Structural Classification of Proteins
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Superfamily: EF-hand

Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: EF Hand-like [47472]
    core: 4 helices; array of 2 hairpins, opened
  4. Superfamily: EF-hand [47473]
    Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
    link to SUPERFAMILY database - Superfamily

Families:

  1. Calbindin D9K [47474] (2)
    made of two EF-hands only
    1. Calbindin D9K [47475]
      1. Cow (Bos taurus) [TaxId: 9913] [47476] (18) picpic
        SQ P02633
      2. Pig (Sus scrofa) [TaxId: 9823] [47477] (1) picpic
  2. S100 proteins [47478] (17)
    dimer: subunits are made of two EF-hands
    1. Calcyclin (S100) [47479]
      1. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [47480] (6) picpic
      2. Human (Homo sapiens), s100a6 [TaxId: 9606] [74719] (4) picpic
      3. Human (Homo sapiens), s100a4 [TaxId: 9606] [81754] (9) picpic
        MTS1 protein
      4. Rat (Rattus norvegicus), s100a1 [TaxId: 10116] [69019] (5) picpic
      5. Rat (Rattus norvegicus), s100b [TaxId: 10116] [47481] (7) picpic
      6. Cow (Bos taurus), s100b [TaxId: 9913] [47482] (6) picpic
      7. Human (Homo sapiens), s100b [TaxId: 9606] [47483] (12) picpic
      8. Human (Homo sapiens), P11 s100a10, calpactin [TaxId: 9606] [47484] (2) picpic
        ligand of annexin II
      9. Human (Homo sapiens), psoriasin s100a7 [TaxId: 9606] [47485] (3) picpic
      10. Pig (Sus scrofa), calgizzarin s100c (s100a11) [TaxId: 9823] [47486] (1) picpic
      11. Rabbit (Oryctolagus cuniculus), calgizzarin s100a11 [TaxId: 9986] [89047] (1) picpic
      12. Human (Homo sapiens), calgranulin s100a8, MRP8 [TaxId: 9606] [47487] (7) picpic
        Migration inhibitory factor-related protein 8
      13. Human (Homo sapiens), calgranulin C, s100a12 [TaxId: 9606] [47488] (3) picpic
      14. Human (Homo sapiens), s100a9 (mrp14) [TaxId: 9606] [69020] (7) picpic
      15. Human (Homo sapiens), s100a3 [TaxId: 9606] [74720] (1) picpic
      16. Human (Homo sapiens), s100p [TaxId: 9606] [81755] (2) picpic
      17. Human (Homo sapiens), s100a13 [TaxId: 9606] [140535] (8) picpic
        SQ Q99584 1-98
  3. Polcalcin [89048] (3)
    calcium-binding pollen allergen; two EF-hands per subunit
    1. Polcalcin phl p 7 [89049]
      1. Timothy grass (Phleum pratense) [TaxId: 15957] [89050] (1) picpic
    2. Polcalcin bet v 4 [101177]
      1. White birch (Betula verrucosa) [TaxId: 3505] [101178] (1) picpic
    3. Polcalcin Che a 3 [109816]
      1. Pigweed (Chenopodium album) [TaxId: 3559] [109817] (4) picpic
        SQ Q84V36
  4. Osteonectin [47489] (1)
    5 helices; two EF-hands plus one of additional helices in the N-terminal part
    1. C-terminal (EC) domain of BM-40/SPARC/osteonectin [47490]
      1. Human (Homo sapiens) [TaxId: 9606] [47491] (3) picpic
  5. Parvalbumin [47492] (9)
    6-helices; array of 3 hairpins, closed
    made with two-helical hairpin and two EF-hands
    1. Oncomodulin [47493]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [47494] (3) picpic
    2. Parvalbumin [47495]
      1. Carp (Cyprinus carpio) [TaxId: 7962] [47496] (7) picpic
      2. Pike (Esox lucius) [TaxId: 8010] [47497] (9) picpic
      3. Leopard shark (Triakis semifasciata) [TaxId: 30493] [47498] (1) picpic
      4. Whiting (Merlangius merlangus) [TaxId: 8058] [47499] (1) picpic
      5. Silver hake (Merluccius bilinearis) [TaxId: 79698] [47500] (1) picpic
      6. Rat (Rattus rattus) [TaxId: 10117] [47501] (4) picpic
        SQ P02625
      7. Human (Homo sapiens) [TaxId: 9606] [109818] (2) picpic
        SQ P20472
      8. Rattus norvegicus [TaxId: 10116] [158476] (1) picpic
  6. Calmodulin-like [47502] (49)
    Duplication: made with two pairs of EF-hands
    1. Troponin C [47503]
      1. Chicken (Gallus gallus) [TaxId: 9031] [47504] (28) picpic
        SQ P09860
      2. Turkey (Meleagris gallopavo) [TaxId: 9103] [47505] (2) picpic
      3. Rabbit (Oryctolagus cuniculus) [TaxId: 9986] [47506] (4) picpic
      4. Chicken (Gallus gallus), cardiac isoform [TaxId: 9031] [47507] (1) picpic
      5. Human (Homo sapiens), cardiac isoform [TaxId: 9606] [47508] (21) picpic
      6. Rainbow trout (Oncorhynchus mykiss) [TaxId: 8022] [109819] (2) picpic
        SQ Q7ZZB9 1-89
    2. Sarcoplasmic calcium-binding protein [47509]
      1. Sandworm (Nereis diversicolor) [TaxId: 126592] [47510] (2) picpic
        SQ P04571
      2. Amphioxus (Branchiostoma lanceolatum) [TaxId: 7740] [47511] (1) picpic
    3. Calcium vector protein [47514]
      1. Amphioxus (Branchiostoma lanceolatum) [TaxId: 7740] [47515] (4) picpic
    4. Calcium-regulated photoprotein [47512]
      structurally most similar to sarcoplasmic calcium-binding protein
      1. Jellyfish (Aequorea aequorea), aequorin [TaxId: 168712] [47513] (9) picpic
      2. Hydrozoa (Obelia longissima), obelin [TaxId: 32570] [63541] (7) picpic
        SQ Q27709
      3. Hydrozoa (Obelia geniculata), obelin [TaxId: 185004] [63542] (1) picpic
      4. Jellyfish (Aequorea victoria), aequorin 1 [TaxId: 6100] [116901] (1) picpic
        SQ P07164 16-196
    5. Calerythrin [101179]
      structurally most similar to sarcoplasmic calcium-binding protein
      1. Saccharopolyspora erythraea [TaxId: 1836] [101180] (1) picpic
    6. EHCABP [69021]
      1. Entamoeba (Entamoeba histolytica) [TaxId: 5759] [69022] (2) picpic
    7. Calmodulin [47516]
      1. Human (Homo sapiens) [TaxId: 9606] [47517] (60) picpic
        SQ P02593
      2. Cow (Bos taurus) [TaxId: 9913] [47518] (56) picpic
        SQ P62157
      3. Rat (Rattus rattus) [TaxId: 10117] [47519] (5) picpic
        SQ P62161
      4. Chicken (Gallus gallus) [TaxId: 9031] [47520] (2) picpic
        mutant with a two residue deletion in the central helix
      5. African frog (Xenopus laevis) [TaxId: 8355] [47521] (13) picpic
      6. Drosophila melanogaster [TaxId: 7227] [47522] (6) picpic
      7. Nematode (Caenorhabditis elegans) [TaxId: 6239] [89051] (1) picpic
      8. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [89052] (3) picpic
      9. Ciliate (Paramecium tetraurelia) [TaxId: 5888] [47523] (4) picpic
        SQ Q42478
      10. Potato (Solanum tuberosum) [TaxId: 4113] [109820] (1) picpic
      11. Rattus norvegicus [TaxId: 10116] [158477] (2) picpic
    8. Calmodulin-related protein NB-1 (CLP) [74721]
      1. Human (Homo sapiens) [TaxId: 9606] [74722] (1) picpic
    9. Caltractin (centrin 2) [89053]
      1. Human (Homo sapiens) [TaxId: 9606] [89054] (5) picpic
      2. Green algae (Chlamydomonas reinhardtii) [TaxId: 3055] [89055] (1) picpic
    10. Cdc4p [63543]
      1. Fission yeast (Schizosaccharomyces pombe) [TaxId: 4896] [63544] (1) picpic
    11. Myosin Light Chain Mlc1p [81756]
      light chain of class V myosin
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [81757] (3) picpic
    12. Myosin Essential Chain [47524]
      1. Bay scallop (Aequipecten irradians) [TaxId: 31199] [47525] (13) picpic
        SQ P13543
      2. Chicken (Gallus gallus) [TaxId: 9031] [47526] (5) picpic
      3. Human (Homo sapiens) [TaxId: 9606] [101181] (3) picpic
    13. Myosin Regulatory Chain [47527]
      1. Bay scallop (Aequipecten irradians) [TaxId: 31199] [47528] (13) picpic
        SQ P07291
      2. Chicken (Gallus gallus) [TaxId: 9031] [47529] (1) picpic
    14. Calcineurin regulatory subunit (B-chain) [47530]
      1. Cow (Bos taurus) [TaxId: 9913] [47531] (3) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [47532] (3) picpic
    15. Calcineurin B-like protein 2 [101182]
      1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [101183] (2) picpic
    16. Recoverin [47533]
      Calcium-myristoyl switch; only one EF-hand is functional
      1. Cow (Bos taurus) [TaxId: 9913] [47534] (11) picpic
    17. Kchip1, Kv4 potassium channel-interacting protein [101184]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [101185] (1) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [116902] (1) picpic
        SQ Q9NZI2
    18. Frequenin (neuronal calcium sensor 1) [47535]
      1. Human (Homo sapiens) [TaxId: 9606] [63545] (1) picpic
      2. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [47536] (2) picpic
    19. Guanylate cyclase activating protein 2, GCAP-2 [47537]
      1. Cow (Bos taurus) [TaxId: 9913] [47538] (1) picpic
    20. Neurocalcin [47539]
      1. Cow (Bos taurus) [TaxId: 9913] [47540] (1) picpic
    21. Calcium- and integrin-binding protein, CIB [47541]
      1. Human (Homo sapiens) [TaxId: 9606] [47542] (5) picpic
        SQ Q99828
    22. Calcium-dependent protein kinase sk5 CLD [109821]
      1. Soybean (Glycine max) [TaxId: 3847] [109822] (2) picpic
        SQ P28583 328-508
    23. Calmodulin-related protein T21P5.17 [109823]
      1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [109824] (1) picpic
        SQ Q9SRP5 2-67
  7. Eps15 homology domain (EH domain) [47543] (4)
    1. Eps15 [47544]
      1. Mouse (Mus musculus) [TaxId: 10090] [47545] (1) picpic
      2. Human (Homo sapiens) [TaxId: 9606] [47546] (5) picpic
    2. Pob1 [63546]
      1. Human (Homo sapiens) [TaxId: 9606] [63547] (1) picpic
    3. Reps1 [63548]
      1. Mouse (Mus musculus) [TaxId: 10090] [63549] (1) picpic
  8. Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [81758] (1)
    4 EF-hands assembled in a compact structure like the Penta-EF-hand proteins; contains additional N-terminal all-alpha subdomain
    1. Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [81759]
      1. Physarum polycephalum [TaxId: 5791] [81760] (2) picpic
  9. Penta-EF-hand proteins [63550] (11)
    1. Apoptosis-linked protein alg-2 [63551]
      1. Mouse (Mus musculus) [TaxId: 10090] [63552] (1) picpic
    2. Sorcin [69023]
      1. Human (Homo sapiens) [TaxId: 9606] [69024] (1) picpic
      2. Chinese hamster (Cricetulus griseus) [TaxId: 10029] [74723] (1) picpic
    3. Grancalcin [47550]
      Calpain small subunit homologue
      1. Human (Homo sapiens) [TaxId: 9606] [47551] (4) picpic
    4. Calpain small (regulatory) subunit (domain VI) [47552]
      1. Human (Homo sapiens) [TaxId: 9606] [47553] (2) picpic
      2. Rat (Rattus norvegicus) [TaxId: 10116] [47554] (6) picpic
      3. Pig (Sus scrofa) [TaxId: 9823] [47555] (6) picpic
    5. Calpain large subunit, C-terminal domain (domain IV) [47556]
      1. Human (Homo sapiens), M-type [TaxId: 9606] [47557] (2) picpic
      2. Rat (Rattus norvegicus), M-type [TaxId: 10116] [47558] (2) picpic
      3. Rat (Rattus norvegicus), mu-type [TaxId: 10116] [101186] (1) picpic
    6. Programmed cell death 6 protein-like protein [116903]
      1. Leishmania major [TaxId: 5664] [116904] (1) picpic
        SQ Q4QG08 53-234
  10. EF-hand modules in multidomain proteins [47547] (8)
    1. Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!) [47548]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [47549] (10) picpic
    2. Dystrophin [47559]
      probably lost calcium-binding function; contains extra helices in each domain
      1. Human (Homo sapiens) [TaxId: 9606] [47560] (2) picpic
    3. Cbl [47561]
      1. Human (Homo sapiens) [TaxId: 9606] [47562] (12) picpic
    4. alpha-Actinin [63553]
      1. Human (Homo sapiens) [TaxId: 9606] [63554] (1) picpic
    5. Nucleobindin 1 (CALNUC) [109825]
      1. Human (Homo sapiens) [TaxId: 9606] [109826] (1) picpic
        SQ Q02818 228-326
    6. Diacylglycerol kinase alpha, N-terminal domain [116905]
      contains two pairs of EF-hands, the modified first pair (res 25-109) does not bind calcium but retains the common fold
      1. Human (Homo sapiens) [TaxId: 9606] [116906] (1) picpic
        SQ O95217 P23743 1-116
    7. DJ-1-binding protein, DJBP [140536]
      1. Human (Homo sapiens) [TaxId: 9606] [140537] (4) picpic
        SQ Q5THR3 1160-1242
    8. Phospholipase C-beta-2 [158478]
      1. Human (Homo sapiens) [TaxId: 9606] [158479] (2) picpic
        SQ Q00722 142-311
  11. p25-alpha [140538] (2)
    Pfam 05517; comprises two degenerate EF-hands and extra C-terminal helix, packed agains the bundle end
    1. Hypothetical protein c32e8.3 [140539]
      1. Caenorhabditis elegans [TaxId: 6239] [140540] (1) picpic
        SQ P91127 8-110
    2. Protein cgi-38 [140541]
      1. Mouse (Mus musculus) [TaxId: 10090] [140542] (1) picpic
        SQ Q9CRB6 1-138
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk