Structural Classification of Proteins
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Superfamily: RuvA domain 2-like

duplication: contains two helix-hairpin-helix (HhH) motifs
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: SAM domain-like [47768]
    4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
  4. Superfamily: RuvA domain 2-like [47781]
    duplication: contains two helix-hairpin-helix (HhH) motifs
    link to SUPERFAMILY database - Superfamily

Families:

  1. DNA helicase RuvA subunit, middle domain [47782] (3)
    1. DNA helicase RuvA subunit, middle domain [47783]
      tetramer; binds Holliday junction
      1. Escherichia coli [TaxId: 562] [47784] (5) picpic
      2. Mycobacterium leprae [TaxId: 1769] [47785] (1) picpic
      3. Thermus thermophilus [TaxId: 274] [81794] (1) picpic
  2. Excinuclease UvrC C-terminal domain [81795] (1)
    1. Excinuclease UvrC C-terminal domain [81796]
      1. Escherichia coli [TaxId: 562] [81797] (1) picpic
  3. NAD+-dependent DNA ligase, domain 3 [47786] (1)
    1. NAD+-dependent DNA ligase, domain 3 [47787]
      duplication: consists of two RuvA-like domains (four HhH motifs); also contains a zinc-finger subdomain
      1. Thermus filiformis [TaxId: 276] [47788] (2) picpic
  4. Topoisomerase V repeat domain [140626] (1)
    1. Topoisomerase V [140627]
      1. Methanopyrus kandleri [TaxId: 2320] [140628] (4) picpic
        SQ Q977W1 294-350! SQ Q977W1 351-409! SQ Q977W1 410-464! SQ Q977W1 465-519
  5. Hef domain-like [140629] (4)
    helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain (scop_fa 81795, that contains a single NMR structure of a monomeric truncated domain, 1kft)
    1. DNA excision repair protein ERCC-1 [140630]
      1. Human (Homo sapiens) [TaxId: 9606] [140631] (2) picpic
        SQ P07992 219-296! SQ P07992 220-297
    2. ATP-dependent RNA helicase PF2015 [140632]
      1. Pyrococcus furiosus [TaxId: 2261] [140633] (2) picpic
        SQ Q8TZH8 694-761
    3. DNA repair endonuclease XPF [140634]
      1. Aeropyrum pernix [TaxId: 56636] [140635] (6) picpic
        SQ Q9YC15 160-229
      2. Human (Homo sapiens) [TaxId: 9606] [140636] (4) picpic
        SQ Q92889 823-905! SQ Q92889 837-898
  6. Tex HhH-containing domain-like [158531] (1)
    tandem repeat of two Ruva_2-like domains
    1. Transcriptional accessory factor Tex [158532]
      1. Pseudomonas aeruginosa [TaxId: 287] [158533] (6) picpic
        SQ Q9HTY8 474-563! SQ Q9HTY8 564-636
  7. ComEA-like [158534] (2)
    sequence similarity to the HhH-motif domains of the PsbU-like and Tex-like families
    1. Uncharacterized protein TTHA1967 [158535]
      1. Thermus thermophilus [TaxId: 274] [158536] (1) picpic
        SQ Q5SGW3 11-75
    2. KIF22, C-terminal domain [158537]
      1. Human (Homo sapiens) [TaxId: 9606] [158538] (1) picpic
        SQ Q14807 570-660
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk