Structural Classification of Proteins

Superfamily: ADP-ribosylation

: uperfamily

Lineage:

Root: scop
Class: Alpha and beta proteins (a+b) [53931]
Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold: ADP-ribosylation [56398]
unusual fold
Superfamily: ADP-ribosylation [56399]
uperfamily

Families:

ADP-ribosylating toxins [56400] (12)
1. Heat-labile toxin, A-chain [56401]
  1. Escherichia coli, type IB [TaxId: 562] [56402] (9)
    1. 1lts
      1. chain a,c [42229]
    2. 1lt3
      complexed with gal, glc; mutant
      1. chain a [42230]
    3. 1lt4
      complexed with gal, glc; mutant
      1. chain a [42231]
    4. 1lta
      complexed with gal
      1. chain a,c [42232]
    5. 1lti
      complexed with gal, nga
      1. chain a,c [42233]
    6. 1ltt
      complexed with gal, glc
      1. chain a,c [42234]
    7. 1ltg
      mutant
      1. chain a,c [42235]
    8. 1ltb
      1. chain a,c [42236]
    9. 1htl
      mutant
      1. chain a,c [42237]
  2. Escherichia coli, type IIB [TaxId: 562] [56403] (1)
    1. 1tii
      1. chain a,c [42238]
2. Diphtheria toxin, N-terminal domain [56404]
  1. Corynebacterium diphtheriae [TaxId: 1717] [56405] (7)
    1. 1f0l
      complexed with apu, cl
      1. region a:1-187 [42239]
      2. region b:1-187 [42240]
    2. 1ddt
      complexed with apu
      1. region a:1-187 [42241]
    3. 1sgk
      1. region a:1-187 [42242]
    4. 1mdt
      complexed with apu
      1. region a:1-187 [42243]
      2. region b:1-187 [42244]
    5. 1xdt
      1. region t:1-188 [42245]
    6. 1tox
      complexed with nad
      1. region a:1-187 [42246]
      2. region b:1-187 [42247]
    7. 1dtp
      one domain only
      complexed with apu
      1. chain a [42248]
3. Exotoxin A, C-terminal domain [56406]
  1. Pseudomonas aeruginosa [TaxId: 287] [56407] (21)
    1. 1ikp
      complexed with cl, na; mutant
      1. region a:395-606 [66183]
    2. 1ikq
      complexed with cl, na
      1. region a:395-606 [66186]
    3. 1xk9
      automatically matched to d1ikpa2
      complexed with p34
      1. region a:399-602 [122074]
    4. 1xk9
      automatically matched to d1ikpa2
      complexed with p34
      1. region b:399-602 [122075]
    5. 1aer
      complexed with amp, tad, tia
      1. chain a [42249]
      2. chain b [42250]
    6. 1dma
      complexed with amp, nca
      1. chain a [42251]
      2. chain b [42252]
    7. 2zit
      automatically matched to d1ikpa2
      complexed with dde, nad
      1. region b:400-605 [154481]
    8. 2zit
      automatically matched to d1ikpa2
      complexed with dde, nad
      1. region d:400-605 [154482]
    9. 2zit
      automatically matched to d1ikpa2
      complexed with dde, nad
      1. region f:400-605 [154483]
    10. 1zm9
      automatically matched to d1ikpa2
      complexed with dde, p34
      1. region b:399-602 [125341]
    11. 1zm9
      automatically matched to d1ikpa2
      complexed with dde, p34
      1. region d:399-602 [125347]
    12. 1zm9
      automatically matched to d1ikpa2
      complexed with dde, p34
      1. region f:399-602 [125353]
    13. 1zm4
      automatically matched to d1ikpa2
      complexed with dde, tad
      1. region b:399-602 [125321]
    14. 1zm4
      automatically matched to d1ikpa2
      complexed with dde, tad
      1. region d:399-602 [125327]
    15. 1zm4
      automatically matched to d1ikpa2
      complexed with dde, tad
      1. region f:399-602 [125333]
    16. 1zm3
      automatically matched to d1ikpa2
      complexed with dde
      1. region b:399-602 [125303]
    17. 1zm3
      automatically matched to d1ikpa2
      complexed with dde
      1. region d:399-602 [125309]
    18. 1zm3
      automatically matched to d1ikpa2
      complexed with dde
      1. region f:399-602 [125315]
    19. 1zm2
      automatically matched to d1ikpa2
      complexed with apr, dde
      1. region b:399-602 [125285]
    20. 1zm2
      automatically matched to d1ikpa2
      complexed with apr, dde
      1. region d:399-602 [125291]
    21. 1zm2
      automatically matched to d1ikpa2
      complexed with apr, dde
      1. region f:399-602 [125297]
4. Pertussis toxin, S1 subunit [56408]
  1. Bordetella pertussis [TaxId: 520] [56409] (3)
    1. 1prt
      1. chain a [42253]
      2. chain g [42254]
    2. 1bcp
      complexed with atp
      1. chain a [42255]
      2. chain g [42256]
    3. 1pto
      complexed with gal, sia
      1. chain a [42257]
      2. chain g [42258]
5. Cholera toxin [56410]
  1. Vibrio cholerae [TaxId: 666] [56411] (9)
    1. 1s5d
      complexed with gal, gol, na; mutant
      1. chain a [98541]
    2. 2a5d
      complexed with gol, gtp, mg, na; mutant
      1. region b:1-186 [144783]
    3. 1s5e
      complexed with gal, na
      1. chain a [98547]
      2. chain b [98548]
    4. 2a5f
      automatically matched to 2A5D B:1-186
      complexed with gol, gtp, mg, na, nad; mutant
      1. region b:3-186 [144784]
    5. 1s5b
      complexed with na; mutant
      1. chain a [98529]
    6. 2a5g
      automatically matched to 2A5D B:1-186
      complexed with gtp, mg, na; mutant
      1. region b:1-186 [144785]
    7. 1s5c
      complexed with na; mutant
      1. chain a [98535]
    8. 1s5f
      complexed with gal, na
      1. chain a [98559]
    9. 1xtc
      1. chain a,c [42259]
6. Vegetative insecticidal protein 2 (VIP2) [56412]
  duplication: consists of two domains of this fold, the second of which is catalytic
  1. Bacillus cereus [TaxId: 1396] [56413] (2)
    1. 1qs1
      1. region a:60-264 [42260]
      2. region a:265-461 [42261]
      3. region b:1060-1264 [42262]
      4. region b:1265-1461 [42263]
      5. region c:2060-2264 [42264]
      6. region c:2265-2461 [42265]
      7. region d:3060-3264 [42266]
      8. region d:3265-3461 [42267]
    2. 1qs2
      1. region a:62-264 [42268]
      2. region a:265-462 [42269]
7. Enzymatic component (Ia) of iota-toxin [82812]
  mammalian-targeted relative of VIP2; C-terminal domain is catalytic, N-terminal domain interacts with Ib (binding component)
  1. Clostridium perfringens [TaxId: 1502] [82813] (4)
    1. 1giq
      complexed with nad
      1. region a:3-209 [76224]
      2. region b:1003-1209 [76226]
      3. region a:210-413 [76225]
      4. region b:1210-1413 [76227]
    2. 1gir
      complexed with ndp
      1. region a:3-209 [76228]
      2. region a:210-413 [76229]
    3. 3buz
      automatically matched to d1giqa1
      complexed with atp, ca, lar, tad
      1. region a:3-209 [155656]
    4. 3buz
      automatically matched to d1giqa2
      complexed with atp, ca, lar, tad
      1. region a:210-413 [155657]
8. Exoenzyme c3 [56414]
  1. Clostridium botulinum [TaxId: 1491] [56415] (14)
    SQ P15879 41-251
    1. 2c8a
      automatically matched to d1g24a_
      complexed with nca, so4
      1. region a:45-251 [130099]
    2. 2c8a
      automatically matched to d1g24a_
      complexed with nca, so4
      1. region b:45-245 [130100]
    3. 2c8a
      automatically matched to d1g24a_
      complexed with nca, so4
      1. region c:45-251 [130101]
    4. 2c8a
      automatically matched to d1g24a_
      complexed with nca, so4
      1. region d:45-246 [130102]
    5. 2a9k
      automatically matched to d1g24a_
      complexed with gdp, mg, nad
      1. region b:45-251 [126443]
    6. 1g24
      1. chain a [42270]
      2. chain b [42271]
      3. chain c [42272]
      4. chain d [42273]
    7. 2a78
      automatically matched to d1g24a_
      complexed with gdp, mg
      1. region b:45-251 [126330]
    8. 2c89
      automatically matched to d1g24a_
      complexed with so4
      1. region a:45-244 [130095]
    9. 2c89
      automatically matched to d1g24a_
      complexed with so4
      1. region b:45-246 [130096]
    10. 2c89
      automatically matched to d1g24a_
      complexed with so4
      1. region c:45-251 [130097]
    11. 2c89
      automatically matched to d1g24a_
      complexed with so4
      1. region d:45-244 [130098]
    12. 1uzi
      complexed with gol, v4o, vo4
      1. chain a [108176]
      2. chain b [108177]
    13. 1gzf
      complexed with adp, nad, nir, so4
      1. chain a [76418]
      2. chain b [76419]
      3. chain c [76420]
      4. chain d [76421]
    14. 1gze
      complexed with hg; mutant
      1. chain a [76414]
      2. chain b [76415]
      3. chain c [76416]
      4. chain d [76417]
  2. Staphylococcus aureus [TaxId: 1280] [103338] (2)
    1. 1ojq
      1. chain a [93146]
    2. 1ojz
      complexed with nad
      1. chain a [93190]
  3. Clostridium botulinum C bacteriophage [TaxId: 12336] [118161] (2)
    SQ Q00901 44-244
    1. 1r45
      complexed with gol, so4
      1. chain a [111683]
      2. chain b [111684]
      3. chain c [111685]
      4. chain d [111686]
    2. 1r4b
      1. chain a [111687]
      2. chain b [111688]
9. Anthrax toxin lethal factor, middle domain [69845]
  includes an all-alpha insert subdomain
  1. Bacillus anthracis [TaxId: 1392] [69846] (10)
    1. 1j7n
      complexed with so4, zn
      1. region a:264-550 [66411]
      2. region b:264-550 [66414]
    2. 1yqy
      automatically matched to d1j7na3
      complexed with 915, zn
      1. region a:265-550 [123904]
    3. 1zxv
      automatically matched to d1j7na3
      complexed with mfm, zn
      1. region a:264-550 [125799]
    4. 1zxv
      automatically matched to d1j7na3
      complexed with mfm, zn
      1. region b:264-550 [125802]
    5. 1pwu
      complexed with small molecule inhibitor
      complexed with gm6, zn; mutant
      1. region a:264-550 [95246]
      2. region b:264-550 [95249]
    6. 1pwp
      complexed with small molecule inhibitor
      complexed with nsc, zn
      1. region a:264-550 [95234]
      2. region b:264-550 [95237]
    7. 1pwv
      complexed with an optimized peptide substrate (chains C and D) in the presence of zinc
      1. region a:264-550 [95252]
      2. region b:264-550 [95255]
    8. 1pww
      complexed with an optimized peptide substrate (chains C and D) in the presence of zinc
      complexed with zn; mutant
      1. region a:264-550 [95258]
      2. region b:264-550 [95261]
    9. 1pwq
      complexed with small molecule inhibitor
      complexed with sd2, zn
      1. region a:264-550 [95240]
      2. region b:264-550 [95243]
    10. 1jky
      1. region a:264-550 [66819]
Ecto-ART [82814] (1)
the two disulfide bridges and N-terminal alpha helices are characteristic for all ecto-ARTs
1. Eukaryotic mono-ADP-ribosyltransferase ART2.2 [82815]
  NAD glycohydrolase and auto-ADP-ribosylation activity
  1. Rat (Rattus norvegicus) [TaxId: 10116] [82816] (6)
    1. 1gxy
      complexed with gol
      1. chain a [76380]
      2. chain b [76381]
    2. 1og1
      complexed with tad
      1. chain a [92862]
    3. 1gxz
      complexed with brt
      1. chain a [76382]
      2. chain b [76383]
    4. 1gy0
      1. chain a [76384]
    5. 1og4
      complexed with nai; mutant
      1. chain a [92864]
    6. 1og3
      complexed with nad; mutant
      1. chain a [92863]
Poly(ADP-ribose) polymerase, C-terminal domain [56416] (3)
1. Poly(ADP-ribose) polymerase, C-terminal domain [56417]
  1. Chicken (Gallus gallus) [TaxId: 9031] [56418] (7)
    1. 1efy
      complexed with bzc
      1. region a:797-1011 [42275]
    2. 1a26
      complexed with cna
      1. region a:797-1012 [42274]
    3. 2paw
      1. region a:797-1009 [42279]
    4. 2pax
      complexed with 4an
      1. region a:797-1011 [42276]
    5. 3pax
      complexed with 3mb
      1. region a:797-1011 [42277]
    6. 1pax
      complexed with dhq
      1. region a:797-1011 [42278]
    7. 4pax
      complexed with nu1
      1. region a:797-1011 [42280]
  2. Mouse (Mus musculus) [TaxId: 10090] [82817] (1)
    1. 1gs0
      1. region a:341-557 [76324]
      2. region b:341-557 [76326]
  3. Human (Homo sapiens) [TaxId: 9606] [103339] (8)
    SQ P09874 661-1010
    1. 2rd6
      automatically matched to d1uk0a2
      complexed with 78p
      1. region a:138-350 [151921]
    2. 2rcw
      automatically matched to d1uk0a2
      complexed with aai
      1. region a:138-350 [151912]
    3. 1wok
      automatically matched to d1uk0a2
      complexed with cnq
      1. region a:799-1011 [121117]
    4. 1wok
      automatically matched to d1uk0a2
      complexed with cnq
      1. region b:799-1011 [121119]
    5. 1wok
      automatically matched to d1uk0a2
      complexed with cnq
      1. region c:799-1011 [121121]
    6. 1wok
      automatically matched to d1uk0a2
      complexed with cnq
      1. region d:799-1011 [121123]
    7. 1uk1
      complexed with frq
      1. region a:799-1011 [107902]
      2. region b:799-1011 [107904]
    8. 1uk0
      complexed with frm
      1. region a:138-350 [99478]
      2. region b:138-350 [99480]
AvrPphF ORF2, a type III effector [111257] (1)
shares the common structural core with other families; unknown function
1. AvrPphF ORF2, a type III effector [111258]
  1. Pseudomonas syringae pv. phaseolicola [TaxId: 319] [111259] (1)
    SQ Q9K2L5 29-204
    1. 1s21
      mutant
      1. chain a [105222]
Tpt1/KptA [118162] (1)
Pfam 01885; contains extra N-terminal domain similar to the "winged helix" DNA-binding domain (scop_sf 46785)
1. Probable RNA 2'-phosphotransferase KptA [118163]
  1. Aeropyrum pernix [TaxId: 56636] [118164] (1)
    SQ Q9YFP5 37-216; d1: (1-76); d2: (88-182)
    1. 1wfx
      Structural genomics target
      complexed with cl, zn
      1. chain a [114596]
BC2332-like [143947] (1)
minimized common structural core with two large, mainly helical insertions on one side forming dimerization "domain"
1. Hypothetical protein BC2332 [143948]
  1. Bacillus cereus [TaxId: 1396] [143949] (2)
    SQ Q81DM5 2-195
    1. 2aua
      1. region a:2-195 [127326]
    2. 2aua
      automatically matched to 2AUA A:2-195
      1. region b:2-195 [127327]
CC0527-like [143950] (1)
Pfam 06108; DUF952
1. Hypothetical protein CC0527 [143951]
  1. Caulobacter crescentus [TaxId: 155892] [143952] (3)
    SQ Q9AAR9 2-114
    1. 2o0q
      1. region a:2-114 [138867]
    2. 2o0p
      mutant
      1. region a:2-114 [138866]
    3. 2jqn
      automatically matched to d2o0qa1
      1. region a:2-114 [148180]