Structural Classification of Proteins
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Family: EF-hand modules in multidomain proteins

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: EF Hand-like [47472]
    core: 4 helices; array of 2 hairpins, opened
  4. Superfamily: EF-hand [47473]
    Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
    link to SUPERFAMILY database - Superfamily
  5. Family: EF-hand modules in multidomain proteins [47547]

Protein Domains:

  1. Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!) [47548]
    1. Rat (Rattus norvegicus) [TaxId: 10116] [47549] (10) picpic
  2. Dystrophin [47559]
    probably lost calcium-binding function; contains extra helices in each domain
    1. Human (Homo sapiens) [TaxId: 9606] [47560] (2) picpic
  3. Cbl [47561]
    1. Human (Homo sapiens) [TaxId: 9606] [47562] (12) picpic
  4. alpha-Actinin [63553]
    1. Human (Homo sapiens) [TaxId: 9606] [63554] (1) picpic
  5. Nucleobindin 1 (CALNUC) [109825]
    1. Human (Homo sapiens) [TaxId: 9606] [109826] (1) picpic
      SQ Q02818 228-326
  6. Diacylglycerol kinase alpha, N-terminal domain [116905]
    contains two pairs of EF-hands, the modified first pair (res 25-109) does not bind calcium but retains the common fold
    1. Human (Homo sapiens) [TaxId: 9606] [116906] (1) picpic
      SQ O95217 P23743 1-116
  7. DJ-1-binding protein, DJBP [140536]
    1. Human (Homo sapiens) [TaxId: 9606] [140537] (4) picpic
      SQ Q5THR3 1160-1242
  8. Phospholipase C-beta-2 [158478]
    1. Human (Homo sapiens) [TaxId: 9606] [158479] (2) picpic
      SQ Q00722 142-311
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk