Structural Classification of Proteins
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Fold: 6-phosphogluconate dehydrogenase C-terminal domain-like

multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

Lineage:

  1. Root: scop
  2. Class: All alpha proteins [46456]
  3. Fold: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178]
    multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

Superfamilies:

  1. 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (12)
    N-terminal domain is Rossmann-fold with a family-specific C-terminal extension
    link to SUPERFAMILY database - Superfamily
    1. Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain [48180] (5)
      Hydroxyisobutyrate dehydrogenase domain is similar to one structural repeat in the 6-phosphogluconate dehydrogenase domain
      1. Hydroxyisobutyrate dehydrogenase [101357]
        forms similar dimeric and tetrameric structures to the 6-phosphogluconate dehydrogenase domain and its dimer, respectively
        1. Thermus thermophilus [TaxId: 274] [101358] (8) picpic
          structural genomics
        2. Salmonella typhimurium [TaxId: 90371] [109948] (1) picpic
          SQ Q8ZLV8
        3. Pseudomonas aeruginosa [TaxId: 287] [158733] (1) picpic
          SQ Q9I5I6 163-296
      2. 6-phosphogluconate dehydrogenase (6PGD) [48181]
        duplication; contains two structural repeats
        1. Sheep (Ovis orientalis aries) [TaxId: 9940] [48182] (5) picpic
        2. Trypanosoma brucei [TaxId: 5691] [48183] (1) picpic
    2. Mannitol 2-dehydrogenase [81843] (1)
      1. Mannitol 2-dehydrogenase [81844]
        1. Pseudomonas fluorescens [TaxId: 294] [81845] (2) picpic
    3. Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) [48184] (2)
      1. Class I ketol-acid reductoisomerase [89101]
        1. Pseudomonas aeruginosa [TaxId: 287] [89102] (1) picpic
      2. Class II ketol-acid reductoisomerase [48185]
        duplication; contains two structural repeats swapped to fold into a figure eight knot
        1. Spinach (Spinacia oleracea) [TaxId: 3562] [48186] (2) picpic
    4. HCDH C-domain-like [48187] (3)
      1. Short chain L-3-hydroxyacyl CoA dehydrogenase [48188]
        Dimer of 5-helical motifs; similar to duplicated motifs of 6PGD and KARI
        1. Human (Homo sapiens) [TaxId: 9606] [48189] (11) picpic
        2. Pig (Sus scrofa) [TaxId: 9823] [48190] (1) picpic
      2. Fatty oxidation complex alpha subunit, C-terminal domain [109949]
        duplication: contains two repeats of this domain
        1. Pseudomonas fragi [TaxId: 296] [109950] (4) picpic
          SQ P28793
    5. Conserved hypothetical protein MTH1747 [74762] (1)
      1. Conserved hypothetical protein MTH1747 [74763]
        1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [74764] (1) picpic
    6. UDP-glucose/GDP-mannose dehydrogenase dimerisation domain [48191] (2)
      1. UDP-glucose dehydrogenase (UDPGDH), middle domain [48192]
        1. Streptococcus pyogenes [TaxId: 1314] [48193] (2) picpic
      2. GDP-mannose 6-dehydrogenase, middle domain [89103]
        forms segment-swapped dimer, unlike the homologous UDPGDH domain
        1. Pseudomonas aeruginosa [TaxId: 287] [89104] (3) picpic
    7. N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [48194] (1)
      1. N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [48195]
        1. Arthrobacter, strain 1c [TaxId: 1663] [48196] (1) picpic
    8. Glycerol-3-phosphate dehydrogenase [48197] (2)
      1. Glycerol-3-phosphate dehydrogenase [48198]
        1. Trypanosome (Leishmania mexicana) [TaxId: 5665] [48199] (7) picpic
          SQ O29390
        2. Archaeoglobus fulgidus [TaxId: 2234] [116983] (1) picpic
    9. Ketopantoate reductase PanE [69084] (1)
      1. Ketopantoate reductase PanE [69085]
        1. Escherichia coli [TaxId: 562] [69086] (5) picpic
    10. ProC C-terminal domain-like [116984] (3)
      similar dimer to the class I KARI
      1. Pyrroline-5-carboxylate reductase ProC [116985]
        1. Neisseria meningitidis, serogroup B [TaxId: 487] [116986] (2) picpic
          SQ Q9K1N1
        2. Streptococcus pyogenes [TaxId: 1314] [140776] (10) picpic
          SQ Q9A1S9 153-256
      2. Hypothetical protein TM1727 [158734]
        1. Thermotoga maritima [TaxId: 2336] [158735] (2) picpic
          SQ Q9X250 155-257
    11. HMD dimerization domain-like [140777] (1)
      dimer similar to those of the GDP-mannose 6-dehydrogenase and class I KARI domains
      1. 5,10-methenyltetrahydromethanopterin hydrogenase, HMD [140778]
        1. Archaeon Methanocaldococcus jannaschii [TaxId: 2190] [140779] (1) picpic
          SQ Q58194 243-344
    12. TyrA dimerization domain-like [140780] (3)
      new dimerisation mode with swapping of C-terminal helices
      1. Prephenate dehydrogenase TyrA [140781]
        1. Aquifex aeolicus [TaxId: 63363] [140782] (4) picpic
          SQ O67636 201-310
        2. Synechocystis sp. pcc 6803 [TaxId: 1148] [140783] (4) picpic
          SQ P73906 166-279
        3. Haemophilus influenzae [TaxId: 727] [158736] (2) picpic
          SQ P43902 244-371
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk