Structural Classification of Proteins

Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase

: beta-alpha-beta(3); 2 layers: alpha/beta

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592]
beta-alpha-beta(3); 2 layers: alpha/beta

Superfamilies:

Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54593] (10)
uperfamily
1. Glyoxalase I (lactoylglutathione lyase) [54594] (3)
  duplication: consists of two clear structural repeats each having this fold
  1. Glyoxalase I (lactoylglutathione lyase) [54595]
    1. Human (Homo sapiens) [TaxId: 9606] [54596] (4)
    2. Escherichia coli [TaxId: 562] [54597] (5)
    3. Leishmania major [TaxId: 5664] [143126] (6)
      SQ Q68RJ8 3-141
      Trypanothione-dependent glyoxalase i
2. Antibiotic resistance proteins [54598] (10)
  duplication: consists of two clear structural repeats each having this fold
  subunit fold and dimeric assembly are similar to those of glyoxalase
  1. Bleomycin resistance protein, BRP [54599]
    Active as dimer
    1. Streptomyces verticillus [TaxId: 29309] [54600] (3)
    2. Streptoalloteichus hindustanus [TaxId: 2017] [54601] (2)
      SQ P17493
    3. Klebsiella pneumoniae [TaxId: 573] [64256] (4)
      the transposon tn5-encoding bleomycin-binding protein, BlmT
  2. Mitomycin resistance protein D, MRD [75394]
    1. Streptomyces lavendulae [TaxId: 1914] [75395] (6)
  3. Fosfomycin resistance protein A (FosA) [82630]
    1. Pseudomonas aeruginosa [TaxId: 287] [82631] (5)
    2. Serratia marcescens [TaxId: 615] [102871] (1)
      gene from transposon tn2921
  4. Fosfomycin resistance protein FosX [102872]
    1. Mesorhizobium loti [TaxId: 381] [102873] (1)
  5. Hypothetical protein BC3580 [117870]
    1. Bacillus cereus [TaxId: 1396] [117871] (1)
      SQ Q81AI8
  6. Hypotheical protein SP0731 [143127]
    1. Streptococcus pneumoniae [TaxId: 1313] [143128] (2)
      SQ Q97RR3 1-115
  7. Uncharacterized protein Atu1953 [160145]
    1. Agrobacterium tumefaciens [TaxId: 358] [160146] (2)
      SQ Q8UE11 2-115
3. Methylmalonyl-CoA epimerase [64257] (1)
  Different association of repeats but a similar dimeric structure to the glyoxalase dimer
  1. Methylmalonyl-CoA epimerase [64258]
    1. Propionibacterium shermanii [TaxId: 1752] [64259] (2)
4. Hypothetical protein YecM (EC4020) [75396] (1)
  Similar subunit fold is to methylmalonyl-CoA epimerase
  1. Hypothetical protein YecM (EC4020) [75397]
    1. Escherichia coli [TaxId: 562] [75398] (1)
5. Extradiol dioxygenases [54602] (10)
  duplication: consists of 2 similar domains with 2 repeats in each
  Similar to the Methylmalonyl-CoA epimerase dimer
  1. 2,3-Dihydroxybiphenyl dioxygenase (DHBD, BPHC enzyme) [54603]
    1. Pseudomonas sp. [TaxId: 306] [54604] (10)
    2. Burkholderia cepacia, formerly Pseudomonas cepacia [TaxId: 292] [54605] (6)
  2. Catechol 2,3-dioxygenase (metapyrocatechase) [54606]
    1. Pseudomonas putida, mt2 [TaxId: 303] [54607] (1)
  3. Homoprotocatechuate 2,3-dioxygenase [89886]
    1. Arthrobacter globiformis [TaxId: 1665] [89887] (3)
    2. Brevibacterium fuscum [TaxId: 47914] [89888] (43)
  4. 4-hydroxyphenylpyruvate dioxygenase, HppD [54608]
    1. Pseudomonas fluorescens [TaxId: 294] [54609] (1)
    2. Streptomyces avermitilis [TaxId: 33903] [110876] (1)
      SQ Q53586
    3. Mouse-ear cress (Arabidopsis thaliana) [TaxId: 3702] [110877] (4)
      SQ P93836 33-428 ! SQ P93836 63-459
    4. Human (Homo sapiens) [TaxId: 9606] [110878] (1)
      SQ P32755
    5. Corn (Zea mays) [TaxId: 4577] [110879] (1)
      SQ O48604 29-423 # 85% sequence identity
6. Hypothetical protein BC1747 [110880] (1)
  subunit fold and dimeric assembly are similar to those of glyoxalase
  1. Hypothetical protein BC1747 [110881]
    1. Bacillus cereus (strain ATCC 14579 / DSM 31) [TaxId: 226900] [110882] (1)
      SQ Q81F54
7. 3-demethylubiquinone-9 3-methyltransferase [110883] (4)
  Pfam 06983; both variants of dimeric assembly are observed in the family (domain swapping)
  1. Hypothetical protein PA1358 [110884]
    1. Pseudomonas aeruginosa [TaxId: 287] [110885] (1)
      SQ Q9I3Y6
  2. Hypothetical protein PA2721 [110886]
    1. Pseudomonas aeruginosa [TaxId: 287] [110887] (1)
      SQ Q9I0C1
  3. Hypothetical protein MW1090 [117872]
    1. Staphylococcus aureus [TaxId: 1280] [117873] (1)
      SQ Q8NX24
  4. Hypothetical protein PA1353 [117874]
    Family assignment by BLAST; HMM assignment is the Glyoxalase family (Pfam 00903)
    1. Pseudomonas aeruginosa [TaxId: 287] [117875] (1)
      SQ Q9I3Z1
8. Hypothetical protein YycE [110888] (1)
  subunit fold and dimeric assembly are similar to those of glyoxalase
  1. Hypothetical protein YycE [110889]
    1. Bacillus subtilis [TaxId: 1423] [110890] (1)
      SQ P37479
9. Hypothetical protein At5g48480 [117876] (1)
  subunit fold and dimeric assembly are similar to those of glyoxalase
  1. Hypothetical protein At5g48480 [117877]
    1. Thale cress (Arabidopsis thaliana) [TaxId: 3702] [117878] (3)
      SQ Q9LV66 20-154
10. BC1024-like [143129] (1)
  duplication: consists of 2 similar domains with 2 repeats in each; similar to the glyoxalase dimer
  1. Hypothetical protein BC1024 [143130]
    1. Bacillus cereus [TaxId: 1396] [143131] (2)
      SQ Q81H03 1-144! SQ Q81H03 145-314