Structural Classification of Proteins
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Family: Hef domain-like

helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain (scop_fa 81795, that contains a single NMR structure of a monomeric truncated domain, 1kft)

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: SAM domain-like [47768]
    4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
  4. Superfamily: RuvA domain 2-like [47781]
    duplication: contains two helix-hairpin-helix (HhH) motifs
    link to SUPERFAMILY database - Superfamily
  5. Family: Hef domain-like [140629]
    helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain (scop_fa 81795, that contains a single NMR structure of a monomeric truncated domain, 1kft)

Protein Domains:

  1. DNA excision repair protein ERCC-1 [140630]
    1. Human (Homo sapiens) [TaxId: 9606] [140631] (2)
      SQ P07992 219-296! SQ P07992 220-297
      1. 2a1j picpicxref
        complexed with hg
        1. region b:219-296 [126001] picpiclink
      2. 1z00 picpicxref
        1. region a:220-297 [124294] picpiclink
  2. ATP-dependent RNA helicase PF2015 [140632]
    1. Pyrococcus furiosus [TaxId: 2261] [140633] (2)
      SQ Q8TZH8 694-761
      1. 1x2i picpic
        1. region a:2-69 [121641] picpiclink
      2. 1x2i picpic
        automatically matched to 1X2I A:2-69
        1. region b:2-69 [121642] picpiclink
  3. DNA repair endonuclease XPF [140634]
    1. Aeropyrum pernix [TaxId: 56636] [140635] (6)
      SQ Q9YC15 160-229
      1. 2bgw picpicxrefxref
        complexed with mg, so4
        1. region a:160-229 [128500] picpiclink
      2. 2bgw picpicxrefxref
        automatically matched to 2BGW A:160-229
        complexed with mg, so4
        1. region b:160-228 [128502] picpiclink
      3. 2bhn picpicxrefxrefxrefxref
        automatically matched to 2BGW A:160-229
        1. region a:160-229 [128534] picpiclink
      4. 2bhn picpicxrefxrefxrefxref
        automatically matched to 2BGW A:160-229
        1. region b:162-229 [128536] picpiclink
      5. 2bhn picpicxrefxrefxrefxref
        automatically matched to 2BGW A:160-229
        1. region c:164-229 [128538] picpiclink
      6. 2bhn picpicxrefxrefxrefxref
        automatically matched to 2BGW A:160-229
        1. region d:160-229 [128540] picpiclink
    2. Human (Homo sapiens) [TaxId: 9606] [140636] (4)
      SQ Q92889 823-905! SQ Q92889 837-898
      1. 2a1j picpicxref
        complexed with hg
        1. region a:837-898 [126000] picpiclink
      2. 2aq0 picpic
        automatically matched to 1Z00 B:823-905
        1. region a:2-84 [127136] picpiclink
      3. 2aq0 picpic
        automatically matched to 1Z00 B:823-905
        1. region b:102-184 [127137] picpiclink
      4. 1z00 picpicxref
        1. region b:823-905 [124295] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk