Structural Classification of Proteins
home mail help root up expand collapse

Family: ADP-ribosylating toxins

Lineage:

  1. Root: scop
  2. Class: Alpha and beta proteins (a+b) [53931]
    Mainly antiparallel beta sheets (segregated alpha and beta regions)
  3. Fold: ADP-ribosylation [56398]
    unusual fold
  4. Superfamily: ADP-ribosylation [56399]
    link to SUPERFAMILY database - Superfamily
  5. Family: ADP-ribosylating toxins [56400]

Protein Domains:

  1. Heat-labile toxin, A-chain [56401]
    1. Escherichia coli, type IB [TaxId: 562] [56402] (9)
      1. 1lts picpicxref
        1. chain a,c [42229] picpiclink
      2. 1lt3 picpicxref
        complexed with gal, glc; mutant
        1. chain a [42230] picpiclink
      3. 1lt4 picpicxref
        complexed with gal, glc; mutant
        1. chain a [42231] picpiclink
      4. 1lta picpicxref
        complexed with gal
        1. chain a,c [42232] picpiclink
      5. 1lti picpicxref
        complexed with gal, nga
        1. chain a,c [42233] picpiclink
      6. 1ltt picpicxref
        complexed with gal, glc
        1. chain a,c [42234] picpiclink
      7. 1ltg picpicxref
        mutant
        1. chain a,c [42235] picpiclink
      8. 1ltb picpicxref
        1. chain a,c [42236] picpiclink
      9. 1htl picpicxref
        mutant
        1. chain a,c [42237] picpiclink
    2. Escherichia coli, type IIB [TaxId: 562] [56403] (1)
      1. 1tii picpicxref
        1. chain a,c [42238] picpiclink
  2. Diphtheria toxin, N-terminal domain [56404]
    1. Corynebacterium diphtheriae [TaxId: 1717] [56405] (7)
      1. 1f0l picpicxrefxref
        complexed with apu, cl
        1. region a:1-187 [42239] picpiclink
        2. region b:1-187 [42240] picpiclink
      2. 1ddt picpicxrefxref
        complexed with apu
        1. region a:1-187 [42241] picpiclink
      3. 1sgk picpicxrefxref
        1. region a:1-187 [42242] picpiclink
      4. 1mdt picpicxrefxref
        complexed with apu
        1. region a:1-187 [42243] picpiclink
        2. region b:1-187 [42244] picpiclink
      5. 1xdt picpicxrefxrefxref
        1. region t:1-188 [42245] picpiclink
      6. 1tox picpicxrefxref
        complexed with nad
        1. region a:1-187 [42246] picpiclink
        2. region b:1-187 [42247] picpiclink
      7. 1dtp picpic
        one domain only
        complexed with apu
        1. chain a [42248] picpiclink
  3. Exotoxin A, C-terminal domain [56406]
    1. Pseudomonas aeruginosa [TaxId: 287] [56407] (21)
      1. 1ikp picpicxrefxref
        complexed with cl, na; mutant
        1. region a:395-606 [66183] picpiclink
      2. 1ikq picpicxrefxref
        complexed with cl, na
        1. region a:395-606 [66186] picpiclink
      3. 1xk9 picpic
        automatically matched to d1ikpa2
        complexed with p34
        1. region a:399-602 [122074] picpiclink
      4. 1xk9 picpic
        automatically matched to d1ikpa2
        complexed with p34
        1. region b:399-602 [122075] picpiclink
      5. 1aer picpic
        complexed with amp, tad, tia
        1. chain a [42249] picpiclink
        2. chain b [42250] picpiclink
      6. 1dma picpic
        complexed with amp, nca
        1. chain a [42251] picpiclink
        2. chain b [42252] picpiclink
      7. 2zit picpic
        automatically matched to d1ikpa2
        complexed with dde, nad
        1. region b:400-605 [154481] picpiclink
      8. 2zit picpic
        automatically matched to d1ikpa2
        complexed with dde, nad
        1. region d:400-605 [154482] picpiclink
      9. 2zit picpic
        automatically matched to d1ikpa2
        complexed with dde, nad
        1. region f:400-605 [154483] picpiclink
      10. 1zm9 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with dde, p34
        1. region b:399-602 [125341] picpiclink
      11. 1zm9 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with dde, p34
        1. region d:399-602 [125347] picpiclink
      12. 1zm9 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with dde, p34
        1. region f:399-602 [125353] picpiclink
      13. 1zm4 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with dde, tad
        1. region b:399-602 [125321] picpiclink
      14. 1zm4 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with dde, tad
        1. region d:399-602 [125327] picpiclink
      15. 1zm4 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with dde, tad
        1. region f:399-602 [125333] picpiclink
      16. 1zm3 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with dde
        1. region b:399-602 [125303] picpiclink
      17. 1zm3 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with dde
        1. region d:399-602 [125309] picpiclink
      18. 1zm3 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with dde
        1. region f:399-602 [125315] picpiclink
      19. 1zm2 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with apr, dde
        1. region b:399-602 [125285] picpiclink
      20. 1zm2 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with apr, dde
        1. region d:399-602 [125291] picpiclink
      21. 1zm2 picpicxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxrefxref
        automatically matched to d1ikpa2
        complexed with apr, dde
        1. region f:399-602 [125297] picpiclink
  4. Pertussis toxin, S1 subunit [56408]
    1. Bordetella pertussis [TaxId: 520] [56409] (3)
      1. 1prt picpicxrefxrefxrefxref
        1. chain a [42253] picpiclink
        2. chain g [42254] picpiclink
      2. 1bcp picpicxrefxrefxrefxref
        complexed with atp
        1. chain a [42255] picpiclink
        2. chain g [42256] picpiclink
      3. 1pto picpicxrefxrefxrefxref
        complexed with gal, sia
        1. chain a [42257] picpiclink
        2. chain g [42258] picpiclink
  5. Cholera toxin [56410]
    1. Vibrio cholerae [TaxId: 666] [56411] (9)
      1. 1s5d picpicxref
        complexed with gal, gol, na; mutant
        1. chain a [98541] picpiclink
      2. 2a5d picpicxref
        complexed with gol, gtp, mg, na; mutant
        1. region b:1-186 [144783] picpiclink
      3. 1s5e picpicxref
        complexed with gal, na
        1. chain a [98547] picpiclink
        2. chain b [98548] picpiclink
      4. 2a5f picpicxref
        automatically matched to 2A5D B:1-186
        complexed with gol, gtp, mg, na, nad; mutant
        1. region b:3-186 [144784] picpiclink
      5. 1s5b picpicxref
        complexed with na; mutant
        1. chain a [98529] picpiclink
      6. 2a5g picpicxref
        automatically matched to 2A5D B:1-186
        complexed with gtp, mg, na; mutant
        1. region b:1-186 [144785] picpiclink
      7. 1s5c picpicxref
        complexed with na; mutant
        1. chain a [98535] picpiclink
      8. 1s5f picpicxref
        complexed with gal, na
        1. chain a [98559] picpiclink
      9. 1xtc picpicxref
        1. chain a,c [42259] picpiclink
  6. Vegetative insecticidal protein 2 (VIP2) [56412]
    duplication: consists of two domains of this fold, the second of which is catalytic
    1. Bacillus cereus [TaxId: 1396] [56413] (2)
      1. 1qs1 picpic
        1. region a:60-264 [42260] picpiclink
        2. region a:265-461 [42261] picpiclink
        3. region b:1060-1264 [42262] picpiclink
        4. region b:1265-1461 [42263] picpiclink
        5. region c:2060-2264 [42264] picpiclink
        6. region c:2265-2461 [42265] picpiclink
        7. region d:3060-3264 [42266] picpiclink
        8. region d:3265-3461 [42267] picpiclink
      2. 1qs2 picpic
        1. region a:62-264 [42268] picpiclink
        2. region a:265-462 [42269] picpiclink
  7. Enzymatic component (Ia) of iota-toxin [82812]
    mammalian-targeted relative of VIP2; C-terminal domain is catalytic, N-terminal domain interacts with Ib (binding component)
    1. Clostridium perfringens [TaxId: 1502] [82813] (4)
      1. 1giq picpic
        complexed with nad
        1. region a:3-209 [76224] picpiclink
        2. region b:1003-1209 [76226] picpiclink
        3. region a:210-413 [76225] picpiclink
        4. region b:1210-1413 [76227] picpiclink
      2. 1gir picpic
        complexed with ndp
        1. region a:3-209 [76228] picpiclink
        2. region a:210-413 [76229] picpiclink
      3. 3buz picpic
        automatically matched to d1giqa1
        complexed with atp, ca, lar, tad
        1. region a:3-209 [155656] picpiclink
      4. 3buz picpic
        automatically matched to d1giqa2
        complexed with atp, ca, lar, tad
        1. region a:210-413 [155657] picpiclink
  8. Exoenzyme c3 [56414]
    1. Clostridium botulinum [TaxId: 1491] [56415] (14)
      SQ P15879 41-251
      1. 2c8a picpic
        automatically matched to d1g24a_
        complexed with nca, so4
        1. region a:45-251 [130099] picpiclink
      2. 2c8a picpic
        automatically matched to d1g24a_
        complexed with nca, so4
        1. region b:45-245 [130100] picpiclink
      3. 2c8a picpic
        automatically matched to d1g24a_
        complexed with nca, so4
        1. region c:45-251 [130101] picpiclink
      4. 2c8a picpic
        automatically matched to d1g24a_
        complexed with nca, so4
        1. region d:45-246 [130102] picpiclink
      5. 2a9k picpicxref
        automatically matched to d1g24a_
        complexed with gdp, mg, nad
        1. region b:45-251 [126443] picpiclink
      6. 1g24 picpic
        1. chain a [42270] picpiclink
        2. chain b [42271] picpiclink
        3. chain c [42272] picpiclink
        4. chain d [42273] picpiclink
      7. 2a78 picpicxref
        automatically matched to d1g24a_
        complexed with gdp, mg
        1. region b:45-251 [126330] picpiclink
      8. 2c89 picpic
        automatically matched to d1g24a_
        complexed with so4
        1. region a:45-244 [130095] picpiclink
      9. 2c89 picpic
        automatically matched to d1g24a_
        complexed with so4
        1. region b:45-246 [130096] picpiclink
      10. 2c89 picpic
        automatically matched to d1g24a_
        complexed with so4
        1. region c:45-251 [130097] picpiclink
      11. 2c89 picpic
        automatically matched to d1g24a_
        complexed with so4
        1. region d:45-244 [130098] picpiclink
      12. 1uzi picpic
        complexed with gol, v4o, vo4
        1. chain a [108176] picpiclink
        2. chain b [108177] picpiclink
      13. 1gzf picpic
        complexed with adp, nad, nir, so4
        1. chain a [76418] picpiclink
        2. chain b [76419] picpiclink
        3. chain c [76420] picpiclink
        4. chain d [76421] picpiclink
      14. 1gze picpic
        complexed with hg; mutant
        1. chain a [76414] picpiclink
        2. chain b [76415] picpiclink
        3. chain c [76416] picpiclink
        4. chain d [76417] picpiclink
    2. Staphylococcus aureus [TaxId: 1280] [103338] (2)
      1. 1ojq picpic
        1. chain a [93146] picpiclink
      2. 1ojz picpic
        complexed with nad
        1. chain a [93190] picpiclink
    3. Clostridium botulinum C bacteriophage [TaxId: 12336] [118161] (2)
      SQ Q00901 44-244
      1. 1r45 picpic
        complexed with gol, so4
        1. chain a [111683] picpiclink
        2. chain b [111684] picpiclink
        3. chain c [111685] picpiclink
        4. chain d [111686] picpiclink
      2. 1r4b picpic
        1. chain a [111687] picpiclink
        2. chain b [111688] picpiclink
  9. Anthrax toxin lethal factor, middle domain [69845]
    includes an all-alpha insert subdomain
    1. Bacillus anthracis [TaxId: 1392] [69846] (10)
      1. 1j7n picpicxref
        complexed with so4, zn
        1. region a:264-550 [66411] picpiclink
        2. region b:264-550 [66414] picpiclink
      2. 1yqy picpicxref
        automatically matched to d1j7na3
        complexed with 915, zn
        1. region a:265-550 [123904] picpiclink
      3. 1zxv picpicxrefxrefxrefxref
        automatically matched to d1j7na3
        complexed with mfm, zn
        1. region a:264-550 [125799] picpiclink
      4. 1zxv picpicxrefxrefxrefxref
        automatically matched to d1j7na3
        complexed with mfm, zn
        1. region b:264-550 [125802] picpiclink
      5. 1pwu picpicxref
        complexed with small molecule inhibitor
        complexed with gm6, zn; mutant
        1. region a:264-550 [95246] picpiclink
        2. region b:264-550 [95249] picpiclink
      6. 1pwp picpicxref
        complexed with small molecule inhibitor
        complexed with nsc, zn
        1. region a:264-550 [95234] picpiclink
        2. region b:264-550 [95237] picpiclink
      7. 1pwv picpicxref
        complexed with an optimized peptide substrate (chains C and D) in the presence of zinc
        1. region a:264-550 [95252] picpiclink
        2. region b:264-550 [95255] picpiclink
      8. 1pww picpicxref
        complexed with an optimized peptide substrate (chains C and D) in the presence of zinc
        complexed with zn; mutant
        1. region a:264-550 [95258] picpiclink
        2. region b:264-550 [95261] picpiclink
      9. 1pwq picpicxref
        complexed with small molecule inhibitor
        complexed with sd2, zn
        1. region a:264-550 [95240] picpiclink
        2. region b:264-550 [95243] picpiclink
      10. 1jky picpicxref
        1. region a:264-550 [66819] picpiclink
Enter search key:
MRC site Generated from scop database 1.75 with scopm 1.101 on Wed Jun 3 10:42:06 2009
Copyright © 1994-2009 The scop authors / scop@mrc-lmb.cam.ac.uk