Structural Classification of Proteins
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Superfamily: CBS-domain pair

link to SUPERFAMILY database - Superfamily

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: CBS-domain pair [54630]
    duplication: tandem repeat of two beta-X-beta-alpha-beta(2)-alpha motifs of similar sequences; 4 layers: a/b/b/a
  4. Superfamily: CBS-domain pair [54631]
    link to SUPERFAMILY database - Superfamily

Families:

  1. CBS-domain pair [54632] (24)
    Pfam 00571; pairs of CBS domains dimerize to form a stable globular domain, a.k.a. Bateman domain
    1. Hypothetical protein TM0935 [102895]
      1. Thermotoga maritima [TaxId: 2336] [102896] (1)
        1. 1o50 picpic
          structural genomics
          1. region a:1-145 [144363] picpiclink
    2. Hypothetical protein MTH1622 [102897]
      1. Archaeon Methanobacterium thermoautotrophicum [TaxId: 145262] [102898] (1)
        1. 1pbj picpic
          structural genomics
          complexed with mg
          1. region a:2-121 [144366] picpiclink
    3. Hypothetical protein Ta0289 [102899]
      contains extra C-terminal zinc-finger domain
      1. Archaeon Thermoplasma acidophilum [TaxId: 2303] [102900] (3)
        1. 1pvm picpicxref
          structural genomics
          complexed with hg
          1. region a:1-142 [144367] picpiclink
          2. region b:1-142 [144368] picpiclink
        2. 2qh1 picpic
          complexed with fe2; mutant
          1. region a:1-142 [150784] picpiclink
        3. 2qh1 picpic
          complexed with fe2; mutant
          1. region b:1-142 [150785] picpiclink
    4. Type II inosine monophosphate dehydrogenase CBS domains [54633]
      contains tandem repeat of two CBS domains inserted into the catalytic TIM-barrel domain; may be disordered in the crystals
      1. Human (Homo sapiens), type I [TaxId: 9606] [89899] (1)
        1. 1jcn picpicxref
          both CBS motifs are partly disordered in both chains, A and B
          complexed with cpr
          1. region a:112-231 [144356] picpiclink
          2. region b:112-231 [144357] picpiclink
      2. Human (Homo sapiens), type II [TaxId: 9606] [54634] (3)
        1. 1b3o picpicxref
          complexed with cpr, sae
          1. region b:112-231 [144354] picpiclink
        2. 1nf7 picpicxref
          both CBS motifs are partly disordered in both chains, A and B
          complexed with k, myd, rvp
          1. region a:112-231 [144359] picpiclink
          2. region b:112-231 [144360] picpiclink
        3. 1nfb picpicxref
          both CBS motifs are partly disordered in both chains, A and B
          complexed with cpr, nad
          1. region a:112-231 [144361] picpiclink
          2. region b:112-231 [144362] picpiclink
      3. Chinese hamster (Cricetulus griseus) [TaxId: 10029] [64260] (1)
        1. 1jr1 picpicxref
          complexed with imp, k, moa
          1. region a:113-232 [144358] picpiclink
      4. Streptococcus pyogenes [TaxId: 1314] [54635] (1)
        1. 1zfj picpicxref
          complexed with imp
          1. region a:95-220 [144739] picpiclink
    5. Hypothetical protein YkuL [117881]
      1. Bacillus subtilis [TaxId: 1423] [117882] (1)
        SQ O31698 9-142
        1. 1yav picpic
          Structural genomics target
          complexed with so4
          1. region a:13-144 [144629] picpiclink
          2. region b:13-144 [144630] picpiclink
    6. Nuclear protein SNF4 [143134]
      duplication: comprises four CBS repeats
      1. Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932] [143135] (3)
        SQ P12904 181-265
        1. 2nyc picpic
          3rd and 4th CBS repeats
          1. region a:181-320 [138812] picpiclink
        2. 2nye picpic
          1. region a:181-320 [148512] picpiclink
        3. 2nye picpic
          1. region b:181-320 [148513] picpiclink
    7. Hypothetical protein TM0892, CBS tandem [143136]
      1. Thermotoga maritima [TaxId: 2336] [143137] (2)
        SQ Q9WZZ4 1-60! SQ Q9WZZ4 61-121
        1. 1vr9 picpic
          1. region a:1-121 [144433] picpiclink
        2. 1vr9 picpic
          1. region b:1-121 [144434] picpiclink
    8. Chloride channel protein, CBS tandem [143138]
      contains additional structures between the two CBS repeats
      1. Marbled electric ray (Torpedo marmorata) [TaxId: 7788] [143139] (2)
        SQ P21564 527-606! SQ P21564 691-770
        1. 2d4z picpic
          1. region a:527-606,a:691-770 [145071] picpiclink
        2. 2d4z picpic
          1. region b:527-606,b:691-770 [145072] picpiclink
    9. Hypothetical protein VC0737 [143140]
      Putative acetoin utilization protein AcuB
      1. Vibrio cholerae [TaxId: 666] [143141] (2)
        SQ Q9KTZ3 21-83! SQ Q9KTZ3 93-159
        1. 2o16 picpic
          complexed with po4
          1. region a:20-158 [145710] picpiclink
        2. 2o16 picpic
          complexed with po4
          1. region b:20-158 [145711] picpiclink
    10. Hypothetical protein Rv2626c [143142]
      1. Mycobacterium tuberculosis [TaxId: 1773] [143143] (4)
        SQ O06186 2-124
        1. 1y5h picpic
          1. region a:2-124 [144595] picpiclink
        2. 1y5h picpic
          1. region b:2-123 [144596] picpiclink
        3. 1xkf picpic
          complexed with zn
          1. region a:2-124 [144578] picpiclink
        4. 1xkf picpic
          complexed with zn
          1. region b:2-123 [144579] picpiclink
    11. Uncharacterized protein PH1780 [160159]
      duplication: comprises four CBS repeats
      1. Pyrococcus horikoshii [TaxId: 53953] [160160] (2)
        SQ O59416 125-281! SQ O59416 126-281
        1. 2yzq picpic
          complexed with sam
          1. region a:123-278 [153904] picpiclink
        2. 2yzq picpic
          complexed with sam
          1. region a:1-122 [153905] picpiclink
    12. Uncharacterized protein ST2348 [160161]
      1. Sulfolobus tokodaii [TaxId: 111955] [160162] (2)
        SQ Q96Y20 1-127
        1. 2ef7 picpic
          1. region a:1-127 [146810] picpiclink
        2. 2ef7 picpic
          automatically matched to 2EF7 A:1-127
          1. region b:4-126 [146811] picpiclink
    13. Magnesium transporter MgtE [160163]
      1. Thermus thermophilus [TaxId: 274] [160164] (4)
        SQ Q5SMG8 132-275
        1. 2yvx picpicxrefxrefxrefxrefxrefxrefxrefxref
          complexed with mg
          1. region a:132-275 [153782] picpiclink
        2. 2yvx picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to 2YVX A:132-275
          complexed with mg
          1. region b:132-275 [153785] picpiclink
        3. 2yvx picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to 2YVX A:132-275
          complexed with mg
          1. region c:132-275 [153788] picpiclink
        4. 2yvx picpicxrefxrefxrefxrefxrefxrefxrefxref
          automatically matched to 2YVX A:132-275
          complexed with mg
          1. region d:132-275 [153791] picpiclink
      2. Enterococcus faecalis [TaxId: 1351] [160165] (1)
        SQ Q830V1 136-262
        1. 2oux picpicxref
          complexed with mg
          1. region a:136-262 [149032] picpiclink
    14. Uncharacterized protein C1556.08c [160166]
      consists of 4 CBS units
      1. Schizosaccharomyces pombe [TaxId: 4896] [160167] (2)
        SQ Q10343 182-334! SQ Q10343 3-181
        1. 2oox picpicxrefxrefxrefxref
          complexed with amp
          1. region e:3-181 [148944] picpiclink
        2. 2oox picpicxrefxrefxrefxref
          complexed with amp
          1. region e:182-334 [148945] picpiclink
    15. Uncharacterized protein PH0107 [160168]
      1. Pyrococcus horikoshii [TaxId: 53953] [160169] (2)
        SQ O57847 4-135
        1. 2yzi picpic
          1. region a:4-135 [153902] picpiclink
        2. 2yzi picpic
          automatically matched to 2YZI A:4-135
          1. region b:4-135 [153903] picpiclink
    16. Uncharacterized protein SSO3205 [160170]
      duplication: comprises four CBS repeats
      1. Sulfolobus solfataricus [TaxId: 2287] [160171] (2)
        SQ Q97U20 1-135! SQ Q97U20 136-276
        1. 3ddj picpic
          complexed with amp, peg
          1. region a:136-276 [157553] picpiclink
        2. 3ddj picpic
          complexed with amp, peg
          1. region a:1-135 [157554] picpiclink
    17. Uncharacterized protein NE2398 [160172]
      1. Nitrosomonas europaea [TaxId: 915] [160173] (4)
        SQ Q82SE2 1-127
        1. 2rc3 picpic
          complexed with br, nad
          1. region a:23-149 [151867] picpiclink
        2. 2rc3 picpic
          automatically matched to 2RC3 A:23-149
          complexed with br, nad
          1. region b:23-149 [151868] picpiclink
        3. 2rc3 picpic
          automatically matched to 2RC3 A:23-149
          complexed with br, nad
          1. region c:23-149 [151869] picpiclink
        4. 2rc3 picpic
          automatically matched to 2RC3 A:23-149
          complexed with br, nad
          1. region d:23-149 [151870] picpiclink
    18. Chloride channel protein 5, ClC-5 [160174]
      1. Human (Homo sapiens) [TaxId: 9606] [160175] (1)
        SQ P51795 578-746
        1. 2j9l picpic
          complexed with atp, cl
          1. region a:578-746 [147943] picpiclink
    19. 5'-AMP-activated protein kinase subunit gamma-1, AMPKg [160176]
      1. Rat (Rattus norvegicus) [TaxId: 10116] [160177] (6)
        SQ P80385 182-326! SQ P80385 23-181
        1. 2v8q picpicxrefxref
          complexed with amp
          1. region e:182-326 [152783] picpiclink
        2. 2v8q picpicxrefxref
          complexed with amp
          1. region e:23-181 [152784] picpiclink
        3. 2v92 picpicxrefxref
          automatically matched to 2V8Q E:182-326
          complexed with amp, atp
          1. region e:182-326 [152793] picpiclink
        4. 2v92 picpicxrefxref
          automatically matched to 2V8Q E:23-181
          complexed with amp, atp
          1. region e:23-181 [152794] picpiclink
        5. 2v9j picpicxrefxref
          automatically matched to 2V8Q E:182-326
          complexed with amp, atp, mg
          1. region e:182-326 [152807] picpiclink
        6. 2v9j picpicxrefxref
          automatically matched to 2V8Q E:23-181
          complexed with amp, atp, mg
          1. region e:23-181 [152808] picpiclink
    20. Uncharacterized protein PAE2072 [160178]
      2 CBS domains = 1 Bateman domain; binds two adenosine nucleotides per subunit (one per one CBS repeat)
      1. Pyrobaculum aerophilum [TaxId: 13773] [160179] (6)
        SQ Q8ZVX8 2-132
        1. 2rih picpic
          automatically matched to 2RIF A:2-132
          complexed with acy, so4
          1. region a:2-132 [152093] picpiclink
        2. 2rih picpic
          automatically matched to 2RIF A:2-132
          complexed with acy, so4
          1. region b:2-131 [152094] picpiclink
        3. 2rif picpic
          complexed with amp, cs
          1. region a:2-132 [152089] picpiclink
        4. 2rif picpic
          automatically matched to 2RIF A:2-132
          complexed with amp, cs
          1. region b:2-130 [152090] picpiclink
        5. 2rif picpic
          automatically matched to 2RIF A:2-132
          complexed with amp, cs
          1. region c:2-129 [152091] picpiclink
        6. 2rif picpic
          automatically matched to 2RIF A:2-132
          complexed with amp, cs
          1. region d:2-131 [152092] picpiclink
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MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk