Structural Classification of Proteins
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Protein: DNA topoisomerase I, 67K N-terminal domain from Escherichia coli [TaxId: 562]

Lineage:

  1. Root: scop
  2. Class: Multi-domain proteins (alpha and beta) [56572]
    Folds consisting of two or more domains belonging to different classes
  3. Fold: Prokaryotic type I DNA topoisomerase [56711]
    4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8
  4. Superfamily: Prokaryotic type I DNA topoisomerase [56712]
    duplication: the protein chain passing through the domains 2-4 makes two structural repeats
    The active site is formed by the toprim and "winged helix" domains (domains 1 and 4); these two domains are also found in the type II topoisomerase (DNA gyrase A) and in the alpha subunit of topoisomerase IV
    link to SUPERFAMILY database - Superfamily
  5. Family: Prokaryotic type I DNA topoisomerase [56713]
    domain 4 contains the catalytic tyrosine residue
  6. Protein: DNA topoisomerase I, 67K N-terminal domain [56714]
  7. Species: Escherichia coli [TaxId: 562] [56715]

PDB Entry Domains:

  1. 1mw9 picpic
    complexed with so4; mutant
    1. chain x [91480] picpiclink
  2. 1cy9 picpic
    2nd and 3rd domains
    1. chain a [43236] picpiclink
    2. chain b [43237] picpiclink
  3. 1mw8 picpic
    complexed with so4, t; mutant
    1. chain x [91479] picpiclink
  4. 1ecl picpic
    mutant
    1. chain a [43238] picpiclink
  5. 1cyy picpic
    2nd and 3rd domains
    complexed with zn
    1. chain a [43239] picpiclink
    2. chain b [43240] picpiclink
  6. 1cy2 picpic
    complexed with po4, tmp
    1. chain a [43241] picpiclink
  7. 1cy1 picpic
    complexed with po4, thp, tmp
    1. chain a [43242] picpiclink
  8. 1cy7 picpic
    complexed with po4, tmp; mutant
    1. chain a [43244] picpiclink
  9. 1cy8 picpic
    complexed with po4, t3p, tmp
    1. chain a [43243] picpiclink
  10. 1cy0 picpic
    complexed with a3p
    1. chain a [43245] picpiclink
  11. 1cy4 picpic
    complexed with po4, tmp
    1. chain a [43246] picpiclink
  12. 1cy6 picpic
    complexed with po4, t3p
    1. chain a [43247] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk