Structural Classification of Proteins
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Fold: Prokaryotic type I DNA topoisomerase

4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8

Lineage:

  1. Root: scop
  2. Class: Multi-domain proteins (alpha and beta) [56572]
    Folds consisting of two or more domains belonging to different classes
  3. Fold: Prokaryotic type I DNA topoisomerase [56711]
    4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8

Superfamilies:

  1. Prokaryotic type I DNA topoisomerase [56712] (1)
    duplication: the protein chain passing through the domains 2-4 makes two structural repeats
    The active site is formed by the toprim and "winged helix" domains (domains 1 and 4); these two domains are also found in the type II topoisomerase (DNA gyrase A) and in the alpha subunit of topoisomerase IV
    link to SUPERFAMILY database - Superfamily
    1. Prokaryotic type I DNA topoisomerase [56713] (3)
      domain 4 contains the catalytic tyrosine residue
      1. DNA topoisomerase I, 67K N-terminal domain [56714]
        1. Escherichia coli [TaxId: 562] [56715] (12)
          1. 1mw9 picpic
            complexed with so4; mutant
            1. chain x [91480] picpiclink
          2. 1cy9 picpic
            2nd and 3rd domains
            1. chain a [43236] picpiclink
            2. chain b [43237] picpiclink
          3. 1mw8 picpic
            complexed with so4, t; mutant
            1. chain x [91479] picpiclink
          4. 1ecl picpic
            mutant
            1. chain a [43238] picpiclink
          5. 1cyy picpic
            2nd and 3rd domains
            complexed with zn
            1. chain a [43239] picpiclink
            2. chain b [43240] picpiclink
          6. 1cy2 picpic
            complexed with po4, tmp
            1. chain a [43241] picpiclink
          7. 1cy1 picpic
            complexed with po4, thp, tmp
            1. chain a [43242] picpiclink
          8. 1cy7 picpic
            complexed with po4, tmp; mutant
            1. chain a [43244] picpiclink
          9. 1cy8 picpic
            complexed with po4, t3p, tmp
            1. chain a [43243] picpiclink
          10. 1cy0 picpic
            complexed with a3p
            1. chain a [43245] picpiclink
          11. 1cy4 picpic
            complexed with po4, tmp
            1. chain a [43246] picpiclink
          12. 1cy6 picpic
            complexed with po4, t3p
            1. chain a [43247] picpiclink
      2. DNA topoisomerase III [56716]
        1. Escherichia coli [TaxId: 562] [56717] (2)
          1. 1i7d picpic
            complexed with cl, so4; mutant
            1. chain a [61886] picpiclink
          2. 1d6m picpic
            1. chain a [43248] picpiclink
      3. Topoisomerase "domain" of reverse gyrase [69890]
        1. Archaeon Archaeoglobus fulgidus [TaxId: 2234] [69891] (2)
          1. 1gku picpicxref
            mutant
            1. region b:499-1054 [65259] picpiclink
          2. 1gl9 picpicxref
            complexed with anp, mg; mutant
            1. region b:499-1054 [65293] picpiclink
            2. region c:499-1054 [65296] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk