink
  3. MJ1267 [64025]
    1. Archaeon Methanococcus jannaschii [TaxId: 2190] [64026] (3)
      1. 1g6h picpic
        complexed with adp, hgc, mg
        1. chain a [60318] picpiclink
      2. 1gaj picpic
        complexed with cl, peg, so4, tbu
        1. chain a [60416] picpiclink
      3. 1g9x picpic
        complexed with adp, hgc, mg; mutant
        1. chain a [76219] picpiclink
        2. chain b [76220] picpiclink
        3. chain c [76221] picpiclink
  4. MJ0796 [64027]
    1. Archaeon Methanococcus jannaschii [TaxId: 2190] [64028] (2)
      1. 1l2t picpic
        complexed with atp, ioh, na; mutant
        1. chain a [73514] picpiclink
        2. chain b [73515] picpiclink
      2. 1f3o picpic
        complexed with adp, mg
        1. chain a [59631] picpiclink
  5. Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain [102378]
    1. Mouse (Mus musculus) [TaxId: 10090] [102379] (8)
      SQ P26361 390-670
      1. 1r0w picpic
        complexed with acy
        1. chain a [96754] picpiclink
        2. chain b [96755] picpiclink
        3. chain c [96756] picpiclink
        4. chain d [96757] picpiclink
      2. 1r0x picpic
        complexed with acy, atp, mg
        1. chain a [96758] picpiclink
        2. chain b [96759] picpiclink
        3. chain c [96760] picpiclink
        4. chain d [96761] picpiclink
      3. 1r0z picpic
        complexed with acy, atp, mg
        1. chain a [96766] picpiclink
        2. chain b [96767] picpiclink
        3. chain c [96768] picpiclink
        4. chain d [96769] picpiclink
      4. 1q3h picpic
        complexed with acy, anp, mg
        1. chain a [95688] picpiclink
        2. chain b [95689] picpiclink
        3. chain c [95690] picpiclink
        4. chain d [95691] picpiclink
      5. 1xf9 picpic
        complexed with acy, atp, mg; mutant
        1. chain a [115245] picpiclink
        2. chain b [115246] picpiclink
        3. chain c [115247] picpiclink
        4. chain d [115248] picpiclink
      6. 1r0y picpic
        complexed with acy, adp
        1. chain a [96762] picpiclink
        2. chain b [96763] picpiclink
        3. chain c [96764] picpiclink
        4. chain d [96765] picpiclink
      7. 1xfa picpic
        complexed with acy, atp, cl, mg; mutant
        1. chain a [115249] picpiclink
        2. chain b [115250] picpiclink
      8. 1r10 picpic
        complexed with acy, atp, mg
        1. chain a [96770] picpiclink
        2. chain b [96771] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [117543] (2)
      SQ P13569 389-671
      1. 1xmi picpic
        complexed with atp, mg; mutant
        1. chain a [115489] picpiclink
        2. chain b [115490] picpiclink
        3. chain c [115491] picpiclink
        4. chain d [115492] picpiclink
        5. chain e [115493] picpiclink
      2. 1xmj picpic
        complexed with atp, mg; mutant
        1. chain a [115494] picpiclink
  6. Peptide transporter Tap1, C-terminal ABC domain [64029]
    1. Human (Homo sapiens) [TaxId: 9606] [64030] (1)
      1. 1jj7 picpic
        complexed with adp, mg
        1. chain a [63114] picpiclink
  7. Maltose transport protein MalK, N-terminal domain [52689]
    1. Archaeon Thermococcus litoralis [TaxId: 2265] [52690] (1)
      1. 1g29 picpicxref
        CASP4
        complexed with cl, dox, mg, na, nh4, pop
        1. region 1:1-240 [32371] picpiclink
        2. region 2:1-240 [32372] picpiclink
    2. Escherichia coli [TaxId: 562] [102380] (13)
      1. 2awn picpicxrefxrefxrefxref
        automatically matched to d1q12a2
        complexed with adp, mg
        1. region a:4-235 [127460] picpiclink
      2. 2awn picpicxrefxrefxrefxref
        automatically matched to d1q12a2
        complexed with adp, mg
        1. region b:4-235 [127462] picpiclink
      3. 2awn picpicxrefxrefxrefxref
        automatically matched to d1q12a2
        complexed with adp, mg
        1. region c:4-235 [127464] picpiclink
      4. 2awn picpicxrefxrefxrefxref
        automatically matched to d1q12a2
        complexed with adp, mg
        1. region d:4-235 [127466] picpiclink
      5. 1q12 picpicxref
        complexed with atp
        1. region a:4-235 [95530] picpiclink
        2. region b:4-235 [95532] picpiclink
        3. region c:4-235 [95534] picpiclink
        4. region d:4-235 [95536] picpiclink
      6. 2r6g picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1q12a2
        complexed with atp, mal; mutant
        1. region a:4-235 [151605] picpiclink
      7. 2r6g picpicxrefxrefxrefxrefxrefxref
        automatically matched to d1q12a2
        complexed with atp, mal; mutant
        1. region b:4-235 [151607] picpiclink
      8. 2awo picpicxrefxrefxrefxref
        automatically matched to d1q12a2
        complexed with adp, mg
        1. region a:4-235 [127468] picpiclink
      9. 2awo picpicxrefxrefxrefxref
        automatically matched to d1q12a2
        complexed with adp, mg
        1. region b:4-235 [127470] picpiclink
      10. 2awo picpicxrefxrefxrefxref
        automatically matched to d1q12a2
        complexed with adp, mg
        1. region c:4-235 [127472] picpiclink
      11. 2awo picpicxrefxrefxrefxref
        automatically matched to d1q12a2
        complexed with adp, mg
        1. region d:4-235 [127474] picpiclink
      12. 1q1e picpicxref
        1. region a:4-235 [95571] picpiclink
        2. region b:4-235 [95573] picpiclink
      13. 1q1b picpicxref
        1. region a:4-235 [95563] picpiclink
        2. region b:4-235 [95565] picpiclink
        3. region c:4-235 [95567] picpiclink
        4. region d:4-235 [95569] picpiclink
  8. Glucose transport protein GlcV, N-terminal domain [89681]
    1. Archaeon Sulfolobus solfataricus [TaxId: 2287] [89682] (5)
      1. 1oxx picpicxref
        complexed with iod; mutant
        1. region k:1-242 [93716] picpiclink
      2. 1oxs picpicxref
        complexed with iod
        1. region c:1-242 [87520] picpiclink
      3. 1oxv picpicxref
        complexed with anp, iod, mg
        1. region a:1-242 [87534] picpiclink
        2. region b:1-242 [87536] picpiclink
        3. region d:1-242 [87538] picpiclink
      4. 1oxu picpicxref
        complexed with adp, iod, mg
        1. region a:1-242 [87528] picpiclink
        2. region b:1-242 [87530] picpiclink
        3. region c:1-242 [87532] picpiclink
      5. 1oxt picpicxref
        1. region a:1-242 [87522] picpiclink
        2. region b:1-242 [87524] picpiclink
        3. region d:1-242 [87526] picpiclink
  9. ABC transporter involved in vitamin B12 uptake, BtuD [75209]
    1. Escherichia coli [TaxId: 562] [75210] (1)
      1. 1l7v picpicxref
        complexed with mse, v4o
        1. chain c [73674] picpiclink
        2. chain d [73675] picpiclink
  10. Haemolysin B ATP-binding protein [89683]
    1. Escherichia coli [TaxId: 562] [89684] (3)
      1. 2pmk picpic
        automatically matched to d1mt0a_
        complexed with 128, adp
        1. region a:467-707 [149669] picpiclink
      2. 2ff7 picpic
        automatically matched to d1mt0a_
        complexed with adp
        1. region a:467-707 [133377] picpiclink
      3. 1mt0 picpic
        complexed with so4
        1. chain a [85096] picpiclink
  11. Multidrug resistance ABC transporter MsbA, C-terminal domain [89685]
    a low-resolution structure of the E. coli MsbA in an open conformation is also available (f.35.1.1)
    1. Vibrio cholerae [TaxId: 666] [89686] (1)
      1. 1pf4 picpicxref
        structure in a closed conformation
        1. region a:321-564 [88052] picpiclink
        2. region b:321-564 [88054] picpiclink
        3. region c:321-564 [88056] picpiclink
        4. region d:321-564 [88058] picpiclink
    2. Salmonella typhimurium [TaxId: 90371] [159568] (12)
      SQ P63359 329-581
      1. 3b60 picpicxrefxrefxrefxref
        complexed with anp
        1. region a:329-581 [154868] picpiclink
      2. 3b60 picpicxrefxrefxrefxref
        automatically matched to 3B60 A:329-581
        complexed with anp
        1. region b:329-581 [154870] picpiclink
      3. 3b60 picpicxrefxrefxrefxref
        automatically matched to 3B60 A:329-581
        complexed with anp
        1. region c:329-581 [154872] picpiclink
      4. 3b60 picpicxrefxrefxrefxref
        automatically matched to 3B60 A:329-581
        complexed with anp
        1. region d:329-581 [154874] picpiclink
      5. 3b5y picpicxrefxrefxrefxref
        automatically matched to 3B60 A:329-581
        complexed with anp
        1. region a:329-581 [154852] picpiclink
      6. 3b5y picpicxrefxrefxrefxref
        automatically matched to 3B60 A:329-581
        complexed with anp
        1. region b:329-581 [154854] picpiclink
      7. 3b5y picpicxrefxrefxrefxref
        automatically matched to 3B60 A:329-581
        complexed with anp
        1. region c:329-581 [154856] picpiclink
      8. 3b5y picpicxrefxrefxrefxref
        automatically matched to 3B60 A:329-581
        complexed with anp
        1. region d:329-581 [154858] picpiclink
      9. 3b5z picpicxrefxrefxrefxref
        automatically matched to 3B60 A:329-581
        complexed with adp, i42
        1. region a:329-581 [154860] picpiclink
      10. 3b5z picpicxrefxrefxrefxref
        automatically matched to 3B60 A:329-581
        complexed with adp, i42
        1. region b:329-581 [154862] picpiclink
      11. 3b5z picpicxrefxrefxrefxref
        automatically matched to 3B60 A:329-581
        complexed with adp, i42
        1. region c:329-581 [154864] picpiclink
      12. 3b5z picpicxrefxrefxrefxref
        automatically matched to 3B60 A:329-581
        complexed with adp, i42
        1. region d:329-581 [154866] picpiclink
  12. Multidrug resistance ABC transporter LmrA, C-terminal domain [102381]
    1. Lactococcus lactis [TaxId: 1358] [102382] (1)
      1. 1mv5 picpic
        complexed with adp, atp, mg
        1. chain a [91469] picpiclink
        2. chain b [91470] picpiclink
        3. chain c [91471] picpiclink
        4. chain d [91472] picpiclink
  13. Rad50 [52691]
    1. Archaeon Pyrococcus furiosus [TaxId: 2261] [52692] (4)
      1. 1f2t picpic
        N- and C-terminal subdomains only; the middle coiled coil domain is deleted
        1. chain a,b [32373] picpiclink
      2. 1f2u picpic
        N- and C-terminal subdomains only; the middle coiled coil domain is deleted
        complexed with atp, mg
        1. chain a,b [32374] picpiclink
        2. chain c,d [32375] picpiclink
      3. 1us8 picpic
        N- and C-terminal subdomains only; the middle coiled coil domain is deleted
        mutant
        1. chain a,b [99859] picpiclink
      4. 1ii8 picpic
        N- and C-terminal subdomains; include a small fragment of the middle coiled coil domain
        complexed with po4
        1. chain a,b [62417] picpiclink
  14. Smc head domain [52693]
    1. Thermotoga maritima [TaxId: 2336] [52694] (1)
      1. 1e69 picpic
        N- and C-terminal subdomains only; the middle coiled coil domain is deleted
        1. chain a [32376] picpiclink
        2. chain b [32377] picpiclink
        3. chain c [32378] picpiclink
        4. chain d [32379] picpiclink
        5. chain e [32380] picpiclink
        6. chain f [32381] picpiclink
    2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [117544] (1)
      SQ P32908 2-214,1024-1223
      1. 1w1w picpicxref
        complexed with atg, mg
        1. chain a [114080] picpiclink
        2. chain b [114081] picpiclink
        3. chain c [114082] picpiclink
        4. chain d [114083] picpiclink
    3. Pyrococcus furiosus [TaxId: 2261] [117545] (2)
      SQ Q877I1 1-167,1012-1173
      1. 1xew picpic
        1. chain x,y [115235] picpiclink
      2. 1xex picpic
        complexed with atp, mg; mutant
        1. chain a,b [115236] picpiclink
  15. Cell division protein MukB [52695]
    1. Escherichia coli [TaxId: 562] [52696] (1)
      1. 1qhl picpic
        N-terminal (sub)domain only; in the absence of the C-terminal domain complementing the central core structure, the P-loop region folds in a helix-loop-helix structure
        1. chain a [32382] picpiclink
  16. DNA repair protein MutS, the C-terminal domain [52697]
    1. Thermus aquaticus [TaxId: 271] [52698] (4)
      1. 1ewq picpicxrefxrefxref
        CASP4
        complexed with edo, so4
        1. region a:542-765 [32383] picpiclink
        2. region b:1542-1762 [32384] picpiclink
      2. 1fw6 picpicxrefxrefxref
        protein/DNA complex; complexed with adp, mg, so4
        1. region a:542-765 [32385] picpiclink
        2. region b:1542-1762 [32386] picpiclink
      3. 1nne picpicxrefxrefxref
        complexed with adp, bef, edo, so4
        1. region a:542-765 [85896] picpiclink
        2. region b:1542-1765 [85900] picpiclink
      4. 1ewr picpicxrefxref
        1. region a:542-765 [32387] picpiclink
        2. region b:1542-1762 [32388] picpiclink
    2. Escherichia coli [TaxId: 562] [52699] (10)
      SQ P23909 2-800
      1. 1wb9 picpicxrefxrefxref
        automatically matched to d1e3ma2
        complexed with adp, mg; mutant
        1. region a:567-800 [120834] picpiclink
      2. 1w7a picpicxrefxrefxref
        complexed with atp, mo3
        1. region a:567-800 [109219] picpiclink
        2. region b:567-800 [109223] picpiclink
      3. 1e3m picpicxrefxrefxref
        complexed with adp, mo4
        1. region a:567-800 [32389] picpiclink
        2. region b:567-800 [32390] picpiclink
      4. 1oh6 picpicxrefxrefxref
        complexed with adp, mo4
        1. region a:567-800 [92988] picpiclink
        2. region b:567-800 [92992] picpiclink
      5. 1wbd picpicxrefxrefxref
        automatically matched to d1e3ma2
        complexed with adp, mg; mutant
        1. region a:567-800 [120842] picpiclink
      6. 1wbb picpicxrefxrefxref
        automatically matched to d1e3ma2
        complexed with adp, mg; mutant
        1. region a:567-800 [120838] picpiclink
      7. 1ng9 picpicxrefxrefxref
        complexed with adp, mo6; mutant
        1. region a:567-800 [80481] picpiclink
        2. region b:567-800 [80485] picpiclink
      8. 1oh7 picpicxrefxrefxref
        complexed with adp, mo4
        1. region a:567-800 [92996] picpiclink
        2. region b:567-800 [93000] picpiclink
      9. 1oh5 picpicxrefxrefxref
        complexed with adp, mo4
        1. region a:567-800 [92980] picpiclink
        2. region b:567-800 [92984] picpiclink
      10. 1oh8 picpicxrefxrefxref
        complexed with adp, mo4
        1. region a:567-800 [93004] picpiclink
        2. region b:567-800 [93008] picpiclink
  17. Putative ABC transporter PF0895 [110560]
    1. Pyrococcus furiosus [TaxId: 2261] [110561] (1)
      SQ Q8U2E3
      1. 1sgw picpic
        Structural genomics target
        complexed with cl, na
        1. chain a [105541] picpiclink
  18. Hypothetical protein PH0022, N-terminal domain [117546]
    1. Pyrococcus horikoshii [TaxId: 53953] [117547] (2)
      SQ O57758
      1. 1v43 picpicxref
        1. region a:7-245 [113523] picpiclink
      2. 1vci picpicxref
        complexed with atp
        1. region a:7-245 [113609] picpiclink
  19. Putative ABC transporter TM0544 [117548]
    1. Thermotoga maritima [TaxId: 2336] [117549] (1)
      SQ Q9WZ14
      1. 1vpl picpic
        Structural genomics target
        complexed with so4
        1. chain a [113966] picpiclink
  20. Putative multidrug export ATP-binding/permease protein SAV1866 [142303]
    1. Staphylococcus aureus [TaxId: 1280] [142304] (4)
      SQ Q99T13 324-578
      1. 2hyd picpicxrefxref
        complexed with adp, na
        1. region a:324-578 [136875] picpiclink
      2. 2hyd picpicxrefxref
        automatically matched to 2HYD A:324-578
        complexed with adp, na
        1. region b:324-578 [136877] picpiclink
      3. 2onj picpicxrefxref
        automatically matched to 2HYD A:324-578
        complexed with anp, na
        1. region a:324-578 [139154] picpiclink
      4. 2onj picpicxrefxref
        automatically matched to 2HYD A:324-578
        complexed with anp, na
        1. region b:324-578 [139156] picpiclink
  21. Molybdate/tungstate import ATP-binding protein WtpC (ModC) [159569]
    1. Archaeoglobus fulgidus [TaxId: 2234] [159570] (4)
      SQ O30144 1-240
      1. 2onk picpicxrefxrefxrefxrefxrefxref
        complexed with mg, po4, wo4
        1. region a:1-240 [148903] picpiclink
      2. 2onk picpicxrefxrefxrefxrefxrefxref
        automatically matched to 2ONK A:1-240
        complexed with mg, po4, wo4
        1. region b:1-240 [148904] picpiclink
      3. 2onk picpicxrefxrefxrefxrefxrefxref
        automatically matched to 2ONK A:1-240
        complexed with mg, po4, wo4
        1. region f:1-240 [148908] picpiclink
      4. 2onk picpicxrefxrefxrefxrefxrefxref
        automatically matched to 2ONK A:1-240
        complexed with mg, po4, wo4
        1. region g:1-240 [148909] picpiclink
  22. Methionine import ATP-binding protein MetN [159571]
    1. Escherichia coli [TaxId: 562] [159572] (4)
      SQ P30750 1-240
      1. 3dhw picpicxrefxrefxrefxrefxrefxrefxrefxref
        1. region c:1-240 [157729] picpiclink
      2. 3dhw picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 3DHW C:1-240
        1. region d:1-240 [157731] picpiclink
      3. 3dhw picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 3DHW C:1-240
        1. region g:1-240 [157735] picpiclink
      4. 3dhw picpicxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to 3DHW C:1-240
        1. region h:1-240 [157737] picpiclink
  23. Sulfate/molybdate ABC transporter, ATP-binding protein [159573]
    1. Methanosarcina acetivorans [TaxId: 2214] [159574] (2)
      SQ Q8TTZ3 1-229
      1. 3d31 picpicxrefxrefxrefxref
        complexed with wo4
        1. region a:1-229 [157262] picpiclink
      2. 3d31 picpicxrefxrefxrefxref
        automatically matched to 3D31 A:1-229
        complexed with wo4
        1. region b:1-229 [157264] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk