Structural Classification of Proteins
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Superfamily: RuvA domain 2-like

duplication: contains two helix-hairpin-helix (HhH) motifs
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: SAM domain-like [47768]
    4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins
  4. Superfamily: RuvA domain 2-like [47781]
    duplication: contains two helix-hairpin-helix (HhH) motifs
    link to SUPERFAMILY database - Superfamily

Families:

  1. DNA helicase RuvA subunit, middle domain [47782] (3)
    1. DNA helicase RuvA subunit, middle domain [47783]
      tetramer; binds Holliday junction
      1. Escherichia coli [TaxId: 562] [47784] (5)
        1. 1cuk picpicxrefxref
          1. region a:65-142 [17946] picpiclink
        2. 1hjp picpicxrefxref
          1. region a:65-140 [17947] picpiclink
        3. 1d8l picpicxref
          1. region a:65-140 [17948] picpiclink
          2. region b:65-140 [17949] picpiclink
        4. 1c7y picpicxrefxref
          protein/DNA complex
          1. region a:65-150 [17950] picpiclink
        5. 1bdx picpicxrefxref
          protein/DNA complex
          1. region a:65-142 [17951] picpiclink
          2. region b:65-142 [17952] picpiclink
          3. region c:65-142 [17953] picpiclink
          4. region d:65-142 [17954] picpiclink
      2. Mycobacterium leprae [TaxId: 1769] [47785] (1)
        1. 1bvs picpicxrefxref
          1. region a:64-134 [17955] picpiclink
          2. region b:64-133 [17956] picpiclink
          3. region c:64-134 [17957] picpiclink
          4. region d:64-133 [17958] picpiclink
          5. region e:64-134 [17959] picpiclink
          6. region f:64-133 [17960] picpiclink
          7. region g:64-134 [17961] picpiclink
          8. region h:64-133 [17962] picpiclink
      3. Thermus thermophilus [TaxId: 274] [81794] (1)
        1. 1ixr picpicxrefxrefxrefxref
          complexed with anp; mutant
          1. region a:63-135 [76925] picpiclink
          2. region b:63-138 [76928] picpiclink
  2. Excinuclease UvrC C-terminal domain [81795] (1)
    1. Excinuclease UvrC C-terminal domain [81796]
      1. Escherichia coli [TaxId: 562] [81797] (1)
        1. 1kft picpic
          1. chain a [77375] picpiclink
  3. NAD+-dependent DNA ligase, domain 3 [47786] (1)
    1. NAD+-dependent DNA ligase, domain 3 [47787]
      duplication: consists of two RuvA-like domains (four HhH motifs); also contains a zinc-finger subdomain
      1. Thermus filiformis [TaxId: 276] [47788] (2)
        1. 1dgs picpicxrefxref
          complexed with amp, zn
          1. region a:401-581 [17963] picpiclink
          2. region b:2401-2581 [17964] picpiclink
        2. 1v9p picpicxrefxref
          complexed with amp, zn
          1. region a:404-584 [100544] picpiclink
          2. region b:2404-2584 [100547] picpiclink
  4. Topoisomerase V repeat domain [140626] (1)
    1. Topoisomerase V [140627]
      1. Methanopyrus kandleri [TaxId: 2320] [140628] (4)
        SQ Q977W1 294-350! SQ Q977W1 351-409! SQ Q977W1 410-464! SQ Q977W1 465-519
        1. 2csb picpicxref
          2nd repeat
          complexed with mg
          1. region a:351-409 [130751] picpiclink
        2. 2csb picpicxref
          1st repeat
          complexed with mg
          1. region a:294-350 [130752] picpiclink
        3. 2csb picpicxref
          3rd repeat
          complexed with mg
          1. region a:410-464 [130753] picpiclink
        4. 2csb picpicxref
          4th repeat
          complexed with mg
          1. region a:465-519 [130754] picpiclink
  5. Hef domain-like [140629] (4)
    helicase/nuclease domain; forms homo and heterodimers; probably includes the Excinuclease UvrC C-terminal domain (scop_fa 81795, that contains a single NMR structure of a monomeric truncated domain, 1kft)
    1. DNA excision repair protein ERCC-1 [140630]
      1. Human (Homo sapiens) [TaxId: 9606] [140631] (2)
        SQ P07992 219-296! SQ P07992 220-297
        1. 2a1j picpicxref
          complexed with hg
          1. region b:219-296 [126001] picpiclink
        2. 1z00 picpicxref
          1. region a:220-297 [124294] picpiclink
    2. ATP-dependent RNA helicase PF2015 [140632]
      1. Pyrococcus furiosus [TaxId: 2261] [140633] (2)
        SQ Q8TZH8 694-761
        1. 1x2i picpic
          1. region a:2-69 [121641] picpiclink
        2. 1x2i picpic
          automatically matched to 1X2I A:2-69
          1. region b:2-69 [121642] picpiclink
    3. DNA repair endonuclease XPF [140634]
      1. Aeropyrum pernix [TaxId: 56636] [140635] (6)
        SQ Q9YC15 160-229
        1. 2bgw picpicxrefxref
          complexed with mg, so4
          1. region a:160-229 [128500] picpiclink
        2. 2bgw picpicxrefxref
          automatically matched to 2BGW A:160-229
          complexed with mg, so4
          1. region b:160-228 [128502] picpiclink
        3. 2bhn picpicxrefxrefxrefxref
          automatically matched to 2BGW A:160-229
          1. region a:160-229 [128534] picpiclink
        4. 2bhn picpicxrefxrefxrefxref
          automatically matched to 2BGW A:160-229
          1. region b:162-229 [128536] picpiclink
        5. 2bhn picpicxrefxrefxrefxref
          automatically matched to 2BGW A:160-229
          1. region c:164-229 [128538] picpiclink
        6. 2bhn picpicxrefxrefxrefxref
          automatically matched to 2BGW A:160-229
          1. region d:160-229 [128540] picpiclink
      2. Human (Homo sapiens) [TaxId: 9606] [140636] (4)
        SQ Q92889 823-905! SQ Q92889 837-898
        1. 2a1j picpicxref
          complexed with hg
          1. region a:837-898 [126000] picpiclink
        2. 2aq0 picpic
          automatically matched to 1Z00 B:823-905
          1. region a:2-84 [127136] picpiclink
        3. 2aq0 picpic
          automatically matched to 1Z00 B:823-905
          1. region b:102-184 [127137] picpiclink
        4. 1z00 picpicxref
          1. region b:823-905 [124295] picpiclink
  6. Tex HhH-containing domain-like [158531] (1)
    tandem repeat of two Ruva_2-like domains
    1. Transcriptional accessory factor Tex [158532]
      1. Pseudomonas aeruginosa [TaxId: 287] [158533] (6)
        SQ Q9HTY8 474-563! SQ Q9HTY8 564-636
        1. 3bzk picpicxrefxrefxref
          automatically matched to 3BZC A:474-563
          1. region a:474-563 [155777] picpiclink
        2. 3bzk picpicxrefxrefxref
          automatically matched to 3BZC A:564-636
          1. region a:564-636 [155778] picpiclink
        3. 3bzc picpicxrefxrefxref
          1. region a:474-563 [155752] picpiclink
        4. 3bzc picpicxrefxrefxref
          1. region a:564-636 [155753] picpiclink
        5. 2oce picpicxrefxrefxref
          1. region a:474-563 [148727] picpiclink
        6. 2oce picpicxrefxrefxref
          1. region a:564-636 [148728] picpiclink
  7. ComEA-like [158534] (2)
    sequence similarity to the HhH-motif domains of the PsbU-like and Tex-like families
    1. Uncharacterized protein TTHA1967 [158535]
      1. Thermus thermophilus [TaxId: 274] [158536] (1)
        SQ Q5SGW3 11-75
        1. 2duy picpic
          complexed with cl
          1. region a:11-75 [146589] picpiclink
    2. KIF22, C-terminal domain [158537]
      1. Human (Homo sapiens) [TaxId: 9606] [158538] (1)
        SQ Q14807 570-660
        1. 2edu picpic
          1. region a:8-98 [146805] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk