Family: Class I aldolase

the catalytic lysine forms schiff-base intermediate with substrate
possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels

Lineage:

1. Root: scop
2. Class: Alpha and beta proteins (a/b) [51349]
   Mainly parallel beta sheets (beta-alpha-beta units)
3. Fold: TIM beta/alpha-barrel [51350]
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites
4. Superfamily: Aldolase [51569]
   Common fold covers whole protein structure
   uperfamily
5. Family: Class I aldolase [51570]
   the catalytic lysine forms schiff-base intermediate with substrate
   possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels

Protein Domains:

1. Deoxyribose-phosphate aldolase DeoC [69394]
   1. Escherichia coli [TaxId: 562] [69395] (4)
      SQ P00882
   2. Thermotoga maritima [TaxId: 2336] [82270] (1)
      TM1559
   3. Aquifex aeolicus [TaxId: 63363] [82271] (1)
   4. Thermus thermophilus [TaxId: 274] [89492] (2)
   5. Archaeon Aeropyrum pernix [TaxId: 56636] [89493] (1)
   6. Archaeon Pyrobaculum aerophilum [TaxId: 13773] [141830] (2)
      SQ Q8ZXK7 1-226
2. Archaeal fructose 1,6-bisphosphate aldolase [102088]
   1. Archaeon Thermoproteus tenax [TaxId: 2271] [102089] (23)
3. N-acetylneuraminate lyase [51571]
   1. Escherichia coli [TaxId: 562] [51572] (4)
   2. Haemophilus influenzae [TaxId: 727] [51573] (6)
4. Dihydrodipicolinate synthase [51574]
   1. Escherichia coli [TaxId: 562] [51575] (14)
   2. Thermotoga maritima [TaxId: 2336] [102090] (1)
   3. Mycobacterium tuberculosis [TaxId: 1773] [141831] (8)
      SQ P63945 5-300
   4. Bacillus anthracis [TaxId: 1392] [141832] (8)
      SQ Q81WN7 1-292
5. Fructose-1,6-bisphosphate aldolase [51576]
   1. Human (Homo sapiens), muscle isozyme [TaxId: 9606] [51577] (3)
   2. Human (Homo sapiens), liver isozyme [TaxId: 9606] [51578] (17)
   3. Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId: 9986] [51580] (42)
   4. Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId: 9986] [63920] (1)
   5. Drosophila melanogaster [TaxId: 7227] [51579] (1)
   6. Plasmodium falciparum [TaxId: 5833] [51581] (1)
   7. Trypanosome (Leishmania mexicana) [TaxId: 5665] [51582] (13)
   8. Trypanosome (Trypanosoma brucei) [TaxId: 5691] [51583] (1)
   9. Plasmodium yoelii yoelii [TaxId: 73239] [141833] (2)
      SQ Q7RMC9 3-258
   10. Human (Homo sapiens), brain isozyme [TaxId: 9606] [141834] (12)
       SQ P09972 2-343
6. KDPG aldolase [51584]
   1. Escherichia coli [TaxId: 562] [51585] (11)
   2. Pseudomonas putida [TaxId: 303] [102091] (1)
   3. Thermotoga maritima [TaxId: 2336] [110357] (7)
      SQ Q9WXS1
7. Hypothetical protein HI0047 [102092]
   putative KHG/KDPG aldolase
   1. Haemophilus influenzae [TaxId: 727] [102093] (1)
8. Type I 3-dehydroquinate dehydratase [51586]
   1. Salmonella typhi [TaxId: 90370] [51587] (3)
   2. Staphylococcus aureus [TaxId: 1280] [117378] (2)
      SQ Q6GII7
9. Transaldolase [51588]
   probably related to class I aldolases by a circular permutation
   1. Escherichia coli [TaxId: 562] [51589] (7)
   2. Human (Homo sapiens) [TaxId: 9606] [51590] (1)
   3. Mouse (Mus musculus) [TaxId: 10090] [141835] (4)
      SQ Q93092 13-331
10. Decameric fructose-6-phosphate aldolase/transaldolase [75085]
    forms helix-swapped pentamers
    1. Escherichia coli [TaxId: 562] [75086] (1)
    2. Thermotoga maritima [TaxId: 2336] [117379] (1)
       SQ Q9WYD1
    3. Thermus thermophilus [TaxId: 274] [141836] (10)
       SQ Q5SJE8 1-211
       clear orthologue of the E.coli protein; annotated as transaldolase in UniProt
11. Putative aldolase YihT [110358]
    1. Salmonella typhimurium [TaxId: 90371] [110359] (1)
       SQ Q9L7R9
12. 2-keto-3-deoxy gluconate aldolase Eda [110360]
    1. Sulfolobus solfataricus [TaxId: 2287] [110361] (4)
       SQ Q97U28

Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009 Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk